PFE vs TMO vs AZN Stock Comparison

Pfizer, Thermo Fisher Scientific and Astrazeneca Prices as of Oct 23, 2026 Peers: Industry group
PFE Pfizer Inc
$30.01 +6.5% 1M +21.6% 1Y
Market cap
$169.80B
P/E
39.2x
Revenue (TTM)
$63.70B
Div. yield
0.06%
Pharmaceuticals Healthcare
4 wins
AZN Astrazeneca Plc
$171.47 +5.0% 1M +2.8% 1Y
Market cap
$266.58B
P/E
25.5x
Revenue (TTM)
$58.67B
Div. yield
–
Pharmaceuticals Healthcare
8 wins

Head to Head

12 decided of 12

Astrazeneca leads on 8 of the 12 questions below (Astrazeneca 8, Pfizer 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionPFETMOAZNLeader
Larger companyMarket capitalisation $169.80B $254.18B $266.58B AZN
Cheaper on earningsLower P/E, profitable companies only 39.2x 36.5x 25.5x AZN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 10.5x 26.1x 17.1x PFE
Faster revenue growthRevenue growth, trailing twelve months -0.2% +7.2% +9.4% AZN
More profitableNet margin, trailing twelve months 6.8% 15.0% 17.8% AZN
Better return on capitalReturn on invested capital 13.4% 7.9% 23.3% AZN
Less leveragedLower net debt / EBITDA 1.9x 3.5x 1.4x AZN
Higher dividend yieldTrailing dividend yield 0.06% 0.00% 0.00% PFE
Better 1-year returnPrice return, last 12 months +21.6% +17.8% +2.8% PFE
Better 5-year returnAnnualised price return, 5 years -7.0%/yr +1.9%/yr +6.8%/yr AZN
Less volatileAnnualised volatility, 1 year 21.6% 29.8% 27.4% PFE
Higher overall scoreMean of the five percentile scores vs peers 65/100 59/100 70/100 AZN

Percentile Scorecard

PFETMOAZN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisPFETMOAZN
Valuation 94 #37 of 624 60 #93 of 228 85 #94 of 624
Growth 23 #465 of 603 35 #144 of 222 69 #185 of 603
Profitability 92 #45 of 555 83 #37 of 210 94 #34 of 555
Financial Health 24 #503 of 657 28 #174 of 241 36 #424 of 657
Shareholder Returns 91 #36 of 370 88 #18 of 138 68 #120 of 370
Overall 65 59 70
  • PFE ranked among 671 companies in Pharmaceuticals and Biotechnology
  • TMO ranked among 248 companies in Medical Devices and Diagnostics
  • AZN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodPFETMOAZNSPY
1 month +6.5%+1.2%+5.0% -1.0%
3 months +22.2%+18.6%+1.4% +2.9%
6 months +11.1%+43.5%-9.6% +6.4%
Year to date +20.5%+16.3%-6.7% +11.4%
1 year +21.6%+17.8%+2.8% +13.1%
3 years -1.4%+47.1%+32.8% +79.4%
3 years, per year -0.5%+13.7%+9.9% +21.5%
5 years -30.5%+10.1%+38.8% +67.7%
5 years, per year -7.0%+1.9%+6.8% +10.9%
10 years -6.7%+347.3%+179.1% +255.2%
10 years, per year -0.7%+16.2%+10.8% +13.5%

Risk

MeasurePFETMOAZNSPY
Volatility, 1Y 21.6%29.8%27.4% 12.7%
Downside volatility, 1Y 21.1%28.3%27.2% 12.7%
Beta vs S&P 500, 1Y 0.240.590.22 1.00
Return / volatility, 1Y 1.000.600.10 1.03
Max drawdown, 5Y -64.8%-41.5%-27.9% -25.4%
From 52-week high -1.3%-3.3%-18.1% -2.5%
52-week high $30.41$696.55$209.48 $779.14
52-week low $23.67$438.34$155.60 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultiplePFETMOAZN
P/E now vs peer median 39.5xmedian 17.2x 35.9xmedian 30.7x 25.4xmedian 17.2x
P/S now vs peer median 2.7xmedian 8.8x 5.4xmedian 3.0x 4.5xmedian 8.8x
EV/EBITDA now vs peer median 8.2xmedian 16.0x 25.9xmedian 17.7x 14.4xmedian 16.0x
P/FCF now vs peer median 15.6xmedian 17.8x 34.0xmedian 23.7x 24.9xmedian 17.8x
P/B now vs peer median 2.0xmedian 2.1x 4.7xmedian 2.4x 5.3xmedian 2.1x
PEG now vs peer median -0.96median 0.32 4.27median 0.96 1.33median 0.32

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsPFETMOAZN
Revenue $63.70B $46.34B $58.67B
Gross profit $46.61B $18.91B $50.25B
Operating income $20.39B $8.15B $13.97B
Net income $4.36B $6.99B $10.45B
Free cash flow $10.99B $7.32B $10.67B
R&D $11.05B $1.40B $15.07B
EPS (diluted) $0.76 $18.78 $6.69
Cash & equivalents $976.00M $4.06B $4.90B
Total debt $63.19B $42.55B $106.76B
Shares (diluted) 5.70B 371.00M 1.56B
Enterprise value $116.45B $233.20B $240.27B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricPFETMOAZN
P/E 39.5x 35.9x 25.4x
P/FCF 15.6x 34.0x 24.9x
P/Operating cash flow 12.8x 27.6x 19.4x
P/S 2.7x 5.4x 4.5x
P/B 2.0x 4.7x 5.3x
P/Tangible book 4.4x 7.3x 21.0x
EV/EBITDA 8.2x 25.9x 14.4x
EV/EBIT 10.9x 35.3x 21.0x
EV/Revenue 3.5x 6.2x 5.0x
EV/FCF 20.3x 39.3x 27.5x
EV/Operating cash flow 16.6x 31.9x 21.4x
PEG (3Y EPS CAGR) -0.96 4.27 1.33

Growth

14 metrics
MetricPFETMOAZN
Revenue growth (1Y) -0.2% 7.2% 9.4%
Revenue CAGR (3Y) -7.0% 2.1% 10.6%
Gross profit growth (1Y) 1.2% 6.2% 9.3%
Gross profit CAGR (3Y) -5.6% 3.0% 13.1%
Operating income growth (1Y) 1.5% 10.0% 23.4%
Operating income CAGR (3Y) -9.9% 6.7% 23.9%
Net income growth (1Y) -59.6% 6.2% 25.9%
Net income CAGR (3Y) -41.3% 6.9% 19.2%
EPS growth (1Y) -59.7% 7.8% 26.0%
EPS CAGR (3Y) -41.3% 8.4% 19.2%
Operating cash flow growth (1Y) -11.8% 18.9% 2.3%
Operating cash flow CAGR (3Y) -2.7% 5.4% 13.7%
Free cash flow growth (1Y) -11.7% 18.6% -4.5%
Free cash flow CAGR (3Y) 1.0% 7.7% 8.5%

Profitability

14 metrics
MetricPFETMOAZN
Gross margin 73.2% 40.8% 85.6%
EBITDA margin 42.4% 23.9% 34.6%
Operating margin 32.0% 17.6% 23.8%
Pretax margin 6.6% 16.5% 21.5%
Net margin 6.8% 15.0% 17.8%
FCF margin 17.2% 15.8% 18.2%
Operating cash flow margin 21.0% 19.5% 23.3%
Return on equity 5.0% 13.4% 21.4%
Return on assets 2.1% 6.2% 9.1%
Return on invested capital 13.4% 7.9% 23.3%
Return on capital employed 11.9% 8.3% 16.8%
Asset turnover 0.3x 0.4x 0.5x
Cash conversion (OCF / net income) 3.1x 1.3x 1.3x
Stock comp / revenue 1.5% 0.7% –

Financial Health

11 metrics
MetricPFETMOAZN
Debt / assets 31.4% 37.6% 27.9%
Debt / equity 0.7x 0.8x 0.6x
Net debt / EBITDA 1.9x 3.5x 1.4x
Debt / FCF 5.8x 5.8x 3.0x
Liabilities / assets 57.5% 53.4% 56.5%
Equity / assets 42.5% 46.6% 43.5%
Interest coverage – 5.6x 15.9x
Current ratio 1.3x 1.6x 0.9x
Quick ratio 0.7x 1.0x 0.7x
Cash ratio 0.4x 0.3x 0.2x
Altman Z-score 2.37 3.98 3.46

Shareholder Returns

7 metrics
MetricPFETMOAZN
Dividend yield 5.7% 0.3% 1.4%
Net buyback yield – 2.0% 0.0%
Shareholder yield 5.7% 2.3% 1.4%
Payout ratio (earnings) 224.5% 9.5% –
Payout ratio (FCF) 89.1% 9.0% –
Dividend growth (1Y) 1.5% 8.5% –
Dividend CAGR (3Y) 2.4% 10.8% –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusPFETMOAZN
Forward P/E 10.5xFY2026 26.1xFY2026 17.1xFY2026
EPS, next fiscal year $2.86FY2026 $25.77FY2026 $10.00FY2026
EPS growth, next FY -11.2%FY2026 +12.7%FY2026 +9.2%FY2026
EPS growth, the year after -4.5% +1.8% +6.2%
Revenue, next fiscal year $60.60BFY2026 $49.99BFY2026 $59.09BFY2026
Revenue growth, next FY -3.2%FY2026 +12.2%FY2026 +0.6%FY2026
Revenue growth, the year after +3.8% -2.9% +7.7%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersPFETMOAZN
Held by institutions 66.9% 90.2% 52.1%
Institutions holding 2,835 2,621 1,496
Change in shares held, QoQ +2.0% +0.8% +7.8%
Institutions buying 1,324 1,141 808
Institutions selling 1,204 1,144 468
Buyers to sellers 1.10 1.00 1.73

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

PFETMOAZN
PFE 1.00 0.26 0.43
TMO 0.26 1.00 0.20
AZN 0.43 0.20 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, PFE, TMO and AZN?

Astrazeneca (AZN) is the largest by market capitalisation: Pfizer (PFE) $169.80B, Thermo Fisher Scientific (TMO) $254.18B, Astrazeneca (AZN) $266.58B.

Which stock is cheaper, PFE, TMO and AZN?

Astrazeneca (AZN) trades on the lowest price-to-earnings ratio (Pfizer (PFE) 39.2x, Thermo Fisher Scientific (TMO) 36.5x, Astrazeneca (AZN) 25.5x). On next year's consensus earnings, Pfizer (PFE) is cheapest (Pfizer (PFE) 10.5x, Thermo Fisher Scientific (TMO) 26.1x, Astrazeneca (AZN) 17.1x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Astrazeneca (AZN) grew revenue fastest over the trailing twelve months: Pfizer (PFE) -0.2%, Thermo Fisher Scientific (TMO) +7.2%, Astrazeneca (AZN) +9.4%.

Which company is more profitable?

Astrazeneca (AZN) has the highest net margin (Pfizer (PFE) 6.8%, Thermo Fisher Scientific (TMO) 15.0%, Astrazeneca (AZN) 17.8%). On return on invested capital, Astrazeneca (AZN) leads (Pfizer (PFE) 13.4%, Thermo Fisher Scientific (TMO) 7.9%, Astrazeneca (AZN) 23.3%).

Which stock has performed better?

Over the past year Pfizer (PFE) returned the most: Pfizer (PFE) +21.6%, Thermo Fisher Scientific (TMO) +17.8%, Astrazeneca (AZN) +2.8%. Over five years, Astrazeneca (AZN) compounded fastest (Pfizer (PFE) -7.0%/yr, Thermo Fisher Scientific (TMO) +1.9%/yr, Astrazeneca (AZN) +6.8%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Pfizer (PFE) has the highest dividend yield: Pfizer (PFE) 0.06%, Thermo Fisher Scientific (TMO) 0.00%, Astrazeneca (AZN) 0.00%. Astrazeneca (AZN) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Pfizer (PFE) has been the steadiest (Pfizer (PFE) 21.6%, Thermo Fisher Scientific (TMO) 29.8%, Astrazeneca (AZN) 27.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, PFE, TMO and AZN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Astrazeneca (AZN) leads on 8. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.