MESO vs BEAM vs CRSP Stock Comparison

Mesoblast, Beam Therapeutics and CRISPR Therapeutics AG Prices as of Oct 28, 2026 Peers: Industry group
MESO Mesoblast Ltd
$13.39 -7.7% 1M -20.0% 1Y
Market cap
$1.73B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
BEAM Beam Therapeutics Inc.
$28.78 +18.8% 1M +8.9% 1Y
Market cap
$2.97B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins
CRSP CRISPR Therapeutics AG
$54.11 +0.0% 1M -15.7% 1Y
Market cap
$5.23B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

8 decided of 12

Beam Therapeutics leads on 5 of the 12 questions below (Beam Therapeutics 5, Mesoblast 2, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionMESOBEAMCRSPLeader
Larger companyMarket capitalisation $1.73B $2.97B $5.23B CRSP
Cheaper on earningsLower P/E, profitable companies only -30.2x -35.1x -11.6x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months — +158.9% -64.8% BEAM
More profitableNet margin, trailing twelve months — -54.7% -3,368.7% BEAM
Better return on capitalReturn on invested capital — — -22.6% –
Less leveragedLower net debt / EBITDA — 3.0x 3.4x BEAM
Higher dividend yieldTrailing dividend yield — 0.00% — –
Better 1-year returnPrice return, last 12 months -20.0% +8.9% -15.7% BEAM
Better 5-year returnAnnualised price return, 5 years +2.0%/yr -20.2%/yr -9.9%/yr MESO
Less volatileAnnualised volatility, 1 year 54.8% 70.7% 57.4% MESO
Higher overall scoreMean of the five percentile scores vs peers — 69/100 45/100 BEAM

Percentile Scorecard

MESOBEAMCRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisMESOBEAMCRSP
Valuation 71 #185 of 625 57 #272 of 625 50 #311 of 625
Growth – 77 #139 of 602 31 #413 of 602
Profitability – 64 #197 of 549 32 #374 of 549
Financial Health 44 #364 of 654 81 #123 of 654 71 #189 of 654
Shareholder Returns – 68 #119 of 367 38 #227 of 367
Overall – 69 45
  • MESO ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodMESOBEAMCRSPSPY
1 month -7.7%+18.8%+0.0% +0.9%
3 months -5.2%+10.6%+13.6% +5.9%
6 months -13.9%-2.0%+6.7% +8.5%
Year to date -25.8%+3.8%+3.2% +13.3%
1 year -20.0%+8.9%-15.7% +12.4%
3 years +472.2%+54.6%+39.7% +88.1%
3 years, per year +78.9%+15.6%+11.8% +23.5%
5 years +10.7%-67.6%-40.8% +68.2%
5 years, per year +2.0%-20.2%-9.9% +11.0%
10 years +55.0%—+223.2% +263.4%
10 years, per year +4.5%—+12.4% +13.8%

Risk

MeasureMESOBEAMCRSPSPY
Volatility, 1Y 54.8%70.7%57.4% 12.7%
Downside volatility, 1Y 54.9%64.0%53.8% 12.7%
Beta vs S&P 500, 1Y 1.532.091.84 1.00
Return / volatility, 1Y -0.360.13-0.27 0.98
Max drawdown, 5Y -87.9%-85.3%-67.7% -25.4%
From 52-week high -36.1%-24.1%-15.7% -0.9%
52-week high $20.96$37.92$64.17 $779.14
52-week low $11.95$20.60$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleMESOBEAMCRSP
P/E now vs peer median -30.2xmedian 17.4x -35.1xmedian 17.4x -11.6xmedian 17.4x
P/S now vs peer median 14.4xmedian 9.1x 19.0xmedian 9.1x 390.6xmedian 9.1x
EV/EBITDA now vs peer median —median 17.1x -5.4xmedian 17.1x -6.7xmedian 17.1x
P/FCF now vs peer median -38.8xmedian 19.0x -8.0xmedian 19.0x -14.1xmedian 19.0x
P/B now vs peer median 3.1xmedian 2.2x 2.8xmedian 2.2x 3.0xmedian 2.2x
PEG now vs peer median —median 0.34 -0.83median 0.34 -3.01median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsMESOBEAMCRSP
Revenue – $156.04M $13.39M
Operating income – -$378.02M -$534.34M
Net income – -$86.52M -$451.14M
Free cash flow – -$372.77M -$371.33M
R&D – $408.66M $278.15M
EPS (diluted) – $-0.82 $-4.67
Cash & equivalents $102.91M $219.83M $291.34M
Total debt $119.24M $100.26M $586.20M
Shares (diluted) 129.49M 104.33M 96.51M
Enterprise value $1.30B -$1.71B -$3.47B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricMESOBEAMCRSP
P/E -30.2x -35.1x -11.6x
P/FCF -38.8x -8.0x -14.1x
P/Operating cash flow – -8.3x -14.2x
P/S 14.4x 19.0x 390.6x
P/B 3.1x 2.8x 3.0x
P/Tangible book 3.1x 2.8x 3.0x
EV/EBITDA – -5.4x -6.7x
EV/EBIT – -5.1x -6.5x
EV/Revenue – 12.3x 257.8x
EV/FCF – -5.1x -9.3x
EV/Operating cash flow – -5.3x -9.3x
PEG (3Y EPS CAGR) – -0.83 -3.01

Growth

14 metrics
MetricMESOBEAMCRSP
Revenue growth (1Y) – 158.9% -64.8%
Revenue CAGR (3Y) – 24.9% -57.1%
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) – 15.2% 3.3%
Operating income CAGR (3Y) – 0.3% -4.1%
Net income growth (1Y) – 78.2% 3.6%
Net income CAGR (3Y) – 35.8% -2.7%
EPS growth (1Y) – 79.0% 13.0%
EPS CAGR (3Y) – 42.4% 3.9%
Operating cash flow growth (1Y) – -4.2% -13.8%
Operating cash flow CAGR (3Y) – -2.0% -2.5%
Free cash flow growth (1Y) – -4.8% -14.1%
Free cash flow CAGR (3Y) – 0.7% -0.9%

Profitability

14 metrics
MetricMESOBEAMCRSP
Gross margin – – –
EBITDA margin – -228.0% -3,850%
Operating margin – -242.3% -3,990%
Pretax margin – -54.4% -3,346%
Net margin – -54.7% -3,369%
FCF margin – -238.9% -2,773%
Operating cash flow margin – -230.3% -2,760%
Return on equity – -7.6% -25.3%
Return on assets – -5.9% -16.8%
Return on invested capital – – -22.6%
Return on capital employed – -27.9% -20.9%
Asset turnover – 0.1x 0.0x
Cash conversion (OCF / net income) – 4.2x 0.8x
Stock comp / revenue – 52.2% 510.2%

Financial Health

11 metrics
MetricMESOBEAMCRSP
Debt / assets 15.4% 7.2% 22.1%
Debt / equity 0.2x 0.1x 0.3x
Net debt / EBITDA – 3.0x 3.4x
Debt / FCF – -0.3x -1.6x
Liabilities / assets 26.5% 23.0% 34.1%
Equity / assets 73.5% 77.0% 65.9%
Interest coverage – – –
Current ratio 2.4x 14.6x 17.8x
Quick ratio 2.0x 14.3x 17.8x
Cash ratio 1.3x 14.3x 17.8x
Altman Z-score – 3.84 2.68

Shareholder Returns

7 metrics
MetricMESOBEAMCRSP
Dividend yield – – –
Net buyback yield – -0.5% -8.2%
Shareholder yield – -0.5% -8.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusMESOBEAMCRSP
EPS, next fiscal year $-0.15FY2027 $-4.22FY2026 $-4.10FY2026
Revenue, next fiscal year $188.99MFY2027 $49.46MFY2026 $38.73MFY2026
Revenue growth, next FY +57.2%FY2027 -64.6%FY2026 +1,003.4%FY2026
Revenue growth, the year after +110.3% +23.6% +266.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersMESOBEAMCRSP
Held by institutions 3.0% 100.0% 78.9%
Institutions holding 73 277 518
Change in shares held, QoQ +17.7% +1.0% -1.0%
Institutions buying 34 154 237
Institutions selling 20 75 139
Buyers to sellers 1.70 2.05 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

MESOBEAMCRSP
MESO 1.00 0.14 0.23
BEAM 0.14 1.00 0.76
CRSP 0.23 0.76 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, MESO, BEAM and CRSP?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Mesoblast (MESO) $1.73B, Beam Therapeutics (BEAM) $2.97B, CRISPR Therapeutics AG (CRSP) $5.23B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: Beam Therapeutics (BEAM) +158.9%, CRISPR Therapeutics AG (CRSP) -64.8%.

Which company is more profitable?

Beam Therapeutics (BEAM) has the highest net margin (Beam Therapeutics (BEAM) -54.7%, CRISPR Therapeutics AG (CRSP) -3,368.7%).

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: Mesoblast (MESO) -20.0%, Beam Therapeutics (BEAM) +8.9%, CRISPR Therapeutics AG (CRSP) -15.7%. Over five years, Mesoblast (MESO) compounded fastest (Mesoblast (MESO) +2.0%/yr, Beam Therapeutics (BEAM) -20.2%/yr, CRISPR Therapeutics AG (CRSP) -9.9%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Mesoblast (MESO) has been the steadiest (Mesoblast (MESO) 54.8%, Beam Therapeutics (BEAM) 70.7%, CRISPR Therapeutics AG (CRSP) 57.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, MESO, BEAM and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Beam Therapeutics (BEAM) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.