NTLA vs LEGN vs IOVA Stock Comparison

Intellia Therapeutics, Legend Biotech and Iovance Biotherapeutics Prices as of Oct 29, 2026 Peers: Industry group
LEGN Legend Biotech Corp
$22.30 +18.5% 1M -30.6% 1Y
Market cap
$3.98B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins

Head to Head

7 decided of 12

Legend Biotech leads on 6 of the 12 questions below (Legend Biotech 6, Iovance Biotherapeutics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionNTLALEGNIOVALeader
Larger companyMarket capitalisation $1.65B $3.98B $3.78B LEGN
Cheaper on earningsLower P/E, profitable companies only -4.1x -43.4x -13.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months +12.6% +59.5% +34.5% LEGN
More profitableNet margin, trailing twelve months -672.2% -7.2% -89.1% LEGN
Better return on capitalReturn on invested capital — -4.2% — –
Less leveragedLower net debt / EBITDA — 28.0x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +0.8% -30.6% +378.0% IOVA
Better 5-year returnAnnualised price return, 5 years -37.0%/yr -15.7%/yr -17.0%/yr LEGN
Less volatileAnnualised volatility, 1 year 79.8% 72.3% 108.2% LEGN
Higher overall scoreMean of the five percentile scores vs peers 50/100 73/100 62/100 LEGN

Percentile Scorecard

NTLALEGNIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisNTLALEGNIOVA
Valuation 35 #404 of 624 89 #70 of 624 65 #222 of 624
Growth 63 #221 of 601 97 #20 of 601 81 #115 of 601
Profitability 39 #331 of 541 80 #108 of 541 63 #203 of 541
Financial Health 72 #181 of 647 54 #299 of 647 62 #244 of 647
Shareholder Returns 40 #216 of 359 44 #201 of 359 41 #213 of 359
Overall 50 73 62
  • NTLA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodNTLALEGNIOVASPY
1 month +10.0%+18.5%-33.8% +0.7%
3 months +19.3%+17.1%+103.8% +3.7%
6 months -1.9%-5.2%+184.5% +7.1%
Year to date +47.2%+2.6%+250.2% +12.8%
1 year +0.8%-30.6%+378.0% +11.9%
3 years -44.5%-66.0%+158.4% +85.2%
3 years, per year -17.8%-30.2%+37.3% +22.8%
5 years -90.1%-57.5%-60.7% +67.6%
5 years, per year -37.0%-15.7%-17.0% +10.9%
10 years +2.1%—+53.0% +262.0%
10 years, per year +0.2%—+4.3% +13.7%

Risk

MeasureNTLALEGNIOVASPY
Volatility, 1Y 79.8%72.3%108.2% 12.7%
Downside volatility, 1Y 81.7%62.7%93.0% 12.6%
Beta vs S&P 500, 1Y 2.460.441.40 1.00
Return / volatility, 1Y 0.01-0.423.49 0.94
Max drawdown, 5Y -95.5%-78.2%-93.4% -25.4%
From 52-week high -25.8%-38.5%-35.7% -1.2%
52-week high $17.84$36.28$14.86 $779.14
52-week low $8.04$16.65$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleNTLALEGNIOVA
P/E now vs peer median -4.4xmedian 17.8x -44.8xmedian 17.8x -14.9xmedian 17.8x
P/S now vs peer median 31.1xmedian 9.1x 3.2xmedian 9.1x 13.3xmedian 9.1x
EV/EBITDA now vs peer median -3.4xmedian 15.0x -195.0xmedian 15.0x -15.3xmedian 15.0x
P/FCF now vs peer median -5.3xmedian 21.7x -63.6xmedian 21.7x -14.6xmedian 21.7x
P/B now vs peer median 2.5xmedian 2.2x 3.3xmedian 2.2x 5.9xmedian 2.2x
PEG now vs peer median -0.27median 0.35 -0.95median 0.35 -0.50median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsNTLALEGNIOVA
Revenue $59.51M $1.27B $324.97M
Gross profit – $727.10M $157.29M
Operating income -$423.48M -$55.25M -$301.31M
Net income -$399.98M -$80.39M -$289.51M
Free cash flow -$348.69M -$64.60M -$296.40M
R&D $346.73M $396.15M $267.72M
EPS (diluted) $-3.00 $-0.50 $-0.64
Cash & equivalents $106.13M $672.90M $110.80M
Total debt – $1.06B –
Shares (diluted) 133.48M 184.32M 450.19M
Enterprise value -$126.19M $1.48B $2.57B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricNTLALEGNIOVA
P/E -4.4x -44.8x -14.9x
P/FCF -5.3x -63.6x -14.6x
P/Operating cash flow -5.3x -46.0x -16.4x
P/S 31.1x 3.2x 13.3x
P/B 2.5x 3.3x 5.9x
P/Tangible book 2.5x 3.3x 9.2x
EV/EBITDA -3.4x -195.0x -15.3x
EV/EBIT -3.3x -65.0x -13.4x
EV/Revenue 23.8x 2.8x 12.4x
EV/FCF -4.1x -55.6x -13.6x
EV/Operating cash flow -4.1x -40.2x -15.3x
PEG (3Y EPS CAGR) -0.27 -0.95 -0.50

Growth

14 metrics
MetricNTLALEGNIOVA
Revenue growth (1Y) 12.6% 59.5% 34.5%
Revenue CAGR (3Y) 3.9% 97.6% 1,009%
Gross profit growth (1Y) – 42.4% 95.1%
Gross profit CAGR (3Y) – 147.5% –
Operating income growth (1Y) 17.3% 75.3% 26.6%
Operating income CAGR (3Y) 2.7% 49.1% 11.1%
Net income growth (1Y) 16.7% 75.3% 25.8%
Net income CAGR (3Y) 4.1% 46.7% 11.6%
EPS growth (1Y) 35.3% 72.0% 44.8%
EPS CAGR (3Y) 16.5% 47.0% 29.9%
Operating cash flow growth (1Y) 17.2% 67.5% 12.9%
Operating cash flow CAGR (3Y) 2.0% 37.1% 7.6%
Free cash flow growth (1Y) 17.3% 77.8% 8.4%
Free cash flow CAGR (3Y) 3.2% 44.5% 5.8%

Profitability

14 metrics
MetricNTLALEGNIOVA
Gross margin – 57.2% 48.4%
EBITDA margin -696.4% -1.5% -81.4%
Operating margin -711.7% -4.3% -92.7%
Pretax margin -671.0% -4.4% -90.4%
Net margin -672.2% -7.2% -89.1%
FCF margin -586.0% -5.1% -91.2%
Operating cash flow margin -582.5% -7.0% -81.3%
Return on equity -59.2% -8.3% -39.7%
Return on assets -49.4% -5.5% -31.4%
Return on invested capital – -4.2% –
Return on capital employed -58.1% -4.3% -37.0%
Asset turnover 0.1x 0.8x 0.4x
Cash conversion (OCF / net income) 0.9x 1.1x 0.9x
Stock comp / revenue 114.1% 5.2% 14.4%

Financial Health

11 metrics
MetricNTLALEGNIOVA
Debt / assets – 8.9% –
Debt / equity – 0.1x –
Net debt / EBITDA – 28.0x –
Debt / FCF – -2.4x –
Liabilities / assets 15.1% 29.8% 19.6%
Equity / assets 84.9% 70.2% 80.4%
Interest coverage – -4.8x –
Current ratio 6.6x 3.0x 4.3x
Quick ratio 5.6x 1.7x 3.7x
Cash ratio 5.5x 1.7x 2.8x
Altman Z-score 3.09 6.90 9.78

Shareholder Returns

7 metrics
MetricNTLALEGNIOVA
Dividend yield – – –
Net buyback yield -7.1% -5.2% -6.8%
Shareholder yield -7.1% -5.2% -6.8%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusNTLALEGNIOVA
EPS, next fiscal year $-3.38FY2026 $-0.04FY2026 $-0.47FY2026
Revenue, next fiscal year $48.94MFY2026 $1.37BFY2026 $434.71MFY2026
Revenue growth, next FY -27.7%FY2026 +32.9%FY2026 +65.0%FY2026
Revenue growth, the year after +158.6% +35.9% +33.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersNTLALEGNIOVA
Held by institutions 100.0% 55.9% 63.3%
Institutions holding 329 218 292
Change in shares held, QoQ +30.5% +7.3% +6.5%
Institutions buying 195 117 174
Institutions selling 78 78 66
Buyers to sellers 2.50 1.50 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

NTLALEGNIOVA
NTLA 1.00 0.08 0.24
LEGN 0.08 1.00 0.14
IOVA 0.24 0.14 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, NTLA, LEGN and IOVA?

Legend Biotech (LEGN) is the largest by market capitalisation: Intellia Therapeutics (NTLA) $1.65B, Legend Biotech (LEGN) $3.98B, Iovance Biotherapeutics (IOVA) $3.78B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Intellia Therapeutics (NTLA) +12.6%, Legend Biotech (LEGN) +59.5%, Iovance Biotherapeutics (IOVA) +34.5%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (Intellia Therapeutics (NTLA) -672.2%, Legend Biotech (LEGN) -7.2%, Iovance Biotherapeutics (IOVA) -89.1%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Intellia Therapeutics (NTLA) +0.8%, Legend Biotech (LEGN) -30.6%, Iovance Biotherapeutics (IOVA) +378.0%. Over five years, Legend Biotech (LEGN) compounded fastest (Intellia Therapeutics (NTLA) -37.0%/yr, Legend Biotech (LEGN) -15.7%/yr, Iovance Biotherapeutics (IOVA) -17.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Legend Biotech (LEGN) has been the steadiest (Intellia Therapeutics (NTLA) 79.8%, Legend Biotech (LEGN) 72.3%, Iovance Biotherapeutics (IOVA) 108.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, NTLA, LEGN and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.