SRPT vs IOVA vs SLBT Stock Comparison

Sarepta Therapeutics, Iovance Biotherapeutics and SL Science Holding Prices as of Oct 28, 2026 Peers: Industry group

Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, Sarepta Therapeutics 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSRPTIOVASLBTLeader
Larger companyMarket capitalisation $2.04B $6.71B $2.64B IOVA
Cheaper on earningsLower P/E, profitable companies only -17.4x -23.0x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 6.7x — — –
Faster revenue growthRevenue growth, trailing twelve months -20.4% +34.5% — IOVA
More profitableNet margin, trailing twelve months -5.9% -89.1% — SRPT
Better return on capitalReturn on invested capital -6.1% — — –
Less leveragedLower net debt / EBITDA -0.6x — — –
Higher dividend yieldTrailing dividend yield — — 0.00% –
Better 1-year returnPrice return, last 12 months -20.2% +576.3% -88.3% IOVA
Better 5-year returnAnnualised price return, 5 years -24.6%/yr -9.4%/yr — IOVA
Less volatileAnnualised volatility, 1 year 81.1% 99.0% 175.5% SRPT
Higher overall scoreMean of the five percentile scores vs peers 67/100 64/100 — SRPT

Percentile Scorecard

SRPTIOVASLBT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSRPTIOVASLBT
Valuation 96 #25 of 625 67 #208 of 625 11 #556 of 625
Growth 64 #217 of 602 81 #113 of 602 –
Profitability 79 #114 of 549 63 #206 of 549 –
Financial Health 33 #436 of 654 64 #235 of 654 58 #276 of 654
Shareholder Returns 61 #145 of 367 45 #204 of 367 –
Overall 67 64 –
  • SRPT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSRPTIOVASLBTSPY
1 month +2.8%+34.8%-37.3% +0.9%
3 months +24.4%+224.8%-53.5% +5.9%
6 months -6.5%+347.4%-87.9% +8.5%
Year to date -10.2%+442.5%-88.5% +13.3%
1 year -20.2%+576.3%-88.3% +12.4%
3 years -81.9%+323.1%— +88.1%
3 years, per year -43.5%+61.8%— +23.5%
5 years -75.6%-39.1%— +68.2%
5 years, per year -24.6%-9.4%— +11.0%
10 years -52.8%+137.0%— +263.4%
10 years, per year -7.2%+9.0%— +13.8%

Risk

MeasureSRPTIOVASLBTSPY
Volatility, 1Y 81.1%99.0%175.5% 12.7%
Downside volatility, 1Y 85.9%71.1%170.6% 12.7%
Beta vs S&P 500, 1Y 2.081.290.23 1.00
Return / volatility, 1Y -0.255.82-0.50 0.98
Max drawdown, 5Y -92.7%-93.4%-91.0% -25.4%
From 52-week high -21.0%-0.3%-90.6% -0.9%
52-week high $24.45$14.86$12.81 $779.14
52-week low $14.86$1.81$1.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSRPTIOVASLBT
P/E now vs peer median -17.4xmedian 17.4x -23.0xmedian 17.4x —median 17.4x
P/S now vs peer median 1.0xmedian 9.1x 20.6xmedian 9.1x —median 9.1x
EV/EBITDA now vs peer median -21.3xmedian 17.1x -24.2xmedian 17.1x —median 17.1x
P/FCF now vs peer median 24.9xmedian 19.0x -22.6xmedian 19.0x -1,406xmedian 19.0x
P/B now vs peer median 1.3xmedian 2.2x 9.1xmedian 2.2x 378.4xmedian 2.2x
PEG now vs peer median -0.33median 0.34 -0.77median 0.34 —median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSRPTIOVASLBT
Revenue $1.97B $324.97M –
Gross profit $1.17B $157.29M –
Operating income -$143.25M -$301.31M –
Net income -$136.73M -$289.51M –
Free cash flow $81.85M -$296.40M –
R&D $789.44M $267.72M –
EPS (diluted) $-1.11 $-0.64 –
Cash & equivalents $571.15M $110.80M $8.31M
Total debt $847.62M – –
Shares (diluted) 105.43M 450.19M –
Enterprise value -$1.19B $5.50B $2.62B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSRPTIOVASLBT
P/E -17.4x -23.0x –
P/FCF 24.9x -22.6x -1,406x
P/Operating cash flow 18.4x -25.4x –
P/S 1.0x 20.6x –
P/B 1.3x 9.1x 378.4x
P/Tangible book 1.4x 14.2x 378.4x
EV/EBITDA -21.3x -24.2x –
EV/EBIT -14.7x -21.3x –
EV/Revenue 1.1x 19.7x –
EV/FCF 25.7x -21.6x –
EV/Operating cash flow 18.9x -24.3x –
PEG (3Y EPS CAGR) -0.33 -0.77 –

Growth

14 metrics
MetricSRPTIOVASLBT
Revenue growth (1Y) -20.4% 34.5% –
Revenue CAGR (3Y) 25.3% 1,009% –
Gross profit growth (1Y) -40.7% 95.1% –
Gross profit CAGR (3Y) 10.6% – –
Operating income growth (1Y) -15,270% 26.6% –
Operating income CAGR (3Y) 34.5% 11.1% –
Net income growth (1Y) -135.9% 25.8% –
Net income CAGR (3Y) 46.8% 11.6% –
EPS growth (1Y) -215.7% 44.8% –
EPS CAGR (3Y) 52.3% 29.9% –
Operating cash flow growth (1Y) 136.9% 12.9% –
Operating cash flow CAGR (3Y) 30.6% 7.6% –
Free cash flow growth (1Y) 118.1% 8.4% –
Free cash flow CAGR (3Y) 29.1% 5.8% –

Profitability

14 metrics
MetricSRPTIOVASLBT
Gross margin 59.1% 48.4% –
EBITDA margin -5.0% -81.4% –
Operating margin -7.3% -92.7% –
Pretax margin -6.6% -90.4% –
Net margin -5.9% -89.1% –
FCF margin 4.1% -91.2% –
Operating cash flow margin 5.6% -81.3% –
Return on equity -9.0% -39.7% –
Return on assets -4.3% -31.4% –
Return on invested capital -6.1% – –
Return on capital employed -5.3% -37.0% –
Asset turnover 0.6x 0.4x –
Cash conversion (OCF / net income) -0.8x 0.9x –
Stock comp / revenue 6.3% 14.4% –

Financial Health

11 metrics
MetricSRPTIOVASLBT
Debt / assets 26.6% – –
Debt / equity 0.6x – –
Net debt / EBITDA -0.6x – –
Debt / FCF 10.4x – –
Liabilities / assets 52.1% 19.6% 21.8%
Equity / assets 47.9% 80.4% 78.2%
Interest coverage – – –
Current ratio 4.4x 4.3x 4.4x
Quick ratio 2.4x 3.7x 4.3x
Cash ratio 1.6x 2.8x 4.3x
Altman Z-score -0.14 17.73 –

Shareholder Returns

7 metrics
MetricSRPTIOVASLBT
Dividend yield – – –
Net buyback yield -1.1% -4.4% –
Shareholder yield -1.1% -4.4% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSRPTIOVASLBT
Forward P/E 6.7xFY2026 – –
EPS, next fiscal year $2.88FY2026 $-0.47FY2026 –
EPS growth, the year after -88.5% – –
Revenue, next fiscal year $1.76BFY2026 $434.71MFY2026 –
Revenue growth, next FY -20.1%FY2026 +65.0%FY2026 –
Revenue growth, the year after -21.5% +33.0% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSRPTIOVASLBT
Held by institutions 100.0% 63.3% –
Institutions holding 324 292 –
Change in shares held, QoQ +4.5% +6.5% –
Institutions buying 148 174 –
Institutions selling 115 66 –
Buyers to sellers 1.29 2.64 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SRPTIOVASLBT
SRPT 1.00 0.29 0.00
IOVA 0.29 1.00 0.01
SLBT 0.00 0.01 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SRPT, IOVA and SLBT?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Sarepta Therapeutics (SRPT) $2.04B, Iovance Biotherapeutics (IOVA) $6.71B, SL Science Holding (SLBT) $2.64B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: Sarepta Therapeutics (SRPT) -20.4%, Iovance Biotherapeutics (IOVA) +34.5%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Sarepta Therapeutics (SRPT) -5.9%, Iovance Biotherapeutics (IOVA) -89.1%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Sarepta Therapeutics (SRPT) -20.2%, Iovance Biotherapeutics (IOVA) +576.3%, SL Science Holding (SLBT) -88.3%. Over five years, Iovance Biotherapeutics (IOVA) compounded fastest (Sarepta Therapeutics (SRPT) -24.6%/yr, Iovance Biotherapeutics (IOVA) -9.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sarepta Therapeutics (SRPT) has been the steadiest (Sarepta Therapeutics (SRPT) 81.1%, Iovance Biotherapeutics (IOVA) 99.0%, SL Science Holding (SLBT) 175.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SRPT, IOVA and SLBT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.