SLBT vs IOVA vs MESO Stock Comparison

SL Science Holding, Iovance Biotherapeutics and Mesoblast Prices as of Oct 28, 2026 Peers: Industry group
MESO Mesoblast Ltd
$13.39 -7.7% 1M -20.0% 1Y
Market cap
$2.01B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

4 decided of 12

Iovance Biotherapeutics leads on 2 of the 12 questions below (Iovance Biotherapeutics 2, Mesoblast 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTIOVAMESOLeader
Larger companyMarket capitalisation $2.74B $4.26B $2.01B IOVA
Cheaper on earningsLower P/E, profitable companies only — -14.7x -30.2x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — +34.5% — –
More profitableNet margin, trailing twelve months — -89.1% — –
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -88.3% +576.3% -20.0% IOVA
Better 5-year returnAnnualised price return, 5 years — -9.4%/yr +2.0%/yr MESO
Less volatileAnnualised volatility, 1 year 175.5% 99.0% 54.8% MESO
Higher overall scoreMean of the five percentile scores vs peers — 64/100 — –

Percentile Scorecard

SLBTIOVAMESO

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTIOVAMESO
Valuation 11 #556 of 625 67 #208 of 625 71 #185 of 625
Growth – 81 #113 of 602 –
Profitability – 63 #206 of 549 –
Financial Health 58 #276 of 654 64 #235 of 654 44 #364 of 654
Shareholder Returns – 45 #204 of 367 –
Overall – 64 –
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 672 companies in Pharmaceuticals and Biotechnology
  • MESO ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTIOVAMESOSPY
1 month -37.3%+34.8%-7.7% +0.9%
3 months -53.5%+224.8%-5.2% +5.9%
6 months -87.9%+347.4%-13.9% +8.5%
Year to date -88.5%+442.5%-25.8% +13.3%
1 year -88.3%+576.3%-20.0% +12.4%
3 years —+323.1%+472.2% +88.1%
3 years, per year —+61.8%+78.9% +23.5%
5 years —-39.1%+10.7% +68.2%
5 years, per year —-9.4%+2.0% +11.0%
10 years —+137.0%+55.0% +263.4%
10 years, per year —+9.0%+4.5% +13.8%

Risk

MeasureSLBTIOVAMESOSPY
Volatility, 1Y 175.5%99.0%54.8% 12.7%
Downside volatility, 1Y 170.6%71.1%54.9% 12.7%
Beta vs S&P 500, 1Y 0.231.291.53 1.00
Return / volatility, 1Y -0.505.82-0.36 0.98
Max drawdown, 5Y -91.0%-93.4%-87.9% -25.4%
From 52-week high -90.6%-0.3%-36.1% -0.9%
52-week high $12.81$14.86$20.96 $779.14
52-week low $1.15$1.81$11.95 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTIOVAMESO
P/E now vs peer median —median 17.4x -23.0xmedian 17.4x -30.2xmedian 17.4x
P/S now vs peer median —median 9.1x 20.6xmedian 9.1x 14.4xmedian 9.1x
EV/EBITDA now vs peer median —median 17.1x -24.2xmedian 17.1x —median 17.1x
P/FCF now vs peer median -1,406xmedian 19.0x -22.6xmedian 19.0x -38.8xmedian 19.0x
P/B now vs peer median 378.4xmedian 2.2x 9.1xmedian 2.2x 3.1xmedian 2.2x
PEG now vs peer median —median 0.34 -0.77median 0.34 —median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTIOVAMESO
Revenue – $324.97M –
Gross profit – $157.29M –
Operating income – -$301.31M –
Net income – -$289.51M –
Free cash flow – -$296.40M –
R&D – $267.72M –
EPS (diluted) – $-0.64 –
Cash & equivalents $8.31M $110.80M $102.91M
Total debt – – $119.24M
Shares (diluted) – 450.19M 129.49M
Enterprise value $2.72B $3.05B $1.58B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTIOVAMESO
P/E – -23.0x -30.2x
P/FCF -1,406x -22.6x -38.8x
P/Operating cash flow – -25.4x –
P/S – 20.6x 14.4x
P/B 378.4x 9.1x 3.1x
P/Tangible book 378.4x 14.2x 3.1x
EV/EBITDA – -24.2x –
EV/EBIT – -21.3x –
EV/Revenue – 19.7x –
EV/FCF – -21.6x –
EV/Operating cash flow – -24.3x –
PEG (3Y EPS CAGR) – -0.77 –

Growth

14 metrics
MetricSLBTIOVAMESO
Revenue growth (1Y) – 34.5% –
Revenue CAGR (3Y) – 1,009% –
Gross profit growth (1Y) – 95.1% –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) – 26.6% –
Operating income CAGR (3Y) – 11.1% –
Net income growth (1Y) – 25.8% –
Net income CAGR (3Y) – 11.6% –
EPS growth (1Y) – 44.8% –
EPS CAGR (3Y) – 29.9% –
Operating cash flow growth (1Y) – 12.9% –
Operating cash flow CAGR (3Y) – 7.6% –
Free cash flow growth (1Y) – 8.4% –
Free cash flow CAGR (3Y) – 5.8% –

Profitability

14 metrics
MetricSLBTIOVAMESO
Gross margin – 48.4% –
EBITDA margin – -81.4% –
Operating margin – -92.7% –
Pretax margin – -90.4% –
Net margin – -89.1% –
FCF margin – -91.2% –
Operating cash flow margin – -81.3% –
Return on equity – -39.7% –
Return on assets – -31.4% –
Return on invested capital – – –
Return on capital employed – -37.0% –
Asset turnover – 0.4x –
Cash conversion (OCF / net income) – 0.9x –
Stock comp / revenue – 14.4% –

Financial Health

11 metrics
MetricSLBTIOVAMESO
Debt / assets – – 15.4%
Debt / equity – – 0.2x
Net debt / EBITDA – – –
Debt / FCF – – –
Liabilities / assets 21.8% 19.6% 26.5%
Equity / assets 78.2% 80.4% 73.5%
Interest coverage – – –
Current ratio 4.4x 4.3x 2.4x
Quick ratio 4.3x 3.7x 2.0x
Cash ratio 4.3x 2.8x 1.3x
Altman Z-score – 17.73 –

Shareholder Returns

7 metrics
MetricSLBTIOVAMESO
Dividend yield – – –
Net buyback yield – -4.4% –
Shareholder yield 0.0% -4.4% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTIOVAMESO
EPS, next fiscal year – $-0.47FY2026 $-0.15FY2027
Revenue, next fiscal year – $434.71MFY2026 $188.99MFY2027
Revenue growth, next FY – +65.0%FY2026 +57.2%FY2027
Revenue growth, the year after – +33.0% +110.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTIOVAMESO
Held by institutions – 63.3% 3.0%
Institutions holding – 292 73
Change in shares held, QoQ – +6.5% +17.7%
Institutions buying – 174 34
Institutions selling – 66 20
Buyers to sellers – 2.64 1.70

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTIOVAMESO
SLBT 1.00 0.01 0.00
IOVA 0.01 1.00 0.29
MESO 0.00 0.29 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, SLBT, IOVA and MESO?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: SL Science Holding (SLBT) $2.74B, Iovance Biotherapeutics (IOVA) $4.26B, Mesoblast (MESO) $2.01B.

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: SL Science Holding (SLBT) -88.3%, Iovance Biotherapeutics (IOVA) +576.3%, Mesoblast (MESO) -20.0%. Over five years, Mesoblast (MESO) compounded fastest (Iovance Biotherapeutics (IOVA) -9.4%/yr, Mesoblast (MESO) +2.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Mesoblast (MESO) has been the steadiest (SL Science Holding (SLBT) 175.5%, Iovance Biotherapeutics (IOVA) 99.0%, Mesoblast (MESO) 54.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, IOVA and MESO?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 2. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.