VCEL vs CRSP vs LEGN Stock Comparison

Vericel, CRISPR Therapeutics AG and Legend Biotech Prices as of Oct 27, 2026 Peers: Industry group
VCEL Vericel Corp
$43.27 +9.0% 1M +18.6% 1Y
Market cap
$2.21B
P/E
91.2x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$4.98B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
LEGN Legend Biotech Corp
$21.56 +12.8% 1M -32.9% 1Y
Market cap
$3.97B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

9 decided of 12

Vericel leads on 5 of the 12 questions below (Vericel 5, CRISPR Therapeutics AG 2, Legend Biotech 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionVCELCRSPLEGNLeader
Larger companyMarket capitalisation $2.21B $4.98B $3.97B CRSP
Cheaper on earningsLower P/E, profitable companies only 91.2x -11.0x -43.3x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 84.8x — — –
Faster revenue growthRevenue growth, trailing twelve months +23.0% -64.8% +59.5% LEGN
More profitableNet margin, trailing twelve months 7.9% -3,368.7% -7.2% VCEL
Better return on capitalReturn on invested capital — -22.6% -4.2% LEGN
Less leveragedLower net debt / EBITDA — 3.4x 28.0x CRSP
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +18.6% -21.7% -32.9% VCEL
Better 5-year returnAnnualised price return, 5 years -3.3%/yr -11.4%/yr -15.9%/yr VCEL
Less volatileAnnualised volatility, 1 year 40.8% 57.2% 72.2% VCEL
Higher overall scoreMean of the five percentile scores vs peers 81/100 44/100 72/100 VCEL

Percentile Scorecard

VCELCRSPLEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisVCELCRSPLEGN
Valuation 82 #116 of 625 49 #322 of 625 89 #70 of 625
Growth 94 #38 of 602 32 #411 of 602 96 #23 of 602
Profitability 88 #66 of 551 32 #375 of 551 80 #112 of 551
Financial Health 69 #207 of 656 71 #190 of 656 54 #305 of 656
Shareholder Returns 73 #99 of 365 38 #228 of 365 43 #209 of 365
Overall 81 44 72
  • VCEL ranked among 672 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodVCELCRSPLEGNSPY
1 month +9.0%-5.1%+12.8% -0.2%
3 months -7.4%+8.2%+13.2% +3.9%
6 months +21.4%-1.1%-8.5% +8.2%
Year to date +20.2%-1.8%-0.8% +12.9%
1 year +18.6%-21.7%-32.9% +12.3%
3 years +31.8%+32.9%-66.1% +87.4%
3 years, per year +9.7%+9.9%-30.3% +23.3%
5 years -15.3%-45.2%-57.9% +67.9%
5 years, per year -3.3%-11.4%-15.9% +10.9%
10 years +1,781.3%+225.3%— +261.1%
10 years, per year +34.1%+12.5%— +13.7%

Risk

MeasureVCELCRSPLEGNSPY
Volatility, 1Y 40.8%57.2%72.2% 12.7%
Downside volatility, 1Y 40.1%53.7%62.7% 12.7%
Beta vs S&P 500, 1Y 0.741.830.43 1.00
Return / volatility, 1Y 0.46-0.38-0.46 0.97
Max drawdown, 5Y -65.4%-67.7%-78.2% -25.4%
From 52-week high -10.4%-21.7%-40.6% -1.2%
52-week high $48.31$65.72$36.28 $779.14
52-week low $29.34$44.34$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleVCELCRSPLEGN
P/E now vs peer median 91.2xmedian 17.2x -11.0xmedian 17.2x -43.3xmedian 17.2x
P/S now vs peer median 7.2xmedian 9.0x 371.5xmedian 9.0x 3.1xmedian 9.0x
EV/EBITDA now vs peer median 65.4xmedian 16.3x -6.2xmedian 16.3x -187.6xmedian 16.3x
P/FCF now vs peer median 35.9xmedian 18.7x -13.4xmedian 18.7x -61.5xmedian 18.7x
P/B now vs peer median 6.0xmedian 2.2x 2.8xmedian 2.2x 3.2xmedian 2.2x
PEG now vs peer median 1.68median 0.33 -2.86median 0.33 -0.92median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsVCELCRSPLEGN
Revenue $306.30M $13.39M $1.27B
Gross profit $228.38M – $727.10M
Operating income $18.24M -$534.34M -$55.25M
Net income $24.22M -$451.14M -$80.39M
Free cash flow $61.66M -$371.33M -$64.60M
R&D $29.17M $278.15M $396.15M
EPS (diluted) $0.46 $-4.67 $-0.50
Cash & equivalents $125.40M $291.34M $672.90M
Total debt – $586.20M $1.06B
Shares (diluted) 52.31M 96.51M 184.32M
Enterprise value $1.63B -$3.72B $1.47B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricVCELCRSPLEGN
P/E 91.2x -11.0x -43.3x
P/FCF 35.9x -13.4x -61.5x
P/Operating cash flow 31.8x -13.5x -44.5x
P/S 7.2x 371.5x 3.1x
P/B 6.0x 2.8x 3.2x
P/Tangible book 6.1x 2.8x 3.2x
EV/EBITDA 65.4x -6.2x -187.6x
EV/EBIT 112.5x -6.0x -62.6x
EV/Revenue 6.7x 238.7x 2.7x
EV/FCF 33.3x -8.6x -53.5x
EV/Operating cash flow 29.4x -8.7x -38.7x
PEG (3Y EPS CAGR) 1.68 -2.86 -0.92

Growth

14 metrics
MetricVCELCRSPLEGN
Revenue growth (1Y) 23.0% -64.8% 59.5%
Revenue CAGR (3Y) 19.8% -57.1% 97.6%
Gross profit growth (1Y) 24.8% – 42.4%
Gross profit CAGR (3Y) 23.9% – 147.5%
Operating income growth (1Y) 1,428% 3.3% 75.3%
Operating income CAGR (3Y) 47.8% -4.1% 49.1%
Net income growth (1Y) 240.8% 3.6% 75.3%
Net income CAGR (3Y) 56.6% -2.7% 46.7%
EPS growth (1Y) 228.1% 13.0% 72.0%
EPS CAGR (3Y) 54.3% 3.9% 47.0%
Operating cash flow growth (1Y) 47.5% -13.8% 67.5%
Operating cash flow CAGR (3Y) 33.7% -2.5% 37.1%
Free cash flow growth (1Y) 842.9% -14.1% 77.8%
Free cash flow CAGR (3Y) 43.2% -0.9% 44.5%

Profitability

14 metrics
MetricVCELCRSPLEGN
Gross margin 74.6% – 57.2%
EBITDA margin 10.2% -3,850% -1.5%
Operating margin 6.0% -3,990% -4.3%
Pretax margin 8.2% -3,346% -4.4%
Net margin 7.9% -3,369% -7.2%
FCF margin 20.1% -2,773% -5.1%
Operating cash flow margin 22.7% -2,760% -7.0%
Return on equity 6.9% -25.3% -8.3%
Return on assets 5.1% -16.8% -5.5%
Return on invested capital – -22.6% -4.2%
Return on capital employed 4.1% -20.9% -4.3%
Asset turnover 0.6x 0.0x 0.8x
Cash conversion (OCF / net income) 2.9x 0.8x 1.1x
Stock comp / revenue 12.2% 510.2% 5.2%

Financial Health

11 metrics
MetricVCELCRSPLEGN
Debt / assets – 22.1% 8.9%
Debt / equity – 0.3x 0.1x
Net debt / EBITDA – 3.4x 28.0x
Debt / FCF – -1.6x -2.4x
Liabilities / assets 26.4% 34.1% 29.8%
Equity / assets 73.6% 65.9% 70.2%
Interest coverage 28.5x – -4.8x
Current ratio 5.0x 17.8x 3.0x
Quick ratio 4.5x 17.8x 1.7x
Cash ratio 3.1x 17.8x 1.7x
Altman Z-score 10.18 2.51 6.74

Shareholder Returns

7 metrics
MetricVCELCRSPLEGN
Dividend yield – – –
Net buyback yield -0.3% -8.6% -5.4%
Shareholder yield -0.3% -8.6% -5.4%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusVCELCRSPLEGN
Forward P/E 84.8xFY2026 – –
EPS, next fiscal year $0.51FY2026 $-4.10FY2026 $-0.04FY2026
EPS growth, next FY +59.4%FY2026 – –
EPS growth, the year after +74.5% – –
Revenue, next fiscal year $324.56MFY2026 $38.73MFY2026 $1.37BFY2026
Revenue growth, next FY +17.5%FY2026 +1,003.4%FY2026 +32.9%FY2026
Revenue growth, the year after +16.1% +266.1% +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersVCELCRSPLEGN
Held by institutions 100.0% 78.9% 55.9%
Institutions holding 317 518 218
Change in shares held, QoQ +0.4% -1.0% +7.3%
Institutions buying 187 237 117
Institutions selling 98 139 78
Buyers to sellers 1.91 1.71 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

VCELCRSPLEGN
VCEL 1.00 0.35 0.14
CRSP 0.35 1.00 0.05
LEGN 0.14 0.05 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, VCEL, CRSP and LEGN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Vericel (VCEL) $2.21B, CRISPR Therapeutics AG (CRSP) $4.98B, Legend Biotech (LEGN) $3.97B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Vericel (VCEL) +23.0%, CRISPR Therapeutics AG (CRSP) -64.8%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Vericel (VCEL) 7.9%, CRISPR Therapeutics AG (CRSP) -3,368.7%, Legend Biotech (LEGN) -7.2%). On return on invested capital, Legend Biotech (LEGN) leads (CRISPR Therapeutics AG (CRSP) -22.6%, Legend Biotech (LEGN) -4.2%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: Vericel (VCEL) +18.6%, CRISPR Therapeutics AG (CRSP) -21.7%, Legend Biotech (LEGN) -32.9%. Over five years, Vericel (VCEL) compounded fastest (Vericel (VCEL) -3.3%/yr, CRISPR Therapeutics AG (CRSP) -11.4%/yr, Legend Biotech (LEGN) -15.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Vericel (VCEL) 40.8%, CRISPR Therapeutics AG (CRSP) 57.2%, Legend Biotech (LEGN) 72.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, VCEL, CRSP and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.