Cabaletta Bio (CABA) Operating Income (2018 - 2025)

Cabaletta Bio (CABA) recorded quarterly Operating Income of -$42.6 million in Q4 2025, up 8.54% quarter-over-quarter from -$46.6 million in Q3 2025, and down 26.12% on a YoY basis from -$57.7 million in Q4 2024.

Cabaletta Bio (CABA) Operating Income (2018 - 2025) Analysis & Trends

Cabaletta Bio's Operating Income history runs 8 years deep, the most recent figure standing at -$42.6 million for Q4 2025.

  • In Q4 2025, Operating Income fell 26.12% year-over-year to -$42.6 million; the TTM figure through Dec 2025 stood at -$172.2 million (down 37.64% YoY), while the FY2025 annual figure was -$172.2 million, down 37.64% from the prior year.
  • Operating Income was -$42.6 million for Q4 2025 at Cabaletta Bio, up from -$46.6 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of -$9.7 million in Q1 2021 to a low of -$46.6 million in Q3 2025.
  • Historically, Operating Income has averaged -$23.6 million across 5 years, with a median of -$17.8 million in 2023.
  • The sharpest annual moves came in 2022 and 2024: Operating Income retreated 1.86% in 2022, then plunged 90.55% in 2024.
  • A 5-year view of Operating Income shows it stood at -$13.9 million in 2021, then fell by 17.34% to -$16.3 million in 2022, then slumped by 41.98% to -$23.1 million in 2023, then plunged by 45.96% to -$33.8 million in 2024, then declined by 26.12% to -$42.6 million in 2025.
  • The last three Operating Income figures came in at -$42.6 million (Q4 2025), -$46.6 million (Q3 2025), and -$45.9 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -19.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.14 Bn
9 Abivax 91.96 Bn 91.96 Bn - -65.83 Mn
10 Cabaletta Bio 151.84 Mn 18.24 Mn - -42.61 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -42.61 Mn
Sep 30, 2025 -46.59 Mn
Jun 30, 2025 -45.91 Mn
Mar 31, 2025 -37.14 Mn
Dec 31, 2024 -33.79 Mn
Sep 30, 2024 -33.05 Mn
Jun 30, 2024 -30.28 Mn
Mar 31, 2024 -28.03 Mn
Dec 31, 2023 -23.15 Mn
Sep 30, 2023 -18.67 Mn
Jun 30, 2023 -15.89 Mn
Mar 31, 2023 -16.96 Mn
Dec 31, 2022 -16.30 Mn
Sep 30, 2022 -11.78 Mn
Jun 30, 2022 -13.06 Mn
Mar 31, 2022 -13.00 Mn
Dec 31, 2021 -13.89 Mn
Sep 30, 2021 -11.56 Mn
Jun 30, 2021 -11.15 Mn
Mar 31, 2021 -9.71 Mn