SRPT vs BEAM vs LEGN Stock Comparison

Sarepta Therapeutics, Beam Therapeutics and Legend Biotech Prices as of Oct 28, 2026 Peers: Industry group
BEAM Beam Therapeutics Inc.
$28.78 +18.8% 1M +8.9% 1Y
Market cap
$2.99B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
LEGN Legend Biotech Corp
$22.53 +21.0% 1M -30.8% 1Y
Market cap
$4.11B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

9 decided of 12

Legend Biotech leads on 4 of the 12 questions below (Legend Biotech 4, Beam Therapeutics 3, Sarepta Therapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSRPTBEAMLEGNLeader
Larger companyMarket capitalisation $2.03B $2.99B $4.11B LEGN
Cheaper on earningsLower P/E, profitable companies only -17.3x -35.0x -44.8x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 6.7x — — –
Faster revenue growthRevenue growth, trailing twelve months -20.4% +158.9% +59.5% BEAM
More profitableNet margin, trailing twelve months -5.9% -54.7% -7.2% SRPT
Better return on capitalReturn on invested capital -6.1% — -4.2% LEGN
Less leveragedLower net debt / EBITDA -0.6x 3.0x 28.0x SRPT
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -20.2% +8.9% -30.8% BEAM
Better 5-year returnAnnualised price return, 5 years -24.6%/yr -20.2%/yr -15.6%/yr LEGN
Less volatileAnnualised volatility, 1 year 81.1% 70.7% 72.3% BEAM
Higher overall scoreMean of the five percentile scores vs peers 67/100 69/100 73/100 LEGN

Percentile Scorecard

SRPTBEAMLEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSRPTBEAMLEGN
Valuation 96 #25 of 625 57 #272 of 625 89 #72 of 625
Growth 64 #217 of 602 77 #139 of 602 96 #23 of 602
Profitability 79 #114 of 549 64 #197 of 549 80 #109 of 549
Financial Health 33 #436 of 654 81 #123 of 654 54 #299 of 654
Shareholder Returns 61 #145 of 367 68 #119 of 367 44 #206 of 367
Overall 67 69 73
  • SRPT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSRPTBEAMLEGNSPY
1 month +2.8%+18.8%+21.0% +0.9%
3 months +24.4%+10.6%+19.5% +5.9%
6 months -6.5%-2.0%-1.1% +8.5%
Year to date -10.2%+3.8%+3.6% +13.3%
1 year -20.2%+8.9%-30.8% +12.4%
3 years -81.9%+54.6%-64.6% +88.1%
3 years, per year -43.5%+15.6%-29.3% +23.5%
5 years -75.6%-67.6%-57.1% +68.2%
5 years, per year -24.6%-20.2%-15.6% +11.0%
10 years -52.8%—— +263.4%
10 years, per year -7.2%—— +13.8%

Risk

MeasureSRPTBEAMLEGNSPY
Volatility, 1Y 81.1%70.7%72.3% 12.7%
Downside volatility, 1Y 85.9%64.0%62.7% 12.7%
Beta vs S&P 500, 1Y 2.082.090.44 1.00
Return / volatility, 1Y -0.250.13-0.43 0.98
Max drawdown, 5Y -92.7%-85.3%-78.2% -25.4%
From 52-week high -21.0%-24.1%-37.9% -0.9%
52-week high $24.45$37.92$36.28 $779.14
52-week low $14.86$20.60$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSRPTBEAMLEGN
P/E now vs peer median -17.4xmedian 17.4x -35.1xmedian 17.4x -45.3xmedian 17.4x
P/S now vs peer median 1.0xmedian 9.1x 19.0xmedian 9.1x 3.3xmedian 9.1x
EV/EBITDA now vs peer median -21.3xmedian 17.1x -5.4xmedian 17.1x -197.3xmedian 17.1x
P/FCF now vs peer median 24.9xmedian 19.0x -8.0xmedian 19.0x -64.3xmedian 19.0x
P/B now vs peer median 1.3xmedian 2.2x 2.8xmedian 2.2x 3.4xmedian 2.2x
PEG now vs peer median -0.33median 0.34 -0.83median 0.34 -0.96median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSRPTBEAMLEGN
Revenue $1.97B $156.04M $1.27B
Gross profit $1.17B – $727.10M
Operating income -$143.25M -$378.02M -$55.25M
Net income -$136.73M -$86.52M -$80.39M
Free cash flow $81.85M -$372.77M -$64.60M
R&D $789.44M $408.66M $396.15M
EPS (diluted) $-1.11 $-0.82 $-0.50
Cash & equivalents $571.15M $219.83M $672.90M
Total debt $847.62M $100.26M $1.06B
Shares (diluted) 105.43M 104.33M 184.32M
Enterprise value -$1.21B -$1.69B $1.61B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSRPTBEAMLEGN
P/E -17.4x -35.1x -45.3x
P/FCF 24.9x -8.0x -64.3x
P/Operating cash flow 18.4x -8.3x -46.5x
P/S 1.0x 19.0x 3.3x
P/B 1.3x 2.8x 3.4x
P/Tangible book 1.4x 2.8x 3.4x
EV/EBITDA -21.3x -5.4x -197.3x
EV/EBIT -14.7x -5.1x -65.8x
EV/Revenue 1.1x 12.3x 2.9x
EV/FCF 25.7x -5.1x -56.3x
EV/Operating cash flow 18.9x -5.3x -40.7x
PEG (3Y EPS CAGR) -0.33 -0.83 -0.96

Growth

14 metrics
MetricSRPTBEAMLEGN
Revenue growth (1Y) -20.4% 158.9% 59.5%
Revenue CAGR (3Y) 25.3% 24.9% 97.6%
Gross profit growth (1Y) -40.7% – 42.4%
Gross profit CAGR (3Y) 10.6% – 147.5%
Operating income growth (1Y) -15,270% 15.2% 75.3%
Operating income CAGR (3Y) 34.5% 0.3% 49.1%
Net income growth (1Y) -135.9% 78.2% 75.3%
Net income CAGR (3Y) 46.8% 35.8% 46.7%
EPS growth (1Y) -215.7% 79.0% 72.0%
EPS CAGR (3Y) 52.3% 42.4% 47.0%
Operating cash flow growth (1Y) 136.9% -4.2% 67.5%
Operating cash flow CAGR (3Y) 30.6% -2.0% 37.1%
Free cash flow growth (1Y) 118.1% -4.8% 77.8%
Free cash flow CAGR (3Y) 29.1% 0.7% 44.5%

Profitability

14 metrics
MetricSRPTBEAMLEGN
Gross margin 59.1% – 57.2%
EBITDA margin -5.0% -228.0% -1.5%
Operating margin -7.3% -242.3% -4.3%
Pretax margin -6.6% -54.4% -4.4%
Net margin -5.9% -54.7% -7.2%
FCF margin 4.1% -238.9% -5.1%
Operating cash flow margin 5.6% -230.3% -7.0%
Return on equity -9.0% -7.6% -8.3%
Return on assets -4.3% -5.9% -5.5%
Return on invested capital -6.1% – -4.2%
Return on capital employed -5.3% -27.9% -4.3%
Asset turnover 0.6x 0.1x 0.8x
Cash conversion (OCF / net income) -0.8x 4.2x 1.1x
Stock comp / revenue 6.3% 52.2% 5.2%

Financial Health

11 metrics
MetricSRPTBEAMLEGN
Debt / assets 26.6% 7.2% 8.9%
Debt / equity 0.6x 0.1x 0.1x
Net debt / EBITDA -0.6x 3.0x 28.0x
Debt / FCF 10.4x -0.3x -2.4x
Liabilities / assets 52.1% 23.0% 29.8%
Equity / assets 47.9% 77.0% 70.2%
Interest coverage – – -4.8x
Current ratio 4.4x 14.6x 3.0x
Quick ratio 2.4x 14.3x 1.7x
Cash ratio 1.6x 14.3x 1.7x
Altman Z-score -0.14 3.84 6.95

Shareholder Returns

7 metrics
MetricSRPTBEAMLEGN
Dividend yield – – –
Net buyback yield -1.1% -0.5% -5.2%
Shareholder yield -1.1% -0.5% -5.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSRPTBEAMLEGN
Forward P/E 6.7xFY2026 – –
EPS, next fiscal year $2.88FY2026 $-4.22FY2026 $-0.04FY2026
EPS growth, the year after -88.5% – –
Revenue, next fiscal year $1.76BFY2026 $49.46MFY2026 $1.37BFY2026
Revenue growth, next FY -20.1%FY2026 -64.6%FY2026 +32.9%FY2026
Revenue growth, the year after -21.5% +23.6% +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSRPTBEAMLEGN
Held by institutions 100.0% 100.0% 55.9%
Institutions holding 324 277 218
Change in shares held, QoQ +4.5% +1.0% +7.3%
Institutions buying 148 154 117
Institutions selling 115 75 78
Buyers to sellers 1.29 2.05 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SRPTBEAMLEGN
SRPT 1.00 0.36 0.09
BEAM 0.36 1.00 0.09
LEGN 0.09 0.09 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SRPT, BEAM and LEGN?

Legend Biotech (LEGN) is the largest by market capitalisation: Sarepta Therapeutics (SRPT) $2.03B, Beam Therapeutics (BEAM) $2.99B, Legend Biotech (LEGN) $4.11B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: Sarepta Therapeutics (SRPT) -20.4%, Beam Therapeutics (BEAM) +158.9%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Sarepta Therapeutics (SRPT) -5.9%, Beam Therapeutics (BEAM) -54.7%, Legend Biotech (LEGN) -7.2%). On return on invested capital, Legend Biotech (LEGN) leads (Sarepta Therapeutics (SRPT) -6.1%, Legend Biotech (LEGN) -4.2%).

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: Sarepta Therapeutics (SRPT) -20.2%, Beam Therapeutics (BEAM) +8.9%, Legend Biotech (LEGN) -30.8%. Over five years, Legend Biotech (LEGN) compounded fastest (Sarepta Therapeutics (SRPT) -24.6%/yr, Beam Therapeutics (BEAM) -20.2%/yr, Legend Biotech (LEGN) -15.6%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Beam Therapeutics (BEAM) has been the steadiest (Sarepta Therapeutics (SRPT) 81.1%, Beam Therapeutics (BEAM) 70.7%, Legend Biotech (LEGN) 72.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SRPT, BEAM and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.