ILMN vs RGEN vs TMO Stock Comparison

Illumina, Repligen and Thermo Fisher Scientific Prices as of Oct 27, 2026 Peers: Industry group
ILMN Illumina, Inc.
$279.47 +3.5% 1M +178.5% 1Y
Market cap
$43.74B
P/E
53.0x
Revenue (TTM)
$4.49B
Div. yield
–
Life Sciences Tools Healthcare
2 wins
RGEN Repligen Corp
$175.80 -7.3% 1M +9.1% 1Y
Market cap
$10.45B
P/E
–
Revenue (TTM)
$805.61M
Div. yield
–
Life Sciences Tools Healthcare
1 win

Head to Head

8 decided of 12

Thermo Fisher Scientific leads on 5 of the 12 questions below (Thermo Fisher Scientific 5, Illumina 2, Repligen 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionILMNRGENTMOLeader
Larger companyMarket capitalisation $43.74B $10.45B $262.53B TMO
Cheaper on earningsLower P/E, profitable companies only 53.0x -885.6x 37.1x TMO
Cheaper on forward earningsLower price / next fiscal year consensus EPS 56.0x 90.6x 26.8x TMO
Faster revenue growthRevenue growth, trailing twelve months +4.9% +13.8% +8.3% RGEN
More profitableNet margin, trailing twelve months 18.4% — — –
Better return on capitalReturn on invested capital 15.1% — — –
Less leveragedLower net debt / EBITDA 0.7x — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +178.5% +9.1% +23.0% ILMN
Better 5-year returnAnnualised price return, 5 years -7.0%/yr -9.5%/yr +2.3%/yr TMO
Less volatileAnnualised volatility, 1 year 50.4% 46.3% 29.8% TMO
Higher overall scoreMean of the five percentile scores vs peers 66/100 56/100 51/100 ILMN

Percentile Scorecard

ILMNRGENTMO

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisILMNRGENTMO
Valuation 51 #111 of 227 43 #129 of 227 50 #113 of 227
Growth 45 #120 of 219 31 #152 of 219 41 #130 of 219
Profitability 97 #8 of 206 68 #66 of 206 70 #63 of 206
Financial Health 51 #117 of 238 83 #41 of 238 –
Shareholder Returns 84 #23 of 134 – 44 #76 of 134
Overall 66 56 51
  • ILMN ranked among 247 companies in Medical Devices and Diagnostics
  • RGEN ranked among 247 companies in Medical Devices and Diagnostics
  • TMO ranked among 247 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodILMNRGENTMOSPY
1 month +3.5%-7.3%+2.9% -0.2%
3 months +44.8%+21.0%+20.3% +3.9%
6 months +120.2%+49.7%+47.4% +8.2%
Year to date +113.1%+7.3%+19.7% +12.9%
1 year +178.5%+9.1%+23.0% +12.3%
3 years +163.0%+47.0%+60.7% +87.4%
3 years, per year +38.1%+13.7%+17.1% +23.3%
5 years -30.5%-39.4%+11.8% +67.9%
5 years, per year -7.0%-9.5%+2.3% +10.9%
10 years +106.3%+513.8%+364.6% +261.1%
10 years, per year +7.5%+19.9%+16.6% +13.7%

Risk

MeasureILMNRGENTMOSPY
Volatility, 1Y 50.4%46.3%29.8% 12.7%
Downside volatility, 1Y 39.1%46.8%28.3% 12.7%
Beta vs S&P 500, 1Y 0.821.210.62 1.00
Return / volatility, 1Y 3.540.200.77 0.97
Max drawdown, 5Y -82.9%-66.2%-41.5% -25.4%
From 52-week high -4.8%-9.6%-0.5% -1.2%
52-week high $293.69$194.57$696.55 $779.14
52-week low $95.03$102.87$438.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleILMNRGENTMO
P/E now vs peer median 51.2xmedian 29.6x -840.2xmedian 29.6x 36.4xmedian 29.6x
P/S now vs peer median 9.4xmedian 2.9x 12.3xmedian 2.9x 5.4xmedian 2.9x
EV/EBITDA now vs peer median 37.3xmedian 17.4x —median 17.4x —median 17.4x
P/FCF now vs peer median 45.3xmedian 22.3x 98.1xmedian 22.3x 34.0xmedian 22.3x
P/B now vs peer median 14.9xmedian 2.3x 4.7xmedian 2.3x 4.7xmedian 2.3x
PEG now vs peer median 1.70median 1.04 29.56median 1.04 4.80median 1.04

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsILMNRGENTMO
Revenue $4.49B $805.61M $47.35B
Gross profit $2.98B – –
Operating income $882.00M $18.24M $8.47B
Net income $825.00M $26.59M $7.09B
Free cash flow $931.00M – –
R&D $960.00M $56.43M $1.40B
EPS (diluted) $5.39 $-0.21 $19.06
Cash & equivalents $1.04B $726.96M $5.46B
Total debt $1.99B – –
Shares (diluted) 153.00M 56.64M 371.00M
Enterprise value $38.51B $10.45B $262.53B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricILMNRGENTMO
P/E 51.2x -840.2x 36.4x
P/FCF 45.3x 98.1x 34.0x
P/Operating cash flow 38.5x 76.4x 27.5x
P/S 9.4x 12.3x 5.4x
P/B 14.9x 4.7x 4.7x
P/Tangible book 17.4x 5.6x 7.0x
EV/EBITDA 37.3x – –
EV/EBIT 48.8x – –
EV/Revenue 9.6x 12.3x 5.4x
EV/FCF 46.2x – –
EV/Operating cash flow 39.3x 76.4x 27.5x
PEG (3Y EPS CAGR) 1.70 29.56 4.80

Growth

14 metrics
MetricILMNRGENTMO
Revenue growth (1Y) 4.9% 13.8% 8.3%
Revenue CAGR (3Y) -1.0% 7.3% 2.9%
Gross profit growth (1Y) 4.6% – –
Gross profit CAGR (3Y) 2.9% – –
Operating income growth (1Y) -31.8% 2,185% 12.8%
Operating income CAGR (3Y) 28.3% -40.5% 7.2%
Net income growth (1Y) -34.4% 1,430% 7.9%
Net income CAGR (3Y) 30.0% -35.9% 6.2%
EPS growth (1Y) -32.7% -777.9% 9.7%
EPS CAGR (3Y) 30.1% -28.4% 7.6%
Operating cash flow growth (1Y) -5.1% -0.8% 21.9%
Operating cash flow CAGR (3Y) 38.1% -4.0% 4.5%
Free cash flow growth (1Y) -9.7% – –
Free cash flow CAGR (3Y) 105.0% – –

Profitability

14 metrics
MetricILMNRGENTMO
Gross margin 66.4% – –
EBITDA margin 25.7% – –
Operating margin 19.6% – –
Pretax margin 22.6% – –
Net margin 18.4% – –
FCF margin 20.7% – –
Operating cash flow margin 24.4% 16.1% 19.7%
Return on equity 29.9% 1.3% 13.2%
Return on assets 12.5% 0.9% 6.2%
Return on invested capital 15.1% – –
Return on capital employed 17.5% – –
Asset turnover 0.7x 0.3x 0.4x
Cash conversion (OCF / net income) 1.3x 4.9x 1.3x
Stock comp / revenue 5.9% 4.2% –

Financial Health

11 metrics
MetricILMNRGENTMO
Debt / assets 29.9% – –
Debt / equity 0.7x – –
Net debt / EBITDA 0.7x – –
Debt / FCF 2.1x – –
Liabilities / assets 57.3% 28.5% –
Equity / assets 42.7% 71.5% 47.9%
Interest coverage 8.9x – –
Current ratio 1.8x 9.9x 1.8x
Quick ratio 1.2x – –
Cash ratio 0.7x – –
Altman Z-score 7.97 – –

Shareholder Returns

7 metrics
MetricILMNRGENTMO
Dividend yield – – 0.3%
Net buyback yield 1.2% – –
Shareholder yield 1.2% – 0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusILMNRGENTMO
Forward P/E 56.0xFY2026 90.6xFY2026 26.8xFY2026
EPS, next fiscal year $4.99FY2026 $1.94FY2026 $25.91FY2026
EPS growth, next FY +3.1%FY2026 +13.5%FY2026 +13.3%FY2026
EPS growth, the year after +25.7% +29.4% +2.0%
Revenue, next fiscal year $4.52BFY2026 $773.94MFY2026 $50.12BFY2026
Revenue growth, next FY +4.1%FY2026 +4.8%FY2026 +12.5%FY2026
Revenue growth, the year after +12.0% +35.9% -2.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersILMNRGENTMO
Held by institutions 100.0% 100.0% 90.2%
Institutions holding 933 482 2,622
Change in shares held, QoQ +0.0% +1.2% +0.8%
Institutions buying 463 272 1,142
Institutions selling 330 141 1,144
Buyers to sellers 1.40 1.93 1.00

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ILMNRGENTMO
ILMN 1.00 0.41 0.50
RGEN 0.41 1.00 0.66
TMO 0.50 0.66 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, ILMN, RGEN and TMO?

Thermo Fisher Scientific (TMO) is the largest by market capitalisation: Illumina (ILMN) $43.74B, Repligen (RGEN) $10.45B, Thermo Fisher Scientific (TMO) $262.53B.

Which stock is cheaper, ILMN, RGEN and TMO?

Thermo Fisher Scientific (TMO) trades on the lowest price-to-earnings ratio (Illumina (ILMN) 53.0x, Repligen (RGEN) -885.6x, Thermo Fisher Scientific (TMO) 37.1x). On next year's consensus earnings, Thermo Fisher Scientific (TMO) is cheapest (Illumina (ILMN) 56.0x, Repligen (RGEN) 90.6x, Thermo Fisher Scientific (TMO) 26.8x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Repligen (RGEN) grew revenue fastest over the trailing twelve months: Illumina (ILMN) +4.9%, Repligen (RGEN) +13.8%, Thermo Fisher Scientific (TMO) +8.3%.

Which stock has performed better?

Over the past year Illumina (ILMN) returned the most: Illumina (ILMN) +178.5%, Repligen (RGEN) +9.1%, Thermo Fisher Scientific (TMO) +23.0%. Over five years, Thermo Fisher Scientific (TMO) compounded fastest (Illumina (ILMN) -7.0%/yr, Repligen (RGEN) -9.5%/yr, Thermo Fisher Scientific (TMO) +2.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Thermo Fisher Scientific (TMO) has been the steadiest (Illumina (ILMN) 50.4%, Repligen (RGEN) 46.3%, Thermo Fisher Scientific (TMO) 29.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ILMN, RGEN and TMO?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Thermo Fisher Scientific (TMO) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.