BioNTech SE (BNTX) Operating Income (2018 - 2025)

BioNTech SE (BNTX) reported Operating Income of -$375.8 million for Q4 2025, down 336.63% on a YoY basis from $158.8 million in Q4 2024, and down 585.32% sequentially from -$54.8 million in Q3 2025.

BioNTech SE (BNTX) Operating Income (2018 - 2025) Analysis & Trends

BioNTech SE (BNTX) has 8 years of Operating Income data on file, last reported at -$375.8 million in Q4 2025.

  • For the quarter ending Q4 2025, Operating Income fell 336.63% year-over-year to -$375.8 million; the trailing twelve-month figure through Dec 2025 stood at -$1.6 billion (down 9.74% YoY), and the FY2025 full-year result was -$1.6 billion, down 13.02% from the prior year.
  • Operating Income declined to -$375.8 million in Q4 2025, from -$54.8 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of $6.1 billion in Q1 2022 to a low of -$1.0 billion in Q2 2024.
  • A 5-year average of $1.7 billion and a median of $362.5 million in 2024 frame the typical range for Operating Income.
  • Across the five-year window, Operating Income jumped 5574.02% in 2021 and sank 575.48% in 2025, its largest moves.
  • Tracing BNTX's Operating Income over 5 years: stood at $5.4 billion in 2021, then sank by 37.51% to $3.4 billion in 2022, then plunged by 83.15% to $566.2 million in 2023, then tumbled by 71.95% to $158.8 million in 2024, then plunged by 336.63% to -$375.8 million in 2025.
  • Business Quant data shows BNTX's Operating Income at -$375.8 million in Q4 2025, -$54.8 million in Q3 2025, and -$567.2 million in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -27.75 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 249.90 Mn
4 NuCana 279.75 Bn 279.75 Bn - -3.72 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -32.68 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 493.00 Mn
9 Revolution Medicines 37.78 Bn 37.78 Bn - -445.22 Mn
10 BioNTech SE 22.13 Bn 22.13 Bn 668.28 Mn -375.75 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -375.75 Mn
Sep 30, 2025 -54.83 Mn
Jun 30, 2025 -567.22 Mn
Mar 31, 2025 -561.81 Mn
Dec 31, 2024 158.79 Mn
Sep 30, 2024 11.53 Mn
Jun 30, 2024 -1.04 Bn
Mar 31, 2024 -551.00 Mn
Dec 31, 2023 566.16 Mn
Sep 30, 2023 79.58 Mn
Jun 30, 2023 -613.39 Mn
Mar 31, 2023 702.39 Mn
Dec 31, 2022 3.36 Bn
Sep 30, 2022 3.22 Bn
Jun 30, 2022 5.07 Bn
Mar 31, 2022 6.12 Bn
Dec 31, 2021 5.38 Bn
Sep 30, 2021 5.57 Bn
Jun 30, 2021 5.06 Bn
Mar 31, 2021 2.01 Bn