SRPT vs LEGN vs VCEL Stock Comparison

Sarepta Therapeutics, Legend Biotech and Vericel Prices as of Oct 27, 2026 Peers: Industry group
LEGN Legend Biotech Corp
$21.56 +12.8% 1M -32.9% 1Y
Market cap
$4.14B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
VCEL Vericel Corp
$43.27 +9.0% 1M +18.6% 1Y
Market cap
$2.14B
P/E
88.2x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins

Head to Head

10 decided of 12

Vericel leads on 5 of the 12 questions below (Vericel 5, Legend Biotech 3, Sarepta Therapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSRPTLEGNVCELLeader
Larger companyMarket capitalisation $2.01B $4.14B $2.14B LEGN
Cheaper on earningsLower P/E, profitable companies only -17.2x -45.2x 88.2x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 6.6x — 84.8x SRPT
Faster revenue growthRevenue growth, trailing twelve months -20.4% +59.5% +23.0% LEGN
More profitableNet margin, trailing twelve months -5.9% -7.2% 7.9% VCEL
Better return on capitalReturn on invested capital -6.1% -4.2% — LEGN
Less leveragedLower net debt / EBITDA -0.6x 28.0x — SRPT
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -19.6% -32.9% +18.6% VCEL
Better 5-year returnAnnualised price return, 5 years -24.9%/yr -15.9%/yr -3.3%/yr VCEL
Less volatileAnnualised volatility, 1 year 81.2% 72.2% 40.8% VCEL
Higher overall scoreMean of the five percentile scores vs peers 67/100 72/100 81/100 VCEL

Percentile Scorecard

SRPTLEGNVCEL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSRPTLEGNVCEL
Valuation 96 #25 of 625 89 #70 of 625 82 #116 of 625
Growth 64 #218 of 602 96 #23 of 602 94 #38 of 602
Profitability 80 #114 of 551 80 #112 of 551 88 #66 of 551
Financial Health 34 #435 of 656 54 #305 of 656 69 #207 of 656
Shareholder Returns 60 #145 of 365 43 #209 of 365 73 #99 of 365
Overall 67 72 81
  • SRPT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSRPTLEGNVCELSPY
1 month +1.2%+12.8%+9.0% -0.2%
3 months +22.4%+13.2%-7.4% +3.9%
6 months -10.3%-8.5%+21.4% +8.2%
Year to date -12.2%-0.8%+20.2% +12.9%
1 year -19.6%-32.9%+18.6% +12.3%
3 years -82.3%-66.1%+31.8% +87.4%
3 years, per year -43.9%-30.3%+9.7% +23.3%
5 years -76.2%-57.9%-15.3% +67.9%
5 years, per year -24.9%-15.9%-3.3% +10.9%
10 years -53.7%—+1,781.3% +261.1%
10 years, per year -7.4%—+34.1% +13.7%

Risk

MeasureSRPTLEGNVCELSPY
Volatility, 1Y 81.2%72.2%40.8% 12.7%
Downside volatility, 1Y 85.9%62.7%40.1% 12.7%
Beta vs S&P 500, 1Y 2.080.430.74 1.00
Return / volatility, 1Y -0.24-0.460.46 0.97
Max drawdown, 5Y -92.7%-78.2%-65.4% -25.4%
From 52-week high -22.7%-40.6%-10.4% -1.2%
52-week high $24.45$36.28$48.31 $779.14
52-week low $14.86$16.65$29.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSRPTLEGNVCEL
P/E now vs peer median -17.0xmedian 17.2x -43.3xmedian 17.2x 91.2xmedian 17.2x
P/S now vs peer median 1.0xmedian 9.0x 3.1xmedian 9.0x 7.2xmedian 9.0x
EV/EBITDA now vs peer median -20.8xmedian 16.3x -187.6xmedian 16.3x 65.4xmedian 16.3x
P/FCF now vs peer median 24.4xmedian 18.7x -61.5xmedian 18.7x 35.9xmedian 18.7x
P/B now vs peer median 1.3xmedian 2.2x 3.2xmedian 2.2x 6.0xmedian 2.2x
PEG now vs peer median -0.33median 0.33 -0.92median 0.33 1.68median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSRPTLEGNVCEL
Revenue $1.97B $1.27B $306.30M
Gross profit $1.17B $727.10M $228.38M
Operating income -$143.25M -$55.25M $18.24M
Net income -$136.73M -$80.39M $24.22M
Free cash flow $81.85M -$64.60M $61.66M
R&D $789.44M $396.15M $29.17M
EPS (diluted) $-1.11 $-0.50 $0.46
Cash & equivalents $571.15M $672.90M $125.40M
Total debt $847.62M $1.06B –
Shares (diluted) 105.43M 184.32M 52.31M
Enterprise value -$1.22B $1.64B $1.56B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSRPTLEGNVCEL
P/E -17.0x -43.3x 91.2x
P/FCF 24.4x -61.5x 35.9x
P/Operating cash flow 18.0x -44.5x 31.8x
P/S 1.0x 3.1x 7.2x
P/B 1.3x 3.2x 6.0x
P/Tangible book 1.3x 3.2x 6.1x
EV/EBITDA -20.8x -187.6x 65.4x
EV/EBIT -14.3x -62.6x 112.5x
EV/Revenue 1.0x 2.7x 6.7x
EV/FCF 25.1x -53.5x 33.3x
EV/Operating cash flow 18.5x -38.7x 29.4x
PEG (3Y EPS CAGR) -0.33 -0.92 1.68

Growth

14 metrics
MetricSRPTLEGNVCEL
Revenue growth (1Y) -20.4% 59.5% 23.0%
Revenue CAGR (3Y) 25.3% 97.6% 19.8%
Gross profit growth (1Y) -40.7% 42.4% 24.8%
Gross profit CAGR (3Y) 10.6% 147.5% 23.9%
Operating income growth (1Y) -15,270% 75.3% 1,428%
Operating income CAGR (3Y) 34.5% 49.1% 47.8%
Net income growth (1Y) -135.9% 75.3% 240.8%
Net income CAGR (3Y) 46.8% 46.7% 56.6%
EPS growth (1Y) -215.7% 72.0% 228.1%
EPS CAGR (3Y) 52.3% 47.0% 54.3%
Operating cash flow growth (1Y) 136.9% 67.5% 47.5%
Operating cash flow CAGR (3Y) 30.6% 37.1% 33.7%
Free cash flow growth (1Y) 118.1% 77.8% 842.9%
Free cash flow CAGR (3Y) 29.1% 44.5% 43.2%

Profitability

14 metrics
MetricSRPTLEGNVCEL
Gross margin 59.1% 57.2% 74.6%
EBITDA margin -5.0% -1.5% 10.2%
Operating margin -7.3% -4.3% 6.0%
Pretax margin -6.6% -4.4% 8.2%
Net margin -5.9% -7.2% 7.9%
FCF margin 4.1% -5.1% 20.1%
Operating cash flow margin 5.6% -7.0% 22.7%
Return on equity -9.0% -8.3% 6.9%
Return on assets -4.3% -5.5% 5.1%
Return on invested capital -6.1% -4.2% –
Return on capital employed -5.3% -4.3% 4.1%
Asset turnover 0.6x 0.8x 0.6x
Cash conversion (OCF / net income) -0.8x 1.1x 2.9x
Stock comp / revenue 6.3% 5.2% 12.2%

Financial Health

11 metrics
MetricSRPTLEGNVCEL
Debt / assets 26.6% 8.9% –
Debt / equity 0.6x 0.1x –
Net debt / EBITDA -0.6x 28.0x –
Debt / FCF 10.4x -2.4x –
Liabilities / assets 52.1% 29.8% 26.4%
Equity / assets 47.9% 70.2% 73.6%
Interest coverage – -4.8x 28.5x
Current ratio 4.4x 3.0x 5.0x
Quick ratio 2.4x 1.7x 4.5x
Cash ratio 1.6x 1.7x 3.1x
Altman Z-score -0.16 6.74 10.18

Shareholder Returns

7 metrics
MetricSRPTLEGNVCEL
Dividend yield – – –
Net buyback yield -1.1% -5.4% -0.3%
Shareholder yield -1.1% -5.4% -0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSRPTLEGNVCEL
Forward P/E 6.6xFY2026 – 84.8xFY2026
EPS, next fiscal year $2.88FY2026 $-0.04FY2026 $0.51FY2026
EPS growth, next FY – – +59.4%FY2026
EPS growth, the year after -88.5% – +74.5%
Revenue, next fiscal year $1.76BFY2026 $1.37BFY2026 $324.56MFY2026
Revenue growth, next FY -20.1%FY2026 +32.9%FY2026 +17.5%FY2026
Revenue growth, the year after -21.5% +35.9% +16.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSRPTLEGNVCEL
Held by institutions 100.0% 55.9% 100.0%
Institutions holding 324 218 317
Change in shares held, QoQ +4.5% +7.3% +0.4%
Institutions buying 148 117 187
Institutions selling 115 78 98
Buyers to sellers 1.29 1.50 1.91

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SRPTLEGNVCEL
SRPT 1.00 0.09 0.20
LEGN 0.09 1.00 0.14
VCEL 0.20 0.14 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SRPT, LEGN and VCEL?

Legend Biotech (LEGN) is the largest by market capitalisation: Sarepta Therapeutics (SRPT) $2.01B, Legend Biotech (LEGN) $4.14B, Vericel (VCEL) $2.14B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Sarepta Therapeutics (SRPT) -20.4%, Legend Biotech (LEGN) +59.5%, Vericel (VCEL) +23.0%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Sarepta Therapeutics (SRPT) -5.9%, Legend Biotech (LEGN) -7.2%, Vericel (VCEL) 7.9%). On return on invested capital, Legend Biotech (LEGN) leads (Sarepta Therapeutics (SRPT) -6.1%, Legend Biotech (LEGN) -4.2%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: Sarepta Therapeutics (SRPT) -19.6%, Legend Biotech (LEGN) -32.9%, Vericel (VCEL) +18.6%. Over five years, Vericel (VCEL) compounded fastest (Sarepta Therapeutics (SRPT) -24.9%/yr, Legend Biotech (LEGN) -15.9%/yr, Vericel (VCEL) -3.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Sarepta Therapeutics (SRPT) 81.2%, Legend Biotech (LEGN) 72.2%, Vericel (VCEL) 40.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SRPT, LEGN and VCEL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.