Autolus Therapeutics (AUTL) EBITDA (2017 - 2025)

Autolus Therapeutics posted quarterly EBITDA of -$90.8 million for Q4 2025, down 62.43% year-on-year from -$241.6 million in Q4 2024, and down 6.91% on a QoQ basis from -$84.9 million in Q3 2025.

Autolus Therapeutics (AUTL) has 9 years of EBITDA data on file, last reported at -$90.8 million in Q4 2025.

  • For the quarter ending Q4 2025, EBITDA fell 62.43% year-over-year to -$90.8 million; the trailing twelve-month figure through Dec 2025 stood at -$263.7 million (down 19.41% YoY), and the FY2025 full-year result was -$263.7 million, down 19.41% from the prior year.
  • EBITDA for Q4 2025 stood at -$90.8 million, down from -$84.9 million in the prior quarter.
  • Across five years, EBITDA topped out at $40.5 million in Q3 2021 and bottomed at -$248.9 million in Q4 2021.
  • The 5-year median for EBITDA is -$53.9 million (2024), against an average of -$50.4 million.
  • The widest annual swing landed in 2022, when EBITDA surged 92.65%; it then sank 295.78% in 2023.
  • A 5-year view of EBITDA shows it stood at -$248.9 million in 2021, then soared by 92.65% to -$18.3 million in 2022, then tumbled by 295.78% to -$72.4 million in 2023, then rose by 22.78% to -$55.9 million in 2024, then slumped by 62.43% to -$90.8 million in 2025.
  • The last three EBITDA figures came in at -$90.8 million (Q4 2025), -$84.9 million (Q3 2025), and -$28.9 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Quantum Biopharma 1,384,976.65 Bn 1,384,976.64 Bn - -13.63 Mn
2 Alterity Therapeutics 777,208.84 Bn 777,208.81 Bn - -
3 Legend Biotech 2,801.00 Bn 2,800.10 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,226.01 Bn 2,225.95 Bn - -
5 Akari Therapeutics 605.66 Bn 605.66 Bn - -14.44 Mn
6 Vertex Pharmaceuticals 110.17 Bn 102.92 Bn 2.59 Bn 1.14 Bn
7 Regeneron Pharmaceuticals 66.86 Bn 58.11 Bn 3.31 Bn 661.60 Mn
8 Evaxion A 65.12 Bn 65.10 Bn - -3.82 Mn
9 Alnylam Pharmaceuticals 39.94 Bn 36.94 Bn 959.66 Mn 201.19 Mn
10 Autolus Therapeutics - - -1.04 Mn -90.77 Mn

Historic Data

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DateValue
Dec 31, 2025 -90.77 Mn
Sep 30, 2025 -84.90 Mn
Jun 30, 2025 -28.95 Mn
Mar 31, 2025 -59.09 Mn
Dec 31, 2024 -55.88 Mn
Sep 30, 2024 -55.08 Mn
Jun 30, 2024 -57.25 Mn
Mar 31, 2024 -52.63 Mn
Dec 31, 2023 -72.37 Mn
Sep 30, 2023 -51.69 Mn
Jun 30, 2023 -40.25 Mn
Mar 31, 2023 -34.17 Mn
Dec 31, 2022 -18.29 Mn
Sep 30, 2022 -56.82 Mn
Jun 30, 2022 -59.54 Mn
Mar 31, 2022 -44.52 Mn
Dec 31, 2021 -248.88 Mn
Sep 30, 2021 40.45 Mn
Jun 30, 2021 31.63 Mn
Mar 31, 2021 31.99 Mn
Dec 31, 2020 -247.10 Mn
Sep 30, 2020 26.40 Mn
Jun 30, 2020 33.86 Mn
Mar 31, 2020 47.57 Mn
Jun 30, 2019 37.35 Mn
Mar 31, 2019 22.13 Mn
Sep 30, 2018 13.83 Mn
Jun 30, 2018 18.86 Mn
Mar 31, 2018 -18.18 Mn
Dec 31, 2017 -8.92 Mn