MESO vs PGEN vs CRSP Stock Comparison

Mesoblast, Precigen and CRISPR Therapeutics AG Prices as of Oct 27, 2026 Peers: Industry group
MESO Mesoblast Ltd
$13.18 -12.8% 1M -21.1% 1Y
Market cap
$1.73B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
PGEN Precigen, Inc.
$6.15 -20.6% 1M +43.0% 1Y
Market cap
$2.18B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$5.16B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

8 decided of 12

Precigen leads on 6 of the 12 questions below (Precigen 6, CRISPR Therapeutics AG 1, Mesoblast 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMESOPGENCRSPLeader
Larger companyMarket capitalisation $1.73B $2.18B $5.16B CRSP
Cheaper on earningsLower P/E, profitable companies only -29.7x -6.5x -11.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 36.2x — –
Faster revenue growthRevenue growth, trailing twelve months — +1,875.0% -64.8% PGEN
More profitableNet margin, trailing twelve months — -392.8% -3,368.7% PGEN
Better return on capitalReturn on invested capital — — -22.6% –
Less leveragedLower net debt / EBITDA — -1.6x 3.4x PGEN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -21.1% +43.0% -21.7% PGEN
Better 5-year returnAnnualised price return, 5 years +1.9%/yr +4.4%/yr -11.4%/yr PGEN
Less volatileAnnualised volatility, 1 year 54.8% 77.9% 57.2% MESO
Higher overall scoreMean of the five percentile scores vs peers — 55/100 44/100 PGEN

Percentile Scorecard

MESOPGENCRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMESOPGENCRSP
Valuation 70 #189 of 625 59 #258 of 625 49 #322 of 625
Growth – 49 #310 of 602 32 #411 of 602
Profitability – 59 #227 of 551 32 #375 of 551
Financial Health 44 #365 of 656 27 #482 of 656 71 #190 of 656
Shareholder Returns – 83 #63 of 365 38 #228 of 365
Overall – 55 44
  • MESO ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMESOPGENCRSPSPY
1 month -12.8%-20.6%-5.1% -0.2%
3 months -8.8%+11.2%+8.2% +3.9%
6 months -13.4%+53.0%-1.1% +8.2%
Year to date -26.9%+47.1%-1.8% +12.9%
1 year -21.1%+43.0%-21.7% +12.3%
3 years +463.2%+508.9%+32.9% +87.4%
3 years, per year +78.0%+82.7%+9.9% +23.3%
5 years +9.7%+24.0%-45.2% +67.9%
5 years, per year +1.9%+4.4%-11.4% +10.9%
10 years +56.2%-76.2%+225.3% +261.1%
10 years, per year +4.6%-13.4%+12.5% +13.7%

Risk

MeasureMESOPGENCRSPSPY
Volatility, 1Y 54.8%77.9%57.2% 12.7%
Downside volatility, 1Y 54.9%69.4%53.7% 12.7%
Beta vs S&P 500, 1Y 1.521.431.83 1.00
Return / volatility, 1Y -0.390.55-0.38 0.97
Max drawdown, 5Y -87.9%-87.8%-67.7% -25.4%
From 52-week high -37.1%-28.2%-21.7% -1.2%
52-week high $20.96$8.56$65.72 $779.14
52-week low $11.95$3.10$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMESOPGENCRSP
P/E now vs peer median -29.7xmedian 17.2x -6.5xmedian 17.2x -11.0xmedian 17.2x
P/S now vs peer median 14.2xmedian 9.0x 25.7xmedian 9.0x 371.5xmedian 9.0x
EV/EBITDA now vs peer median —median 16.3x -65.8xmedian 16.3x -6.2xmedian 16.3x
P/FCF now vs peer median -38.2xmedian 18.7x -19.1xmedian 18.7x -13.4xmedian 18.7x
P/B now vs peer median 3.0xmedian 2.2x 50.5xmedian 2.2x 2.8xmedian 2.2x
PEG now vs peer median —median 0.33 0.05median 0.33 -2.86median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMESOPGENCRSP
Revenue – $85.72M $13.39M
Gross profit – $77.72M –
Operating income – -$39.50M -$534.34M
Net income – -$157.71M -$451.14M
Free cash flow – -$115.22M -$371.33M
R&D – $32.29M $278.15M
EPS (diluted) – $-0.81 $-4.67
Cash & equivalents $102.91M $16.33M $291.34M
Total debt $119.24M $93.88M $586.20M
Shares (diluted) 129.49M 413.69M 96.51M
Enterprise value $1.30B $1.87B -$3.54B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMESOPGENCRSP
P/E -29.7x -6.5x -11.0x
P/FCF -38.2x -19.1x -13.4x
P/Operating cash flow – -19.3x -13.5x
P/S 14.2x 25.7x 371.5x
P/B 3.0x 50.5x 2.8x
P/Tangible book 3.0x 53.7x 2.8x
EV/EBITDA – -65.8x -6.2x
EV/EBIT – -57.2x -6.0x
EV/Revenue – 26.3x 238.7x
EV/FCF – -19.6x -8.6x
EV/Operating cash flow – -19.8x -8.7x
PEG (3Y EPS CAGR) – 0.05 -2.86

Growth

14 metrics
MetricMESOPGENCRSP
Revenue growth (1Y) – 1,875% -64.8%
Revenue CAGR (3Y) – 57.1% -57.1%
Gross profit growth (1Y) – 259,173% –
Gross profit CAGR (3Y) – 69.2% –
Operating income growth (1Y) – 62.1% 3.3%
Operating income CAGR (3Y) – 18.9% -4.1%
Net income growth (1Y) – -26.7% 3.6%
Net income CAGR (3Y) – -108.9% -2.7%
EPS growth (1Y) – -93.8% 13.0%
EPS CAGR (3Y) – -123.2% 3.9%
Operating cash flow growth (1Y) – -72.3% -13.8%
Operating cash flow CAGR (3Y) – -15.9% -2.5%
Free cash flow growth (1Y) – -65.1% -14.1%
Free cash flow CAGR (3Y) – -15.3% -0.9%

Profitability

14 metrics
MetricMESOPGENCRSP
Gross margin – 90.7% –
EBITDA margin – -40.0% -3,850%
Operating margin – -46.1% -3,990%
Pretax margin – -184.0% -3,346%
Net margin – -392.8% -3,369%
FCF margin – -134.4% -2,773%
Operating cash flow margin – -133.2% -2,760%
Return on equity – -494.3% -25.3%
Return on assets – -102.1% -16.8%
Return on invested capital – – -22.6%
Return on capital employed – -31.6% -20.9%
Asset turnover – 0.6x 0.0x
Cash conversion (OCF / net income) – 0.7x 0.8x
Stock comp / revenue – 15.3% 510.2%

Financial Health

11 metrics
MetricMESOPGENCRSP
Debt / assets 15.4% 55.1% 22.1%
Debt / equity 0.2x 2.2x 0.3x
Net debt / EBITDA – -1.6x 3.4x
Debt / FCF – -0.8x -1.6x
Liabilities / assets 26.5% 74.4% 34.1%
Equity / assets 73.5% 25.6% 65.9%
Interest coverage – -4.1x –
Current ratio 2.4x 4.6x 17.8x
Quick ratio 2.0x 3.8x 17.8x
Cash ratio 1.3x 1.3x 17.8x
Altman Z-score – -8.25 2.51

Shareholder Returns

7 metrics
MetricMESOPGENCRSP
Dividend yield – – –
Net buyback yield – -0.1% -8.6%
Shareholder yield – -0.1% -8.6%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMESOPGENCRSP
Forward P/E – 36.2xFY2026 –
EPS, next fiscal year $-0.15FY2027 $0.17FY2026 $-4.10FY2026
EPS growth, the year after – +288.2% –
Revenue, next fiscal year $188.99MFY2027 $249.17MFY2026 $38.73MFY2026
Revenue growth, next FY +57.2%FY2027 +2,474.1%FY2026 +1,003.4%FY2026
Revenue growth, the year after +110.3% +82.3% +266.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMESOPGENCRSP
Held by institutions 3.0% 39.2% 78.9%
Institutions holding 73 210 518
Change in shares held, QoQ +17.7% +4.9% -1.0%
Institutions buying 34 123 237
Institutions selling 20 46 139
Buyers to sellers 1.70 2.67 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MESOPGENCRSP
MESO 1.00 0.20 0.22
PGEN 0.20 1.00 0.37
CRSP 0.22 0.37 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, MESO, PGEN and CRSP?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Mesoblast (MESO) $1.73B, Precigen (PGEN) $2.18B, CRISPR Therapeutics AG (CRSP) $5.16B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Precigen (PGEN) +1,875.0%, CRISPR Therapeutics AG (CRSP) -64.8%.

Which company is more profitable?

Precigen (PGEN) has the highest net margin (Precigen (PGEN) -392.8%, CRISPR Therapeutics AG (CRSP) -3,368.7%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Mesoblast (MESO) -21.1%, Precigen (PGEN) +43.0%, CRISPR Therapeutics AG (CRSP) -21.7%. Over five years, Precigen (PGEN) compounded fastest (Mesoblast (MESO) +1.9%/yr, Precigen (PGEN) +4.4%/yr, CRISPR Therapeutics AG (CRSP) -11.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Mesoblast (MESO) has been the steadiest (Mesoblast (MESO) 54.8%, Precigen (PGEN) 77.9%, CRISPR Therapeutics AG (CRSP) 57.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MESO, PGEN and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.