MESO vs SLDB vs SLBT Stock Comparison

Mesoblast, Solid Biosciences and SL Science Holding Prices as of Oct 27, 2026 Peers: Industry group
MESO Mesoblast Ltd
$13.18 -12.8% 1M -21.1% 1Y
Market cap
$1.72B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
SLDB Solid Biosciences Inc.
$6.19 -15.1% 1M +4.9% 1Y
Market cap
$906.68M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
SLBT SL Science Holding Ltd
$1.19 -24.2% 1M -88.5% 1Y
Market cap
$2.66B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

4 decided of 12

Mesoblast leads on 2 of the 12 questions below (Mesoblast 2, SL Science Holding 1, Solid Biosciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMESOSLDBSLBTLeader
Larger companyMarket capitalisation $1.72B $906.68M $2.66B SLBT
Cheaper on earningsLower P/E, profitable companies only -29.7x -4.4x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — — — –
More profitableNet margin, trailing twelve months — — — –
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -21.1% +4.9% -88.5% SLDB
Better 5-year returnAnnualised price return, 5 years +1.9%/yr -26.0%/yr — MESO
Less volatileAnnualised volatility, 1 year 54.8% 78.4% 175.4% MESO
Higher overall scoreMean of the five percentile scores vs peers — 42/100 — –

Percentile Scorecard

MESOSLDBSLBT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMESOSLDBSLBT
Valuation 70 #189 of 625 34 #413 of 625 11 #555 of 625
Growth – 19 #488 of 602 –
Profitability – 50 #276 of 551 –
Financial Health 44 #365 of 656 88 #78 of 656 58 #279 of 656
Shareholder Returns – 18 #300 of 365 –
Overall – 42 –
  • MESO ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SLDB ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMESOSLDBSLBTSPY
1 month -12.8%-15.1%-24.2% -0.2%
3 months -8.8%-22.3%-56.7% +3.9%
6 months -13.4%-16.9%-84.9% +8.2%
Year to date -26.9%+9.8%-88.7% +12.9%
1 year -21.1%+4.9%-88.5% +12.3%
3 years +463.2%+227.5%— +87.4%
3 years, per year +78.0%+48.5%— +23.3%
5 years +9.7%-77.8%— +67.9%
5 years, per year +1.9%-26.0%— +10.9%
10 years +56.2%—— +261.1%
10 years, per year +4.6%—— +13.7%

Risk

MeasureMESOSLDBSLBTSPY
Volatility, 1Y 54.8%78.4%175.4% 12.7%
Downside volatility, 1Y 54.9%77.0%170.6% 12.7%
Beta vs S&P 500, 1Y 1.522.120.23 1.00
Return / volatility, 1Y -0.390.06-0.50 0.97
Max drawdown, 5Y -87.9%-94.9%-91.0% -25.4%
From 52-week high -37.1%-44.5%-90.7% -1.2%
52-week high $20.96$11.15$12.81 $779.14
52-week low $11.95$3.93$1.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMESOSLDBSLBT
P/E now vs peer median -29.7xmedian 17.2x -4.3xmedian 17.2x —median 17.2x
P/S now vs peer median 14.2xmedian 9.0x —median 9.0x —median 9.0x
EV/EBITDA now vs peer median —median 16.3x -2.4xmedian 16.3x —median 16.3x
P/FCF now vs peer median -38.2xmedian 18.7x -4.7xmedian 18.7x -1,382xmedian 18.7x
P/B now vs peer median 3.0xmedian 2.2x 2.4xmedian 2.2x 372.2xmedian 2.2x
PEG now vs peer median —median 0.33 -0.13median 0.33 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMESOSLDBSLBT
Operating income – -$212.15M –
Net income – -$207.10M –
Free cash flow – -$187.82M –
R&D – $167.40M –
EPS (diluted) – $-1.44 –
Cash & equivalents $102.91M $159.39M $8.31M
Total debt $119.24M – –
Shares (diluted) 129.49M 143.69M –
Enterprise value $1.29B -$275.67M $2.65B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMESOSLDBSLBT
P/E -29.7x -4.3x –
P/FCF -38.2x -4.7x -1,382x
P/Operating cash flow – -4.8x –
P/S 14.2x – –
P/B 3.0x 2.4x 372.2x
P/Tangible book 3.0x 2.4x 372.2x
EV/EBITDA – -2.4x –
EV/EBIT – -2.4x –
EV/Revenue – – –
EV/FCF – -2.7x –
EV/Operating cash flow – -2.7x –
PEG (3Y EPS CAGR) – -0.13 –

Growth

14 metrics
MetricMESOSLDBSLBT
Revenue growth (1Y) – – –
Revenue CAGR (3Y) – – –
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) – -35.3% –
Operating income CAGR (3Y) – -22.8% –
Net income growth (1Y) – -34.4% –
Net income CAGR (3Y) – -31.9% –
EPS growth (1Y) – 11.9% –
EPS CAGR (3Y) – 32.0% –
Operating cash flow growth (1Y) – -52.4% –
Operating cash flow CAGR (3Y) – -19.2% –
Free cash flow growth (1Y) – -52.3% –
Free cash flow CAGR (3Y) – -18.4% –

Profitability

14 metrics
MetricMESOSLDBSLBT
Gross margin – – –
EBITDA margin – – –
Operating margin – – –
Pretax margin – – –
Net margin – – –
FCF margin – – –
Operating cash flow margin – – –
Return on equity – -55.4% –
Return on assets – -49.1% –
Return on invested capital – – –
Return on capital employed – -54.0% –
Asset turnover – – –
Cash conversion (OCF / net income) – 0.9x –
Stock comp / revenue – – –

Financial Health

11 metrics
MetricMESOSLDBSLBT
Debt / assets 15.4% – –
Debt / equity 0.2x – –
Net debt / EBITDA – – –
Debt / FCF – – –
Liabilities / assets 26.5% 11.1% 21.8%
Equity / assets 73.5% 88.9% 78.2%
Interest coverage – – –
Current ratio 2.4x 13.8x 4.4x
Quick ratio 2.0x 13.2x 4.3x
Cash ratio 1.3x 13.2x 4.3x
Altman Z-score – – –

Shareholder Returns

7 metrics
MetricMESOSLDBSLBT
Dividend yield – – –
Net buyback yield – -27.0% –
Shareholder yield – -27.0% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMESOSLDBSLBT
EPS, next fiscal year $-0.15FY2027 $-1.63FY2026 –
Revenue, next fiscal year $188.99MFY2027 $0.00FY2026 –
Revenue growth, next FY +57.2%FY2027 – –
Revenue growth, the year after +110.3% – –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMESOSLDBSLBT
Held by institutions 3.0% 79.7% –
Institutions holding 73 157 –
Change in shares held, QoQ +17.7% +18.9% –
Institutions buying 34 101 –
Institutions selling 20 37 –
Buyers to sellers 1.70 2.73 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MESOSLDBSLBT
MESO 1.00 0.26 0.00
SLDB 0.26 1.00 -0.02
SLBT 0.00 -0.02 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, MESO, SLDB and SLBT?

SL Science Holding (SLBT) is the largest by market capitalisation: Mesoblast (MESO) $1.72B, Solid Biosciences (SLDB) $906.68M, SL Science Holding (SLBT) $2.66B.

Which stock has performed better?

Over the past year Solid Biosciences (SLDB) returned the most: Mesoblast (MESO) -21.1%, Solid Biosciences (SLDB) +4.9%, SL Science Holding (SLBT) -88.5%. Over five years, Mesoblast (MESO) compounded fastest (Mesoblast (MESO) +1.9%/yr, Solid Biosciences (SLDB) -26.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Mesoblast (MESO) has been the steadiest (Mesoblast (MESO) 54.8%, Solid Biosciences (SLDB) 78.4%, SL Science Holding (SLBT) 175.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MESO, SLDB and SLBT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Mesoblast (MESO) leads on 2. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.