SRPT vs VCEL vs IOVA Stock Comparison

Sarepta Therapeutics, Vericel and Iovance Biotherapeutics Prices as of Oct 27, 2026 Peers: Industry group
VCEL Vericel Corp
$43.27 +9.0% 1M +18.6% 1Y
Market cap
$2.21B
P/E
91.2x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

8 decided of 12

Vericel leads on 4 of the 12 questions below (Vericel 4, Iovance Biotherapeutics 3, Sarepta Therapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSRPTVCELIOVALeader
Larger companyMarket capitalisation $2.00B $2.21B $6.60B IOVA
Cheaper on earningsLower P/E, profitable companies only -17.0x 91.2x -22.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 6.6x 84.8x — SRPT
Faster revenue growthRevenue growth, trailing twelve months -20.4% +23.0% +34.5% IOVA
More profitableNet margin, trailing twelve months -5.9% 7.9% -89.1% VCEL
Better return on capitalReturn on invested capital -6.1% — — –
Less leveragedLower net debt / EBITDA -0.6x — — –
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months -19.6% +18.6% +531.2% IOVA
Better 5-year returnAnnualised price return, 5 years -24.9%/yr -3.3%/yr -10.4%/yr VCEL
Less volatileAnnualised volatility, 1 year 81.2% 40.8% 99.2% VCEL
Higher overall scoreMean of the five percentile scores vs peers 67/100 81/100 64/100 VCEL

Percentile Scorecard

SRPTVCELIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSRPTVCELIOVA
Valuation 96 #25 of 625 82 #116 of 625 67 #209 of 625
Growth 64 #218 of 602 94 #38 of 602 81 #114 of 602
Profitability 80 #114 of 551 88 #66 of 551 62 #210 of 551
Financial Health 34 #435 of 656 69 #207 of 656 64 #238 of 656
Shareholder Returns 60 #145 of 365 73 #99 of 365 44 #205 of 365
Overall 67 81 64
  • SRPT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSRPTVCELIOVASPY
1 month +1.2%+9.0%+32.5% -0.2%
3 months +22.4%-7.4%+210.2% +3.9%
6 months -10.3%+21.4%+331.4% +8.2%
Year to date -12.2%+20.2%+434.1% +12.9%
1 year -19.6%+18.6%+531.2% +12.3%
3 years -82.3%+31.8%+316.6% +87.4%
3 years, per year -43.9%+9.7%+61.0% +23.3%
5 years -76.2%-15.3%-42.3% +67.9%
5 years, per year -24.9%-3.3%-10.4% +10.9%
10 years -53.7%+1,781.3%+143.0% +261.1%
10 years, per year -7.4%+34.1%+9.3% +13.7%

Risk

MeasureSRPTVCELIOVASPY
Volatility, 1Y 81.2%40.8%99.2% 12.7%
Downside volatility, 1Y 85.9%40.1%71.2% 12.7%
Beta vs S&P 500, 1Y 2.080.741.28 1.00
Return / volatility, 1Y -0.240.465.36 0.97
Max drawdown, 5Y -92.7%-65.4%-93.4% -25.4%
From 52-week high -22.7%-10.4%-1.9% -1.2%
52-week high $24.45$48.31$14.86 $779.14
52-week low $14.86$29.34$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSRPTVCELIOVA
P/E now vs peer median -17.0xmedian 17.2x 91.2xmedian 17.2x -22.7xmedian 17.2x
P/S now vs peer median 1.0xmedian 9.0x 7.2xmedian 9.0x 20.3xmedian 9.0x
EV/EBITDA now vs peer median -20.8xmedian 16.3x 65.4xmedian 16.3x -23.9xmedian 16.3x
P/FCF now vs peer median 24.4xmedian 18.7x 35.9xmedian 18.7x -22.3xmedian 18.7x
P/B now vs peer median 1.3xmedian 2.2x 6.0xmedian 2.2x 9.0xmedian 2.2x
PEG now vs peer median -0.33median 0.33 1.68median 0.33 -0.76median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSRPTVCELIOVA
Revenue $1.97B $306.30M $324.97M
Gross profit $1.17B $228.38M $157.29M
Operating income -$143.25M $18.24M -$301.31M
Net income -$136.73M $24.22M -$289.51M
Free cash flow $81.85M $61.66M -$296.40M
R&D $789.44M $29.17M $267.72M
EPS (diluted) $-1.11 $0.46 $-0.64
Cash & equivalents $571.15M $125.40M $110.80M
Total debt $847.62M – –
Shares (diluted) 105.43M 52.31M 450.19M
Enterprise value -$1.24B $1.63B $5.40B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSRPTVCELIOVA
P/E -17.0x 91.2x -22.7x
P/FCF 24.4x 35.9x -22.3x
P/Operating cash flow 18.0x 31.8x -25.0x
P/S 1.0x 7.2x 20.3x
P/B 1.3x 6.0x 9.0x
P/Tangible book 1.3x 6.1x 14.0x
EV/EBITDA -20.8x 65.4x -23.9x
EV/EBIT -14.3x 112.5x -20.9x
EV/Revenue 1.0x 6.7x 19.4x
EV/FCF 25.1x 33.3x -21.3x
EV/Operating cash flow 18.5x 29.4x -23.9x
PEG (3Y EPS CAGR) -0.33 1.68 -0.76

Growth

14 metrics
MetricSRPTVCELIOVA
Revenue growth (1Y) -20.4% 23.0% 34.5%
Revenue CAGR (3Y) 25.3% 19.8% 1,009%
Gross profit growth (1Y) -40.7% 24.8% 95.1%
Gross profit CAGR (3Y) 10.6% 23.9% –
Operating income growth (1Y) -15,270% 1,428% 26.6%
Operating income CAGR (3Y) 34.5% 47.8% 11.1%
Net income growth (1Y) -135.9% 240.8% 25.8%
Net income CAGR (3Y) 46.8% 56.6% 11.6%
EPS growth (1Y) -215.7% 228.1% 44.8%
EPS CAGR (3Y) 52.3% 54.3% 29.9%
Operating cash flow growth (1Y) 136.9% 47.5% 12.9%
Operating cash flow CAGR (3Y) 30.6% 33.7% 7.6%
Free cash flow growth (1Y) 118.1% 842.9% 8.4%
Free cash flow CAGR (3Y) 29.1% 43.2% 5.8%

Profitability

14 metrics
MetricSRPTVCELIOVA
Gross margin 59.1% 74.6% 48.4%
EBITDA margin -5.0% 10.2% -81.4%
Operating margin -7.3% 6.0% -92.7%
Pretax margin -6.6% 8.2% -90.4%
Net margin -5.9% 7.9% -89.1%
FCF margin 4.1% 20.1% -91.2%
Operating cash flow margin 5.6% 22.7% -81.3%
Return on equity -9.0% 6.9% -39.7%
Return on assets -4.3% 5.1% -31.4%
Return on invested capital -6.1% – –
Return on capital employed -5.3% 4.1% -37.0%
Asset turnover 0.6x 0.6x 0.4x
Cash conversion (OCF / net income) -0.8x 2.9x 0.9x
Stock comp / revenue 6.3% 12.2% 14.4%

Financial Health

11 metrics
MetricSRPTVCELIOVA
Debt / assets 26.6% – –
Debt / equity 0.6x – –
Net debt / EBITDA -0.6x – –
Debt / FCF 10.4x – –
Liabilities / assets 52.1% 26.4% 19.6%
Equity / assets 47.9% 73.6% 80.4%
Interest coverage – 28.5x –
Current ratio 4.4x 5.0x 4.3x
Quick ratio 2.4x 4.5x 3.7x
Cash ratio 1.6x 3.1x 2.8x
Altman Z-score -0.16 10.18 17.38

Shareholder Returns

7 metrics
MetricSRPTVCELIOVA
Dividend yield – – –
Net buyback yield -1.1% -0.3% -4.5%
Shareholder yield -1.1% -0.3% -4.5%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSRPTVCELIOVA
Forward P/E 6.6xFY2026 84.8xFY2026 –
EPS, next fiscal year $2.88FY2026 $0.51FY2026 $-0.47FY2026
EPS growth, next FY – +59.4%FY2026 –
EPS growth, the year after -88.5% +74.5% –
Revenue, next fiscal year $1.76BFY2026 $324.56MFY2026 $434.71MFY2026
Revenue growth, next FY -20.1%FY2026 +17.5%FY2026 +65.0%FY2026
Revenue growth, the year after -21.5% +16.1% +33.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSRPTVCELIOVA
Held by institutions 100.0% 100.0% 63.3%
Institutions holding 324 317 292
Change in shares held, QoQ +4.5% +0.4% +6.5%
Institutions buying 148 187 174
Institutions selling 115 98 66
Buyers to sellers 1.29 1.91 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SRPTVCELIOVA
SRPT 1.00 0.20 0.29
VCEL 0.20 1.00 0.21
IOVA 0.29 0.21 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SRPT, VCEL and IOVA?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Sarepta Therapeutics (SRPT) $2.00B, Vericel (VCEL) $2.21B, Iovance Biotherapeutics (IOVA) $6.60B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: Sarepta Therapeutics (SRPT) -20.4%, Vericel (VCEL) +23.0%, Iovance Biotherapeutics (IOVA) +34.5%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Sarepta Therapeutics (SRPT) -5.9%, Vericel (VCEL) 7.9%, Iovance Biotherapeutics (IOVA) -89.1%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Sarepta Therapeutics (SRPT) -19.6%, Vericel (VCEL) +18.6%, Iovance Biotherapeutics (IOVA) +531.2%. Over five years, Vericel (VCEL) compounded fastest (Sarepta Therapeutics (SRPT) -24.9%/yr, Vericel (VCEL) -3.3%/yr, Iovance Biotherapeutics (IOVA) -10.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Sarepta Therapeutics (SRPT) 81.2%, Vericel (VCEL) 40.8%, Iovance Biotherapeutics (IOVA) 99.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SRPT, VCEL and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.