MRK vs PFE vs TAK Stock Comparison

Merck, Pfizer and Takeda Pharmaceutical Prices as of Oct 23, 2026 Peers: Industry group
MRK Merck & Co., Inc.
$145.28 -1.9% 1M +66.6% 1Y
Market cap
$346.73B
P/E
109.3x
Revenue (TTM)
$66.57B
Div. yield
0.02%
Pharmaceuticals Healthcare
4 wins
PFE Pfizer Inc
$30.01 +6.5% 1M +21.6% 1Y
Market cap
$169.80B
P/E
39.2x
Revenue (TTM)
$63.70B
Div. yield
0.06%
Pharmaceuticals Healthcare
7 wins

Head to Head

12 decided of 12

Pfizer leads on 7 of the 12 questions below (Pfizer 7, Merck 4, Takeda Pharmaceutical 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMRKPFETAKLeader
Larger companyMarket capitalisation $346.73B $169.80B $64.39B MRK
Cheaper on earningsLower P/E, profitable companies only 109.3x 39.2x 112.1x PFE
Cheaper on forward earningsLower price / next fiscal year consensus EPS 58.3x 10.5x 50.6x PFE
Faster revenue growthRevenue growth, trailing twelve months +4.6% -0.2% +0.7% MRK
More profitableNet margin, trailing twelve months 4.8% 6.8% 1.2% PFE
Better return on capitalReturn on invested capital 3.6% 13.4% 3.5% PFE
Less leveragedLower net debt / EBITDA 3.6x 1.9x 3.5x PFE
Higher dividend yieldTrailing dividend yield 0.02% 0.06% 0.00% PFE
Better 1-year returnPrice return, last 12 months +66.6% +21.6% +44.0% MRK
Better 5-year returnAnnualised price return, 5 years +12.4%/yr -7.0%/yr +7.6%/yr MRK
Less volatileAnnualised volatility, 1 year 29.4% 21.6% 21.5% TAK
Higher overall scoreMean of the five percentile scores vs peers 61/100 65/100 62/100 PFE

Percentile Scorecard

MRKPFETAK

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMRKPFETAK
Valuation 79 #134 of 624 94 #37 of 624 97 #18 of 624
Growth 36 #387 of 603 23 #465 of 603 21 #479 of 603
Profitability 91 #53 of 555 92 #45 of 555 85 #83 of 555
Financial Health 20 #528 of 657 24 #503 of 657 34 #433 of 657
Shareholder Returns 81 #71 of 370 91 #36 of 370 73 #99 of 370
Overall 61 65 62
  • MRK ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PFE ranked among 671 companies in Pharmaceuticals and Biotechnology
  • TAK ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMRKPFETAKSPY
1 month -1.9%+6.5%+7.5% -1.0%
3 months +10.8%+22.2%+17.4% +2.9%
6 months +29.8%+11.1%+21.8% +6.4%
Year to date +38.0%+20.5%+29.9% +11.4%
1 year +66.6%+21.6%+44.0% +13.1%
3 years +41.0%-1.4%+38.9% +79.4%
3 years, per year +12.1%-0.5%+11.6% +21.5%
5 years +79.0%-30.5%+43.9% +67.7%
5 years, per year +12.4%-7.0%+7.6% +10.9%
10 years +137.4%-6.7%-11.3% +255.2%
10 years, per year +9.0%-0.7%-1.2% +13.5%

Risk

MeasureMRKPFETAKSPY
Volatility, 1Y 29.4%21.6%21.5% 12.7%
Downside volatility, 1Y 24.2%21.1%20.2% 12.7%
Beta vs S&P 500, 1Y 0.130.240.11 1.00
Return / volatility, 1Y 2.271.002.05 1.03
Max drawdown, 5Y -44.7%-64.8%-26.4% -25.4%
From 52-week high -7.1%-1.3%-0.6% -2.5%
52-week high $156.45$30.41$20.37 $779.14
52-week low $82.49$23.67$13.23 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMRKPFETAK
P/E now vs peer median 113.1xmedian 17.2x 39.5xmedian 17.2x 111.1xmedian 17.2x
P/S now vs peer median 5.4xmedian 8.8x 2.7xmedian 8.8x 1.4xmedian 8.8x
EV/EBITDA now vs peer median 30.9xmedian 16.0x 8.2xmedian 16.0x 12.3xmedian 16.0x
P/FCF now vs peer median 22.3xmedian 17.8x 15.6xmedian 17.8x 12.4xmedian 17.8x
P/B now vs peer median 8.5xmedian 2.1x 2.0xmedian 2.1x 1.4xmedian 2.1x
PEG now vs peer median 71.19median 0.32 -0.96median 0.32 -2.73median 0.32

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMRKPFETAK
Revenue $66.57B $63.70B $46.49B
Gross profit $48.57B $46.61B $30.58B
Operating income $6.38B $20.39B $2.71B
Net income $3.17B $4.36B -$1.04B
Free cash flow $16.06B $10.99B $5.20B
R&D $30.45B $11.05B $4.53B
EPS (diluted) $1.28 $0.76 $0.18
Cash & equivalents $6.85B $976.00M $2.85B
Total debt $193.74B $63.19B $126.30B
Shares (diluted) 2.47B 5.70B 3.15B
Enterprise value $301.10B $116.45B $40.75B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMRKPFETAK
P/E 113.1x 39.5x 111.1x
P/FCF 22.3x 15.6x 12.4x
P/Operating cash flow 18.0x 12.8x 10.3x
P/S 5.4x 2.7x 1.4x
P/B 8.5x 2.0x 1.4x
P/Tangible book 21.1x 4.4x 2.5x
EV/EBITDA 30.9x 8.2x 12.3x
EV/EBIT 63.5x 10.9x 33.1x
EV/Revenue 6.1x 3.5x 1.9x
EV/FCF 25.2x 20.3x 17.3x
EV/Operating cash flow 20.3x 16.6x 14.3x
PEG (3Y EPS CAGR) 71.19 -0.96 -2.73

Growth

14 metrics
MetricMRKPFETAK
Revenue growth (1Y) 4.6% -0.2% 0.7%
Revenue CAGR (3Y) 4.5% -7.0% 14.8%
Gross profit growth (1Y) -0.3% 1.2% -0.8%
Gross profit CAGR (3Y) 4.5% -5.6% -0.2%
Operating income growth (1Y) -66.6% 1.5% -43.4%
Operating income CAGR (3Y) 1.9% -9.9% -14.3%
Net income growth (1Y) -80.7% -59.6% -209.1%
Net income CAGR (3Y) 0.5% -41.3% -35.3%
EPS growth (1Y) -80.3% -59.7% -75.7%
EPS CAGR (3Y) 1.6% -41.3% -40.6%
Operating cash flow growth (1Y) 7.7% -11.8% -14.8%
Operating cash flow CAGR (3Y) 9.8% -2.7% -4.4%
Free cash flow growth (1Y) 9.1% -11.7% -13.3%
Free cash flow CAGR (3Y) 14.0% 1.0% -5.2%

Profitability

14 metrics
MetricMRKPFETAK
Gross margin 73.0% 73.2% 65.8%
EBITDA margin 19.7% 42.4% 15.6%
Operating margin 9.6% 32.0% 5.8%
Pretax margin 8.9% 6.6% 2.6%
Net margin 4.8% 6.8% 1.2%
FCF margin 24.1% 17.2% 11.2%
Operating cash flow margin 30.0% 21.0% 13.5%
Return on equity 7.2% 5.0% 1.2%
Return on assets 2.5% 2.1% 0.6%
Return on invested capital 3.6% 13.4% 3.5%
Return on capital employed 6.3% 11.9% 3.0%
Asset turnover 0.5x 0.3x 0.5x
Cash conversion (OCF / net income) 6.3x 3.1x -6.0x
Stock comp / revenue 1.3% 1.5% 1.0%

Financial Health

11 metrics
MetricMRKPFETAK
Debt / assets 41.5% 31.4% 32.0%
Debt / equity 1.3x 0.7x 0.7x
Net debt / EBITDA 3.6x 1.9x 3.5x
Debt / FCF 3.4x 5.8x 6.0x
Liabilities / assets 67.7% 57.5% 51.7%
Equity / assets 32.3% 42.5% 48.3%
Interest coverage – – 0.8x
Current ratio 1.3x 1.3x 3.2x
Quick ratio 0.7x 0.7x 1.9x
Cash ratio 0.3x 0.4x 0.9x
Altman Z-score 3.89 2.37 1.57

Shareholder Returns

7 metrics
MetricMRKPFETAK
Dividend yield 2.3% 5.7% 1.5%
Net buyback yield 1.1% – 1.0%
Shareholder yield 3.4% 5.7% 2.5%
Payout ratio (earnings) 261.8% 224.5% –
Payout ratio (FCF) 51.7% 89.1% –
Dividend growth (1Y) 3.3% 1.5% –
Dividend CAGR (3Y) 4.7% 2.4% –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMRKPFETAK
Forward P/E 58.3xFY2026 10.5xFY2026 50.6xFY2026
EPS, next fiscal year $2.49FY2026 $2.86FY2026 $0.40FY2026
EPS growth, next FY -72.3%FY2026 -11.2%FY2026 +5.3%FY2026
EPS growth, the year after +257.4% -4.5% +62.5%
Revenue, next fiscal year $69.45BFY2026 $60.60BFY2026 $28.25BFY2026
Revenue growth, next FY +6.8%FY2026 -3.2%FY2026 -0.8%FY2026
Revenue growth, the year after -3.8% +3.8% +11.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMRKPFETAK
Held by institutions 79.9% 66.9% 3.3%
Institutions holding 3,794 2,835 378
Change in shares held, QoQ +2.6% +2.0% +6.2%
Institutions buying 1,840 1,324 212
Institutions selling 1,464 1,204 98
Buyers to sellers 1.26 1.10 2.16

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MRKPFETAK
MRK 1.00 0.44 0.42
PFE 0.44 1.00 0.43
TAK 0.42 0.43 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, MRK, PFE and TAK?

Merck (MRK) is the largest by market capitalisation: Merck (MRK) $346.73B, Pfizer (PFE) $169.80B, Takeda Pharmaceutical (TAK) $64.39B.

Which stock is cheaper, MRK, PFE and TAK?

Pfizer (PFE) trades on the lowest price-to-earnings ratio (Merck (MRK) 109.3x, Pfizer (PFE) 39.2x, Takeda Pharmaceutical (TAK) 112.1x). On next year's consensus earnings, Pfizer (PFE) is cheapest (Merck (MRK) 58.3x, Pfizer (PFE) 10.5x, Takeda Pharmaceutical (TAK) 50.6x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Merck (MRK) grew revenue fastest over the trailing twelve months: Merck (MRK) +4.6%, Pfizer (PFE) -0.2%, Takeda Pharmaceutical (TAK) +0.7%.

Which company is more profitable?

Pfizer (PFE) has the highest net margin (Merck (MRK) 4.8%, Pfizer (PFE) 6.8%, Takeda Pharmaceutical (TAK) 1.2%). On return on invested capital, Pfizer (PFE) leads (Merck (MRK) 3.6%, Pfizer (PFE) 13.4%, Takeda Pharmaceutical (TAK) 3.5%).

Which stock has performed better?

Over the past year Merck (MRK) returned the most: Merck (MRK) +66.6%, Pfizer (PFE) +21.6%, Takeda Pharmaceutical (TAK) +44.0%. Over five years, Merck (MRK) compounded fastest (Merck (MRK) +12.4%/yr, Pfizer (PFE) -7.0%/yr, Takeda Pharmaceutical (TAK) +7.6%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Pfizer (PFE) has the highest dividend yield: Merck (MRK) 0.02%, Pfizer (PFE) 0.06%, Takeda Pharmaceutical (TAK) 0.00%. Takeda Pharmaceutical (TAK) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Takeda Pharmaceutical (TAK) has been the steadiest (Merck (MRK) 29.4%, Pfizer (PFE) 21.6%, Takeda Pharmaceutical (TAK) 21.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MRK, PFE and TAK?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Pfizer (PFE) leads on 7. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.