SLBT vs IOVA vs SRPT Stock Comparison

SL Science Holding, Iovance Biotherapeutics and Sarepta Therapeutics Prices as of Oct 28, 2026 Peers: Industry group

Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, Sarepta Therapeutics 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTIOVASRPTLeader
Larger companyMarket capitalisation $2.64B $6.71B $2.04B IOVA
Cheaper on earningsLower P/E, profitable companies only — -23.0x -17.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 6.7x –
Faster revenue growthRevenue growth, trailing twelve months — +34.5% -20.4% IOVA
More profitableNet margin, trailing twelve months — -89.1% -5.9% SRPT
Better return on capitalReturn on invested capital — — -6.1% –
Less leveragedLower net debt / EBITDA — — -0.6x –
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months -88.3% +576.3% -20.2% IOVA
Better 5-year returnAnnualised price return, 5 years — -9.4%/yr -24.6%/yr IOVA
Less volatileAnnualised volatility, 1 year 175.5% 99.0% 81.1% SRPT
Higher overall scoreMean of the five percentile scores vs peers — 64/100 67/100 SRPT

Percentile Scorecard

SLBTIOVASRPT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTIOVASRPT
Valuation 11 #556 of 625 67 #208 of 625 96 #25 of 625
Growth – 81 #113 of 602 64 #217 of 602
Profitability – 63 #206 of 549 79 #114 of 549
Financial Health 58 #276 of 654 64 #235 of 654 33 #436 of 654
Shareholder Returns – 45 #204 of 367 61 #145 of 367
Overall – 64 67
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTIOVASRPTSPY
1 month -37.3%+34.8%+2.8% +0.9%
3 months -53.5%+224.8%+24.4% +5.9%
6 months -87.9%+347.4%-6.5% +8.5%
Year to date -88.5%+442.5%-10.2% +13.3%
1 year -88.3%+576.3%-20.2% +12.4%
3 years —+323.1%-81.9% +88.1%
3 years, per year —+61.8%-43.5% +23.5%
5 years —-39.1%-75.6% +68.2%
5 years, per year —-9.4%-24.6% +11.0%
10 years —+137.0%-52.8% +263.4%
10 years, per year —+9.0%-7.2% +13.8%

Risk

MeasureSLBTIOVASRPTSPY
Volatility, 1Y 175.5%99.0%81.1% 12.7%
Downside volatility, 1Y 170.6%71.1%85.9% 12.7%
Beta vs S&P 500, 1Y 0.231.292.08 1.00
Return / volatility, 1Y -0.505.82-0.25 0.98
Max drawdown, 5Y -91.0%-93.4%-92.7% -25.4%
From 52-week high -90.6%-0.3%-21.0% -0.9%
52-week high $12.81$14.86$24.45 $779.14
52-week low $1.15$1.81$14.86 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTIOVASRPT
P/E now vs peer median —median 17.4x -23.0xmedian 17.4x -17.4xmedian 17.4x
P/S now vs peer median —median 9.1x 20.6xmedian 9.1x 1.0xmedian 9.1x
EV/EBITDA now vs peer median —median 17.1x -24.2xmedian 17.1x -21.3xmedian 17.1x
P/FCF now vs peer median -1,406xmedian 19.0x -22.6xmedian 19.0x 24.9xmedian 19.0x
P/B now vs peer median 378.4xmedian 2.2x 9.1xmedian 2.2x 1.3xmedian 2.2x
PEG now vs peer median —median 0.34 -0.77median 0.34 -0.33median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTIOVASRPT
Revenue – $324.97M $1.97B
Gross profit – $157.29M $1.17B
Operating income – -$301.31M -$143.25M
Net income – -$289.51M -$136.73M
Free cash flow – -$296.40M $81.85M
R&D – $267.72M $789.44M
EPS (diluted) – $-0.64 $-1.11
Cash & equivalents $8.31M $110.80M $571.15M
Total debt – – $847.62M
Shares (diluted) – 450.19M 105.43M
Enterprise value $2.62B $5.50B -$1.19B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTIOVASRPT
P/E – -23.0x -17.4x
P/FCF -1,406x -22.6x 24.9x
P/Operating cash flow – -25.4x 18.4x
P/S – 20.6x 1.0x
P/B 378.4x 9.1x 1.3x
P/Tangible book 378.4x 14.2x 1.4x
EV/EBITDA – -24.2x -21.3x
EV/EBIT – -21.3x -14.7x
EV/Revenue – 19.7x 1.1x
EV/FCF – -21.6x 25.7x
EV/Operating cash flow – -24.3x 18.9x
PEG (3Y EPS CAGR) – -0.77 -0.33

Growth

14 metrics
MetricSLBTIOVASRPT
Revenue growth (1Y) – 34.5% -20.4%
Revenue CAGR (3Y) – 1,009% 25.3%
Gross profit growth (1Y) – 95.1% -40.7%
Gross profit CAGR (3Y) – – 10.6%
Operating income growth (1Y) – 26.6% -15,270%
Operating income CAGR (3Y) – 11.1% 34.5%
Net income growth (1Y) – 25.8% -135.9%
Net income CAGR (3Y) – 11.6% 46.8%
EPS growth (1Y) – 44.8% -215.7%
EPS CAGR (3Y) – 29.9% 52.3%
Operating cash flow growth (1Y) – 12.9% 136.9%
Operating cash flow CAGR (3Y) – 7.6% 30.6%
Free cash flow growth (1Y) – 8.4% 118.1%
Free cash flow CAGR (3Y) – 5.8% 29.1%

Profitability

14 metrics
MetricSLBTIOVASRPT
Gross margin – 48.4% 59.1%
EBITDA margin – -81.4% -5.0%
Operating margin – -92.7% -7.3%
Pretax margin – -90.4% -6.6%
Net margin – -89.1% -5.9%
FCF margin – -91.2% 4.1%
Operating cash flow margin – -81.3% 5.6%
Return on equity – -39.7% -9.0%
Return on assets – -31.4% -4.3%
Return on invested capital – – -6.1%
Return on capital employed – -37.0% -5.3%
Asset turnover – 0.4x 0.6x
Cash conversion (OCF / net income) – 0.9x -0.8x
Stock comp / revenue – 14.4% 6.3%

Financial Health

11 metrics
MetricSLBTIOVASRPT
Debt / assets – – 26.6%
Debt / equity – – 0.6x
Net debt / EBITDA – – -0.6x
Debt / FCF – – 10.4x
Liabilities / assets 21.8% 19.6% 52.1%
Equity / assets 78.2% 80.4% 47.9%
Interest coverage – – –
Current ratio 4.4x 4.3x 4.4x
Quick ratio 4.3x 3.7x 2.4x
Cash ratio 4.3x 2.8x 1.6x
Altman Z-score – 17.73 -0.14

Shareholder Returns

7 metrics
MetricSLBTIOVASRPT
Dividend yield – – –
Net buyback yield – -4.4% -1.1%
Shareholder yield 0.0% -4.4% -1.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTIOVASRPT
Forward P/E – – 6.7xFY2026
EPS, next fiscal year – $-0.47FY2026 $2.88FY2026
EPS growth, the year after – – -88.5%
Revenue, next fiscal year – $434.71MFY2026 $1.76BFY2026
Revenue growth, next FY – +65.0%FY2026 -20.1%FY2026
Revenue growth, the year after – +33.0% -21.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTIOVASRPT
Held by institutions – 63.3% 100.0%
Institutions holding – 292 324
Change in shares held, QoQ – +6.5% +4.5%
Institutions buying – 174 148
Institutions selling – 66 115
Buyers to sellers – 2.64 1.29

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTIOVASRPT
SLBT 1.00 0.01 0.00
IOVA 0.01 1.00 0.29
SRPT 0.00 0.29 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SLBT, IOVA and SRPT?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: SL Science Holding (SLBT) $2.64B, Iovance Biotherapeutics (IOVA) $6.71B, Sarepta Therapeutics (SRPT) $2.04B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: Iovance Biotherapeutics (IOVA) +34.5%, Sarepta Therapeutics (SRPT) -20.4%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Iovance Biotherapeutics (IOVA) -89.1%, Sarepta Therapeutics (SRPT) -5.9%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: SL Science Holding (SLBT) -88.3%, Iovance Biotherapeutics (IOVA) +576.3%, Sarepta Therapeutics (SRPT) -20.2%. Over five years, Iovance Biotherapeutics (IOVA) compounded fastest (Iovance Biotherapeutics (IOVA) -9.4%/yr, Sarepta Therapeutics (SRPT) -24.6%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sarepta Therapeutics (SRPT) has been the steadiest (SL Science Holding (SLBT) 175.5%, Iovance Biotherapeutics (IOVA) 99.0%, Sarepta Therapeutics (SRPT) 81.1%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, IOVA and SRPT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.