NTRA vs CAI vs SHC Stock Comparison

Natera, Caris Life Sciences and Sotera Health Prices as of Oct 23, 2026 Peers: Industry group
NTRA Natera, Inc.
$403.95 +3.4% 1M +107.2% 1Y
Market cap
$58.02B
P/E
–
Revenue (TTM)
$2.71B
Div. yield
–
Diagnostic Labs Healthcare
3 wins
SHC Sotera Health Co
$18.10 -1.0% 1M +7.1% 1Y
Market cap
$5.26B
P/E
32.2x
Revenue (TTM)
$1.22B
Div. yield
–
Diagnostic Labs Healthcare
4 wins

Head to Head

11 decided of 12

Sotera Health leads on 4 of the 12 questions below (Sotera Health 4, Caris Life Sciences 4, Natera 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionNTRACAISHCLeader
Larger companyMarket capitalisation $58.02B $9.19B $5.26B NTRA
Cheaper on earningsLower P/E, profitable companies only -301.5x 87.4x 32.2x SHC
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 290.9x 19.7x SHC
Faster revenue growthRevenue growth, trailing twelve months +37.8% +85.4% +8.1% CAI
More profitableNet margin, trailing twelve months -7.1% 10.6% 13.4% SHC
Better return on capitalReturn on invested capital -11.7% 15.6% 9.1% CAI
Less leveragedLower net debt / EBITDA 4.5x -2.2x 3.3x CAI
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +107.2% +1.1% +7.1% NTRA
Better 5-year returnAnnualised price return, 5 years +28.6%/yr — -7.0%/yr NTRA
Less volatileAnnualised volatility, 1 year 47.9% 69.5% 28.4% SHC
Higher overall scoreMean of the five percentile scores vs peers 50/100 69/100 58/100 CAI

Percentile Scorecard

NTRACAISHC

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisNTRACAISHC
Valuation 16 #78 of 93 23 #72 of 93 50 #47 of 93
Growth 71 #26 of 88 99 #2 of 88 67 #30 of 88
Profitability 33 #59 of 87 87 #12 of 87 80 #18 of 87
Financial Health 86 #15 of 100 82 #19 of 100 35 #65 of 100
Shareholder Returns 44 #32 of 56 53 #27 of 56 –
Overall 50 69 58
  • NTRA ranked among 103 companies in Healthcare Providers
  • CAI ranked among 103 companies in Healthcare Providers
  • SHC ranked among 103 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodNTRACAISHCSPY
1 month +3.4%+1.1%-1.0% -1.0%
3 months +54.2%+106.2%+4.3% +2.9%
6 months +98.3%+58.4%+16.2% +6.4%
Year to date +76.3%+18.6%+2.6% +11.4%
1 year +107.2%+1.1%+7.1% +13.1%
3 years +890.3%—+39.1% +79.4%
3 years, per year +114.9%—+11.6% +21.5%
5 years +251.5%—-30.4% +67.7%
5 years, per year +28.6%—-7.0% +10.9%
10 years +3,943.5%—— +255.2%
10 years, per year +44.8%—— +13.5%

Risk

MeasureNTRACAISHCSPY
Volatility, 1Y 47.9%69.5%28.4% 12.7%
Downside volatility, 1Y 44.1%68.9%26.8% 12.7%
Beta vs S&P 500, 1Y 1.211.340.99 1.00
Return / volatility, 1Y 2.240.020.25 1.03
Max drawdown, 5Y -76.4%-63.0%-78.2% -25.4%
From 52-week high -5.1%-1.1%-7.5% -2.5%
52-week high $425.64$32.35$19.57 $779.14
52-week low $182.65$14.55$13.13 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleNTRACAISHC
P/E now vs peer median -300.8xmedian 25.3x 86.1xmedian 25.3x 31.6xmedian 25.3x
P/S now vs peer median 21.4xmedian 1.6x 9.1xmedian 1.6x 4.2xmedian 1.6x
EV/EBITDA now vs peer median -254.2xmedian 14.6x 48.0xmedian 14.6x 12.8xmedian 14.6x
P/FCF now vs peer median 689.0xmedian 22.7x 73.0xmedian 22.7x 45.8xmedian 22.7x
P/B now vs peer median 31.8xmedian 3.3x 15.3xmedian 3.3x 7.8xmedian 3.3x
PEG now vs peer median -9.07median 0.66 —median 0.66 0.84median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsNTRACAISHC
Revenue $2.71B $989.61M $1.22B
Gross profit $1.71B $689.36M $668.51M
Operating income -$289.67M $153.26M $411.34M
Net income -$192.36M $105.14M $163.48M
Free cash flow $84.20M $123.96M $112.70M
R&D $787.38M $117.14M –
EPS (diluted) $-1.34 $0.37 $0.57
Cash & equivalents $1.10B $690.92M $356.72M
Total debt $321.26M $393.15M $2.14B
Shares (diluted) 143.28M 282.89M 288.15M
Enterprise value $53.70B $6.01B $3.94B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricNTRACAISHC
P/E -300.8x 86.1x 31.6x
P/FCF 689.0x 73.0x 45.8x
P/Operating cash flow 254.2x 53.6x 17.7x
P/S 21.4x 9.1x 4.2x
P/B 31.8x 15.3x 7.8x
P/Tangible book 39.7x 15.3x 13.1x
EV/EBITDA -254.2x 48.0x 12.8x
EV/EBIT -196.7x 56.4x 16.9x
EV/Revenue 21.1x 8.7x 5.7x
EV/FCF 676.9x 69.7x 61.6x
EV/Operating cash flow 249.7x 51.3x 23.8x
PEG (3Y EPS CAGR) -9.07 – 0.84

Growth

14 metrics
MetricNTRACAISHC
Revenue growth (1Y) 37.8% 85.4% 8.1%
Revenue CAGR (3Y) 42.7% – 7.6%
Gross profit growth (1Y) 43.6% 141.2% 7.1%
Gross profit CAGR (3Y) 68.1% – 8.1%
Operating income growth (1Y) 1.3% 188.2% 21.8%
Operating income CAGR (3Y) 17.3% – 23.2%
Net income growth (1Y) 24.0% 137.7% 580.5%
Net income CAGR (3Y) 27.8% – 37.7%
EPS growth (1Y) 27.7% 103.0% 574.9%
EPS CAGR (3Y) 33.2% – 37.5%
Operating cash flow growth (1Y) 22.2% 227.3% 9.8%
Operating cash flow CAGR (3Y) 38.6% – 61.3%
Free cash flow growth (1Y) -26.8% 188.2% 0.0%
Free cash flow CAGR (3Y) 30.4% – 32.6%

Profitability

14 metrics
MetricNTRACAISHC
Gross margin 63.2% 69.7% 55.0%
EBITDA margin -8.3% 18.2% 44.6%
Operating margin -10.7% 15.5% 33.8%
Pretax margin -9.3% 10.6% 21.7%
Net margin -7.1% 10.6% 13.4%
FCF margin 3.1% 12.5% 9.3%
Operating cash flow margin 8.4% 17.0% 24.0%
Return on equity -10.7% 17.7% 25.4%
Return on assets -7.3% 8.8% 5.0%
Return on invested capital -11.7% 15.6% 9.1%
Return on capital employed -13.9% 15.3% 13.5%
Asset turnover 1.0x 0.8x 0.4x
Cash conversion (OCF / net income) -1.2x 1.6x 1.8x
Stock comp / revenue 14.1% 6.6% 3.1%

Financial Health

11 metrics
MetricNTRACAISHC
Debt / assets 3.0% 32.0% 64.7%
Debt / equity 0.0x 0.7x 3.2x
Net debt / EBITDA 4.5x -2.2x 3.3x
Debt / FCF 1.0x 3.2x 19.0x
Liabilities / assets 31.5% 51.9% 79.9%
Equity / assets 68.5% 48.1% 20.1%
Interest coverage -75.9x 3.3x –
Current ratio 3.0x 5.5x 2.8x
Quick ratio 2.8x 4.8x 2.4x
Cash ratio 2.0x 4.1x 1.5x
Altman Z-score 41.25 7.66 1.91

Shareholder Returns

7 metrics
MetricNTRACAISHC
Dividend yield – – –
Net buyback yield -0.1% 0.1% –
Shareholder yield -0.1% 0.1% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusNTRACAISHC
Forward P/E – 290.9xFY2026 19.7xFY2026
EPS, next fiscal year $-1.47FY2026 $0.11FY2026 $0.92FY2026
EPS growth, next FY – – +7.0%FY2026
EPS growth, the year after – +236.4% +21.7%
Revenue, next fiscal year $3.07BFY2026 $1.06BFY2026 $1.33BFY2026
Revenue growth, next FY +32.8%FY2026 +30.1%FY2026 +14.8%FY2026
Revenue growth, the year after +6.9% +21.6% -4.2%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersNTRACAISHC
Held by institutions 95.5% 52.0% 100.0%
Institutions holding 847 245 316
Change in shares held, QoQ +2.7% -6.3% +5.9%
Institutions buying 513 175 220
Institutions selling 240 47 64
Buyers to sellers 2.14 3.72 3.44

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

NTRACAISHC
NTRA 1.00 0.55 0.36
CAI 0.55 1.00 0.38
SHC 0.36 0.38 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, NTRA, CAI and SHC?

Natera (NTRA) is the largest by market capitalisation: Natera (NTRA) $58.02B, Caris Life Sciences (CAI) $9.19B, Sotera Health (SHC) $5.26B.

Which stock is cheaper, NTRA, CAI and SHC?

Sotera Health (SHC) trades on the lowest price-to-earnings ratio (Natera (NTRA) -301.5x, Caris Life Sciences (CAI) 87.4x, Sotera Health (SHC) 32.2x). On next year's consensus earnings, Sotera Health (SHC) is cheapest (Caris Life Sciences (CAI) 290.9x, Sotera Health (SHC) 19.7x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Caris Life Sciences (CAI) grew revenue fastest over the trailing twelve months: Natera (NTRA) +37.8%, Caris Life Sciences (CAI) +85.4%, Sotera Health (SHC) +8.1%.

Which company is more profitable?

Sotera Health (SHC) has the highest net margin (Natera (NTRA) -7.1%, Caris Life Sciences (CAI) 10.6%, Sotera Health (SHC) 13.4%). On return on invested capital, Caris Life Sciences (CAI) leads (Natera (NTRA) -11.7%, Caris Life Sciences (CAI) 15.6%, Sotera Health (SHC) 9.1%).

Which stock has performed better?

Over the past year Natera (NTRA) returned the most: Natera (NTRA) +107.2%, Caris Life Sciences (CAI) +1.1%, Sotera Health (SHC) +7.1%. Over five years, Natera (NTRA) compounded fastest (Natera (NTRA) +28.6%/yr, Sotera Health (SHC) -7.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Natera (NTRA) 47.9%, Caris Life Sciences (CAI) 69.5%, Sotera Health (SHC) 28.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, NTRA, CAI and SHC?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sotera Health (SHC) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.