SHC vs CSTL vs BLLN Stock Comparison

Sotera Health, Castle Biosciences and BillionToOne Prices as of Oct 27, 2026 Peers: Industry group
SHC Sotera Health Co
$18.49 +0.8% 1M +10.7% 1Y
Market cap
$5.36B
P/E
32.8x
Revenue (TTM)
$1.22B
Div. yield
–
Diagnostic Labs Healthcare
7 wins
CSTL Castle Biosciences Inc
$34.51 -3.6% 1M +44.0% 1Y
Market cap
$1.12B
P/E
–
Revenue (TTM)
$357.28M
Div. yield
–
Diagnostic Labs Healthcare
1 win
BLLN BillionToOne, Inc.
$114.07 -7.3% 1M
Market cap
$5.50B
P/E
183.0x
Revenue (TTM)
$397.41M
Div. yield
–
Diagnostic Labs Healthcare
3 wins

Head to Head

11 decided of 12

Sotera Health leads on 7 of the 12 questions below (Sotera Health 7, BillionToOne 3, Castle Biosciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSHCCSTLBLLNLeader
Larger companyMarket capitalisation $5.36B $1.12B $5.50B BLLN
Cheaper on earningsLower P/E, profitable companies only 32.8x -57.5x 183.0x SHC
Cheaper on forward earningsLower price / next fiscal year consensus EPS 20.1x — 150.1x SHC
Faster revenue growthRevenue growth, trailing twelve months +8.1% +3.2% +90.1% BLLN
More profitableNet margin, trailing twelve months 13.4% -5.4% 7.6% SHC
Better return on capitalReturn on invested capital 9.1% -6.7% 7.0% SHC
Less leveragedLower net debt / EBITDA 3.3x 15.5x -9.1x BLLN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +10.7% +44.0% — CSTL
Better 5-year returnAnnualised price return, 5 years -5.8%/yr -11.6%/yr — SHC
Less volatileAnnualised volatility, 1 year 28.4% 58.3% 94.5% SHC
Higher overall scoreMean of the five percentile scores vs peers 59/100 50/100 57/100 SHC

Percentile Scorecard

SHCCSTLBLLN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSHCCSTLBLLN
Valuation 52 #45 of 92 47 #49 of 92 20 #74 of 92
Growth 66 #30 of 87 52 #42 of 87 100 #1 of 87
Profitability 82 #16 of 86 39 #53 of 86 60 #35 of 86
Financial Health 37 #62 of 97 92 #9 of 97 97 #4 of 97
Shareholder Returns – 20 #45 of 56 7 #52 of 56
Overall 59 50 57
  • SHC ranked among 102 companies in Healthcare Providers
  • CSTL ranked among 102 companies in Healthcare Providers
  • BLLN ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSHCCSTLBLLNSPY
1 month +0.8%-3.6%-7.3% -0.2%
3 months +4.1%+44.5%-14.6% +3.9%
6 months +19.0%+39.8%+45.8% +8.2%
Year to date +4.8%-11.3%+39.4% +12.9%
1 year +10.7%+44.0%— +12.3%
3 years +47.8%+164.2%— +87.4%
3 years, per year +13.9%+38.3%— +23.3%
5 years -25.6%-46.0%— +67.9%
5 years, per year -5.8%-11.6%— +10.9%

Risk

MeasureSHCCSTLBLLNSPY
Volatility, 1Y 28.4%58.3%94.5% 12.7%
Downside volatility, 1Y 27.0%61.4%107.8% 12.7%
Beta vs S&P 500, 1Y 1.010.961.66 1.00
Return / volatility, 1Y 0.380.76— 0.97
Max drawdown, 5Y -78.2%-82.1%-50.8% -25.4%
From 52-week high -5.5%-19.8%-23.9% -1.2%
52-week high $19.57$43.04$149.97 $779.14
52-week low $13.13$18.15$64.03 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSHCCSTLBLLN
P/E now vs peer median 32.3xmedian 24.6x -54.0xmedian 24.6x 176.1xmedian 24.6x
P/S now vs peer median 4.3xmedian 1.6x 2.9xmedian 1.6x 13.4xmedian 1.6x
EV/EBITDA now vs peer median 13.0xmedian 14.6x -48.2xmedian 14.6x 97.2xmedian 14.6x
P/FCF now vs peer median 46.8xmedian 21.6x -2,153xmedian 21.6x 161.0xmedian 21.6x
P/B now vs peer median 7.9xmedian 3.2x 2.2xmedian 3.2x 10.0xmedian 3.2x
PEG now vs peer median 0.86median 0.66 -1.28median 0.66 —median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSHCCSTLBLLN
Revenue $1.22B $357.28M $397.41M
Gross profit $668.51M $276.03M $283.22M
Operating income $411.34M -$32.11M $43.30M
Net income $163.48M -$19.42M $37.71M
Free cash flow $112.70M -$489.00K $33.18M
R&D – $55.45M $59.21M
EPS (diluted) $0.57 $-0.64 $0.55
Cash & equivalents $356.72M $62.12M $548.63M
Total debt $2.14B $10.08M $91.03M
Shares (diluted) 288.15M 30.40M 54.46M
Enterprise value $4.04B $1.32K $3.72B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSHCCSTLBLLN
P/E 32.3x -54.0x 176.1x
P/FCF 46.8x -2,153x 161.0x
P/Operating cash flow 18.1x 24.7x 117.8x
P/S 4.3x 2.9x 13.4x
P/B 7.9x 2.2x 10.0x
P/Tangible book 13.3x 2.2x 10.0x
EV/EBITDA 13.0x -48.2x 97.2x
EV/EBIT 17.2x -24.8x 112.8x
EV/Revenue 5.8x 2.2x 12.3x
EV/FCF 62.6x -1,628x 147.2x
EV/Operating cash flow 24.2x 18.7x 107.7x
PEG (3Y EPS CAGR) 0.86 -1.28 –

Growth

14 metrics
MetricSHCCSTLBLLN
Revenue growth (1Y) 8.1% 3.2% 90.1%
Revenue CAGR (3Y) 7.6% 28.7% –
Gross profit growth (1Y) 7.1% -1.6% 122.4%
Gross profit CAGR (3Y) 8.1% 29.2% –
Operating income growth (1Y) 21.8% -39.3% 253.2%
Operating income CAGR (3Y) 23.2% 30.8% –
Net income growth (1Y) 580.5% -105.1% 223.2%
Net income CAGR (3Y) 37.7% 39.8% –
EPS growth (1Y) 574.9% -99.3% 118.7%
EPS CAGR (3Y) 37.5% 42.3% –
Operating cash flow growth (1Y) 9.8% -31.8% –
Operating cash flow CAGR (3Y) 61.3% 45.1% –
Free cash flow growth (1Y) 0.0% -101.4% –
Free cash flow CAGR (3Y) 32.6% 78.8% –

Profitability

14 metrics
MetricSHCCSTLBLLN
Gross margin 55.0% 77.3% 71.3%
EBITDA margin 44.6% -4.6% 12.6%
Operating margin 33.8% -9.0% 10.9%
Pretax margin 21.7% -5.4% 9.5%
Net margin 13.4% -5.4% 7.6%
FCF margin 9.3% -0.1% 8.3%
Operating cash flow margin 24.0% 11.9% 11.4%
Return on equity 25.4% -4.2% 7.2%
Return on assets 5.0% -3.5% 5.3%
Return on invested capital 9.1% -6.7% 7.0%
Return on capital employed 13.5% -6.4% 6.6%
Asset turnover 0.4x 0.6x 0.6x
Cash conversion (OCF / net income) 1.8x -2.2x 1.2x
Stock comp / revenue 3.1% 12.6% 6.4%

Financial Health

11 metrics
MetricSHCCSTLBLLN
Debt / assets 64.7% 1.8% 12.5%
Debt / equity 3.2x 0.0x 0.2x
Net debt / EBITDA 3.3x 15.5x -9.1x
Debt / FCF 19.0x -20.6x 2.7x
Liabilities / assets 79.9% 16.2% 26.4%
Equity / assets 20.1% 83.8% 73.6%
Interest coverage – -85.6x 1,056x
Current ratio 2.8x 6.0x 11.7x
Quick ratio 2.4x 5.6x 11.2x
Cash ratio 1.5x 4.7x 9.8x
Altman Z-score 1.94 7.39 17.86

Shareholder Returns

7 metrics
MetricSHCCSTLBLLN
Dividend yield – – –
Net buyback yield – -0.5% -5.7%
Shareholder yield – -0.5% -5.7%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSHCCSTLBLLN
Forward P/E 20.1xFY2026 – 150.1xFY2026
EPS, next fiscal year $0.92FY2026 $-1.31FY2026 $0.76FY2026
EPS growth, next FY +7.0%FY2026 – +442.9%FY2026
EPS growth, the year after +21.7% – +22.4%
Revenue, next fiscal year $1.33BFY2026 $385.85MFY2026 $481.76MFY2026
Revenue growth, next FY +14.8%FY2026 +12.1%FY2026 +57.9%FY2026
Revenue growth, the year after -4.2% +2.3% +27.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSHCCSTLBLLN
Held by institutions 100.0% 89.6% 32.6%
Institutions holding 316 177 155
Change in shares held, QoQ +5.9% -1.0% +34.7%
Institutions buying 220 104 127
Institutions selling 64 55 13
Buyers to sellers 3.44 1.89 9.77

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SHCCSTLBLLN
SHC 1.00 0.33 0.14
CSTL 0.33 1.00 0.16
BLLN 0.14 0.16 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, SHC, CSTL and BLLN?

BillionToOne (BLLN) is the largest by market capitalisation: Sotera Health (SHC) $5.36B, Castle Biosciences (CSTL) $1.12B, BillionToOne (BLLN) $5.50B.

Which stock is cheaper, SHC, CSTL and BLLN?

Sotera Health (SHC) trades on the lowest price-to-earnings ratio (Sotera Health (SHC) 32.8x, Castle Biosciences (CSTL) -57.5x, BillionToOne (BLLN) 183.0x). On next year's consensus earnings, Sotera Health (SHC) is cheapest (Sotera Health (SHC) 20.1x, BillionToOne (BLLN) 150.1x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

BillionToOne (BLLN) grew revenue fastest over the trailing twelve months: Sotera Health (SHC) +8.1%, Castle Biosciences (CSTL) +3.2%, BillionToOne (BLLN) +90.1%.

Which company is more profitable?

Sotera Health (SHC) has the highest net margin (Sotera Health (SHC) 13.4%, Castle Biosciences (CSTL) -5.4%, BillionToOne (BLLN) 7.6%). On return on invested capital, Sotera Health (SHC) leads (Sotera Health (SHC) 9.1%, Castle Biosciences (CSTL) -6.7%, BillionToOne (BLLN) 7.0%).

Which stock has performed better?

Over the past year Castle Biosciences (CSTL) returned the most: Sotera Health (SHC) +10.7%, Castle Biosciences (CSTL) +44.0%. Over five years, Sotera Health (SHC) compounded fastest (Sotera Health (SHC) -5.8%/yr, Castle Biosciences (CSTL) -11.6%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Sotera Health (SHC) 28.4%, Castle Biosciences (CSTL) 58.3%, BillionToOne (BLLN) 94.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SHC, CSTL and BLLN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sotera Health (SHC) leads on 7. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.