MESO vs CRSP vs VCEL Stock Comparison

Mesoblast, CRISPR Therapeutics AG and Vericel Prices as of Oct 26, 2026 Peers: Industry group
MESO Mesoblast Ltd
$12.39 -18.1% 1M -26.3% 1Y
Market cap
$1.70B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
CRSP CRISPR Therapeutics AG
$49.01 -9.6% 1M -27.5% 1Y
Market cap
$4.95B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
VCEL Vericel Corp
$43.04 +8.4% 1M +18.5% 1Y
Market cap
$2.23B
P/E
92.1x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins

Head to Head

7 decided of 12

Vericel leads on 5 of the 12 questions below (Vericel 5, CRISPR Therapeutics AG 1, Mesoblast 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMESOCRSPVCELLeader
Larger companyMarket capitalisation $1.70B $4.95B $2.23B CRSP
Cheaper on earningsLower P/E, profitable companies only -27.9x -11.0x 92.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 84.4x –
Faster revenue growthRevenue growth, trailing twelve months — -64.8% +23.0% VCEL
More profitableNet margin, trailing twelve months — -3,368.7% 7.9% VCEL
Better return on capitalReturn on invested capital — -22.6% — –
Less leveragedLower net debt / EBITDA — 3.4x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -26.3% -27.5% +18.5% VCEL
Better 5-year returnAnnualised price return, 5 years +0.4%/yr -12.0%/yr -3.2%/yr MESO
Less volatileAnnualised volatility, 1 year 54.6% 57.1% 40.9% VCEL
Higher overall scoreMean of the five percentile scores vs peers — 44/100 81/100 VCEL

Percentile Scorecard

MESOCRSPVCEL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMESOCRSPVCEL
Valuation 71 #183 of 626 48 #327 of 626 81 #119 of 626
Growth – 32 #414 of 604 94 #37 of 604
Profitability – 32 #379 of 555 88 #68 of 555
Financial Health 44 #366 of 658 71 #191 of 658 69 #207 of 658
Shareholder Returns – 38 #230 of 368 73 #100 of 368
Overall – 44 81
  • MESO ranked among 673 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 673 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 673 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMESOCRSPVCELSPY
1 month -18.1%-9.6%+8.4% -0.8%
3 months -14.9%+4.9%-5.0% +3.5%
6 months -19.2%-3.9%+16.6% +7.0%
Year to date -31.3%-6.5%+19.5% +12.2%
1 year -26.3%-27.5%+18.5% +13.0%
3 years +429.5%+26.5%+31.1% +86.3%
3 years, per year +74.4%+8.2%+9.5% +23.1%
5 years +2.2%-47.2%-14.9% +68.6%
5 years, per year +0.4%-12.0%-3.2% +11.0%
10 years +52.6%+231.1%+1,693.3% +258.0%
10 years, per year +4.3%+12.7%+33.5% +13.6%

Risk

MeasureMESOCRSPVCELSPY
Volatility, 1Y 54.6%57.1%40.9% 12.7%
Downside volatility, 1Y 54.9%53.7%40.1% 12.7%
Beta vs S&P 500, 1Y 1.501.820.74 1.00
Return / volatility, 1Y -0.48-0.480.45 1.02
Max drawdown, 5Y -87.9%-67.7%-65.4% -25.4%
From 52-week high -40.9%-25.4%-10.9% -1.8%
52-week high $20.96$65.72$48.31 $779.14
52-week low $11.95$44.34$29.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMESOCRSPVCEL
P/E now vs peer median -27.9xmedian 17.1x -10.5xmedian 17.1x 90.8xmedian 17.1x
P/S now vs peer median 13.3xmedian 8.8x 353.7xmedian 8.8x 7.2xmedian 8.8x
EV/EBITDA now vs peer median —median 17.1x -5.7xmedian 17.1x 65.0xmedian 17.1x
P/FCF now vs peer median -35.9xmedian 18.0x -12.8xmedian 18.0x 35.7xmedian 18.0x
P/B now vs peer median 2.8xmedian 2.1x 2.7xmedian 2.1x 6.0xmedian 2.1x
PEG now vs peer median —median 0.31 -2.72median 0.31 1.67median 0.31

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMESOCRSPVCEL
Revenue – $13.39M $306.30M
Gross profit – – $228.38M
Operating income – -$534.34M $18.24M
Net income – -$451.14M $24.22M
Free cash flow – -$371.33M $61.66M
R&D – $278.15M $29.17M
EPS (diluted) – $-4.67 $0.46
Cash & equivalents $102.91M $291.34M $125.40M
Total debt $119.24M $586.20M –
Shares (diluted) 129.49M 96.51M 52.31M
Enterprise value $1.27B -$3.75B $1.65B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMESOCRSPVCEL
P/E -27.9x -10.5x 90.8x
P/FCF -35.9x -12.8x 35.7x
P/Operating cash flow – -12.8x 31.6x
P/S 13.3x 353.7x 7.2x
P/B 2.8x 2.7x 6.0x
P/Tangible book 2.8x 2.7x 6.0x
EV/EBITDA – -5.7x 65.0x
EV/EBIT – -5.5x 111.9x
EV/Revenue – 221.0x 6.7x
EV/FCF – -8.0x 33.1x
EV/Operating cash flow – -8.0x 29.3x
PEG (3Y EPS CAGR) – -2.72 1.67

Growth

14 metrics
MetricMESOCRSPVCEL
Revenue growth (1Y) – -64.8% 23.0%
Revenue CAGR (3Y) – -57.1% 19.8%
Gross profit growth (1Y) – – 24.8%
Gross profit CAGR (3Y) – – 23.9%
Operating income growth (1Y) – 3.3% 1,428%
Operating income CAGR (3Y) – -4.1% 47.8%
Net income growth (1Y) – 3.6% 240.8%
Net income CAGR (3Y) – -2.7% 56.6%
EPS growth (1Y) – 13.0% 228.1%
EPS CAGR (3Y) – 3.9% 54.3%
Operating cash flow growth (1Y) – -13.8% 47.5%
Operating cash flow CAGR (3Y) – -2.5% 33.7%
Free cash flow growth (1Y) – -14.1% 842.9%
Free cash flow CAGR (3Y) – -0.9% 43.2%

Profitability

14 metrics
MetricMESOCRSPVCEL
Gross margin – – 74.6%
EBITDA margin – -3,850% 10.2%
Operating margin – -3,990% 6.0%
Pretax margin – -3,346% 8.2%
Net margin – -3,369% 7.9%
FCF margin – -2,773% 20.1%
Operating cash flow margin – -2,760% 22.7%
Return on equity – -25.3% 6.9%
Return on assets – -16.8% 5.1%
Return on invested capital – -22.6% –
Return on capital employed – -20.9% 4.1%
Asset turnover – 0.0x 0.6x
Cash conversion (OCF / net income) – 0.8x 2.9x
Stock comp / revenue – 510.2% 12.2%

Financial Health

11 metrics
MetricMESOCRSPVCEL
Debt / assets 15.4% 22.1% –
Debt / equity 0.2x 0.3x –
Net debt / EBITDA – 3.4x –
Debt / FCF – -1.6x –
Liabilities / assets 26.5% 34.1% 26.4%
Equity / assets 73.5% 65.9% 73.6%
Interest coverage – – 28.5x
Current ratio 2.4x 17.8x 5.0x
Quick ratio 2.0x 17.8x 4.5x
Cash ratio 1.3x 17.8x 3.1x
Altman Z-score – 2.36 10.12

Shareholder Returns

7 metrics
MetricMESOCRSPVCEL
Dividend yield – – –
Net buyback yield – -9.0% -0.3%
Shareholder yield – -9.0% -0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMESOCRSPVCEL
Forward P/E – – 84.4xFY2026
EPS, next fiscal year $-0.15FY2027 $-4.10FY2026 $0.51FY2026
EPS growth, next FY – – +59.4%FY2026
EPS growth, the year after – – +74.5%
Revenue, next fiscal year $188.99MFY2027 $38.73MFY2026 $324.56MFY2026
Revenue growth, next FY +57.2%FY2027 +1,003.4%FY2026 +17.5%FY2026
Revenue growth, the year after +110.3% +266.1% +16.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMESOCRSPVCEL
Held by institutions 3.0% 78.9% 100.0%
Institutions holding 73 518 317
Change in shares held, QoQ +17.7% -1.0% +0.4%
Institutions buying 34 237 187
Institutions selling 20 139 98
Buyers to sellers 1.70 1.71 1.91

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MESOCRSPVCEL
MESO 1.00 0.22 0.10
CRSP 0.22 1.00 0.35
VCEL 0.10 0.35 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, MESO, CRSP and VCEL?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Mesoblast (MESO) $1.70B, CRISPR Therapeutics AG (CRSP) $4.95B, Vericel (VCEL) $2.23B.

Which company is growing faster?

Vericel (VCEL) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Vericel (VCEL) +23.0%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Vericel (VCEL) 7.9%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: Mesoblast (MESO) -26.3%, CRISPR Therapeutics AG (CRSP) -27.5%, Vericel (VCEL) +18.5%. Over five years, Mesoblast (MESO) compounded fastest (Mesoblast (MESO) +0.4%/yr, CRISPR Therapeutics AG (CRSP) -12.0%/yr, Vericel (VCEL) -3.2%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Mesoblast (MESO) 54.6%, CRISPR Therapeutics AG (CRSP) 57.1%, Vericel (VCEL) 40.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MESO, CRSP and VCEL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.