BioNTech SE (BNTX) Operating Income (2018 - 2025)

BioNTech SE's (BNTX) quarterly Operating Income came in at -$375.8 million in Q4 2025, down 336.63% year-on-year from $158.8 million in Q4 2024, and down 585.32% quarter-over-quarter from -$54.8 million in Q3 2025.

BioNTech SE (BNTX) Operating Income (2018 - 2025) Analysis & Trends

BioNTech SE has disclosed Operating Income across 8 years of filings, most recently posting -$375.8 million for Q4 2025.

  • Operating Income for Q4 2025 came in at -$375.8 million, down 336.63% year-over-year; the trailing twelve-month figure through Dec 2025 was -$1.6 billion (down 9.74% YoY), and the FY2025 annual result was -$1.6 billion, down 13.02% from the prior year.
  • Operating Income came in at -$375.8 million for Q4 2025 at BioNTech SE, down from -$54.8 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of $5.6 billion in Q3 2021 to a low of -$1.0 billion in Q2 2024.
  • The 5-year median for Operating Income is $362.5 million (2024), against an average of $1.5 billion.
  • Across the five-year window, Operating Income jumped 5574.02% in 2021 and tumbled 575.48% in 2025, its largest moves.
  • BioNTech SE's Operating Income stood at $5.4 billion in 2021, then plunged by 37.51% to $3.4 billion in 2022, then tumbled by 83.15% to $566.2 million in 2023, then slumped by 71.95% to $158.8 million in 2024, then tumbled by 336.63% to -$375.8 million in 2025.
  • The last three Operating Income figures came in at -$375.8 million (Q4 2025), -$54.8 million (Q3 2025), and -$567.2 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -19.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.14 Bn
9 Abivax 91.96 Bn 91.96 Bn - -65.83 Mn
10 BioNTech SE 27.38 Bn 10.07 Bn 668.28 Mn -375.75 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -375.75 Mn
Sep 30, 2025 -54.83 Mn
Jun 30, 2025 -567.22 Mn
Mar 31, 2025 -561.81 Mn
Dec 31, 2024 158.79 Mn
Sep 30, 2024 11.53 Mn
Jun 30, 2024 -1.04 Bn
Mar 31, 2024 -551.00 Mn
Dec 31, 2023 566.16 Mn
Sep 30, 2023 79.58 Mn
Jun 30, 2023 -613.39 Mn
Mar 31, 2023 702.39 Mn
Dec 31, 2022 3.36 Bn
Sep 30, 2022 2.41 Bn
Jun 30, 2022 2.36 Bn
Mar 31, 2022 5.33 Bn
Dec 31, 2021 5.38 Bn
Sep 30, 2021 5.57 Bn
Jun 30, 2021 5.06 Bn
Mar 31, 2021 2.01 Bn