SLDB vs CRSP vs SLBT Stock Comparison

Solid Biosciences, CRISPR Therapeutics AG and SL Science Holding Prices as of Oct 27, 2026 Peers: Industry group
SLDB Solid Biosciences Inc.
$6.19 -15.1% 1M +4.9% 1Y
Market cap
$934.70M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$5.15B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

5 decided of 12

CRISPR Therapeutics AG leads on 4 of the 12 questions below (CRISPR Therapeutics AG 4, Solid Biosciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLDBCRSPSLBTLeader
Larger companyMarket capitalisation $934.70M $5.15B $2.65B CRSP
Cheaper on earningsLower P/E, profitable companies only -4.5x -11.4x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — -64.8% — –
More profitableNet margin, trailing twelve months — -3,368.7% — –
Better return on capitalReturn on invested capital — -22.6% — –
Less leveragedLower net debt / EBITDA — 3.4x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +4.9% -21.7% -88.5% SLDB
Better 5-year returnAnnualised price return, 5 years -26.0%/yr -11.4%/yr — CRSP
Less volatileAnnualised volatility, 1 year 78.4% 57.2% 175.4% CRSP
Higher overall scoreMean of the five percentile scores vs peers 42/100 44/100 — CRSP

Percentile Scorecard

SLDBCRSPSLBT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLDBCRSPSLBT
Valuation 34 #413 of 625 49 #322 of 625 11 #555 of 625
Growth 19 #488 of 602 32 #411 of 602 –
Profitability 50 #276 of 551 32 #375 of 551 –
Financial Health 88 #78 of 656 71 #190 of 656 58 #279 of 656
Shareholder Returns 18 #300 of 365 38 #228 of 365 –
Overall 42 44 –
  • SLDB ranked among 672 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLDBCRSPSLBTSPY
1 month -15.1%-5.1%-24.2% -0.2%
3 months -22.3%+8.2%-56.7% +3.9%
6 months -16.9%-1.1%-84.9% +8.2%
Year to date +9.8%-1.8%-88.7% +12.9%
1 year +4.9%-21.7%-88.5% +12.3%
3 years +227.5%+32.9%— +87.4%
3 years, per year +48.5%+9.9%— +23.3%
5 years -77.8%-45.2%— +67.9%
5 years, per year -26.0%-11.4%— +10.9%
10 years —+225.3%— +261.1%
10 years, per year —+12.5%— +13.7%

Risk

MeasureSLDBCRSPSLBTSPY
Volatility, 1Y 78.4%57.2%175.4% 12.7%
Downside volatility, 1Y 77.0%53.7%170.6% 12.7%
Beta vs S&P 500, 1Y 2.121.830.23 1.00
Return / volatility, 1Y 0.06-0.38-0.50 0.97
Max drawdown, 5Y -94.9%-67.7%-91.0% -25.4%
From 52-week high -44.5%-21.7%-90.7% -1.2%
52-week high $11.15$65.72$12.81 $779.14
52-week low $3.93$44.34$1.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLDBCRSPSLBT
P/E now vs peer median -4.3xmedian 17.2x -11.0xmedian 17.2x —median 17.2x
P/S now vs peer median —median 9.0x 371.5xmedian 9.0x —median 9.0x
EV/EBITDA now vs peer median -2.4xmedian 16.3x -6.2xmedian 16.3x —median 16.3x
P/FCF now vs peer median -4.7xmedian 18.7x -13.4xmedian 18.7x -1,382xmedian 18.7x
P/B now vs peer median 2.4xmedian 2.2x 2.8xmedian 2.2x 372.2xmedian 2.2x
PEG now vs peer median -0.13median 0.33 -2.86median 0.33 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLDBCRSPSLBT
Revenue – $13.39M –
Operating income -$212.15M -$534.34M –
Net income -$207.10M -$451.14M –
Free cash flow -$187.82M -$371.33M –
R&D $167.40M $278.15M –
EPS (diluted) $-1.44 $-4.67 –
Cash & equivalents $159.39M $291.34M $8.31M
Total debt – $586.20M –
Shares (diluted) 143.69M 96.51M –
Enterprise value -$247.65M -$3.55B $2.64B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLDBCRSPSLBT
P/E -4.3x -11.0x –
P/FCF -4.7x -13.4x -1,382x
P/Operating cash flow -4.8x -13.5x –
P/S – 371.5x –
P/B 2.4x 2.8x 372.2x
P/Tangible book 2.4x 2.8x 372.2x
EV/EBITDA -2.4x -6.2x –
EV/EBIT -2.4x -6.0x –
EV/Revenue – 238.7x –
EV/FCF -2.7x -8.6x –
EV/Operating cash flow -2.7x -8.7x –
PEG (3Y EPS CAGR) -0.13 -2.86 –

Growth

14 metrics
MetricSLDBCRSPSLBT
Revenue growth (1Y) – -64.8% –
Revenue CAGR (3Y) – -57.1% –
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) -35.3% 3.3% –
Operating income CAGR (3Y) -22.8% -4.1% –
Net income growth (1Y) -34.4% 3.6% –
Net income CAGR (3Y) -31.9% -2.7% –
EPS growth (1Y) 11.9% 13.0% –
EPS CAGR (3Y) 32.0% 3.9% –
Operating cash flow growth (1Y) -52.4% -13.8% –
Operating cash flow CAGR (3Y) -19.2% -2.5% –
Free cash flow growth (1Y) -52.3% -14.1% –
Free cash flow CAGR (3Y) -18.4% -0.9% –

Profitability

14 metrics
MetricSLDBCRSPSLBT
Gross margin – – –
EBITDA margin – -3,850% –
Operating margin – -3,990% –
Pretax margin – -3,346% –
Net margin – -3,369% –
FCF margin – -2,773% –
Operating cash flow margin – -2,760% –
Return on equity -55.4% -25.3% –
Return on assets -49.1% -16.8% –
Return on invested capital – -22.6% –
Return on capital employed -54.0% -20.9% –
Asset turnover – 0.0x –
Cash conversion (OCF / net income) 0.9x 0.8x –
Stock comp / revenue – 510.2% –

Financial Health

11 metrics
MetricSLDBCRSPSLBT
Debt / assets – 22.1% –
Debt / equity – 0.3x –
Net debt / EBITDA – 3.4x –
Debt / FCF – -1.6x –
Liabilities / assets 11.1% 34.1% 21.8%
Equity / assets 88.9% 65.9% 78.2%
Interest coverage – – –
Current ratio 13.8x 17.8x 4.4x
Quick ratio 13.2x 17.8x 4.3x
Cash ratio 13.2x 17.8x 4.3x
Altman Z-score – 2.51 –

Shareholder Returns

7 metrics
MetricSLDBCRSPSLBT
Dividend yield – – –
Net buyback yield -27.0% -8.6% –
Shareholder yield -27.0% -8.6% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLDBCRSPSLBT
EPS, next fiscal year $-1.63FY2026 $-4.10FY2026 –
Revenue, next fiscal year $0.00FY2026 $38.73MFY2026 –
Revenue growth, next FY – +1,003.4%FY2026 –
Revenue growth, the year after – +266.1% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLDBCRSPSLBT
Held by institutions 79.7% 78.9% –
Institutions holding 157 518 –
Change in shares held, QoQ +18.9% -1.0% –
Institutions buying 101 237 –
Institutions selling 37 139 –
Buyers to sellers 2.73 1.71 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLDBCRSPSLBT
SLDB 1.00 0.50 -0.02
CRSP 0.50 1.00 -0.04
SLBT -0.02 -0.04 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SLDB, CRSP and SLBT?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Solid Biosciences (SLDB) $934.70M, CRISPR Therapeutics AG (CRSP) $5.15B, SL Science Holding (SLBT) $2.65B.

Which stock has performed better?

Over the past year Solid Biosciences (SLDB) returned the most: Solid Biosciences (SLDB) +4.9%, CRISPR Therapeutics AG (CRSP) -21.7%, SL Science Holding (SLBT) -88.5%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (Solid Biosciences (SLDB) -26.0%/yr, CRISPR Therapeutics AG (CRSP) -11.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Solid Biosciences (SLDB) 78.4%, CRISPR Therapeutics AG (CRSP) 57.2%, SL Science Holding (SLBT) 175.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLDB, CRSP and SLBT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, CRISPR Therapeutics AG (CRSP) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.