NTRA vs GH vs GRAL Stock Comparison

Natera, Guardant Health and Grail Prices as of Oct 23, 2026 Peers: Industry group
NTRA Natera, Inc.
$403.95 +3.4% 1M +107.2% 1Y
Market cap
$58.02B
P/E
–
Revenue (TTM)
$2.71B
Div. yield
–
Diagnostic Labs Healthcare
5 wins
GH Guardant Health, Inc.
$169.08 -4.1% 1M +143.8% 1Y
Market cap
$23.05B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
2 wins
GRAL GRAIL, Inc.
$132.55 +22.1% 1M +60.4% 1Y
Market cap
$6.04B
P/E
–
Revenue (TTM)
$157.21M
Div. yield
–
Diagnostic Labs Healthcare

Head to Head

7 decided of 12

Natera leads on 5 of the 12 questions below (Natera 5, Guardant Health 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionNTRAGHGRALLeader
Larger companyMarket capitalisation $58.02B $23.05B $6.04B NTRA
Cheaper on earningsLower P/E, profitable companies only -301.5x -50.8x -15.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months +37.8% +42.7% +17.1% GH
More profitableNet margin, trailing twelve months -7.1% -38.3% -249.1% NTRA
Better return on capitalReturn on invested capital -11.7% — — –
Less leveragedLower net debt / EBITDA 4.5x — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +107.2% +143.8% +60.4% GH
Better 5-year returnAnnualised price return, 5 years +28.6%/yr +9.1%/yr — NTRA
Less volatileAnnualised volatility, 1 year 47.9% 57.4% 111.3% NTRA
Higher overall scoreMean of the five percentile scores vs peers 50/100 27/100 42/100 NTRA

Percentile Scorecard

NTRAGHGRAL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisNTRAGHGRAL
Valuation 16 #78 of 93 17 #77 of 93 8 #86 of 93
Growth 71 #26 of 88 48 #46 of 88 58 #38 of 88
Profitability 33 #59 of 87 7 #81 of 87 6 #82 of 87
Financial Health 86 #15 of 100 50 #51 of 100 99 #2 of 100
Shareholder Returns 44 #32 of 56 15 #48 of 56 –
Overall 50 27 42
  • NTRA ranked among 103 companies in Healthcare Providers
  • GH ranked among 103 companies in Healthcare Providers
  • GRAL ranked among 103 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodNTRAGHGRALSPY
1 month +3.4%-4.1%+22.1% -1.0%
3 months +54.2%+14.8%+95.4% +2.9%
6 months +98.3%+90.2%+143.6% +6.4%
Year to date +76.3%+65.5%+54.9% +11.4%
1 year +107.2%+143.8%+60.4% +13.1%
3 years +890.3%+541.9%— +79.4%
3 years, per year +114.9%+85.9%— +21.5%
5 years +251.5%+54.6%— +67.7%
5 years, per year +28.6%+9.1%— +10.9%
10 years +3,943.5%—— +255.2%
10 years, per year +44.8%—— +13.5%

Risk

MeasureNTRAGHGRALSPY
Volatility, 1Y 47.9%57.4%111.3% 12.7%
Downside volatility, 1Y 44.1%48.6%125.8% 12.7%
Beta vs S&P 500, 1Y 1.211.012.62 1.00
Return / volatility, 1Y 2.242.500.54 1.03
Max drawdown, 5Y -76.4%-86.7%-62.9% -25.4%
From 52-week high -5.1%-9.7%-14.0% -2.5%
52-week high $425.64$187.22$154.08 $779.14
52-week low $182.65$69.35$43.03 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleNTRAGHGRAL
P/E now vs peer median -300.8xmedian 25.3x -49.5xmedian 25.3x -14.6xmedian 25.3x
P/S now vs peer median 21.4xmedian 1.6x 19.1xmedian 1.6x 37.7xmedian 1.6x
EV/EBITDA now vs peer median -254.2xmedian 14.6x -49.9xmedian 14.6x -12.5xmedian 14.6x
P/FCF now vs peer median 689.0xmedian 22.7x -93.8xmedian 22.7x -20.0xmedian 22.7x
P/B now vs peer median 31.8xmedian 3.3x -101.4xmedian 3.3x 2.3xmedian 3.3x
PEG now vs peer median -9.07median 0.66 -4.99median 0.66 —median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsNTRAGHGRAL
Revenue $2.71B $1.18B $157.21M
Gross profit $1.71B $769.16M $75.51M
Operating income -$289.67M -$470.26M -$559.25M
Net income -$192.36M -$453.44M -$391.59M
Free cash flow $84.20M -$240.72M -$296.16M
R&D $787.38M $375.79M $190.72M
EPS (diluted) $-1.34 $-3.41 $-9.08
Cash & equivalents $1.10B $1.05B $55.65M
Total debt $321.26M – –
Shares (diluted) 143.28M 132.87M 43.11M
Enterprise value $53.70B $19.11B $2.91B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricNTRAGHGRAL
P/E -300.8x -49.5x -14.6x
P/FCF 689.0x -93.8x -20.0x
P/Operating cash flow 254.2x -122.0x -20.1x
P/S 21.4x 19.1x 37.7x
P/B 31.8x -101.4x 2.3x
P/Tangible book 39.7x -91.0x 7.8x
EV/EBITDA -254.2x -49.9x -12.5x
EV/EBIT -196.7x -45.8x -9.0x
EV/Revenue 21.1x 18.2x 32.2x
EV/FCF 676.9x -89.5x -17.1x
EV/Operating cash flow 249.7x -116.3x -17.2x
PEG (3Y EPS CAGR) -9.07 -4.99 –

Growth

14 metrics
MetricNTRAGHGRAL
Revenue growth (1Y) 37.8% 42.7% 17.1%
Revenue CAGR (3Y) 42.7% 32.4% –
Gross profit growth (1Y) 43.6% 47.7% 30.2%
Gross profit CAGR (3Y) 68.1% – –
Operating income growth (1Y) 1.3% -2.1% 11.6%
Operating income CAGR (3Y) 17.3% 4.8% –
Net income growth (1Y) 24.0% -9.6% 11.6%
Net income CAGR (3Y) 27.8% 3.7% –
EPS growth (1Y) 27.7% -2.4% 26.6%
EPS CAGR (3Y) 33.2% 9.9% –
Operating cash flow growth (1Y) 22.2% 22.4% 20.3%
Operating cash flow CAGR (3Y) 38.6% 18.1% –
Free cash flow growth (1Y) -26.8% 11.4% 20.3%
Free cash flow CAGR (3Y) 30.4% 14.4% –

Profitability

14 metrics
MetricNTRAGHGRAL
Gross margin 63.2% 65.0% 48.0%
EBITDA margin -8.3% -36.5% -257.6%
Operating margin -10.7% -39.7% -355.7%
Pretax margin -9.3% -38.4% -336.8%
Net margin -7.1% -38.3% -249.1%
FCF margin 3.1% -20.3% -188.4%
Operating cash flow margin 8.4% -15.7% -187.5%
Return on equity -10.7% – -15.5%
Return on assets -7.3% -23.7% -13.9%
Return on invested capital -11.7% – –
Return on capital employed -13.9% -29.9% -20.4%
Asset turnover 1.0x 0.6x 0.1x
Cash conversion (OCF / net income) -1.2x 0.4x 0.8x
Stock comp / revenue 14.1% 16.2% 40.9%

Financial Health

11 metrics
MetricNTRAGHGRAL
Debt / assets 3.0% – –
Debt / equity 0.0x – –
Net debt / EBITDA 4.5x – –
Debt / FCF 1.0x – –
Liabilities / assets 31.5% 111.7% 10.6%
Equity / assets 68.5% -11.7% 89.4%
Interest coverage -75.9x -97.6x –
Current ratio 3.0x 4.0x 10.9x
Quick ratio 2.8x 3.5x 10.6x
Cash ratio 2.0x 3.1x 10.3x
Altman Z-score 41.25 4.44 6.43

Shareholder Returns

7 metrics
MetricNTRAGHGRAL
Dividend yield – – –
Net buyback yield -0.1% -1.8% –
Shareholder yield -0.1% -1.8% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusNTRAGHGRAL
EPS, next fiscal year $-1.47FY2026 $-3.34FY2026 $-9.20FY2026
Revenue, next fiscal year $3.07BFY2026 $1.42BFY2026 $169.83MFY2026
Revenue growth, next FY +32.8%FY2026 +44.5%FY2026 +15.4%FY2026
Revenue growth, the year after +6.9% +27.0% +38.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersNTRAGHGRAL
Held by institutions 95.5% 100.0% 85.4%
Institutions holding 847 594 372
Change in shares held, QoQ +2.7% -2.6% +8.4%
Institutions buying 513 353 182
Institutions selling 240 180 100
Buyers to sellers 2.14 1.96 1.82

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

NTRAGHGRAL
NTRA 1.00 0.54 0.43
GH 0.54 1.00 0.41
GRAL 0.43 0.41 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, NTRA, GH and GRAL?

Natera (NTRA) is the largest by market capitalisation: Natera (NTRA) $58.02B, Guardant Health (GH) $23.05B, Grail (GRAL) $6.04B.

Which company is growing faster?

Guardant Health (GH) grew revenue fastest over the trailing twelve months: Natera (NTRA) +37.8%, Guardant Health (GH) +42.7%, Grail (GRAL) +17.1%.

Which company is more profitable?

Natera (NTRA) has the highest net margin (Natera (NTRA) -7.1%, Guardant Health (GH) -38.3%, Grail (GRAL) -249.1%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Natera (NTRA) +107.2%, Guardant Health (GH) +143.8%, Grail (GRAL) +60.4%. Over five years, Natera (NTRA) compounded fastest (Natera (NTRA) +28.6%/yr, Guardant Health (GH) +9.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Natera (NTRA) has been the steadiest (Natera (NTRA) 47.9%, Guardant Health (GH) 57.4%, Grail (GRAL) 111.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, NTRA, GH and GRAL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Natera (NTRA) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.