Autolus Therapeutics (AUTL) Operating Income (2018 - 2025)

Autolus Therapeutics posted quarterly Operating Income of -$72.5 million for Q4 2025, up 4.48% year-on-year from -$69.4 million in Q4 2024, and down 1.18% on a QoQ basis from -$71.6 million in Q3 2025.

Autolus Therapeutics (AUTL) has 5 years of Operating Income data on file, last reported at -$72.5 million in Q4 2025.

  • For the quarter ending Q4 2025, Operating Income rose 4.48% year-over-year to -$72.5 million; the trailing twelve-month figure through Dec 2025 stood at -$270.5 million (down 12.06% YoY), and the FY2025 full-year result was -$270.5 million, down 12.06% from the prior year.
  • Operating Income for Q4 2025 stood at -$72.5 million, down from -$71.6 million in the prior quarter.
  • Across five years, Operating Income topped out at -$11.6 million in Q4 2022 and bottomed at -$75.9 million in Q4 2024.
  • The 4-year median for Operating Income is -$48.8 million (2023), against an average of -$51.0 million.
  • The widest annual swing landed in 2023, when Operating Income plunged 357.26%; it then advanced 4.48% in 2025.
  • A 4-year view of Operating Income shows it stood at -$11.6 million in 2022, then sank by 357.26% to -$53.3 million in 2023, then plunged by 42.41% to -$75.9 million in 2024, then rose by 4.48% to -$72.5 million in 2025.
  • The last three Operating Income figures came in at -$72.5 million (Q4 2025), -$71.6 million (Q3 2025), and -$61.2 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Quantum Biopharma 1,384,976.65 Bn 1,384,976.64 Bn - -2.97 Mn
2 Alterity Therapeutics 777,208.84 Bn 777,208.81 Bn - -
3 Legend Biotech 2,801.00 Bn 2,800.10 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,226.01 Bn 2,225.95 Bn - -
5 Akari Therapeutics 605.66 Bn 605.66 Bn - -15.76 Mn
6 Vertex Pharmaceuticals 110.17 Bn 102.92 Bn 2.59 Bn 1.14 Bn
7 Regeneron Pharmaceuticals 66.86 Bn 58.11 Bn 3.31 Bn 642.90 Mn
8 Evaxion A 65.12 Bn 65.10 Bn - -3.82 Mn
9 Alnylam Pharmaceuticals 39.94 Bn 36.94 Bn 959.66 Mn 268.64 Mn
10 Autolus Therapeutics - - -1.04 Mn -72.47 Mn

Historic Data

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DateValue
Dec 31, 2025 -72.47 Mn
Sep 30, 2025 -71.62 Mn
Jun 30, 2025 -61.22 Mn
Mar 31, 2025 -65.24 Mn
Dec 31, 2024 -75.86 Mn
Sep 30, 2024 -67.88 Mn
Jun 30, 2024 -58.93 Mn
Mar 31, 2024 -38.76 Mn
Dec 31, 2023 -53.27 Mn
Sep 30, 2023 -42.91 Mn
Jun 30, 2023 -44.38 Mn
Mar 31, 2023 -39.15 Mn
Dec 31, 2022 -11.65 Mn
Sep 30, 2022 -37.35 Mn
Jun 30, 2022 -39.06 Mn
Mar 31, 2022 -36.19 Mn
Sep 30, 2018 -57.53 Mn