VCEL vs LEGN vs MESO Stock Comparison

Vericel, Legend Biotech and Mesoblast Prices as of Oct 27, 2026 Peers: Industry group
VCEL Vericel Corp
$43.27 +9.0% 1M +18.6% 1Y
Market cap
$2.17B
P/E
89.7x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
LEGN Legend Biotech Corp
$21.56 +12.8% 1M -32.9% 1Y
Market cap
$4.19B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
MESO Mesoblast Ltd
$13.18 -12.8% 1M -21.1% 1Y
Market cap
$1.72B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

7 decided of 12

Vericel leads on 4 of the 12 questions below (Vericel 4, Legend Biotech 2, Mesoblast 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionVCELLEGNMESOLeader
Larger companyMarket capitalisation $2.17B $4.19B $1.72B LEGN
Cheaper on earningsLower P/E, profitable companies only 89.7x -45.7x -29.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 84.8x — — –
Faster revenue growthRevenue growth, trailing twelve months +23.0% +59.5% — LEGN
More profitableNet margin, trailing twelve months 7.9% -7.2% — VCEL
Better return on capitalReturn on invested capital — -4.2% — –
Less leveragedLower net debt / EBITDA — 28.0x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +18.6% -32.9% -21.1% VCEL
Better 5-year returnAnnualised price return, 5 years -3.3%/yr -15.9%/yr +1.9%/yr MESO
Less volatileAnnualised volatility, 1 year 40.8% 72.2% 54.8% VCEL
Higher overall scoreMean of the five percentile scores vs peers 81/100 72/100 — VCEL

Percentile Scorecard

VCELLEGNMESO

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisVCELLEGNMESO
Valuation 82 #116 of 625 89 #70 of 625 70 #189 of 625
Growth 94 #38 of 602 96 #23 of 602 –
Profitability 88 #66 of 551 80 #112 of 551 –
Financial Health 69 #207 of 656 54 #305 of 656 44 #365 of 656
Shareholder Returns 73 #99 of 365 43 #209 of 365 –
Overall 81 72 –
  • VCEL ranked among 672 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • MESO ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodVCELLEGNMESOSPY
1 month +9.0%+12.8%-12.8% -0.2%
3 months -7.4%+13.2%-8.8% +3.9%
6 months +21.4%-8.5%-13.4% +8.2%
Year to date +20.2%-0.8%-26.9% +12.9%
1 year +18.6%-32.9%-21.1% +12.3%
3 years +31.8%-66.1%+463.2% +87.4%
3 years, per year +9.7%-30.3%+78.0% +23.3%
5 years -15.3%-57.9%+9.7% +67.9%
5 years, per year -3.3%-15.9%+1.9% +10.9%
10 years +1,781.3%—+56.2% +261.1%
10 years, per year +34.1%—+4.6% +13.7%

Risk

MeasureVCELLEGNMESOSPY
Volatility, 1Y 40.8%72.2%54.8% 12.7%
Downside volatility, 1Y 40.1%62.7%54.9% 12.7%
Beta vs S&P 500, 1Y 0.740.431.52 1.00
Return / volatility, 1Y 0.46-0.46-0.39 0.97
Max drawdown, 5Y -65.4%-78.2%-87.9% -25.4%
From 52-week high -10.4%-40.6%-37.1% -1.2%
52-week high $48.31$36.28$20.96 $779.14
52-week low $29.34$16.65$11.95 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleVCELLEGNMESO
P/E now vs peer median 91.2xmedian 17.2x -43.3xmedian 17.2x -29.7xmedian 17.2x
P/S now vs peer median 7.2xmedian 9.0x 3.1xmedian 9.0x 14.2xmedian 9.0x
EV/EBITDA now vs peer median 65.4xmedian 16.3x -187.6xmedian 16.3x —median 16.3x
P/FCF now vs peer median 35.9xmedian 18.7x -61.5xmedian 18.7x -38.2xmedian 18.7x
P/B now vs peer median 6.0xmedian 2.2x 3.2xmedian 2.2x 3.0xmedian 2.2x
PEG now vs peer median 1.68median 0.33 -0.92median 0.33 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsVCELLEGNMESO
Revenue $306.30M $1.27B –
Gross profit $228.38M $727.10M –
Operating income $18.24M -$55.25M –
Net income $24.22M -$80.39M –
Free cash flow $61.66M -$64.60M –
R&D $29.17M $396.15M –
EPS (diluted) $0.46 $-0.50 –
Cash & equivalents $125.40M $672.90M $102.91M
Total debt – $1.06B $119.24M
Shares (diluted) 52.31M 184.32M 129.49M
Enterprise value $1.59B $1.69B $1.29B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricVCELLEGNMESO
P/E 91.2x -43.3x -29.7x
P/FCF 35.9x -61.5x -38.2x
P/Operating cash flow 31.8x -44.5x –
P/S 7.2x 3.1x 14.2x
P/B 6.0x 3.2x 3.0x
P/Tangible book 6.1x 3.2x 3.0x
EV/EBITDA 65.4x -187.6x –
EV/EBIT 112.5x -62.6x –
EV/Revenue 6.7x 2.7x –
EV/FCF 33.3x -53.5x –
EV/Operating cash flow 29.4x -38.7x –
PEG (3Y EPS CAGR) 1.68 -0.92 –

Growth

14 metrics
MetricVCELLEGNMESO
Revenue growth (1Y) 23.0% 59.5% –
Revenue CAGR (3Y) 19.8% 97.6% –
Gross profit growth (1Y) 24.8% 42.4% –
Gross profit CAGR (3Y) 23.9% 147.5% –
Operating income growth (1Y) 1,428% 75.3% –
Operating income CAGR (3Y) 47.8% 49.1% –
Net income growth (1Y) 240.8% 75.3% –
Net income CAGR (3Y) 56.6% 46.7% –
EPS growth (1Y) 228.1% 72.0% –
EPS CAGR (3Y) 54.3% 47.0% –
Operating cash flow growth (1Y) 47.5% 67.5% –
Operating cash flow CAGR (3Y) 33.7% 37.1% –
Free cash flow growth (1Y) 842.9% 77.8% –
Free cash flow CAGR (3Y) 43.2% 44.5% –

Profitability

14 metrics
MetricVCELLEGNMESO
Gross margin 74.6% 57.2% –
EBITDA margin 10.2% -1.5% –
Operating margin 6.0% -4.3% –
Pretax margin 8.2% -4.4% –
Net margin 7.9% -7.2% –
FCF margin 20.1% -5.1% –
Operating cash flow margin 22.7% -7.0% –
Return on equity 6.9% -8.3% –
Return on assets 5.1% -5.5% –
Return on invested capital – -4.2% –
Return on capital employed 4.1% -4.3% –
Asset turnover 0.6x 0.8x –
Cash conversion (OCF / net income) 2.9x 1.1x –
Stock comp / revenue 12.2% 5.2% –

Financial Health

11 metrics
MetricVCELLEGNMESO
Debt / assets – 8.9% 15.4%
Debt / equity – 0.1x 0.2x
Net debt / EBITDA – 28.0x –
Debt / FCF – -2.4x –
Liabilities / assets 26.4% 29.8% 26.5%
Equity / assets 73.6% 70.2% 73.5%
Interest coverage 28.5x -4.8x –
Current ratio 5.0x 3.0x 2.4x
Quick ratio 4.5x 1.7x 2.0x
Cash ratio 3.1x 1.7x 1.3x
Altman Z-score 10.18 6.74 –

Shareholder Returns

7 metrics
MetricVCELLEGNMESO
Dividend yield – – –
Net buyback yield -0.3% -5.4% –
Shareholder yield -0.3% -5.4% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusVCELLEGNMESO
Forward P/E 84.8xFY2026 – –
EPS, next fiscal year $0.51FY2026 $-0.04FY2026 $-0.15FY2027
EPS growth, next FY +59.4%FY2026 – –
EPS growth, the year after +74.5% – –
Revenue, next fiscal year $324.56MFY2026 $1.37BFY2026 $188.99MFY2027
Revenue growth, next FY +17.5%FY2026 +32.9%FY2026 +57.2%FY2027
Revenue growth, the year after +16.1% +35.9% +110.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersVCELLEGNMESO
Held by institutions 100.0% 55.9% 3.0%
Institutions holding 317 218 73
Change in shares held, QoQ +0.4% +7.3% +17.7%
Institutions buying 187 117 34
Institutions selling 98 78 20
Buyers to sellers 1.91 1.50 1.70

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

VCELLEGNMESO
VCEL 1.00 0.14 0.10
LEGN 0.14 1.00 0.14
MESO 0.10 0.14 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, VCEL, LEGN and MESO?

Legend Biotech (LEGN) is the largest by market capitalisation: Vericel (VCEL) $2.17B, Legend Biotech (LEGN) $4.19B, Mesoblast (MESO) $1.72B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Vericel (VCEL) +23.0%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Vericel (VCEL) 7.9%, Legend Biotech (LEGN) -7.2%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: Vericel (VCEL) +18.6%, Legend Biotech (LEGN) -32.9%, Mesoblast (MESO) -21.1%. Over five years, Mesoblast (MESO) compounded fastest (Vericel (VCEL) -3.3%/yr, Legend Biotech (LEGN) -15.9%/yr, Mesoblast (MESO) +1.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Vericel (VCEL) 40.8%, Legend Biotech (LEGN) 72.2%, Mesoblast (MESO) 54.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, VCEL, LEGN and MESO?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.