SLBT vs CRSP vs IOVA Stock Comparison

SL Science Holding, CRISPR Therapeutics AG and Iovance Biotherapeutics Prices as of Oct 29, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$54.26 -3.1% 1M -13.3% 1Y
Market cap
$4.94B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, CRISPR Therapeutics AG 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTCRSPIOVALeader
Larger companyMarket capitalisation $2.82B $4.94B $3.78B CRSP
Cheaper on earningsLower P/E, profitable companies only — -11.0x -13.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — -64.8% +34.5% IOVA
More profitableNet margin, trailing twelve months — -3,368.7% -89.1% IOVA
Better return on capitalReturn on invested capital — -22.6% — –
Less leveragedLower net debt / EBITDA — 3.4x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -88.7% -13.3% +378.0% IOVA
Better 5-year returnAnnualised price return, 5 years — -9.9%/yr -17.0%/yr CRSP
Less volatileAnnualised volatility, 1 year 175.5% 57.3% 108.2% CRSP
Higher overall scoreMean of the five percentile scores vs peers — 45/100 62/100 IOVA

Percentile Scorecard

SLBTCRSPIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTCRSPIOVA
Valuation 11 #556 of 624 51 #308 of 624 65 #222 of 624
Growth – 32 #412 of 601 81 #115 of 601
Profitability – 32 #367 of 541 63 #203 of 541
Financial Health 58 #271 of 647 71 #188 of 647 62 #244 of 647
Shareholder Returns – 38 #222 of 359 41 #213 of 359
Overall – 45 62
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTCRSPIOVASPY
1 month -36.1%-3.1%-33.8% +0.7%
3 months -56.5%+12.0%+103.8% +3.7%
6 months -87.4%+3.7%+184.5% +7.1%
Year to date -88.9%+3.5%+250.2% +12.8%
1 year -88.7%-13.3%+378.0% +11.9%
3 years —+39.4%+158.4% +85.2%
3 years, per year —+11.7%+37.3% +22.8%
5 years —-40.6%-60.7% +67.6%
5 years, per year —-9.9%-17.0% +10.9%
10 years —+224.1%+53.0% +262.0%
10 years, per year —+12.5%+4.3% +13.7%

Risk

MeasureSLBTCRSPIOVASPY
Volatility, 1Y 175.5%57.3%108.2% 12.7%
Downside volatility, 1Y 170.0%53.8%93.0% 12.6%
Beta vs S&P 500, 1Y 0.241.841.40 1.00
Return / volatility, 1Y -0.51-0.233.49 0.94
Max drawdown, 5Y -91.0%-67.7%-93.4% -25.4%
From 52-week high -90.9%-15.2%-35.7% -1.2%
52-week high $12.81$63.99$14.86 $779.14
52-week low $1.15$44.34$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTCRSPIOVA
P/E now vs peer median —median 17.8x -11.6xmedian 17.8x -14.9xmedian 17.8x
P/S now vs peer median —median 9.1x 391.6xmedian 9.1x 13.3xmedian 9.1x
EV/EBITDA now vs peer median —median 15.0x -6.7xmedian 15.0x -15.3xmedian 15.0x
P/FCF now vs peer median -1,359xmedian 21.7x -14.1xmedian 21.7x -14.6xmedian 21.7x
P/B now vs peer median 365.9xmedian 2.2x 3.0xmedian 2.2x 5.9xmedian 2.2x
PEG now vs peer median —median 0.35 -3.01median 0.35 -0.50median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTCRSPIOVA
Revenue – $13.39M $324.97M
Gross profit – – $157.29M
Operating income – -$534.34M -$301.31M
Net income – -$451.14M -$289.51M
Free cash flow – -$371.33M -$296.40M
R&D – $278.15M $267.72M
EPS (diluted) – $-4.67 $-0.64
Cash & equivalents $8.31M $291.34M $110.80M
Total debt – $586.20M –
Shares (diluted) – 96.51M 450.19M
Enterprise value $2.80B -$3.76B $2.57B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTCRSPIOVA
P/E – -11.6x -14.9x
P/FCF -1,359x -14.1x -14.6x
P/Operating cash flow – -14.2x -16.4x
P/S – 391.6x 13.3x
P/B 365.9x 3.0x 5.9x
P/Tangible book 365.9x 3.0x 9.2x
EV/EBITDA – -6.7x -15.3x
EV/EBIT – -6.5x -13.4x
EV/Revenue – 258.9x 12.4x
EV/FCF – -9.3x -13.6x
EV/Operating cash flow – -9.4x -15.3x
PEG (3Y EPS CAGR) – -3.01 -0.50

Growth

14 metrics
MetricSLBTCRSPIOVA
Revenue growth (1Y) – -64.8% 34.5%
Revenue CAGR (3Y) – -57.1% 1,009%
Gross profit growth (1Y) – – 95.1%
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) – 3.3% 26.6%
Operating income CAGR (3Y) – -4.1% 11.1%
Net income growth (1Y) – 3.6% 25.8%
Net income CAGR (3Y) – -2.7% 11.6%
EPS growth (1Y) – 13.0% 44.8%
EPS CAGR (3Y) – 3.9% 29.9%
Operating cash flow growth (1Y) – -13.8% 12.9%
Operating cash flow CAGR (3Y) – -2.5% 7.6%
Free cash flow growth (1Y) – -14.1% 8.4%
Free cash flow CAGR (3Y) – -0.9% 5.8%

Profitability

14 metrics
MetricSLBTCRSPIOVA
Gross margin – – 48.4%
EBITDA margin – -3,850% -81.4%
Operating margin – -3,990% -92.7%
Pretax margin – -3,346% -90.4%
Net margin – -3,369% -89.1%
FCF margin – -2,773% -91.2%
Operating cash flow margin – -2,760% -81.3%
Return on equity – -25.3% -39.7%
Return on assets – -16.8% -31.4%
Return on invested capital – -22.6% –
Return on capital employed – -20.9% -37.0%
Asset turnover – 0.0x 0.4x
Cash conversion (OCF / net income) – 0.8x 0.9x
Stock comp / revenue – 510.2% 14.4%

Financial Health

11 metrics
MetricSLBTCRSPIOVA
Debt / assets – 22.1% –
Debt / equity – 0.3x –
Net debt / EBITDA – 3.4x –
Debt / FCF – -1.6x –
Liabilities / assets 21.8% 34.1% 19.6%
Equity / assets 78.2% 65.9% 80.4%
Interest coverage – – –
Current ratio 4.4x 17.8x 4.3x
Quick ratio 4.3x 17.8x 3.7x
Cash ratio 4.3x 17.8x 2.8x
Altman Z-score – 2.69 9.78

Shareholder Returns

7 metrics
MetricSLBTCRSPIOVA
Dividend yield – – –
Net buyback yield – -8.1% -6.8%
Shareholder yield 0.0% -8.1% -6.8%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTCRSPIOVA
EPS, next fiscal year – $-4.10FY2026 $-0.47FY2026
Revenue, next fiscal year – $38.73MFY2026 $434.71MFY2026
Revenue growth, next FY – +1,003.4%FY2026 +65.0%FY2026
Revenue growth, the year after – +266.1% +33.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTCRSPIOVA
Held by institutions – 78.9% 63.3%
Institutions holding – 519 292
Change in shares held, QoQ – -1.0% +6.5%
Institutions buying – 238 174
Institutions selling – 139 66
Buyers to sellers – 1.71 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTCRSPIOVA
SLBT 1.00 -0.04 0.01
CRSP -0.04 1.00 0.33
IOVA 0.01 0.33 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SLBT, CRSP and IOVA?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: SL Science Holding (SLBT) $2.82B, CRISPR Therapeutics AG (CRSP) $4.94B, Iovance Biotherapeutics (IOVA) $3.78B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Iovance Biotherapeutics (IOVA) +34.5%.

Which company is more profitable?

Iovance Biotherapeutics (IOVA) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Iovance Biotherapeutics (IOVA) -89.1%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: SL Science Holding (SLBT) -88.7%, CRISPR Therapeutics AG (CRSP) -13.3%, Iovance Biotherapeutics (IOVA) +378.0%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -9.9%/yr, Iovance Biotherapeutics (IOVA) -17.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (SL Science Holding (SLBT) 175.5%, CRISPR Therapeutics AG (CRSP) 57.3%, Iovance Biotherapeutics (IOVA) 108.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, CRSP and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.