LEGN vs VCEL vs MESO Stock Comparison

Legend Biotech, Vericel and Mesoblast Prices as of Oct 26, 2026 Peers: Industry group
LEGN Legend Biotech Corp
$20.39 +6.7% 1M -36.0% 1Y
Market cap
$3.76B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins
VCEL Vericel Corp
$43.04 +8.4% 1M +18.5% 1Y
Market cap
$2.20B
P/E
90.8x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
MESO Mesoblast Ltd
$12.39 -18.1% 1M -26.3% 1Y
Market cap
$1.60B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

7 decided of 12

Vericel leads on 4 of the 12 questions below (Vericel 4, Legend Biotech 2, Mesoblast 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionLEGNVCELMESOLeader
Larger companyMarket capitalisation $3.76B $2.20B $1.60B LEGN
Cheaper on earningsLower P/E, profitable companies only -41.0x 90.8x -27.9x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 84.4x — –
Faster revenue growthRevenue growth, trailing twelve months +59.5% +23.0% — LEGN
More profitableNet margin, trailing twelve months -7.2% 7.9% — VCEL
Better return on capitalReturn on invested capital -4.2% — — –
Less leveragedLower net debt / EBITDA 28.0x — — –
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months -36.0% +18.5% -26.3% VCEL
Better 5-year returnAnnualised price return, 5 years -17.0%/yr -3.2%/yr +0.4%/yr MESO
Less volatileAnnualised volatility, 1 year 72.1% 40.9% 54.6% VCEL
Higher overall scoreMean of the five percentile scores vs peers 72/100 80/100 — VCEL

Percentile Scorecard

LEGNVCELMESO

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisLEGNVCELMESO
Valuation 86 #40 of 275 79 #58 of 275 62 #104 of 275
Growth 97 #9 of 253 95 #13 of 253 –
Profitability 79 #48 of 224 90 #23 of 224 –
Financial Health 54 #138 of 296 70 #89 of 296 48 #156 of 296
Shareholder Returns 45 #70 of 126 67 #42 of 126 –
Overall 72 80 –
  • LEGN ranked among 305 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 305 companies in Pharmaceuticals and Biotechnology
  • MESO ranked among 305 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodLEGNVCELMESOSPY
1 month +6.7%+8.4%-18.1% -0.8%
3 months +5.8%-5.0%-14.9% +3.5%
6 months -13.8%+16.6%-19.2% +7.0%
Year to date -6.2%+19.5%-31.3% +12.2%
1 year -36.0%+18.5%-26.3% +13.0%
3 years -68.0%+31.1%+429.5% +86.3%
3 years, per year -31.6%+9.5%+74.4% +23.1%
5 years -60.6%-14.9%+2.2% +68.6%
5 years, per year -17.0%-3.2%+0.4% +11.0%
10 years —+1,693.3%+52.6% +258.0%
10 years, per year —+33.5%+4.3% +13.6%

Risk

MeasureLEGNVCELMESOSPY
Volatility, 1Y 72.1%40.9%54.6% 12.7%
Downside volatility, 1Y 62.7%40.1%54.9% 12.7%
Beta vs S&P 500, 1Y 0.410.741.50 1.00
Return / volatility, 1Y -0.500.45-0.48 1.02
Max drawdown, 5Y -78.2%-65.4%-87.9% -25.4%
From 52-week high -43.8%-10.9%-40.9% -1.8%
52-week high $36.28$48.31$20.96 $779.14
52-week low $16.65$29.34$11.95 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleLEGNVCELMESO
P/E now vs peer median -41.0xmedian 10.4x 90.8xmedian 10.4x -27.9xmedian 10.4x
P/S now vs peer median 3.0xmedian 6.4x 7.2xmedian 6.4x 13.3xmedian 6.4x
EV/EBITDA now vs peer median -175.9xmedian 10.7x 65.0xmedian 10.7x —median 10.7x
P/FCF now vs peer median -58.2xmedian 12.5x 35.7xmedian 12.5x -35.9xmedian 12.5x
P/B now vs peer median 3.1xmedian 1.6x 6.0xmedian 1.6x 2.8xmedian 1.6x
PEG now vs peer median -0.87median 0.29 1.67median 0.29 —median 0.29

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsLEGNVCELMESO
Revenue $1.27B $306.30M –
Gross profit $727.10M $228.38M –
Operating income -$55.25M $18.24M –
Net income -$80.39M $24.22M –
Free cash flow -$64.60M $61.66M –
R&D $396.15M $29.17M –
EPS (diluted) $-0.50 $0.46 –
Cash & equivalents $672.90M $125.40M $102.91M
Total debt $1.06B – $119.24M
Shares (diluted) 184.32M 52.31M 129.49M
Enterprise value $1.26B $1.62B $1.17B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricLEGNVCELMESO
P/E -41.0x 90.8x -27.9x
P/FCF -58.2x 35.7x -35.9x
P/Operating cash flow -42.0x 31.6x –
P/S 3.0x 7.2x 13.3x
P/B 3.1x 6.0x 2.8x
P/Tangible book 3.1x 6.0x 2.8x
EV/EBITDA -175.9x 65.0x –
EV/EBIT -58.7x 111.9x –
EV/Revenue 2.6x 6.7x –
EV/FCF -50.2x 33.1x –
EV/Operating cash flow -36.3x 29.3x –
PEG (3Y EPS CAGR) -0.87 1.67 –

Growth

14 metrics
MetricLEGNVCELMESO
Revenue growth (1Y) 59.5% 23.0% –
Revenue CAGR (3Y) 97.6% 19.8% –
Gross profit growth (1Y) 42.4% 24.8% –
Gross profit CAGR (3Y) 147.5% 23.9% –
Operating income growth (1Y) 75.3% 1,428% –
Operating income CAGR (3Y) 49.1% 47.8% –
Net income growth (1Y) 75.3% 240.8% –
Net income CAGR (3Y) 46.7% 56.6% –
EPS growth (1Y) 72.0% 228.1% –
EPS CAGR (3Y) 47.0% 54.3% –
Operating cash flow growth (1Y) 67.5% 47.5% –
Operating cash flow CAGR (3Y) 37.1% 33.7% –
Free cash flow growth (1Y) 77.8% 842.9% –
Free cash flow CAGR (3Y) 44.5% 43.2% –

Profitability

14 metrics
MetricLEGNVCELMESO
Gross margin 57.2% 74.6% –
EBITDA margin -1.5% 10.2% –
Operating margin -4.3% 6.0% –
Pretax margin -4.4% 8.2% –
Net margin -7.2% 7.9% –
FCF margin -5.1% 20.1% –
Operating cash flow margin -7.0% 22.7% –
Return on equity -8.3% 6.9% –
Return on assets -5.5% 5.1% –
Return on invested capital -4.2% – –
Return on capital employed -4.3% 4.1% –
Asset turnover 0.8x 0.6x –
Cash conversion (OCF / net income) 1.1x 2.9x –
Stock comp / revenue 5.2% 12.2% –

Financial Health

11 metrics
MetricLEGNVCELMESO
Debt / assets 8.9% – 15.4%
Debt / equity 0.1x – 0.2x
Net debt / EBITDA 28.0x – –
Debt / FCF -2.4x – –
Liabilities / assets 29.8% 26.4% 26.5%
Equity / assets 70.2% 73.6% 73.5%
Interest coverage -4.8x 28.5x –
Current ratio 3.0x 5.0x 2.4x
Quick ratio 1.7x 4.5x 2.0x
Cash ratio 1.7x 3.1x 1.3x
Altman Z-score 6.50 10.12 –

Shareholder Returns

7 metrics
MetricLEGNVCELMESO
Dividend yield – – –
Net buyback yield -5.7% -0.3% –
Shareholder yield -5.7% -0.3% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusLEGNVCELMESO
Forward P/E – 84.4xFY2026 –
EPS, next fiscal year $-0.04FY2026 $0.51FY2026 $-0.15FY2027
EPS growth, next FY – +59.4%FY2026 –
EPS growth, the year after – +74.5% –
Revenue, next fiscal year $1.37BFY2026 $324.56MFY2026 $188.99MFY2027
Revenue growth, next FY +32.9%FY2026 +17.5%FY2026 +57.2%FY2027
Revenue growth, the year after +35.9% +16.1% +110.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersLEGNVCELMESO
Held by institutions 55.9% 100.0% 3.0%
Institutions holding 218 317 73
Change in shares held, QoQ +7.3% +0.4% +17.7%
Institutions buying 117 187 34
Institutions selling 78 98 20
Buyers to sellers 1.50 1.91 1.70

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

LEGNVCELMESO
LEGN 1.00 0.14 0.13
VCEL 0.14 1.00 0.10
MESO 0.13 0.10 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, LEGN, VCEL and MESO?

Legend Biotech (LEGN) is the largest by market capitalisation: Legend Biotech (LEGN) $3.76B, Vericel (VCEL) $2.20B, Mesoblast (MESO) $1.60B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Legend Biotech (LEGN) +59.5%, Vericel (VCEL) +23.0%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Legend Biotech (LEGN) -7.2%, Vericel (VCEL) 7.9%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: Legend Biotech (LEGN) -36.0%, Vericel (VCEL) +18.5%, Mesoblast (MESO) -26.3%. Over five years, Mesoblast (MESO) compounded fastest (Legend Biotech (LEGN) -17.0%/yr, Vericel (VCEL) -3.2%/yr, Mesoblast (MESO) +0.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Legend Biotech (LEGN) 72.1%, Vericel (VCEL) 40.9%, Mesoblast (MESO) 54.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, LEGN, VCEL and MESO?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.