SLDB vs LEGN vs CRSP Stock Comparison

Solid Biosciences, Legend Biotech and CRISPR Therapeutics AG Prices as of Oct 28, 2026 Peers: Industry group
SLDB Solid Biosciences Inc.
$6.48 -11.0% 1M +9.5% 1Y
Market cap
$931.10M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
LEGN Legend Biotech Corp
$22.53 +21.0% 1M -30.8% 1Y
Market cap
$4.15B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
CRSP CRISPR Therapeutics AG
$54.11 +0.0% 1M -15.7% 1Y
Market cap
$5.23B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

9 decided of 12

CRISPR Therapeutics AG leads on 4 of the 12 questions below (CRISPR Therapeutics AG 4, Legend Biotech 4, Solid Biosciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLDBLEGNCRSPLeader
Larger companyMarket capitalisation $931.10M $4.15B $5.23B CRSP
Cheaper on earningsLower P/E, profitable companies only -4.5x -45.3x -11.6x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — +59.5% -64.8% LEGN
More profitableNet margin, trailing twelve months — -7.2% -3,368.7% LEGN
Better return on capitalReturn on invested capital — -4.2% -22.6% LEGN
Less leveragedLower net debt / EBITDA — 28.0x 3.4x CRSP
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +9.5% -30.8% -15.7% SLDB
Better 5-year returnAnnualised price return, 5 years -26.6%/yr -15.6%/yr -9.9%/yr CRSP
Less volatileAnnualised volatility, 1 year 78.6% 72.3% 57.4% CRSP
Higher overall scoreMean of the five percentile scores vs peers 42/100 73/100 45/100 LEGN

Percentile Scorecard

SLDBLEGNCRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLDBLEGNCRSP
Valuation 35 #407 of 625 89 #72 of 625 50 #311 of 625
Growth 19 #486 of 602 96 #23 of 602 31 #413 of 602
Profitability 49 #279 of 549 80 #109 of 549 32 #374 of 549
Financial Health 88 #79 of 654 54 #299 of 654 71 #189 of 654
Shareholder Returns 20 #295 of 367 44 #206 of 367 38 #227 of 367
Overall 42 73 45
  • SLDB ranked among 672 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLDBLEGNCRSPSPY
1 month -11.0%+21.0%+0.0% +0.9%
3 months -19.4%+19.5%+13.6% +5.9%
6 months -8.1%-1.1%+6.7% +8.5%
Year to date +14.9%+3.6%+3.2% +13.3%
1 year +9.5%-30.8%-15.7% +12.4%
3 years +242.9%-64.6%+39.7% +88.1%
3 years, per year +50.8%-29.3%+11.8% +23.5%
5 years -78.7%-57.1%-40.8% +68.2%
5 years, per year -26.6%-15.6%-9.9% +11.0%
10 years ——+223.2% +263.4%
10 years, per year ——+12.4% +13.8%

Risk

MeasureSLDBLEGNCRSPSPY
Volatility, 1Y 78.6%72.3%57.4% 12.7%
Downside volatility, 1Y 77.0%62.7%53.8% 12.7%
Beta vs S&P 500, 1Y 2.130.441.84 1.00
Return / volatility, 1Y 0.12-0.43-0.27 0.98
Max drawdown, 5Y -94.9%-78.2%-67.7% -25.4%
From 52-week high -41.9%-37.9%-15.7% -0.9%
52-week high $11.15$36.28$64.17 $779.14
52-week low $3.93$16.65$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLDBLEGNCRSP
P/E now vs peer median -4.5xmedian 17.4x -45.3xmedian 17.4x -11.6xmedian 17.4x
P/S now vs peer median —median 9.1x 3.3xmedian 9.1x 390.6xmedian 9.1x
EV/EBITDA now vs peer median -2.6xmedian 17.1x -197.3xmedian 17.1x -6.7xmedian 17.1x
P/FCF now vs peer median -5.0xmedian 19.0x -64.3xmedian 19.0x -14.1xmedian 19.0x
P/B now vs peer median 2.5xmedian 2.2x 3.4xmedian 2.2x 3.0xmedian 2.2x
PEG now vs peer median -0.14median 0.34 -0.96median 0.34 -3.01median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLDBLEGNCRSP
Revenue – $1.27B $13.39M
Gross profit – $727.10M –
Operating income -$212.15M -$55.25M -$534.34M
Net income -$207.10M -$80.39M -$451.14M
Free cash flow -$187.82M -$64.60M -$371.33M
R&D $167.40M $396.15M $278.15M
EPS (diluted) $-1.44 $-0.50 $-4.67
Cash & equivalents $159.39M $672.90M $291.34M
Total debt – $1.06B $586.20M
Shares (diluted) 143.69M 184.32M 96.51M
Enterprise value -$251.25M $1.65B -$3.47B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLDBLEGNCRSP
P/E -4.5x -45.3x -11.6x
P/FCF -5.0x -64.3x -14.1x
P/Operating cash flow -5.0x -46.5x -14.2x
P/S – 3.3x 390.6x
P/B 2.5x 3.4x 3.0x
P/Tangible book 2.5x 3.4x 3.0x
EV/EBITDA -2.6x -197.3x -6.7x
EV/EBIT -2.6x -65.8x -6.5x
EV/Revenue – 2.9x 257.8x
EV/FCF -2.9x -56.3x -9.3x
EV/Operating cash flow -3.0x -40.7x -9.3x
PEG (3Y EPS CAGR) -0.14 -0.96 -3.01

Growth

14 metrics
MetricSLDBLEGNCRSP
Revenue growth (1Y) – 59.5% -64.8%
Revenue CAGR (3Y) – 97.6% -57.1%
Gross profit growth (1Y) – 42.4% –
Gross profit CAGR (3Y) – 147.5% –
Operating income growth (1Y) -35.3% 75.3% 3.3%
Operating income CAGR (3Y) -22.8% 49.1% -4.1%
Net income growth (1Y) -34.4% 75.3% 3.6%
Net income CAGR (3Y) -31.9% 46.7% -2.7%
EPS growth (1Y) 11.9% 72.0% 13.0%
EPS CAGR (3Y) 32.0% 47.0% 3.9%
Operating cash flow growth (1Y) -52.4% 67.5% -13.8%
Operating cash flow CAGR (3Y) -19.2% 37.1% -2.5%
Free cash flow growth (1Y) -52.3% 77.8% -14.1%
Free cash flow CAGR (3Y) -18.4% 44.5% -0.9%

Profitability

14 metrics
MetricSLDBLEGNCRSP
Gross margin – 57.2% –
EBITDA margin – -1.5% -3,850%
Operating margin – -4.3% -3,990%
Pretax margin – -4.4% -3,346%
Net margin – -7.2% -3,369%
FCF margin – -5.1% -2,773%
Operating cash flow margin – -7.0% -2,760%
Return on equity -55.4% -8.3% -25.3%
Return on assets -49.1% -5.5% -16.8%
Return on invested capital – -4.2% -22.6%
Return on capital employed -54.0% -4.3% -20.9%
Asset turnover – 0.8x 0.0x
Cash conversion (OCF / net income) 0.9x 1.1x 0.8x
Stock comp / revenue – 5.2% 510.2%

Financial Health

11 metrics
MetricSLDBLEGNCRSP
Debt / assets – 8.9% 22.1%
Debt / equity – 0.1x 0.3x
Net debt / EBITDA – 28.0x 3.4x
Debt / FCF – -2.4x -1.6x
Liabilities / assets 11.1% 29.8% 34.1%
Equity / assets 88.9% 70.2% 65.9%
Interest coverage – -4.8x –
Current ratio 13.8x 3.0x 17.8x
Quick ratio 13.2x 1.7x 17.8x
Cash ratio 13.2x 1.7x 17.8x
Altman Z-score – 6.95 2.68

Shareholder Returns

7 metrics
MetricSLDBLEGNCRSP
Dividend yield – – –
Net buyback yield -25.8% -5.2% -8.2%
Shareholder yield -25.8% -5.2% -8.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLDBLEGNCRSP
EPS, next fiscal year $-1.63FY2026 $-0.04FY2026 $-4.10FY2026
Revenue, next fiscal year $0.00FY2026 $1.37BFY2026 $38.73MFY2026
Revenue growth, next FY – +32.9%FY2026 +1,003.4%FY2026
Revenue growth, the year after – +35.9% +266.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLDBLEGNCRSP
Held by institutions 79.7% 55.9% 78.9%
Institutions holding 157 218 518
Change in shares held, QoQ +18.9% +7.3% -1.0%
Institutions buying 101 117 237
Institutions selling 37 78 139
Buyers to sellers 2.73 1.50 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLDBLEGNCRSP
SLDB 1.00 0.02 0.50
LEGN 0.02 1.00 0.05
CRSP 0.50 0.05 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SLDB, LEGN and CRSP?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Solid Biosciences (SLDB) $931.10M, Legend Biotech (LEGN) $4.15B, CRISPR Therapeutics AG (CRSP) $5.23B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Legend Biotech (LEGN) +59.5%, CRISPR Therapeutics AG (CRSP) -64.8%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (Legend Biotech (LEGN) -7.2%, CRISPR Therapeutics AG (CRSP) -3,368.7%). On return on invested capital, Legend Biotech (LEGN) leads (Legend Biotech (LEGN) -4.2%, CRISPR Therapeutics AG (CRSP) -22.6%).

Which stock has performed better?

Over the past year Solid Biosciences (SLDB) returned the most: Solid Biosciences (SLDB) +9.5%, Legend Biotech (LEGN) -30.8%, CRISPR Therapeutics AG (CRSP) -15.7%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (Solid Biosciences (SLDB) -26.6%/yr, Legend Biotech (LEGN) -15.6%/yr, CRISPR Therapeutics AG (CRSP) -9.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Solid Biosciences (SLDB) 78.6%, Legend Biotech (LEGN) 72.3%, CRISPR Therapeutics AG (CRSP) 57.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLDB, LEGN and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, CRISPR Therapeutics AG (CRSP) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.