MESO vs NGNE vs BEAM Stock Comparison

Mesoblast, Neurogene and Beam Therapeutics Prices as of Oct 27, 2026 Peers: Industry group
MESO Mesoblast Ltd
$13.18 -12.8% 1M -21.1% 1Y
Market cap
$1.72B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
NGNE Neurogene Inc.
$26.99 -4.7% 1M -15.8% 1Y
Market cap
$631.57M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
BEAM Beam Therapeutics Inc.
$24.90 +2.6% 1M -6.8% 1Y
Market cap
$2.78B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

5 decided of 12

Beam Therapeutics leads on 3 of the 12 questions below (Beam Therapeutics 3, Mesoblast 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMESONGNEBEAMLeader
Larger companyMarket capitalisation $1.72B $631.57M $2.78B BEAM
Cheaper on earningsLower P/E, profitable companies only -29.7x -5.7x -32.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — — +158.9% –
More profitableNet margin, trailing twelve months — — -54.7% –
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — — 3.0x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -21.1% -15.8% -6.8% BEAM
Better 5-year returnAnnualised price return, 5 years +1.9%/yr -27.8%/yr -23.4%/yr MESO
Less volatileAnnualised volatility, 1 year 54.8% 78.1% 69.2% MESO
Higher overall scoreMean of the five percentile scores vs peers — 47/100 69/100 BEAM

Percentile Scorecard

MESONGNEBEAM

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMESONGNEBEAM
Valuation 70 #189 of 625 47 #331 of 625 54 #286 of 625
Growth – 22 #473 of 602 77 #137 of 602
Profitability – 54 #256 of 551 64 #198 of 551
Financial Health 44 #365 of 656 72 #185 of 656 81 #128 of 656
Shareholder Returns – 41 #216 of 365 67 #123 of 365
Overall – 47 69
  • MESO ranked among 672 companies in Pharmaceuticals and Biotechnology
  • NGNE ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMESONGNEBEAMSPY
1 month -12.8%-4.7%+2.6% -0.2%
3 months -8.8%-18.8%-5.3% +3.9%
6 months -13.4%-1.7%-18.5% +8.2%
Year to date -26.9%+31.0%-10.2% +12.9%
1 year -21.1%-15.8%-6.8% +12.3%
3 years +463.2%+92.8%+33.7% +87.4%
3 years, per year +78.0%+24.5%+10.2% +23.3%
5 years +9.7%-80.3%-73.6% +67.9%
5 years, per year +1.9%-27.8%-23.4% +10.9%
10 years +56.2%-87.4%— +261.1%
10 years, per year +4.6%-18.7%— +13.7%

Risk

MeasureMESONGNEBEAMSPY
Volatility, 1Y 54.8%78.1%69.2% 12.7%
Downside volatility, 1Y 54.9%76.4%63.8% 12.7%
Beta vs S&P 500, 1Y 1.521.562.06 1.00
Return / volatility, 1Y -0.39-0.20-0.10 0.97
Max drawdown, 5Y -87.9%-95.3%-85.3% -25.4%
From 52-week high -37.1%-37.0%-34.3% -1.2%
52-week high $20.96$42.84$37.92 $779.14
52-week low $11.95$16.37$20.60 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMESONGNEBEAM
P/E now vs peer median -29.7xmedian 17.2x -5.5xmedian 17.2x -30.4xmedian 17.2x
P/S now vs peer median 14.2xmedian 9.0x —median 9.0x 16.5xmedian 9.0x
EV/EBITDA now vs peer median —median 16.3x -3.2xmedian 16.3x -4.3xmedian 16.3x
P/FCF now vs peer median -38.2xmedian 18.7x -6.9xmedian 18.7x -6.9xmedian 18.7x
P/B now vs peer median 3.0xmedian 2.2x 2.8xmedian 2.2x 2.4xmedian 2.2x
PEG now vs peer median —median 0.33 -0.16median 0.33 -0.72median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMESONGNEBEAM
Revenue – – $156.04M
Operating income – -$121.35M -$378.02M
Net income – -$111.16M -$86.52M
Free cash flow – -$87.75M -$372.77M
R&D – $88.50M $408.66M
EPS (diluted) – $-4.93 $-0.82
Cash & equivalents $102.91M $112.49M $219.83M
Total debt $119.24M – $100.26M
Shares (diluted) 129.49M 22.55M 104.33M
Enterprise value $1.29B -$371.43M -$1.91B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMESONGNEBEAM
P/E -29.7x -5.5x -30.4x
P/FCF -38.2x -6.9x -6.9x
P/Operating cash flow – -7.0x -7.2x
P/S 14.2x – 16.5x
P/B 3.0x 2.8x 2.4x
P/Tangible book 3.0x 2.8x 2.4x
EV/EBITDA – -3.2x -4.3x
EV/EBIT – -3.2x -4.0x
EV/Revenue – – 9.7x
EV/FCF – -4.4x -4.1x
EV/Operating cash flow – -4.4x -4.2x
PEG (3Y EPS CAGR) – -0.16 -0.72

Growth

14 metrics
MetricMESONGNEBEAM
Revenue growth (1Y) – – 158.9%
Revenue CAGR (3Y) – – 24.9%
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) – -26.8% 15.2%
Operating income CAGR (3Y) – -33.6% 0.3%
Net income growth (1Y) – -31.7% 78.2%
Net income CAGR (3Y) – -32.0% 35.8%
EPS growth (1Y) – -23.0% 79.0%
EPS CAGR (3Y) – 34.1% 42.4%
Operating cash flow growth (1Y) – -18.5% -4.2%
Operating cash flow CAGR (3Y) – -19.9% -2.0%
Free cash flow growth (1Y) – -17.8% -4.8%
Free cash flow CAGR (3Y) – -19.1% 0.7%

Profitability

14 metrics
MetricMESONGNEBEAM
Gross margin – – –
EBITDA margin – – -228.0%
Operating margin – – -242.3%
Pretax margin – – -54.4%
Net margin – – -54.7%
FCF margin – – -238.9%
Operating cash flow margin – – -230.3%
Return on equity – -49.1% -7.6%
Return on assets – -44.0% -5.9%
Return on invested capital – – –
Return on capital employed – -52.2% -27.9%
Asset turnover – – 0.1x
Cash conversion (OCF / net income) – 0.8x 4.2x
Stock comp / revenue – – 52.2%

Financial Health

11 metrics
MetricMESONGNEBEAM
Debt / assets 15.4% – 7.2%
Debt / equity 0.2x – 0.1x
Net debt / EBITDA – – 3.0x
Debt / FCF – – -0.3x
Liabilities / assets 26.5% 11.1% 23.0%
Equity / assets 73.5% 88.9% 77.0%
Interest coverage – -60,673x –
Current ratio 2.4x 10.6x 14.6x
Quick ratio 2.0x 10.5x 14.3x
Cash ratio 1.3x 10.5x 14.3x
Altman Z-score – – 3.08

Shareholder Returns

7 metrics
MetricMESONGNEBEAM
Dividend yield – – –
Net buyback yield – -6.1% -0.6%
Shareholder yield – -6.1% -0.6%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMESONGNEBEAM
EPS, next fiscal year $-0.15FY2027 $-5.76FY2026 $-4.22FY2026
Revenue, next fiscal year $188.99MFY2027 $0.00FY2026 $49.46MFY2026
Revenue growth, next FY +57.2%FY2027 – -64.6%FY2026
Revenue growth, the year after +110.3% – +23.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMESONGNEBEAM
Held by institutions 3.0% 76.8% 100.0%
Institutions holding 73 113 277
Change in shares held, QoQ +17.7% +2.0% +1.0%
Institutions buying 34 61 154
Institutions selling 20 31 75
Buyers to sellers 1.70 1.97 2.05

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MESONGNEBEAM
MESO 1.00 0.27 0.14
NGNE 0.27 1.00 0.33
BEAM 0.14 0.33 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, MESO, NGNE and BEAM?

Beam Therapeutics (BEAM) is the largest by market capitalisation: Mesoblast (MESO) $1.72B, Neurogene (NGNE) $631.57M, Beam Therapeutics (BEAM) $2.78B.

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: Mesoblast (MESO) -21.1%, Neurogene (NGNE) -15.8%, Beam Therapeutics (BEAM) -6.8%. Over five years, Mesoblast (MESO) compounded fastest (Mesoblast (MESO) +1.9%/yr, Neurogene (NGNE) -27.8%/yr, Beam Therapeutics (BEAM) -23.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Mesoblast (MESO) has been the steadiest (Mesoblast (MESO) 54.8%, Neurogene (NGNE) 78.1%, Beam Therapeutics (BEAM) 69.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MESO, NGNE and BEAM?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Beam Therapeutics (BEAM) leads on 3. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.