MRNA vs BIIB vs BNTX Stock Comparison

Moderna, Biogen and BioNTech SE Prices as of Oct 28, 2026 Peers: Industry group
MRNA Moderna, Inc.
$214.16 +8.6% 1M +744.8% 1Y
Market cap
$88.13B
P/E
–
Revenue (TTM)
$2.23B
Div. yield
–
Biotechnology Healthcare
3 wins
BIIB Biogen Inc.
$244.05 +6.7% 1M +63.6% 1Y
Market cap
$36.94B
P/E
106.3x
Revenue (TTM)
$10.30B
Div. yield
–
Biotechnology Healthcare
5 wins
BNTX BioNTech SE
$87.99 -11.2% 1M -16.2% 1Y
Market cap
$21.52B
P/E
–
Revenue (TTM)
$3.09B
Div. yield
–
Biotechnology Healthcare
1 win

Head to Head

9 decided of 12

Biogen leads on 5 of the 12 questions below (Biogen 5, Moderna 3, BioNTech SE 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMRNABIIBBNTXLeader
Larger companyMarket capitalisation $88.13B $36.94B $21.52B MRNA
Cheaper on earningsLower P/E, profitable companies only -28.0x 106.3x -10.9x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 19.1x — –
Faster revenue growthRevenue growth, trailing twelve months -27.6% +2.3% -1.1% BIIB
More profitableNet margin, trailing twelve months -141.4% 3.4% -63.5% BIIB
Better return on capitalReturn on invested capital -43.3% 1.3% -10.7% BIIB
Less leveragedLower net debt / EBITDA 1.5x 4.5x 8.7x MRNA
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +744.8% +63.6% -16.2% MRNA
Better 5-year returnAnnualised price return, 5 years -9.1%/yr -1.8%/yr -20.6%/yr BIIB
Less volatileAnnualised volatility, 1 year 130.6% 34.2% 46.7% BIIB
Higher overall scoreMean of the five percentile scores vs peers 57/100 59/100 65/100 BNTX

Percentile Scorecard

MRNABIIBBNTX

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMRNABIIBBNTX
Valuation 69 #192 of 625 92 #54 of 625 91 #59 of 625
Growth 19 #488 of 602 26 #446 of 602 14 #516 of 602
Profitability 57 #235 of 549 87 #73 of 549 77 #126 of 549
Financial Health 55 #298 of 654 33 #437 of 654 89 #71 of 654
Shareholder Returns 85 #57 of 367 – 52 #178 of 367
Overall 57 59 65
  • MRNA ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BIIB ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BNTX ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMRNABIIBBNTXSPY
1 month +8.6%+6.7%-11.2% +0.9%
3 months +293.0%+16.6%-5.3% +5.9%
6 months +368.4%+25.6%-13.4% +8.5%
Year to date +626.2%+38.7%-7.6% +13.3%
1 year +744.8%+63.6%-16.2% +12.4%
3 years +197.8%+4.1%-3.5% +88.1%
3 years, per year +43.9%+1.3%-1.2% +23.5%
5 years -38.0%-8.5%-68.4% +68.2%
5 years, per year -9.1%-1.8%-20.6% +11.0%
10 years —-14.0%— +263.4%
10 years, per year —-1.5%— +13.8%

Risk

MeasureMRNABIIBBNTXSPY
Volatility, 1Y 130.6%34.2%46.7% 12.7%
Downside volatility, 1Y 79.5%32.7%46.6% 12.7%
Beta vs S&P 500, 1Y 2.160.250.95 1.00
Return / volatility, 1Y 5.701.86-0.35 0.98
Max drawdown, 5Y -93.9%-64.4%-78.4% -25.4%
From 52-week high -12.9%-3.9%-26.3% -0.9%
52-week high $245.81$253.84$119.34 $779.14
52-week low $22.36$147.86$83.89 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMRNABIIBBNTX
P/E now vs peer median -27.1xmedian 17.4x 103.8xmedian 17.4x -10.8xmedian 17.4x
P/S now vs peer median 38.4xmedian 9.1x 3.5xmedian 9.1x 7.2xmedian 9.1x
EV/EBITDA now vs peer median -26.3xmedian 17.1x 31.7xmedian 17.1x -5.8xmedian 17.1x
P/FCF now vs peer median -68.7xmedian 19.0x 17.4xmedian 19.0x 21.4xmedian 19.0x
P/B now vs peer median 12.6xmedian 2.2x 1.9xmedian 2.2x 1.1xmedian 2.2x
PEG now vs peer median 0.42median 0.34 -2.70median 0.34 0.31median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMRNABIIBBNTX
Revenue $2.23B $10.30B $3.09B
Gross profit $521.00M $7.62B $2.34B
Operating income -$3.32B $445.10M -$2.33B
Net income -$3.15B $347.50M -$1.97B
Free cash flow -$1.24B $2.07B $1.04B
R&D $2.88B $2.15B $2.54B
EPS (diluted) $-7.92 $2.35 $-8.13
Cash & equivalents $1.72B $1.30B $11.13B
Total debt $591.00M $7.29B $102.80M
Shares (diluted) 398.00M 147.80M 241.70M
Enterprise value $67.49B $26.26B -$24.96B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMRNABIIBBNTX
P/E -27.1x 103.8x -10.8x
P/FCF -68.7x 17.4x 21.4x
P/Operating cash flow -79.6x 16.1x 28.1x
P/S 38.4x 3.5x 7.2x
P/B 12.6x 1.9x 1.1x
P/Tangible book 12.6x 6.5x 1.1x
EV/EBITDA -26.3x 31.7x -5.8x
EV/EBIT -24.4x 94.5x -3.8x
EV/Revenue 36.3x 4.1x 2.9x
EV/FCF -65.0x 20.3x 8.6x
EV/Operating cash flow -75.4x 18.7x 11.3x
PEG (3Y EPS CAGR) 0.42 -2.70 0.31

Growth

14 metrics
MetricMRNABIIBBNTX
Revenue growth (1Y) -27.6% 2.3% -1.1%
Revenue CAGR (3Y) -40.6% 1.0% -31.0%
Gross profit growth (1Y) -67.8% 0.6% -6.4%
Gross profit CAGR (3Y) -56.0% 0.5% -34.2%
Operating income growth (1Y) -1.4% -76.6% -142.6%
Operating income CAGR (3Y) -103.9% -34.8% -33.8%
Net income growth (1Y) -8.5% -78.4% -417.0%
Net income CAGR (3Y) -66.4% -38.1% -34.6%
EPS growth (1Y) -5.8% -78.5% -393.7%
EPS CAGR (3Y) -65.1% -38.5% -34.9%
Operating cash flow growth (1Y) 60.2% -8.4% 142.8%
Operating cash flow CAGR (3Y) -68.1% 18.2% -56.6%
Free cash flow growth (1Y) 64.4% -10.1% 164.1%
Free cash flow CAGR (3Y) -18.2% 24.9% -53.1%

Profitability

14 metrics
MetricMRNABIIBBNTX
Gross margin 23.4% 74.0% 75.5%
EBITDA margin -138.2% 12.9% -49.7%
Operating margin -149.0% 4.3% -75.2%
Pretax margin -138.6% 4.3% -61.4%
Net margin -141.4% 3.4% -63.5%
FCF margin -55.8% 20.1% 33.6%
Operating cash flow margin -48.2% 21.8% 25.6%
Return on equity -44.5% 1.8% -10.3%
Return on assets -28.1% 1.1% -9.0%
Return on invested capital -43.3% 1.3% -10.7%
Return on capital employed -38.2% 1.6% -9.9%
Asset turnover 0.2x 0.3x 0.1x
Cash conversion (OCF / net income) 0.3x 6.5x -0.4x
Stock comp / revenue 20.7% 2.9% 3.6%

Financial Health

11 metrics
MetricMRNABIIBBNTX
Debt / assets 5.4% 22.7% 0.4%
Debt / equity 0.1x 0.4x 0.0x
Net debt / EBITDA 1.5x 4.5x 8.7x
Debt / FCF -0.5x 3.5x 0.1x
Liabilities / assets 38.3% 41.0% 12.7%
Equity / assets 61.7% 59.0% 87.3%
Interest coverage – – -41.1x
Current ratio 2.3x 1.9x 65.1x
Quick ratio 2.0x 0.9x 50.7x
Cash ratio 2.0x 0.3x 50.0x
Altman Z-score 12.42 3.07 6.36

Shareholder Returns

7 metrics
MetricMRNABIIBBNTX
Dividend yield – – –
Net buyback yield -0.1% – -2.9%
Shareholder yield -0.1% – -2.9%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMRNABIIBBNTX
Forward P/E – 19.1xFY2026 –
EPS, next fiscal year $-8.02FY2026 $12.81FY2026 $-6.21FY2026
EPS growth, next FY – -16.2%FY2026 –
EPS growth, the year after – +36.5% –
Revenue, next fiscal year $2.04BFY2026 $9.96BFY2026 $1.90BFY2026
Revenue growth, next FY +5.1%FY2026 +0.7%FY2026 -43.7%FY2026
Revenue growth, the year after +26.8% +11.9% +11.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMRNABIIBBNTX
Held by institutions 80.2% 96.4% 19.4%
Institutions holding 784 1,036 281
Change in shares held, QoQ +3.4% +6.0% -1.2%
Institutions buying 402 548 136
Institutions selling 238 294 73
Buyers to sellers 1.69 1.86 1.86

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MRNABIIBBNTX
MRNA 1.00 0.22 0.59
BIIB 0.22 1.00 0.21
BNTX 0.59 0.21 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, MRNA, BIIB and BNTX?

Moderna (MRNA) is the largest by market capitalisation: Moderna (MRNA) $88.13B, Biogen (BIIB) $36.94B, BioNTech SE (BNTX) $21.52B.

Which company is growing faster?

Biogen (BIIB) grew revenue fastest over the trailing twelve months: Moderna (MRNA) -27.6%, Biogen (BIIB) +2.3%, BioNTech SE (BNTX) -1.1%.

Which company is more profitable?

Biogen (BIIB) has the highest net margin (Moderna (MRNA) -141.4%, Biogen (BIIB) 3.4%, BioNTech SE (BNTX) -63.5%). On return on invested capital, Biogen (BIIB) leads (Moderna (MRNA) -43.3%, Biogen (BIIB) 1.3%, BioNTech SE (BNTX) -10.7%).

Which stock has performed better?

Over the past year Moderna (MRNA) returned the most: Moderna (MRNA) +744.8%, Biogen (BIIB) +63.6%, BioNTech SE (BNTX) -16.2%. Over five years, Biogen (BIIB) compounded fastest (Moderna (MRNA) -9.1%/yr, Biogen (BIIB) -1.8%/yr, BioNTech SE (BNTX) -20.6%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Biogen (BIIB) has been the steadiest (Moderna (MRNA) 130.6%, Biogen (BIIB) 34.2%, BioNTech SE (BNTX) 46.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MRNA, BIIB and BNTX?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Biogen (BIIB) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.