LEGN vs SRPT vs PGEN Stock Comparison

Legend Biotech, Sarepta Therapeutics and Precigen Prices as of Oct 28, 2026 Peers: Industry group
LEGN Legend Biotech Corp
$22.53 +21.0% 1M -30.8% 1Y
Market cap
$4.15B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
PGEN Precigen, Inc.
$6.08 -22.2% 1M +49.8% 1Y
Market cap
$2.18B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

10 decided of 12

Legend Biotech leads on 4 of the 12 questions below (Legend Biotech 4, Precigen 4, Sarepta Therapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionLEGNSRPTPGENLeader
Larger companyMarket capitalisation $4.15B $2.04B $2.18B LEGN
Cheaper on earningsLower P/E, profitable companies only -45.3x -17.4x -6.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 6.7x 35.8x SRPT
Faster revenue growthRevenue growth, trailing twelve months +59.5% -20.4% +1,875.0% PGEN
More profitableNet margin, trailing twelve months -7.2% -5.9% -392.8% SRPT
Better return on capitalReturn on invested capital -4.2% -6.1% — LEGN
Less leveragedLower net debt / EBITDA 28.0x -0.6x -1.6x PGEN
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months -30.8% -20.2% +49.8% PGEN
Better 5-year returnAnnualised price return, 5 years -15.6%/yr -24.6%/yr +4.7%/yr PGEN
Less volatileAnnualised volatility, 1 year 72.3% 81.1% 77.7% LEGN
Higher overall scoreMean of the five percentile scores vs peers 73/100 67/100 55/100 LEGN

Percentile Scorecard

LEGNSRPTPGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisLEGNSRPTPGEN
Valuation 89 #72 of 625 96 #25 of 625 58 #265 of 625
Growth 96 #23 of 602 64 #217 of 602 48 #311 of 602
Profitability 80 #109 of 549 79 #114 of 549 59 #225 of 549
Financial Health 54 #299 of 654 33 #436 of 654 27 #480 of 654
Shareholder Returns 44 #206 of 367 61 #145 of 367 82 #66 of 367
Overall 73 67 55
  • LEGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodLEGNSRPTPGENSPY
1 month +21.0%+2.8%-22.2% +0.9%
3 months +19.5%+24.4%+11.6% +5.9%
6 months -1.1%-6.5%+47.6% +8.5%
Year to date +3.6%-10.2%+45.5% +13.3%
1 year -30.8%-20.2%+49.8% +12.4%
3 years -64.6%-81.9%+502.0% +88.1%
3 years, per year -29.3%-43.5%+82.0% +23.5%
5 years -57.1%-75.6%+25.9% +68.2%
5 years, per year -15.6%-24.6%+4.7% +11.0%
10 years —-52.8%-76.4% +263.4%
10 years, per year —-7.2%-13.4% +13.8%

Risk

MeasureLEGNSRPTPGENSPY
Volatility, 1Y 72.3%81.1%77.7% 12.7%
Downside volatility, 1Y 62.7%85.9%69.0% 12.7%
Beta vs S&P 500, 1Y 0.442.081.43 1.00
Return / volatility, 1Y -0.43-0.250.64 0.98
Max drawdown, 5Y -78.2%-92.7%-87.8% -25.4%
From 52-week high -37.9%-21.0%-29.0% -0.9%
52-week high $36.28$24.45$8.56 $779.14
52-week low $16.65$14.86$3.10 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleLEGNSRPTPGEN
P/E now vs peer median -45.3xmedian 17.4x -17.4xmedian 17.4x -6.4xmedian 17.4x
P/S now vs peer median 3.3xmedian 9.1x 1.0xmedian 9.1x 25.4xmedian 9.1x
EV/EBITDA now vs peer median -197.3xmedian 17.1x -21.3xmedian 17.1x -65.1xmedian 17.1x
P/FCF now vs peer median -64.3xmedian 19.0x 24.9xmedian 19.0x -18.9xmedian 19.0x
P/B now vs peer median 3.4xmedian 2.2x 1.3xmedian 2.2x 50.0xmedian 2.2x
PEG now vs peer median -0.96median 0.34 -0.33median 0.34 0.05median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsLEGNSRPTPGEN
Revenue $1.27B $1.97B $85.72M
Gross profit $727.10M $1.17B $77.72M
Operating income -$55.25M -$143.25M -$39.50M
Net income -$80.39M -$136.73M -$157.71M
Free cash flow -$64.60M $81.85M -$115.22M
R&D $396.15M $789.44M $32.29M
EPS (diluted) $-0.50 $-1.11 $-0.81
Cash & equivalents $672.90M $571.15M $16.33M
Total debt $1.06B $847.62M $93.88M
Shares (diluted) 184.32M 105.43M 413.69M
Enterprise value $1.65B -$1.19B $1.86B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricLEGNSRPTPGEN
P/E -45.3x -17.4x -6.4x
P/FCF -64.3x 24.9x -18.9x
P/Operating cash flow -46.5x 18.4x -19.1x
P/S 3.3x 1.0x 25.4x
P/B 3.4x 1.3x 50.0x
P/Tangible book 3.4x 1.4x 53.0x
EV/EBITDA -197.3x -21.3x -65.1x
EV/EBIT -65.8x -14.7x -56.5x
EV/Revenue 2.9x 1.1x 26.0x
EV/FCF -56.3x 25.7x -19.4x
EV/Operating cash flow -40.7x 18.9x -19.6x
PEG (3Y EPS CAGR) -0.96 -0.33 0.05

Growth

14 metrics
MetricLEGNSRPTPGEN
Revenue growth (1Y) 59.5% -20.4% 1,875%
Revenue CAGR (3Y) 97.6% 25.3% 57.1%
Gross profit growth (1Y) 42.4% -40.7% 259,173%
Gross profit CAGR (3Y) 147.5% 10.6% 69.2%
Operating income growth (1Y) 75.3% -15,270% 62.1%
Operating income CAGR (3Y) 49.1% 34.5% 18.9%
Net income growth (1Y) 75.3% -135.9% -26.7%
Net income CAGR (3Y) 46.7% 46.8% -108.9%
EPS growth (1Y) 72.0% -215.7% -93.8%
EPS CAGR (3Y) 47.0% 52.3% -123.2%
Operating cash flow growth (1Y) 67.5% 136.9% -72.3%
Operating cash flow CAGR (3Y) 37.1% 30.6% -15.9%
Free cash flow growth (1Y) 77.8% 118.1% -65.1%
Free cash flow CAGR (3Y) 44.5% 29.1% -15.3%

Profitability

14 metrics
MetricLEGNSRPTPGEN
Gross margin 57.2% 59.1% 90.7%
EBITDA margin -1.5% -5.0% -40.0%
Operating margin -4.3% -7.3% -46.1%
Pretax margin -4.4% -6.6% -184.0%
Net margin -7.2% -5.9% -392.8%
FCF margin -5.1% 4.1% -134.4%
Operating cash flow margin -7.0% 5.6% -133.2%
Return on equity -8.3% -9.0% -494.3%
Return on assets -5.5% -4.3% -102.1%
Return on invested capital -4.2% -6.1% –
Return on capital employed -4.3% -5.3% -31.6%
Asset turnover 0.8x 0.6x 0.6x
Cash conversion (OCF / net income) 1.1x -0.8x 0.7x
Stock comp / revenue 5.2% 6.3% 15.3%

Financial Health

11 metrics
MetricLEGNSRPTPGEN
Debt / assets 8.9% 26.6% 55.1%
Debt / equity 0.1x 0.6x 2.2x
Net debt / EBITDA 28.0x -0.6x -1.6x
Debt / FCF -2.4x 10.4x -0.8x
Liabilities / assets 29.8% 52.1% 74.4%
Equity / assets 70.2% 47.9% 25.6%
Interest coverage -4.8x – -4.1x
Current ratio 3.0x 4.4x 4.6x
Quick ratio 1.7x 2.4x 3.8x
Cash ratio 1.7x 1.6x 1.3x
Altman Z-score 6.95 -0.14 -8.36

Shareholder Returns

7 metrics
MetricLEGNSRPTPGEN
Dividend yield – – –
Net buyback yield -5.2% -1.1% -0.1%
Shareholder yield -5.2% -1.1% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusLEGNSRPTPGEN
Forward P/E – 6.7xFY2026 35.8xFY2026
EPS, next fiscal year $-0.04FY2026 $2.88FY2026 $0.17FY2026
EPS growth, the year after – -88.5% +288.2%
Revenue, next fiscal year $1.37BFY2026 $1.76BFY2026 $249.17MFY2026
Revenue growth, next FY +32.9%FY2026 -20.1%FY2026 +2,474.1%FY2026
Revenue growth, the year after +35.9% -21.5% +82.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersLEGNSRPTPGEN
Held by institutions 55.9% 100.0% 39.2%
Institutions holding 218 324 210
Change in shares held, QoQ +7.3% +4.5% +4.9%
Institutions buying 117 148 123
Institutions selling 78 115 46
Buyers to sellers 1.50 1.29 2.67

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

LEGNSRPTPGEN
LEGN 1.00 0.09 0.07
SRPT 0.09 1.00 0.23
PGEN 0.07 0.23 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, LEGN, SRPT and PGEN?

Legend Biotech (LEGN) is the largest by market capitalisation: Legend Biotech (LEGN) $4.15B, Sarepta Therapeutics (SRPT) $2.04B, Precigen (PGEN) $2.18B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Legend Biotech (LEGN) +59.5%, Sarepta Therapeutics (SRPT) -20.4%, Precigen (PGEN) +1,875.0%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Legend Biotech (LEGN) -7.2%, Sarepta Therapeutics (SRPT) -5.9%, Precigen (PGEN) -392.8%). On return on invested capital, Legend Biotech (LEGN) leads (Legend Biotech (LEGN) -4.2%, Sarepta Therapeutics (SRPT) -6.1%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Legend Biotech (LEGN) -30.8%, Sarepta Therapeutics (SRPT) -20.2%, Precigen (PGEN) +49.8%. Over five years, Precigen (PGEN) compounded fastest (Legend Biotech (LEGN) -15.6%/yr, Sarepta Therapeutics (SRPT) -24.6%/yr, Precigen (PGEN) +4.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Legend Biotech (LEGN) has been the steadiest (Legend Biotech (LEGN) 72.3%, Sarepta Therapeutics (SRPT) 81.1%, Precigen (PGEN) 77.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, LEGN, SRPT and PGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.