TAK vs RGC vs PFE Stock Comparison

Takeda Pharmaceutical, Regencell Bioscience Holdings and Pfizer Prices as of Oct 28, 2026 Peers: Industry group
PFE Pfizer Inc
$29.48 +2.6% 1M +20.3% 1Y
Market cap
$171.28B
P/E
39.5x
Revenue (TTM)
$63.70B
Div. yield
0.06%
Pharmaceuticals Healthcare
7 wins

Head to Head

11 decided of 12

Pfizer leads on 7 of the 12 questions below (Pfizer 7, Takeda Pharmaceutical 3, Regencell Bioscience Holdings 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionTAKRGCPFELeader
Larger companyMarket capitalisation $63.88B $3.51B $171.28B PFE
Cheaper on earningsLower P/E, profitable companies only 111.2x -307.3x 39.5x PFE
Cheaper on forward earningsLower price / next fiscal year consensus EPS 50.4x — 10.3x PFE
Faster revenue growthRevenue growth, trailing twelve months +0.7% — -0.2% TAK
More profitableNet margin, trailing twelve months 1.2% — 6.8% PFE
Better return on capitalReturn on invested capital 3.5% — 13.4% PFE
Less leveragedLower net debt / EBITDA 3.5x — 1.9x PFE
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.06% –
Better 1-year returnPrice return, last 12 months +42.9% -57.9% +20.3% TAK
Better 5-year returnAnnualised price return, 5 years +7.5%/yr +83.2%/yr -7.6%/yr RGC
Less volatileAnnualised volatility, 1 year 21.5% 142.6% 21.6% TAK
Higher overall scoreMean of the five percentile scores vs peers 62/100 — 65/100 PFE

Percentile Scorecard

TAKRGCPFE

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisTAKRGCPFE
Valuation 98 #16 of 625 38 #390 of 625 95 #30 of 625
Growth 21 #476 of 602 – 23 #462 of 602
Profitability 85 #82 of 549 – 92 #45 of 549
Financial Health 34 #430 of 654 90 #67 of 654 23 #504 of 654
Shareholder Returns 74 #98 of 367 – 92 #30 of 367
Overall 62 – 65
  • TAK ranked among 672 companies in Pharmaceuticals and Biotechnology
  • RGC ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PFE ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodTAKRGCPFESPY
1 month +6.6%+17.3%+2.6% +0.9%
3 months +13.5%+28.7%+17.2% +5.9%
6 months +23.6%-74.9%+12.3% +8.5%
Year to date +29.2%-65.4%+18.4% +13.3%
1 year +42.9%-57.9%+20.3% +12.4%
3 years +49.6%+1,595.0%-2.1% +88.1%
3 years, per year +14.4%+157.0%-0.7% +23.5%
5 years +43.7%+1,957.2%-32.6% +68.2%
5 years, per year +7.5%+83.2%-7.6% +11.0%
10 years -12.4%—-7.7% +263.4%
10 years, per year -1.3%—-0.8% +13.8%

Risk

MeasureTAKRGCPFESPY
Volatility, 1Y 21.5%142.6%21.6% 12.7%
Downside volatility, 1Y 20.2%134.4%21.1% 12.7%
Beta vs S&P 500, 1Y 0.111.490.23 1.00
Return / volatility, 1Y 1.99-0.410.94 0.98
Max drawdown, 5Y -26.4%-93.9%-64.8% -25.4%
From 52-week high -1.4%-86.3%-3.1% -0.9%
52-week high $20.43$52.88$30.41 $779.14
52-week low $13.23$4.78$23.67 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleTAKRGCPFE
P/E now vs peer median 110.5xmedian 17.4x -307.3xmedian 17.4x 38.8xmedian 17.4x
P/S now vs peer median 1.4xmedian 9.1x —median 9.1x 2.6xmedian 9.1x
EV/EBITDA now vs peer median 12.3xmedian 17.1x —median 17.1x 8.1xmedian 17.1x
P/FCF now vs peer median 12.3xmedian 19.0x -468.5xmedian 19.0x 15.3xmedian 19.0x
P/B now vs peer median 1.4xmedian 2.2x 270.1xmedian 2.2x 2.0xmedian 2.2x
PEG now vs peer median -2.72median 0.34 —median 0.34 -0.94median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsTAKRGCPFE
Revenue $46.49B – $63.70B
Gross profit $30.58B – $46.61B
Operating income $2.71B – $20.39B
Net income -$1.04B – $4.36B
Free cash flow $5.20B – $10.99B
R&D $4.53B – $11.05B
EPS (diluted) $0.18 – $0.76
Cash & equivalents $2.85B $14.19M $976.00M
Total debt $126.30B $21.88K $63.19B
Shares (diluted) 3.15B 494.60M 5.70B
Enterprise value $40.25B $3.48B $117.93B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricTAKRGCPFE
P/E 110.5x -307.3x 38.8x
P/FCF 12.3x -468.5x 15.3x
P/Operating cash flow 10.2x – 12.5x
P/S 1.4x – 2.6x
P/B 1.4x 270.1x 2.0x
P/Tangible book 2.5x 270.1x 4.4x
EV/EBITDA 12.3x – 8.1x
EV/EBIT 33.0x – 10.8x
EV/Revenue 1.9x – 3.4x
EV/FCF 17.2x – 20.0x
EV/Operating cash flow 14.3x – 16.4x
PEG (3Y EPS CAGR) -2.72 – -0.94

Growth

14 metrics
MetricTAKRGCPFE
Revenue growth (1Y) 0.7% – -0.2%
Revenue CAGR (3Y) 14.8% – -7.0%
Gross profit growth (1Y) -0.8% – 1.2%
Gross profit CAGR (3Y) -0.2% – -5.6%
Operating income growth (1Y) -43.4% – 1.5%
Operating income CAGR (3Y) -14.3% – -9.9%
Net income growth (1Y) -209.1% – -59.6%
Net income CAGR (3Y) -35.3% – -41.3%
EPS growth (1Y) -75.7% – -59.7%
EPS CAGR (3Y) -40.6% – -41.3%
Operating cash flow growth (1Y) -14.8% – -11.8%
Operating cash flow CAGR (3Y) -4.4% – -2.7%
Free cash flow growth (1Y) -13.3% – -11.7%
Free cash flow CAGR (3Y) -5.2% – 1.0%

Profitability

14 metrics
MetricTAKRGCPFE
Gross margin 65.8% – 73.2%
EBITDA margin 15.6% – 42.4%
Operating margin 5.8% – 32.0%
Pretax margin 2.6% – 6.6%
Net margin 1.2% – 6.8%
FCF margin 11.2% – 17.2%
Operating cash flow margin 13.5% – 21.0%
Return on equity 1.2% – 5.0%
Return on assets 0.6% – 2.1%
Return on invested capital 3.5% – 13.4%
Return on capital employed 3.0% – 11.9%
Asset turnover 0.5x – 0.3x
Cash conversion (OCF / net income) -6.0x – 3.1x
Stock comp / revenue 1.0% – 1.5%

Financial Health

11 metrics
MetricTAKRGCPFE
Debt / assets 32.0% 0.1% 31.4%
Debt / equity 0.7x 0.0x 0.7x
Net debt / EBITDA 3.5x – 1.9x
Debt / FCF 6.0x – 5.8x
Liabilities / assets 51.7% 9.4% 57.5%
Equity / assets 48.3% 90.6% 42.5%
Interest coverage 0.8x – –
Current ratio 3.2x 10.8x 1.3x
Quick ratio 1.9x 10.7x 0.7x
Cash ratio 0.9x 10.7x 0.4x
Altman Z-score 1.57 – 2.36

Shareholder Returns

7 metrics
MetricTAKRGCPFE
Dividend yield 1.5% – 5.8%
Net buyback yield 1.0% – –
Shareholder yield 2.6% 0.0% 5.8%
Payout ratio (earnings) – – 224.5%
Payout ratio (FCF) – – 89.1%
Dividend growth (1Y) – – 1.5%
Dividend CAGR (3Y) – – 2.4%

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusTAKRGCPFE
Forward P/E 50.4xFY2026 – 10.3xFY2026
EPS, next fiscal year $0.40FY2026 – $2.85FY2026
EPS growth, next FY +5.3%FY2026 – -11.5%FY2026
EPS growth, the year after +62.5% – -4.6%
Revenue, next fiscal year $28.27BFY2026 – $60.59BFY2026
Revenue growth, next FY -0.8%FY2026 – -3.2%FY2026
Revenue growth, the year after +11.9% – +3.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersTAKRGCPFE
Held by institutions 3.3% 0.3% 66.9%
Institutions holding 378 36 2,836
Change in shares held, QoQ +6.2% +117.2% +2.0%
Institutions buying 212 28 1,325
Institutions selling 98 5 1,204
Buyers to sellers 2.16 5.60 1.10

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

TAKRGCPFE
TAK 1.00 0.02 0.43
RGC 0.02 1.00 0.07
PFE 0.43 0.07 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, TAK, RGC and PFE?

Pfizer (PFE) is the largest by market capitalisation: Takeda Pharmaceutical (TAK) $63.88B, Regencell Bioscience Holdings (RGC) $3.51B, Pfizer (PFE) $171.28B.

Which stock is cheaper, TAK, RGC and PFE?

Pfizer (PFE) trades on the lowest price-to-earnings ratio (Takeda Pharmaceutical (TAK) 111.2x, Regencell Bioscience Holdings (RGC) -307.3x, Pfizer (PFE) 39.5x). On next year's consensus earnings, Pfizer (PFE) is cheapest (Takeda Pharmaceutical (TAK) 50.4x, Pfizer (PFE) 10.3x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Takeda Pharmaceutical (TAK) grew revenue fastest over the trailing twelve months: Takeda Pharmaceutical (TAK) +0.7%, Pfizer (PFE) -0.2%.

Which company is more profitable?

Pfizer (PFE) has the highest net margin (Takeda Pharmaceutical (TAK) 1.2%, Pfizer (PFE) 6.8%). On return on invested capital, Pfizer (PFE) leads (Takeda Pharmaceutical (TAK) 3.5%, Pfizer (PFE) 13.4%).

Which stock has performed better?

Over the past year Takeda Pharmaceutical (TAK) returned the most: Takeda Pharmaceutical (TAK) +42.9%, Regencell Bioscience Holdings (RGC) -57.9%, Pfizer (PFE) +20.3%. Over five years, Regencell Bioscience Holdings (RGC) compounded fastest (Takeda Pharmaceutical (TAK) +7.5%/yr, Regencell Bioscience Holdings (RGC) +83.2%/yr, Pfizer (PFE) -7.6%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Takeda Pharmaceutical (TAK) 0.00%, Regencell Bioscience Holdings (RGC) 0.00%, Pfizer (PFE) 0.06%. Takeda Pharmaceutical (TAK) and Regencell Bioscience Holdings (RGC) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Takeda Pharmaceutical (TAK) has been the steadiest (Takeda Pharmaceutical (TAK) 21.5%, Regencell Bioscience Holdings (RGC) 142.6%, Pfizer (PFE) 21.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, TAK, RGC and PFE?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Pfizer (PFE) leads on 7. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.