SRPT vs CRSP vs PGEN Stock Comparison

Sarepta Therapeutics, CRISPR Therapeutics AG and Precigen Prices as of Oct 27, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$5.16B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
PGEN Precigen, Inc.
$6.15 -20.6% 1M +43.0% 1Y
Market cap
$2.18B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

10 decided of 12

Sarepta Therapeutics leads on 4 of the 12 questions below (Sarepta Therapeutics 4, Precigen 4, CRISPR Therapeutics AG 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSRPTCRSPPGENLeader
Larger companyMarket capitalisation $2.02B $5.16B $2.18B CRSP
Cheaper on earningsLower P/E, profitable companies only -17.3x -11.4x -6.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 6.6x — 36.2x SRPT
Faster revenue growthRevenue growth, trailing twelve months -20.4% -64.8% +1,875.0% PGEN
More profitableNet margin, trailing twelve months -5.9% -3,368.7% -392.8% SRPT
Better return on capitalReturn on invested capital -6.1% -22.6% — SRPT
Less leveragedLower net debt / EBITDA -0.6x 3.4x -1.6x PGEN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -19.6% -21.7% +43.0% PGEN
Better 5-year returnAnnualised price return, 5 years -24.9%/yr -11.4%/yr +4.4%/yr PGEN
Less volatileAnnualised volatility, 1 year 81.2% 57.2% 77.9% CRSP
Higher overall scoreMean of the five percentile scores vs peers 67/100 44/100 55/100 SRPT

Percentile Scorecard

SRPTCRSPPGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSRPTCRSPPGEN
Valuation 96 #25 of 625 49 #322 of 625 59 #258 of 625
Growth 64 #218 of 602 32 #411 of 602 49 #310 of 602
Profitability 80 #114 of 551 32 #375 of 551 59 #227 of 551
Financial Health 34 #435 of 656 71 #190 of 656 27 #482 of 656
Shareholder Returns 60 #145 of 365 38 #228 of 365 83 #63 of 365
Overall 67 44 55
  • SRPT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSRPTCRSPPGENSPY
1 month +1.2%-5.1%-20.6% -0.2%
3 months +22.4%+8.2%+11.2% +3.9%
6 months -10.3%-1.1%+53.0% +8.2%
Year to date -12.2%-1.8%+47.1% +12.9%
1 year -19.6%-21.7%+43.0% +12.3%
3 years -82.3%+32.9%+508.9% +87.4%
3 years, per year -43.9%+9.9%+82.7% +23.3%
5 years -76.2%-45.2%+24.0% +67.9%
5 years, per year -24.9%-11.4%+4.4% +10.9%
10 years -53.7%+225.3%-76.2% +261.1%
10 years, per year -7.4%+12.5%-13.4% +13.7%

Risk

MeasureSRPTCRSPPGENSPY
Volatility, 1Y 81.2%57.2%77.9% 12.7%
Downside volatility, 1Y 85.9%53.7%69.4% 12.7%
Beta vs S&P 500, 1Y 2.081.831.43 1.00
Return / volatility, 1Y -0.24-0.380.55 0.97
Max drawdown, 5Y -92.7%-67.7%-87.8% -25.4%
From 52-week high -22.7%-21.7%-28.2% -1.2%
52-week high $24.45$65.72$8.56 $779.14
52-week low $14.86$44.34$3.10 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSRPTCRSPPGEN
P/E now vs peer median -17.0xmedian 17.2x -11.0xmedian 17.2x -6.5xmedian 17.2x
P/S now vs peer median 1.0xmedian 9.0x 371.5xmedian 9.0x 25.7xmedian 9.0x
EV/EBITDA now vs peer median -20.8xmedian 16.3x -6.2xmedian 16.3x -65.8xmedian 16.3x
P/FCF now vs peer median 24.4xmedian 18.7x -13.4xmedian 18.7x -19.1xmedian 18.7x
P/B now vs peer median 1.3xmedian 2.2x 2.8xmedian 2.2x 50.5xmedian 2.2x
PEG now vs peer median -0.33median 0.33 -2.86median 0.33 0.05median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSRPTCRSPPGEN
Revenue $1.97B $13.39M $85.72M
Gross profit $1.17B – $77.72M
Operating income -$143.25M -$534.34M -$39.50M
Net income -$136.73M -$451.14M -$157.71M
Free cash flow $81.85M -$371.33M -$115.22M
R&D $789.44M $278.15M $32.29M
EPS (diluted) $-1.11 $-4.67 $-0.81
Cash & equivalents $571.15M $291.34M $16.33M
Total debt $847.62M $586.20M $93.88M
Shares (diluted) 105.43M 96.51M 413.69M
Enterprise value -$1.21B -$3.54B $1.87B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSRPTCRSPPGEN
P/E -17.0x -11.0x -6.5x
P/FCF 24.4x -13.4x -19.1x
P/Operating cash flow 18.0x -13.5x -19.3x
P/S 1.0x 371.5x 25.7x
P/B 1.3x 2.8x 50.5x
P/Tangible book 1.3x 2.8x 53.7x
EV/EBITDA -20.8x -6.2x -65.8x
EV/EBIT -14.3x -6.0x -57.2x
EV/Revenue 1.0x 238.7x 26.3x
EV/FCF 25.1x -8.6x -19.6x
EV/Operating cash flow 18.5x -8.7x -19.8x
PEG (3Y EPS CAGR) -0.33 -2.86 0.05

Growth

14 metrics
MetricSRPTCRSPPGEN
Revenue growth (1Y) -20.4% -64.8% 1,875%
Revenue CAGR (3Y) 25.3% -57.1% 57.1%
Gross profit growth (1Y) -40.7% – 259,173%
Gross profit CAGR (3Y) 10.6% – 69.2%
Operating income growth (1Y) -15,270% 3.3% 62.1%
Operating income CAGR (3Y) 34.5% -4.1% 18.9%
Net income growth (1Y) -135.9% 3.6% -26.7%
Net income CAGR (3Y) 46.8% -2.7% -108.9%
EPS growth (1Y) -215.7% 13.0% -93.8%
EPS CAGR (3Y) 52.3% 3.9% -123.2%
Operating cash flow growth (1Y) 136.9% -13.8% -72.3%
Operating cash flow CAGR (3Y) 30.6% -2.5% -15.9%
Free cash flow growth (1Y) 118.1% -14.1% -65.1%
Free cash flow CAGR (3Y) 29.1% -0.9% -15.3%

Profitability

14 metrics
MetricSRPTCRSPPGEN
Gross margin 59.1% – 90.7%
EBITDA margin -5.0% -3,850% -40.0%
Operating margin -7.3% -3,990% -46.1%
Pretax margin -6.6% -3,346% -184.0%
Net margin -5.9% -3,369% -392.8%
FCF margin 4.1% -2,773% -134.4%
Operating cash flow margin 5.6% -2,760% -133.2%
Return on equity -9.0% -25.3% -494.3%
Return on assets -4.3% -16.8% -102.1%
Return on invested capital -6.1% -22.6% –
Return on capital employed -5.3% -20.9% -31.6%
Asset turnover 0.6x 0.0x 0.6x
Cash conversion (OCF / net income) -0.8x 0.8x 0.7x
Stock comp / revenue 6.3% 510.2% 15.3%

Financial Health

11 metrics
MetricSRPTCRSPPGEN
Debt / assets 26.6% 22.1% 55.1%
Debt / equity 0.6x 0.3x 2.2x
Net debt / EBITDA -0.6x 3.4x -1.6x
Debt / FCF 10.4x -1.6x -0.8x
Liabilities / assets 52.1% 34.1% 74.4%
Equity / assets 47.9% 65.9% 25.6%
Interest coverage – – -4.1x
Current ratio 4.4x 17.8x 4.6x
Quick ratio 2.4x 17.8x 3.8x
Cash ratio 1.6x 17.8x 1.3x
Altman Z-score -0.16 2.51 -8.25

Shareholder Returns

7 metrics
MetricSRPTCRSPPGEN
Dividend yield – – –
Net buyback yield -1.1% -8.6% -0.1%
Shareholder yield -1.1% -8.6% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSRPTCRSPPGEN
Forward P/E 6.6xFY2026 – 36.2xFY2026
EPS, next fiscal year $2.88FY2026 $-4.10FY2026 $0.17FY2026
EPS growth, the year after -88.5% – +288.2%
Revenue, next fiscal year $1.76BFY2026 $38.73MFY2026 $249.17MFY2026
Revenue growth, next FY -20.1%FY2026 +1,003.4%FY2026 +2,474.1%FY2026
Revenue growth, the year after -21.5% +266.1% +82.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSRPTCRSPPGEN
Held by institutions 100.0% 78.9% 39.2%
Institutions holding 324 518 210
Change in shares held, QoQ +4.5% -1.0% +4.9%
Institutions buying 148 237 123
Institutions selling 115 139 46
Buyers to sellers 1.29 1.71 2.67

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SRPTCRSPPGEN
SRPT 1.00 0.39 0.23
CRSP 0.39 1.00 0.37
PGEN 0.23 0.37 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, SRPT, CRSP and PGEN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Sarepta Therapeutics (SRPT) $2.02B, CRISPR Therapeutics AG (CRSP) $5.16B, Precigen (PGEN) $2.18B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Sarepta Therapeutics (SRPT) -20.4%, CRISPR Therapeutics AG (CRSP) -64.8%, Precigen (PGEN) +1,875.0%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Sarepta Therapeutics (SRPT) -5.9%, CRISPR Therapeutics AG (CRSP) -3,368.7%, Precigen (PGEN) -392.8%). On return on invested capital, Sarepta Therapeutics (SRPT) leads (Sarepta Therapeutics (SRPT) -6.1%, CRISPR Therapeutics AG (CRSP) -22.6%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Sarepta Therapeutics (SRPT) -19.6%, CRISPR Therapeutics AG (CRSP) -21.7%, Precigen (PGEN) +43.0%. Over five years, Precigen (PGEN) compounded fastest (Sarepta Therapeutics (SRPT) -24.9%/yr, CRISPR Therapeutics AG (CRSP) -11.4%/yr, Precigen (PGEN) +4.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Sarepta Therapeutics (SRPT) 81.2%, CRISPR Therapeutics AG (CRSP) 57.2%, Precigen (PGEN) 77.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SRPT, CRSP and PGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sarepta Therapeutics (SRPT) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.