SLBT vs CRSP vs LEGN Stock Comparison

SL Science Holding, CRISPR Therapeutics AG and Legend Biotech Prices as of Oct 29, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$54.26 -3.1% 1M -13.3% 1Y
Market cap
$5.24B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins
LEGN Legend Biotech Corp
$22.30 +18.5% 1M -30.6% 1Y
Market cap
$4.11B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

9 decided of 12

CRISPR Therapeutics AG leads on 5 of the 12 questions below (CRISPR Therapeutics AG 5, Legend Biotech 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTCRSPLEGNLeader
Larger companyMarket capitalisation $2.55B $5.24B $4.11B CRSP
Cheaper on earningsLower P/E, profitable companies only — -11.6x -44.8x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — -64.8% +59.5% LEGN
More profitableNet margin, trailing twelve months — -3,368.7% -7.2% LEGN
Better return on capitalReturn on invested capital — -22.6% -4.2% LEGN
Less leveragedLower net debt / EBITDA — 3.4x 28.0x CRSP
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months -88.7% -13.3% -30.6% CRSP
Better 5-year returnAnnualised price return, 5 years — -9.9%/yr -15.7%/yr CRSP
Less volatileAnnualised volatility, 1 year 175.5% 57.3% 72.3% CRSP
Higher overall scoreMean of the five percentile scores vs peers — 45/100 73/100 LEGN

Percentile Scorecard

SLBTCRSPLEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTCRSPLEGN
Valuation 11 #556 of 624 51 #308 of 624 89 #70 of 624
Growth – 32 #412 of 601 97 #20 of 601
Profitability – 32 #367 of 541 80 #108 of 541
Financial Health 58 #271 of 647 71 #188 of 647 54 #299 of 647
Shareholder Returns – 38 #222 of 359 44 #201 of 359
Overall – 45 73
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTCRSPLEGNSPY
1 month -36.1%-3.1%+18.5% +0.7%
3 months -56.5%+12.0%+17.1% +3.7%
6 months -87.4%+3.7%-5.2% +7.1%
Year to date -88.9%+3.5%+2.6% +12.8%
1 year -88.7%-13.3%-30.6% +11.9%
3 years —+39.4%-66.0% +85.2%
3 years, per year —+11.7%-30.2% +22.8%
5 years —-40.6%-57.5% +67.6%
5 years, per year —-9.9%-15.7% +10.9%
10 years —+224.1%— +262.0%
10 years, per year —+12.5%— +13.7%

Risk

MeasureSLBTCRSPLEGNSPY
Volatility, 1Y 175.5%57.3%72.3% 12.7%
Downside volatility, 1Y 170.0%53.8%62.7% 12.6%
Beta vs S&P 500, 1Y 0.241.840.44 1.00
Return / volatility, 1Y -0.51-0.23-0.42 0.94
Max drawdown, 5Y -91.0%-67.7%-78.2% -25.4%
From 52-week high -90.9%-15.2%-38.5% -1.2%
52-week high $12.81$63.99$36.28 $779.14
52-week low $1.15$44.34$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTCRSPLEGN
P/E now vs peer median —median 17.8x -11.6xmedian 17.8x -44.8xmedian 17.8x
P/S now vs peer median —median 9.1x 391.6xmedian 9.1x 3.2xmedian 9.1x
EV/EBITDA now vs peer median —median 15.0x -6.7xmedian 15.0x -195.0xmedian 15.0x
P/FCF now vs peer median -1,359xmedian 21.7x -14.1xmedian 21.7x -63.6xmedian 21.7x
P/B now vs peer median 365.9xmedian 2.2x 3.0xmedian 2.2x 3.3xmedian 2.2x
PEG now vs peer median —median 0.35 -3.01median 0.35 -0.95median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTCRSPLEGN
Revenue – $13.39M $1.27B
Gross profit – – $727.10M
Operating income – -$534.34M -$55.25M
Net income – -$451.14M -$80.39M
Free cash flow – -$371.33M -$64.60M
R&D – $278.15M $396.15M
EPS (diluted) – $-4.67 $-0.50
Cash & equivalents $8.31M $291.34M $672.90M
Total debt – $586.20M $1.06B
Shares (diluted) – 96.51M 184.32M
Enterprise value $2.54B -$3.45B $1.61B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTCRSPLEGN
P/E – -11.6x -44.8x
P/FCF -1,359x -14.1x -63.6x
P/Operating cash flow – -14.2x -46.0x
P/S – 391.6x 3.2x
P/B 365.9x 3.0x 3.3x
P/Tangible book 365.9x 3.0x 3.3x
EV/EBITDA – -6.7x -195.0x
EV/EBIT – -6.5x -65.0x
EV/Revenue – 258.9x 2.8x
EV/FCF – -9.3x -55.6x
EV/Operating cash flow – -9.4x -40.2x
PEG (3Y EPS CAGR) – -3.01 -0.95

Growth

14 metrics
MetricSLBTCRSPLEGN
Revenue growth (1Y) – -64.8% 59.5%
Revenue CAGR (3Y) – -57.1% 97.6%
Gross profit growth (1Y) – – 42.4%
Gross profit CAGR (3Y) – – 147.5%
Operating income growth (1Y) – 3.3% 75.3%
Operating income CAGR (3Y) – -4.1% 49.1%
Net income growth (1Y) – 3.6% 75.3%
Net income CAGR (3Y) – -2.7% 46.7%
EPS growth (1Y) – 13.0% 72.0%
EPS CAGR (3Y) – 3.9% 47.0%
Operating cash flow growth (1Y) – -13.8% 67.5%
Operating cash flow CAGR (3Y) – -2.5% 37.1%
Free cash flow growth (1Y) – -14.1% 77.8%
Free cash flow CAGR (3Y) – -0.9% 44.5%

Profitability

14 metrics
MetricSLBTCRSPLEGN
Gross margin – – 57.2%
EBITDA margin – -3,850% -1.5%
Operating margin – -3,990% -4.3%
Pretax margin – -3,346% -4.4%
Net margin – -3,369% -7.2%
FCF margin – -2,773% -5.1%
Operating cash flow margin – -2,760% -7.0%
Return on equity – -25.3% -8.3%
Return on assets – -16.8% -5.5%
Return on invested capital – -22.6% -4.2%
Return on capital employed – -20.9% -4.3%
Asset turnover – 0.0x 0.8x
Cash conversion (OCF / net income) – 0.8x 1.1x
Stock comp / revenue – 510.2% 5.2%

Financial Health

11 metrics
MetricSLBTCRSPLEGN
Debt / assets – 22.1% 8.9%
Debt / equity – 0.3x 0.1x
Net debt / EBITDA – 3.4x 28.0x
Debt / FCF – -1.6x -2.4x
Liabilities / assets 21.8% 34.1% 29.8%
Equity / assets 78.2% 65.9% 70.2%
Interest coverage – – -4.8x
Current ratio 4.4x 17.8x 3.0x
Quick ratio 4.3x 17.8x 1.7x
Cash ratio 4.3x 17.8x 1.7x
Altman Z-score – 2.69 6.90

Shareholder Returns

7 metrics
MetricSLBTCRSPLEGN
Dividend yield – – –
Net buyback yield – -8.1% -5.2%
Shareholder yield 0.0% -8.1% -5.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTCRSPLEGN
EPS, next fiscal year – $-4.10FY2026 $-0.04FY2026
Revenue, next fiscal year – $38.73MFY2026 $1.37BFY2026
Revenue growth, next FY – +1,003.4%FY2026 +32.9%FY2026
Revenue growth, the year after – +266.1% +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTCRSPLEGN
Held by institutions – 78.9% 55.9%
Institutions holding – 519 218
Change in shares held, QoQ – -1.0% +7.3%
Institutions buying – 238 117
Institutions selling – 139 78
Buyers to sellers – 1.71 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTCRSPLEGN
SLBT 1.00 -0.04 -0.03
CRSP -0.04 1.00 0.05
LEGN -0.03 0.05 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SLBT, CRSP and LEGN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: SL Science Holding (SLBT) $2.55B, CRISPR Therapeutics AG (CRSP) $5.24B, Legend Biotech (LEGN) $4.11B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Legend Biotech (LEGN) -7.2%). On return on invested capital, Legend Biotech (LEGN) leads (CRISPR Therapeutics AG (CRSP) -22.6%, Legend Biotech (LEGN) -4.2%).

Which stock has performed better?

Over the past year CRISPR Therapeutics AG (CRSP) returned the most: SL Science Holding (SLBT) -88.7%, CRISPR Therapeutics AG (CRSP) -13.3%, Legend Biotech (LEGN) -30.6%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -9.9%/yr, Legend Biotech (LEGN) -15.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (SL Science Holding (SLBT) 175.5%, CRISPR Therapeutics AG (CRSP) 57.3%, Legend Biotech (LEGN) 72.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, CRSP and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, CRISPR Therapeutics AG (CRSP) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.