PFE vs AZN vs TAK Stock Comparison

Pfizer, Astrazeneca and Takeda Pharmaceutical Prices as of Oct 27, 2026 Peers: Industry group
PFE Pfizer Inc
$29.80 +3.9% 1M +20.3% 1Y
Market cap
$169.85B
P/E
39.2x
Revenue (TTM)
$63.70B
Div. yield
5.77%
Pharmaceuticals Healthcare
2 wins
AZN Astrazeneca Plc
$170.02 +2.1% 1M +1.1% 1Y
Market cap
$263.53B
P/E
25.2x
Revenue (TTM)
$58.67B
Div. yield
1.41%
Pharmaceuticals Healthcare
7 wins

Head to Head

12 decided of 12

Astrazeneca leads on 7 of the 12 questions below (Astrazeneca 7, Takeda Pharmaceutical 3, Pfizer 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionPFEAZNTAKLeader
Larger companyMarket capitalisation $169.85B $263.53B $64.57B AZN
Cheaper on earningsLower P/E, profitable companies only 39.2x 25.2x 111.3x AZN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 10.5x 17.0x 50.7x PFE
Faster revenue growthRevenue growth, trailing twelve months -0.2% +9.4% +0.7% AZN
More profitableNet margin, trailing twelve months 6.8% 17.8% 1.2% AZN
Better return on capitalReturn on invested capital 13.4% 23.3% 3.5% AZN
Less leveragedLower net debt / EBITDA 1.9x 1.4x 3.5x AZN
Higher dividend yieldTrailing dividend yield 5.77% 1.41% 1.53% PFE
Better 1-year returnPrice return, last 12 months +20.3% +1.1% +43.2% TAK
Better 5-year returnAnnualised price return, 5 years -7.2%/yr +6.5%/yr +7.5%/yr TAK
Less volatileAnnualised volatility, 1 year 21.6% 27.4% 21.5% TAK
Higher overall scoreMean of the five percentile scores vs peers 65/100 71/100 62/100 AZN

Percentile Scorecard

PFEAZNTAK

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisPFEAZNTAK
Valuation 95 #35 of 625 86 #91 of 625 97 #17 of 625
Growth 24 #461 of 602 70 #183 of 602 21 #478 of 602
Profitability 92 #45 of 551 94 #34 of 551 85 #82 of 551
Financial Health 24 #502 of 656 36 #420 of 656 34 #431 of 656
Shareholder Returns 91 #35 of 365 70 #111 of 365 73 #98 of 365
Overall 65 71 62
  • PFE ranked among 672 companies in Pharmaceuticals and Biotechnology
  • AZN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • TAK ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodPFEAZNTAKSPY
1 month +3.9%+2.1%+7.6% -0.2%
3 months +18.0%-1.4%+15.6% +3.9%
6 months +12.5%-8.9%+23.6% +8.2%
Year to date +19.7%-7.5%+30.1% +12.9%
1 year +20.3%+1.1%+43.2% +12.3%
3 years -1.0%+37.4%+50.6% +87.4%
3 years, per year -0.3%+11.2%+14.6% +23.3%
5 years -31.0%+36.7%+43.8% +67.9%
5 years, per year -7.2%+6.5%+7.5% +10.9%
10 years -8.3%+197.9%-10.9% +261.1%
10 years, per year -0.9%+11.5%-1.2% +13.7%

Risk

MeasurePFEAZNTAKSPY
Volatility, 1Y 21.6%27.4%21.5% 12.7%
Downside volatility, 1Y 21.1%27.2%20.2% 12.7%
Beta vs S&P 500, 1Y 0.230.210.11 1.00
Return / volatility, 1Y 0.940.042.01 0.97
Max drawdown, 5Y -64.8%-27.9%-26.4% -25.4%
From 52-week high -2.0%-18.8%-0.7% -1.2%
52-week high $30.41$209.48$20.43 $779.14
52-week low $23.67$155.60$13.23 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultiplePFEAZNTAK
P/E now vs peer median 39.2xmedian 17.2x 25.2xmedian 17.2x 111.3xmedian 17.2x
P/S now vs peer median 2.7xmedian 9.0x 4.5xmedian 9.0x 1.4xmedian 9.0x
EV/EBITDA now vs peer median 8.2xmedian 16.3x 14.3xmedian 16.3x 12.4xmedian 16.3x
P/FCF now vs peer median 15.5xmedian 18.7x 24.7xmedian 18.7x 12.4xmedian 18.7x
P/B now vs peer median 2.0xmedian 2.2x 5.2xmedian 2.2x 1.4xmedian 2.2x
PEG now vs peer median -0.95median 0.33 1.31median 0.33 -2.74median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsPFEAZNTAK
Revenue $63.70B $58.67B $46.49B
Gross profit $46.61B $50.25B $30.58B
Operating income $20.39B $13.97B $2.71B
Net income $4.36B $10.45B -$1.04B
Free cash flow $10.99B $10.67B $5.20B
R&D $11.05B $15.07B $4.53B
EPS (diluted) $0.76 $6.69 $0.18
Cash & equivalents $976.00M $4.90B $2.85B
Total debt $63.19B $32.35B $126.30B
Shares (diluted) 5.70B 1.56B 3.15B
Enterprise value $116.80B $237.29B $40.94B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricPFEAZNTAK
P/E 39.2x 25.2x 111.3x
P/FCF 15.5x 24.7x 12.4x
P/Operating cash flow 12.7x 19.2x 10.3x
P/S 2.7x 4.5x 1.4x
P/B 2.0x 5.2x 1.4x
P/Tangible book 4.4x 20.8x 2.5x
EV/EBITDA 8.2x 14.3x 12.4x
EV/EBIT 10.9x 20.8x 33.2x
EV/Revenue 3.5x 5.0x 1.9x
EV/FCF 20.1x 27.3x 17.3x
EV/Operating cash flow 16.5x 21.2x 14.3x
PEG (3Y EPS CAGR) -0.95 1.31 -2.74

Growth

14 metrics
MetricPFEAZNTAK
Revenue growth (1Y) -0.2% 9.4% 0.7%
Revenue CAGR (3Y) -7.0% 10.6% 14.8%
Gross profit growth (1Y) 1.2% 9.3% -0.8%
Gross profit CAGR (3Y) -5.6% 13.1% -0.2%
Operating income growth (1Y) 1.5% 23.4% -43.4%
Operating income CAGR (3Y) -9.9% 23.9% -14.3%
Net income growth (1Y) -59.6% 25.9% -209.1%
Net income CAGR (3Y) -41.3% 19.2% -35.3%
EPS growth (1Y) -59.7% 26.0% -75.7%
EPS CAGR (3Y) -41.3% 19.2% -40.6%
Operating cash flow growth (1Y) -11.8% 2.3% -14.8%
Operating cash flow CAGR (3Y) -2.7% 13.7% -4.4%
Free cash flow growth (1Y) -11.7% -4.5% -13.3%
Free cash flow CAGR (3Y) 1.0% 8.5% -5.2%

Profitability

14 metrics
MetricPFEAZNTAK
Gross margin 73.2% 85.6% 65.8%
EBITDA margin 42.4% 34.6% 15.6%
Operating margin 32.0% 23.8% 5.8%
Pretax margin 6.6% 21.5% 2.6%
Net margin 6.8% 17.8% 1.2%
FCF margin 17.2% 18.2% 11.2%
Operating cash flow margin 21.0% 23.3% 13.5%
Return on equity 5.0% 21.4% 1.2%
Return on assets 2.1% 9.1% 0.6%
Return on invested capital 13.4% 23.3% 3.5%
Return on capital employed 11.9% 16.8% 3.0%
Asset turnover 0.3x 0.5x 0.5x
Cash conversion (OCF / net income) 3.1x 1.3x -6.0x
Stock comp / revenue 1.5% – 1.0%

Financial Health

11 metrics
MetricPFEAZNTAK
Debt / assets 31.4% 27.9% 32.0%
Debt / equity 0.7x 0.6x 0.7x
Net debt / EBITDA 1.9x 1.4x 3.5x
Debt / FCF 5.8x 3.0x 6.0x
Liabilities / assets 57.5% 56.5% 51.7%
Equity / assets 42.5% 43.5% 48.3%
Interest coverage – 15.9x 0.8x
Current ratio 1.3x 0.9x 3.2x
Quick ratio 0.7x 0.7x 1.9x
Cash ratio 0.4x 0.2x 0.9x
Altman Z-score 2.36 3.43 1.57

Shareholder Returns

7 metrics
MetricPFEAZNTAK
Dividend yield 5.8% 1.4% 1.5%
Net buyback yield – 0.0% 1.0%
Shareholder yield 5.8% 1.4% 2.5%
Payout ratio (earnings) 224.5% – –
Payout ratio (FCF) 89.1% – –
Dividend growth (1Y) 1.5% – –
Dividend CAGR (3Y) 2.4% – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusPFEAZNTAK
Forward P/E 10.5xFY2026 17.0xFY2026 50.7xFY2026
EPS, next fiscal year $2.85FY2026 $10.00FY2026 $0.40FY2026
EPS growth, next FY -11.5%FY2026 +9.2%FY2026 +5.3%FY2026
EPS growth, the year after -4.6% +6.1% +62.5%
Revenue, next fiscal year $60.59BFY2026 $59.02BFY2026 $28.27BFY2026
Revenue growth, next FY -3.2%FY2026 +0.5%FY2026 -0.8%FY2026
Revenue growth, the year after +3.9% +8.0% +11.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersPFEAZNTAK
Held by institutions 66.9% 52.1% 3.3%
Institutions holding 2,835 1,496 378
Change in shares held, QoQ +2.0% +7.8% +6.2%
Institutions buying 1,324 808 212
Institutions selling 1,204 468 98
Buyers to sellers 1.10 1.73 2.16

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

PFEAZNTAK
PFE 1.00 0.42 0.43
AZN 0.42 1.00 0.52
TAK 0.43 0.52 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, PFE, AZN and TAK?

Astrazeneca (AZN) is the largest by market capitalisation: Pfizer (PFE) $169.85B, Astrazeneca (AZN) $263.53B, Takeda Pharmaceutical (TAK) $64.57B.

Which stock is cheaper, PFE, AZN and TAK?

Astrazeneca (AZN) trades on the lowest price-to-earnings ratio (Pfizer (PFE) 39.2x, Astrazeneca (AZN) 25.2x, Takeda Pharmaceutical (TAK) 111.3x). On next year's consensus earnings, Pfizer (PFE) is cheapest (Pfizer (PFE) 10.5x, Astrazeneca (AZN) 17.0x, Takeda Pharmaceutical (TAK) 50.7x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Astrazeneca (AZN) grew revenue fastest over the trailing twelve months: Pfizer (PFE) -0.2%, Astrazeneca (AZN) +9.4%, Takeda Pharmaceutical (TAK) +0.7%.

Which company is more profitable?

Astrazeneca (AZN) has the highest net margin (Pfizer (PFE) 6.8%, Astrazeneca (AZN) 17.8%, Takeda Pharmaceutical (TAK) 1.2%). On return on invested capital, Astrazeneca (AZN) leads (Pfizer (PFE) 13.4%, Astrazeneca (AZN) 23.3%, Takeda Pharmaceutical (TAK) 3.5%).

Which stock has performed better?

Over the past year Takeda Pharmaceutical (TAK) returned the most: Pfizer (PFE) +20.3%, Astrazeneca (AZN) +1.1%, Takeda Pharmaceutical (TAK) +43.2%. Over five years, Takeda Pharmaceutical (TAK) compounded fastest (Pfizer (PFE) -7.2%/yr, Astrazeneca (AZN) +6.5%/yr, Takeda Pharmaceutical (TAK) +7.5%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Pfizer (PFE) has the highest dividend yield: Pfizer (PFE) 5.77%, Astrazeneca (AZN) 1.41%, Takeda Pharmaceutical (TAK) 1.53%.

Which stock is riskier?

By one-year price volatility, Takeda Pharmaceutical (TAK) has been the steadiest (Pfizer (PFE) 21.6%, Astrazeneca (AZN) 27.4%, Takeda Pharmaceutical (TAK) 21.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, PFE, AZN and TAK?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Astrazeneca (AZN) leads on 7. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.