VCEL vs CRSP vs SRPT Stock Comparison

Vericel, CRISPR Therapeutics AG and Sarepta Therapeutics Prices as of Oct 26, 2026 Peers: Industry group
VCEL Vericel Corp
$43.04 +8.4% 1M +18.5% 1Y
Market cap
$2.21B
P/E
91.2x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins
CRSP CRISPR Therapeutics AG
$49.01 -9.6% 1M -27.5% 1Y
Market cap
$4.97B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

10 decided of 12

Vericel leads on 6 of the 12 questions below (Vericel 6, Sarepta Therapeutics 3, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionVCELCRSPSRPTLeader
Larger companyMarket capitalisation $2.21B $4.97B $1.99B CRSP
Cheaper on earningsLower P/E, profitable companies only 91.2x -11.0x -17.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 84.4x — 6.2x SRPT
Faster revenue growthRevenue growth, trailing twelve months +23.0% -64.8% -20.4% VCEL
More profitableNet margin, trailing twelve months 7.9% -3,368.7% -5.9% VCEL
Better return on capitalReturn on invested capital — -22.6% -6.1% SRPT
Less leveragedLower net debt / EBITDA — 3.4x -0.6x SRPT
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +18.5% -27.5% -21.2% VCEL
Better 5-year returnAnnualised price return, 5 years -3.2%/yr -12.0%/yr -25.3%/yr VCEL
Less volatileAnnualised volatility, 1 year 40.9% 57.1% 81.2% VCEL
Higher overall scoreMean of the five percentile scores vs peers 81/100 44/100 67/100 VCEL

Percentile Scorecard

VCELCRSPSRPT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisVCELCRSPSRPT
Valuation 81 #119 of 626 48 #327 of 626 97 #23 of 626
Growth 94 #37 of 604 32 #414 of 604 63 #222 of 604
Profitability 88 #68 of 555 32 #379 of 555 79 #116 of 555
Financial Health 69 #207 of 658 71 #191 of 658 34 #438 of 658
Shareholder Returns 73 #100 of 368 38 #230 of 368 61 #146 of 368
Overall 81 44 67
  • VCEL ranked among 673 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 673 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 673 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodVCELCRSPSRPTSPY
1 month +8.4%-9.6%-3.7% -0.8%
3 months -5.0%+4.9%+13.2% +3.5%
6 months +16.6%-3.9%-14.3% +7.0%
Year to date +19.5%-6.5%-16.4% +12.2%
1 year +18.5%-27.5%-21.2% +13.0%
3 years +31.1%+26.5%-83.2% +86.3%
3 years, per year +9.5%+8.2%-44.8% +23.1%
5 years -14.9%-47.2%-76.7% +68.6%
5 years, per year -3.2%-12.0%-25.3% +11.0%
10 years +1,693.3%+231.1%-59.6% +258.0%
10 years, per year +33.5%+12.7%-8.7% +13.6%

Risk

MeasureVCELCRSPSRPTSPY
Volatility, 1Y 40.9%57.1%81.2% 12.7%
Downside volatility, 1Y 40.1%53.7%85.9% 12.7%
Beta vs S&P 500, 1Y 0.741.822.07 1.00
Return / volatility, 1Y 0.45-0.48-0.26 1.02
Max drawdown, 5Y -65.4%-67.7%-92.7% -25.4%
From 52-week high -10.9%-25.4%-26.5% -1.8%
52-week high $48.31$65.72$24.45 $779.14
52-week low $29.34$44.34$14.86 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleVCELCRSPSRPT
P/E now vs peer median 90.8xmedian 17.1x -10.5xmedian 17.1x -16.2xmedian 17.1x
P/S now vs peer median 7.2xmedian 8.8x 353.7xmedian 8.8x 1.0xmedian 8.8x
EV/EBITDA now vs peer median 65.0xmedian 17.1x -5.7xmedian 17.1x -19.9xmedian 17.1x
P/FCF now vs peer median 35.7xmedian 18.0x -12.8xmedian 18.0x 23.2xmedian 18.0x
P/B now vs peer median 6.0xmedian 2.1x 2.7xmedian 2.1x 1.2xmedian 2.1x
PEG now vs peer median 1.67median 0.31 -2.72median 0.31 -0.31median 0.31

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsVCELCRSPSRPT
Revenue $306.30M $13.39M $1.97B
Gross profit $228.38M – $1.17B
Operating income $18.24M -$534.34M -$143.25M
Net income $24.22M -$451.14M -$136.73M
Free cash flow $61.66M -$371.33M $81.85M
R&D $29.17M $278.15M $789.44M
EPS (diluted) $0.46 $-4.67 $-1.11
Cash & equivalents $125.40M $291.34M $571.15M
Total debt – $586.20M $847.62M
Shares (diluted) 52.31M 96.51M 105.43M
Enterprise value $1.63B -$3.73B -$1.24B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricVCELCRSPSRPT
P/E 90.8x -10.5x -16.2x
P/FCF 35.7x -12.8x 23.2x
P/Operating cash flow 31.6x -12.8x 17.1x
P/S 7.2x 353.7x 1.0x
P/B 6.0x 2.7x 1.2x
P/Tangible book 6.0x 2.7x 1.3x
EV/EBITDA 65.0x -5.7x -19.9x
EV/EBIT 111.9x -5.5x -13.7x
EV/Revenue 6.7x 221.0x 1.0x
EV/FCF 33.1x -8.0x 23.9x
EV/Operating cash flow 29.3x -8.0x 17.6x
PEG (3Y EPS CAGR) 1.67 -2.72 -0.31

Growth

14 metrics
MetricVCELCRSPSRPT
Revenue growth (1Y) 23.0% -64.8% -20.4%
Revenue CAGR (3Y) 19.8% -57.1% 25.3%
Gross profit growth (1Y) 24.8% – -40.7%
Gross profit CAGR (3Y) 23.9% – 10.6%
Operating income growth (1Y) 1,428% 3.3% -15,270%
Operating income CAGR (3Y) 47.8% -4.1% 34.5%
Net income growth (1Y) 240.8% 3.6% -135.9%
Net income CAGR (3Y) 56.6% -2.7% 46.8%
EPS growth (1Y) 228.1% 13.0% -215.7%
EPS CAGR (3Y) 54.3% 3.9% 52.3%
Operating cash flow growth (1Y) 47.5% -13.8% 136.9%
Operating cash flow CAGR (3Y) 33.7% -2.5% 30.6%
Free cash flow growth (1Y) 842.9% -14.1% 118.1%
Free cash flow CAGR (3Y) 43.2% -0.9% 29.1%

Profitability

14 metrics
MetricVCELCRSPSRPT
Gross margin 74.6% – 59.1%
EBITDA margin 10.2% -3,850% -5.0%
Operating margin 6.0% -3,990% -7.3%
Pretax margin 8.2% -3,346% -6.6%
Net margin 7.9% -3,369% -5.9%
FCF margin 20.1% -2,773% 4.1%
Operating cash flow margin 22.7% -2,760% 5.6%
Return on equity 6.9% -25.3% -9.0%
Return on assets 5.1% -16.8% -4.3%
Return on invested capital – -22.6% -6.1%
Return on capital employed 4.1% -20.9% -5.3%
Asset turnover 0.6x 0.0x 0.6x
Cash conversion (OCF / net income) 2.9x 0.8x -0.8x
Stock comp / revenue 12.2% 510.2% 6.3%

Financial Health

11 metrics
MetricVCELCRSPSRPT
Debt / assets – 22.1% 26.6%
Debt / equity – 0.3x 0.6x
Net debt / EBITDA – 3.4x -0.6x
Debt / FCF – -1.6x 10.4x
Liabilities / assets 26.4% 34.1% 52.1%
Equity / assets 73.6% 65.9% 47.9%
Interest coverage 28.5x – –
Current ratio 5.0x 17.8x 4.4x
Quick ratio 4.5x 17.8x 2.4x
Cash ratio 3.1x 17.8x 1.6x
Altman Z-score 10.12 2.36 -0.19

Shareholder Returns

7 metrics
MetricVCELCRSPSRPT
Dividend yield – – –
Net buyback yield -0.3% -9.0% -1.1%
Shareholder yield -0.3% -9.0% -1.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusVCELCRSPSRPT
Forward P/E 84.4xFY2026 – 6.2xFY2026
EPS, next fiscal year $0.51FY2026 $-4.10FY2026 $2.88FY2026
EPS growth, next FY +59.4%FY2026 – –
EPS growth, the year after +74.5% – -88.5%
Revenue, next fiscal year $324.56MFY2026 $38.73MFY2026 $1.76BFY2026
Revenue growth, next FY +17.5%FY2026 +1,003.4%FY2026 -20.1%FY2026
Revenue growth, the year after +16.1% +266.1% -21.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersVCELCRSPSRPT
Held by institutions 100.0% 78.9% 100.0%
Institutions holding 317 518 324
Change in shares held, QoQ +0.4% -1.0% +4.5%
Institutions buying 187 237 148
Institutions selling 98 139 115
Buyers to sellers 1.91 1.71 1.29

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

VCELCRSPSRPT
VCEL 1.00 0.35 0.20
CRSP 0.35 1.00 0.38
SRPT 0.20 0.38 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, VCEL, CRSP and SRPT?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Vericel (VCEL) $2.21B, CRISPR Therapeutics AG (CRSP) $4.97B, Sarepta Therapeutics (SRPT) $1.99B.

Which company is growing faster?

Vericel (VCEL) grew revenue fastest over the trailing twelve months: Vericel (VCEL) +23.0%, CRISPR Therapeutics AG (CRSP) -64.8%, Sarepta Therapeutics (SRPT) -20.4%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Vericel (VCEL) 7.9%, CRISPR Therapeutics AG (CRSP) -3,368.7%, Sarepta Therapeutics (SRPT) -5.9%). On return on invested capital, Sarepta Therapeutics (SRPT) leads (CRISPR Therapeutics AG (CRSP) -22.6%, Sarepta Therapeutics (SRPT) -6.1%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: Vericel (VCEL) +18.5%, CRISPR Therapeutics AG (CRSP) -27.5%, Sarepta Therapeutics (SRPT) -21.2%. Over five years, Vericel (VCEL) compounded fastest (Vericel (VCEL) -3.2%/yr, CRISPR Therapeutics AG (CRSP) -12.0%/yr, Sarepta Therapeutics (SRPT) -25.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Vericel (VCEL) 40.9%, CRISPR Therapeutics AG (CRSP) 57.1%, Sarepta Therapeutics (SRPT) 81.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, VCEL, CRSP and SRPT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.