SLBT vs SLDB vs IOVA Stock Comparison

SL Science Holding, Solid Biosciences and Iovance Biotherapeutics Prices as of Oct 28, 2026 Peers: Industry group
SLDB Solid Biosciences Inc.
$6.48 -11.0% 1M +9.5% 1Y
Market cap
$931.10M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

5 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, Solid Biosciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTSLDBIOVALeader
Larger companyMarket capitalisation $2.64B $931.10M $6.71B IOVA
Cheaper on earningsLower P/E, profitable companies only — -4.5x -23.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — — +34.5% –
More profitableNet margin, trailing twelve months — — -89.1% –
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — — — –
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months -88.3% +9.5% +576.3% IOVA
Better 5-year returnAnnualised price return, 5 years — -26.6%/yr -9.4%/yr IOVA
Less volatileAnnualised volatility, 1 year 175.5% 78.6% 99.0% SLDB
Higher overall scoreMean of the five percentile scores vs peers — 42/100 64/100 IOVA

Percentile Scorecard

SLBTSLDBIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTSLDBIOVA
Valuation 11 #556 of 625 35 #407 of 625 67 #208 of 625
Growth – 19 #486 of 602 81 #113 of 602
Profitability – 49 #279 of 549 63 #206 of 549
Financial Health 58 #276 of 654 88 #79 of 654 64 #235 of 654
Shareholder Returns – 20 #295 of 367 45 #204 of 367
Overall – 42 64
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SLDB ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTSLDBIOVASPY
1 month -37.3%-11.0%+34.8% +0.9%
3 months -53.5%-19.4%+224.8% +5.9%
6 months -87.9%-8.1%+347.4% +8.5%
Year to date -88.5%+14.9%+442.5% +13.3%
1 year -88.3%+9.5%+576.3% +12.4%
3 years —+242.9%+323.1% +88.1%
3 years, per year —+50.8%+61.8% +23.5%
5 years —-78.7%-39.1% +68.2%
5 years, per year —-26.6%-9.4% +11.0%
10 years ——+137.0% +263.4%
10 years, per year ——+9.0% +13.8%

Risk

MeasureSLBTSLDBIOVASPY
Volatility, 1Y 175.5%78.6%99.0% 12.7%
Downside volatility, 1Y 170.6%77.0%71.1% 12.7%
Beta vs S&P 500, 1Y 0.232.131.29 1.00
Return / volatility, 1Y -0.500.125.82 0.98
Max drawdown, 5Y -91.0%-94.9%-93.4% -25.4%
From 52-week high -90.6%-41.9%-0.3% -0.9%
52-week high $12.81$11.15$14.86 $779.14
52-week low $1.15$3.93$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTSLDBIOVA
P/E now vs peer median —median 17.4x -4.5xmedian 17.4x -23.0xmedian 17.4x
P/S now vs peer median —median 9.1x —median 9.1x 20.6xmedian 9.1x
EV/EBITDA now vs peer median —median 17.1x -2.6xmedian 17.1x -24.2xmedian 17.1x
P/FCF now vs peer median -1,406xmedian 19.0x -5.0xmedian 19.0x -22.6xmedian 19.0x
P/B now vs peer median 378.4xmedian 2.2x 2.5xmedian 2.2x 9.1xmedian 2.2x
PEG now vs peer median —median 0.34 -0.14median 0.34 -0.77median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTSLDBIOVA
Revenue – – $324.97M
Gross profit – – $157.29M
Operating income – -$212.15M -$301.31M
Net income – -$207.10M -$289.51M
Free cash flow – -$187.82M -$296.40M
R&D – $167.40M $267.72M
EPS (diluted) – $-1.44 $-0.64
Cash & equivalents $8.31M $159.39M $110.80M
Shares (diluted) – 143.69M 450.19M
Enterprise value $2.62B -$251.25M $5.50B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTSLDBIOVA
P/E – -4.5x -23.0x
P/FCF -1,406x -5.0x -22.6x
P/Operating cash flow – -5.0x -25.4x
P/S – – 20.6x
P/B 378.4x 2.5x 9.1x
P/Tangible book 378.4x 2.5x 14.2x
EV/EBITDA – -2.6x -24.2x
EV/EBIT – -2.6x -21.3x
EV/Revenue – – 19.7x
EV/FCF – -2.9x -21.6x
EV/Operating cash flow – -3.0x -24.3x
PEG (3Y EPS CAGR) – -0.14 -0.77

Growth

14 metrics
MetricSLBTSLDBIOVA
Revenue growth (1Y) – – 34.5%
Revenue CAGR (3Y) – – 1,009%
Gross profit growth (1Y) – – 95.1%
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) – -35.3% 26.6%
Operating income CAGR (3Y) – -22.8% 11.1%
Net income growth (1Y) – -34.4% 25.8%
Net income CAGR (3Y) – -31.9% 11.6%
EPS growth (1Y) – 11.9% 44.8%
EPS CAGR (3Y) – 32.0% 29.9%
Operating cash flow growth (1Y) – -52.4% 12.9%
Operating cash flow CAGR (3Y) – -19.2% 7.6%
Free cash flow growth (1Y) – -52.3% 8.4%
Free cash flow CAGR (3Y) – -18.4% 5.8%

Profitability

14 metrics
MetricSLBTSLDBIOVA
Gross margin – – 48.4%
EBITDA margin – – -81.4%
Operating margin – – -92.7%
Pretax margin – – -90.4%
Net margin – – -89.1%
FCF margin – – -91.2%
Operating cash flow margin – – -81.3%
Return on equity – -55.4% -39.7%
Return on assets – -49.1% -31.4%
Return on invested capital – – –
Return on capital employed – -54.0% -37.0%
Asset turnover – – 0.4x
Cash conversion (OCF / net income) – 0.9x 0.9x
Stock comp / revenue – – 14.4%

Financial Health

11 metrics
MetricSLBTSLDBIOVA
Debt / assets – – –
Debt / equity – – –
Net debt / EBITDA – – –
Debt / FCF – – –
Liabilities / assets 21.8% 11.1% 19.6%
Equity / assets 78.2% 88.9% 80.4%
Interest coverage – – –
Current ratio 4.4x 13.8x 4.3x
Quick ratio 4.3x 13.2x 3.7x
Cash ratio 4.3x 13.2x 2.8x
Altman Z-score – – 17.73

Shareholder Returns

7 metrics
MetricSLBTSLDBIOVA
Dividend yield – – –
Net buyback yield – -25.8% -4.4%
Shareholder yield 0.0% -25.8% -4.4%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTSLDBIOVA
EPS, next fiscal year – $-1.63FY2026 $-0.47FY2026
Revenue, next fiscal year – $0.00FY2026 $434.71MFY2026
Revenue growth, next FY – – +65.0%FY2026
Revenue growth, the year after – – +33.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTSLDBIOVA
Held by institutions – 79.7% 63.3%
Institutions holding – 157 292
Change in shares held, QoQ – +18.9% +6.5%
Institutions buying – 101 174
Institutions selling – 37 66
Buyers to sellers – 2.73 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTSLDBIOVA
SLBT 1.00 -0.02 0.01
SLDB -0.02 1.00 0.29
IOVA 0.01 0.29 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SLBT, SLDB and IOVA?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: SL Science Holding (SLBT) $2.64B, Solid Biosciences (SLDB) $931.10M, Iovance Biotherapeutics (IOVA) $6.71B.

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: SL Science Holding (SLBT) -88.3%, Solid Biosciences (SLDB) +9.5%, Iovance Biotherapeutics (IOVA) +576.3%. Over five years, Iovance Biotherapeutics (IOVA) compounded fastest (Solid Biosciences (SLDB) -26.6%/yr, Iovance Biotherapeutics (IOVA) -9.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Solid Biosciences (SLDB) has been the steadiest (SL Science Holding (SLBT) 175.5%, Solid Biosciences (SLDB) 78.6%, Iovance Biotherapeutics (IOVA) 99.0%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, SLDB and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.