VCEL vs SRPT vs CRSP Stock Comparison

Vericel, Sarepta Therapeutics and CRISPR Therapeutics AG Prices as of Nov 2, 2026 Peers: Industry group
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VCEL Vericel Corp
$40.51 +0.9% 1M +15.5% 1Y
Market cap
$2.30B
P/E
94.8x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins
CRSP CRISPR Therapeutics AG
$49.99 -9.8% 1M -21.9% 1Y
Market cap
$5.06B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

10 decided of 12

Vericel leads on 6 of the 12 questions below (Vericel 6, Sarepta Therapeutics 3, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionVCELSRPTCRSPLeader
Larger companyMarket capitalisation $2.30B $2.01B $5.06B CRSP
Cheaper on earningsLower P/E, profitable companies only 94.8x -17.2x -11.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 80.6x 6.4x — SRPT
Faster revenue growthRevenue growth, trailing twelve months +23.0% -20.4% -64.8% VCEL
More profitableNet margin, trailing twelve months 7.9% -5.9% -3,368.7% VCEL
Better return on capitalReturn on invested capital — -6.1% -22.6% SRPT
Less leveragedLower net debt / EBITDA — -0.6x 3.4x SRPT
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +15.5% -23.7% -21.9% VCEL
Better 5-year returnAnnualised price return, 5 years -4.1%/yr -26.7%/yr -12.4%/yr VCEL
Less volatileAnnualised volatility, 1 year 41.3% 81.2% 57.5% VCEL
Higher overall scoreMean of the five percentile scores vs peers 81/100 67/100 44/100 VCEL

Percentile Scorecard

VCELSRPTCRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisVCELSRPTCRSP
Valuation 82 #115 of 623 96 #24 of 623 49 #317 of 623
Growth 94 #36 of 601 64 #219 of 601 32 #410 of 601
Profitability 88 #65 of 553 79 #116 of 553 32 #377 of 553
Financial Health 68 #208 of 654 34 #431 of 654 71 #190 of 654
Shareholder Returns 72 #103 of 367 61 #144 of 367 37 #230 of 367
Overall 81 67 44
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodVCELSRPTCRSPSPY
1 month +0.9%+4.7%-9.8% -2.3%
3 months -12.0%+15.4%+0.8% -0.7%
6 months +11.0%-16.9%-6.7% +4.8%
Year to date +12.5%-14.9%-4.7% +10.3%
1 year +15.5%-23.7%-21.9% +10.3%
3 years +9.9%-76.5%-2.0% +73.0%
3 years, per year +3.2%-38.3%-0.7% +20.1%
5 years -19.0%-78.8%-48.4% +61.9%
5 years, per year -4.1%-26.7%-12.4% +10.1%
10 years +1,741.4%-51.0%+225.6% +258.6%
10 years, per year +33.8%-6.9%+12.5% +13.6%

Risk

MeasureVCELSRPTCRSPSPY
Volatility, 1Y 41.3%81.2%57.5% 12.8%
Downside volatility, 1Y 41.1%85.6%54.4% 12.8%
Beta vs S&P 500, 1Y 0.762.081.88 1.00
Return / volatility, 1Y 0.38-0.29-0.38 0.80
Max drawdown, 5Y -64.7%-92.7%-67.7% -25.4%
From 52-week high -16.1%-25.1%-19.3% -3.5%
52-week high $48.31$24.45$61.97 $779.14
52-week low $29.34$14.86$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleVCELSRPTCRSP
P/E now vs peer median 85.4xmedian 17.4x -16.5xmedian 17.4x -10.7xmedian 17.4x
P/S now vs peer median 6.8xmedian 8.9x 1.0xmedian 8.9x 360.8xmedian 8.9x
EV/EBITDA now vs peer median 60.9xmedian 17.0x -20.2xmedian 17.0x -5.9xmedian 17.0x
P/FCF now vs peer median 33.6xmedian 21.4x 23.6xmedian 21.4x -13.0xmedian 21.4x
P/B now vs peer median 5.6xmedian 2.1x 1.3xmedian 2.1x 2.8xmedian 2.1x
PEG now vs peer median 1.57median 0.35 -0.32median 0.35 -2.78median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsVCELSRPTCRSP
Revenue $306.30M $1.97B $25.17M
Gross profit $228.38M $1.17B –
Operating income $18.24M -$143.25M -$532.33M
Net income $24.22M -$136.73M -$456.14M
Free cash flow $61.66M $81.85M -$376.72M
R&D $29.17M $789.44M $291.14M
EPS (diluted) $0.46 $-1.11 $-4.72
Cash & equivalents $125.40M $571.15M $192.03M
Total debt – $847.62M $586.93M
Shares (diluted) 52.31M 105.43M 96.74M
Enterprise value $1.72B -$1.23B -$3.99B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricVCELSRPTCRSP
P/E 85.4x -16.5x -10.7x
P/FCF 33.6x 23.6x -13.0x
P/Operating cash flow 29.8x 17.4x -13.1x
P/S 6.8x 1.0x 360.8x
P/B 5.6x 1.3x 2.8x
P/Tangible book 5.7x 1.3x 2.8x
EV/EBITDA 60.9x -20.2x -5.9x
EV/EBIT 104.8x -13.9x -5.7x
EV/Revenue 6.2x 1.0x 228.0x
EV/FCF 31.0x 24.4x -8.2x
EV/Operating cash flow 27.4x 18.0x -8.3x
PEG (3Y EPS CAGR) 1.57 -0.32 -2.78

Growth

14 metrics
MetricVCELSRPTCRSP
Revenue growth (1Y) 23.0% -20.4% -64.8%
Revenue CAGR (3Y) 19.8% 25.3% -57.1%
Gross profit growth (1Y) 24.8% -40.7% –
Gross profit CAGR (3Y) 23.9% 10.6% –
Operating income growth (1Y) 1,428% -15,270% 3.3%
Operating income CAGR (3Y) 47.8% 34.5% -4.1%
Net income growth (1Y) 240.8% -135.9% 3.6%
Net income CAGR (3Y) 56.6% 46.8% -2.7%
EPS growth (1Y) 228.1% -215.7% 13.0%
EPS CAGR (3Y) 54.3% 52.3% 3.9%
Operating cash flow growth (1Y) 47.5% 136.9% -13.8%
Operating cash flow CAGR (3Y) 33.7% 30.6% -2.5%
Free cash flow growth (1Y) 842.9% 118.1% -14.1%
Free cash flow CAGR (3Y) 43.2% 29.1% -0.9%

Profitability

14 metrics
MetricVCELSRPTCRSP
Gross margin 74.6% 59.1% –
EBITDA margin 10.2% -5.0% -3,850%
Operating margin 6.0% -7.3% -3,990%
Pretax margin 8.2% -6.6% -3,346%
Net margin 7.9% -5.9% -3,369%
FCF margin 20.1% 4.1% -2,773%
Operating cash flow margin 22.7% 5.6% -2,760%
Return on equity 6.9% -9.0% -25.3%
Return on assets 5.1% -4.3% -16.8%
Return on invested capital – -6.1% -22.6%
Return on capital employed 4.1% -5.3% -20.9%
Asset turnover 0.6x 0.6x 0.0x
Cash conversion (OCF / net income) 2.9x -0.8x 0.8x
Stock comp / revenue 12.2% 6.3% 510.2%

Financial Health

11 metrics
MetricVCELSRPTCRSP
Debt / assets – 26.6% 22.1%
Debt / equity – 0.6x 0.3x
Net debt / EBITDA – -0.6x 3.4x
Debt / FCF – 10.4x -1.6x
Liabilities / assets 26.4% 52.1% 34.1%
Equity / assets 73.6% 47.9% 65.9%
Interest coverage 28.5x – –
Current ratio 5.0x 4.4x 17.8x
Quick ratio 4.5x 2.4x 17.8x
Cash ratio 3.1x 1.6x 17.8x
Altman Z-score 9.54 -0.18 2.42

Shareholder Returns

7 metrics
MetricVCELSRPTCRSP
Dividend yield – – –
Net buyback yield -0.3% -1.1% -8.8%
Shareholder yield -0.3% -1.1% -8.8%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusVCELSRPTCRSP
Forward P/E 80.6xFY2026 6.4xFY2026 –
EPS, next fiscal year $0.51FY2026 $2.88FY2026 $-4.10FY2026
EPS growth, next FY +59.4%FY2026 – –
EPS growth, the year after +74.5% -88.5% –
Revenue, next fiscal year $324.56MFY2026 $1.76BFY2026 $38.73MFY2026
Revenue growth, next FY +17.5%FY2026 -20.1%FY2026 +1,003.4%FY2026
Revenue growth, the year after +16.1% -21.5% +266.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersVCELSRPTCRSP
Held by institutions 100.0% 100.0% 78.9%
Institutions holding 319 326 520
Change in shares held, QoQ +0.4% +4.5% -1.0%
Institutions buying 188 148 238
Institutions selling 99 117 139
Buyers to sellers 1.90 1.26 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

VCELSRPTCRSP
VCEL 1.00 0.20 0.35
SRPT 0.20 1.00 0.36
CRSP 0.35 0.36 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, VCEL, SRPT and CRSP?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Vericel (VCEL) $2.30B, Sarepta Therapeutics (SRPT) $2.01B, CRISPR Therapeutics AG (CRSP) $5.06B.

Which company is growing faster?

Vericel (VCEL) grew revenue fastest over the trailing twelve months: Vericel (VCEL) +23.0%, Sarepta Therapeutics (SRPT) -20.4%, CRISPR Therapeutics AG (CRSP) -64.8%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Vericel (VCEL) 7.9%, Sarepta Therapeutics (SRPT) -5.9%, CRISPR Therapeutics AG (CRSP) -3,368.7%). On return on invested capital, Sarepta Therapeutics (SRPT) leads (Sarepta Therapeutics (SRPT) -6.1%, CRISPR Therapeutics AG (CRSP) -22.6%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: Vericel (VCEL) +15.5%, Sarepta Therapeutics (SRPT) -23.7%, CRISPR Therapeutics AG (CRSP) -21.9%. Over five years, Vericel (VCEL) compounded fastest (Vericel (VCEL) -4.1%/yr, Sarepta Therapeutics (SRPT) -26.7%/yr, CRISPR Therapeutics AG (CRSP) -12.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Vericel (VCEL) 41.3%, Sarepta Therapeutics (SRPT) 81.2%, CRISPR Therapeutics AG (CRSP) 57.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, VCEL, SRPT and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.