VCEL vs LEGN vs IOVA Stock Comparison

Vericel, Legend Biotech and Iovance Biotherapeutics Prices as of Nov 5, 2026 Peers: Industry group
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VCEL Vericel Corp
$51.78 +29.3% 1M +39.2% 1Y
Market cap
$2.64B
P/E
79.6x
Revenue (TTM)
$324.17M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
LEGN Legend Biotech Corp
$22.54 +20.4% 1M -29.6% 1Y
Market cap
$4.15B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

7 decided of 12

Vericel leads on 4 of the 12 questions below (Vericel 4, Legend Biotech 2, Iovance Biotherapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionVCELLEGNIOVALeader
Larger companyMarket capitalisation $2.64B $4.15B $3.58B LEGN
Cheaper on earningsLower P/E, profitable companies only 79.6x -45.3x -16.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 101.5x — — –
Faster revenue growthRevenue growth, trailing twelve months +25.3% +59.5% +51.3% LEGN
More profitableNet margin, trailing twelve months 10.3% -7.2% -58.2% VCEL
Better return on capitalReturn on invested capital — -4.2% — –
Less leveragedLower net debt / EBITDA — -130.2x — –
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +39.2% -29.6% +327.6% IOVA
Better 5-year returnAnnualised price return, 5 years +2.4%/yr -14.3%/yr -20.9%/yr VCEL
Less volatileAnnualised volatility, 1 year 44.3% 72.7% 109.9% VCEL
Higher overall scoreMean of the five percentile scores vs peers 81/100 74/100 67/100 VCEL

Percentile Scorecard

VCELLEGNIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisVCELLEGNIOVA
Valuation 81 #123 of 634 88 #77 of 634 70 #190 of 634
Growth 94 #39 of 608 96 #23 of 608 91 #58 of 608
Profitability 89 #65 of 557 80 #110 of 557 67 #182 of 557
Financial Health 70 #195 of 654 59 #267 of 654 68 #213 of 654
Shareholder Returns 73 #109 of 403 44 #225 of 403 39 #245 of 403
Overall 81 74 67
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodVCELLEGNIOVASPY
1 month +29.3%+20.4%-40.3% -5.9%
3 months +15.7%+16.9%+24.6% -4.6%
6 months +47.4%-21.1%+118.0% +0.2%
Year to date +43.8%+3.7%+183.5% +7.5%
1 year +39.2%-29.6%+327.6% +8.2%
3 years +43.2%-65.8%+79.2% +68.3%
3 years, per year +12.7%-30.1%+21.5% +19.0%
5 years +12.4%-53.7%-69.0% +56.5%
5 years, per year +2.4%-14.3%-20.9% +9.4%
10 years +2,308.4%—+33.4% +251.5%
10 years, per year +37.5%—+2.9% +13.4%

Risk

MeasureVCELLEGNIOVASPY
Volatility, 1Y 44.3%72.7%109.9% 13.6%
Downside volatility, 1Y 41.2%62.9%95.6% 14.2%
Beta vs S&P 500, 1Y 0.430.501.60 1.00
Return / volatility, 1Y 0.88-0.412.98 0.60
Max drawdown, 5Y -60.2%-78.2%-93.4% -25.4%
From 52-week high 0.0%-37.9%-47.9% -5.9%
52-week high $51.78$36.28$14.86 $779.14
52-week low $29.34$16.65$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleVCELLEGNIOVA
P/E now vs peer median 79.6xmedian 17.8x -45.3xmedian 17.8x -16.0xmedian 17.8x
P/S now vs peer median 8.2xmedian 8.1x 3.3xmedian 8.1x 9.4xmedian 8.1x
EV/EBITDA now vs peer median 60.6xmedian 15.7x 917.1xmedian 15.7x -16.6xmedian 15.7x
P/FCF now vs peer median 45.7xmedian 21.0x -64.3xmedian 21.0x -16.6xmedian 21.0x
P/B now vs peer median 6.9xmedian 2.0x 3.4xmedian 2.0x 4.4xmedian 2.0x
PEG now vs peer median 1.13median 0.36 -0.96median 0.36 -0.46median 0.36

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsVCELLEGNIOVA
Revenue $324.17M $1.27B $378.98M
Gross profit $241.41M $727.10M $201.75M
Operating income $26.97M -$55.25M -$230.38M
Net income $33.31M -$80.39M -$220.56M
Free cash flow $57.89M -$64.60M -$216.07M
R&D $29.74M $396.15M $241.88M
EPS (diluted) $0.63 $-0.50 $-0.48
Cash & equivalents $133.50M $672.90M $57.93M
Total debt – $156.40M –
Shares (diluted) 52.96M 184.32M 455.92M
Enterprise value $2.03B $1.65B $2.30B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricVCELLEGNIOVA
P/E 79.6x -45.3x -16.0x
P/FCF 45.7x -64.3x -16.6x
P/Operating cash flow 40.5x -46.5x -18.9x
P/S 8.2x 3.3x 9.4x
P/B 6.9x 3.4x 4.4x
P/Tangible book 7.0x 3.4x 6.5x
EV/EBITDA 60.6x 917.1x -16.6x
EV/EBIT 91.7x -65.8x -13.9x
EV/Revenue 7.6x 2.9x 8.5x
EV/FCF 42.7x -56.3x -14.8x
EV/Operating cash flow 37.9x -40.7x -16.9x
PEG (3Y EPS CAGR) 1.13 -0.96 -0.46

Growth

14 metrics
MetricVCELLEGNIOVA
Revenue growth (1Y) 25.3% 59.5% 51.3%
Revenue CAGR (3Y) 20.5% 97.6% 712.3%
Gross profit growth (1Y) 26.4% 42.4% 144.4%
Gross profit CAGR (3Y) 24.4% 147.5% –
Operating income growth (1Y) 279.4% 75.3% 44.7%
Operating income CAGR (3Y) 59.5% 49.1% 19.8%
Net income growth (1Y) 154.6% 75.3% 44.5%
Net income CAGR (3Y) 73.8% 46.7% 20.1%
EPS growth (1Y) 149.5% 72.0% 55.7%
EPS CAGR (3Y) 70.1% 47.0% 35.0%
Operating cash flow growth (1Y) 10.4% 67.5% 41.2%
Operating cash flow CAGR (3Y) 26.6% 37.1% 18.9%
Free cash flow growth (1Y) 184.1% 77.8% 38.6%
Free cash flow CAGR (3Y) 45.2% 44.5% 17.0%

Profitability

14 metrics
MetricVCELLEGNIOVA
Gross margin 74.5% 57.2% 53.2%
EBITDA margin 12.6% 0.3% -50.9%
Operating margin 8.3% -4.3% -60.8%
Pretax margin 10.5% -4.4% -58.5%
Net margin 10.3% -7.2% -58.2%
FCF margin 17.9% -5.1% -57.0%
Operating cash flow margin 20.1% -7.0% -50.1%
Return on equity 9.1% -8.3% -28.5%
Return on assets 6.7% -5.5% -23.1%
Return on invested capital – -4.2% –
Return on capital employed 5.9% -4.3% -27.2%
Asset turnover 0.6x 0.8x 0.4x
Cash conversion (OCF / net income) 2.0x 1.1x 0.9x
Stock comp / revenue 11.3% 5.2% 12.3%

Financial Health

11 metrics
MetricVCELLEGNIOVA
Debt / assets – 8.9% –
Debt / equity – 0.1x –
Net debt / EBITDA – -130.2x –
Debt / FCF – -2.4x –
Liabilities / assets 25.7% 29.8% 18.0%
Equity / assets 74.3% 70.2% 82.0%
Interest coverage 42.0x -4.8x –
Current ratio 5.1x 3.0x 5.2x
Quick ratio 4.6x 1.7x 4.6x
Cash ratio 3.1x 1.7x 3.6x
Altman Z-score 12.26 6.95 8.06

Shareholder Returns

7 metrics
MetricVCELLEGNIOVA
Dividend yield – – –
Net buyback yield -0.3% -5.2% -8.2%
Shareholder yield -0.3% -5.2% -8.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusVCELLEGNIOVA
Forward P/E 101.5xFY2026 – –
EPS, next fiscal year $0.51FY2026 $-0.04FY2026 $-0.47FY2026
EPS growth, next FY +59.4%FY2026 – –
EPS growth, the year after +74.5% – –
Revenue, next fiscal year $324.56MFY2026 $1.37BFY2026 $435.90MFY2026
Revenue growth, next FY +17.5%FY2026 +32.9%FY2026 +65.4%FY2026
Revenue growth, the year after +16.1% +35.9% +33.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersVCELLEGNIOVA
Held by institutions 100.0% 55.9% 63.3%
Institutions holding 319 218 292
Change in shares held, QoQ +0.4% +7.3% +6.5%
Institutions buying 188 117 174
Institutions selling 99 78 66
Buyers to sellers 1.90 1.50 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

VCELLEGNIOVA
VCEL 1.00 0.14 0.09
LEGN 0.14 1.00 0.14
IOVA 0.09 0.14 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, VCEL, LEGN and IOVA?

Legend Biotech (LEGN) is the largest by market capitalisation: Vericel (VCEL) $2.64B, Legend Biotech (LEGN) $4.15B, Iovance Biotherapeutics (IOVA) $3.58B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Vericel (VCEL) +25.3%, Legend Biotech (LEGN) +59.5%, Iovance Biotherapeutics (IOVA) +51.3%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Vericel (VCEL) 10.3%, Legend Biotech (LEGN) -7.2%, Iovance Biotherapeutics (IOVA) -58.2%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Vericel (VCEL) +39.2%, Legend Biotech (LEGN) -29.6%, Iovance Biotherapeutics (IOVA) +327.6%. Over five years, Vericel (VCEL) compounded fastest (Vericel (VCEL) +2.4%/yr, Legend Biotech (LEGN) -14.3%/yr, Iovance Biotherapeutics (IOVA) -20.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Vericel (VCEL) 44.3%, Legend Biotech (LEGN) 72.7%, Iovance Biotherapeutics (IOVA) 109.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, VCEL, LEGN and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.