ICLR vs YDES vs TMO Stock Comparison

Icon, YD Bio and Thermo Fisher Scientific Prices as of Oct 26, 2026 Peers: Industry group
ICLR Icon Plc
$183.78 +6.6% 1M +3.2% 1Y
Market cap
$14.35B
P/E
43.6x
Revenue (TTM)
$8.33B
Div. yield
–
Contract Research Healthcare
2 wins
YDES YD Bio Ltd
$5.29 -7.7% 1M -69.2% 1Y
Market cap
$406.99M
P/E
–
Revenue (TTM)
—
Div. yield
–
Biotechnology Healthcare

Head to Head

8 decided of 12

Thermo Fisher Scientific leads on 6 of the 12 questions below (Thermo Fisher Scientific 6, Icon 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionICLRYDESTMOLeader
Larger companyMarket capitalisation $14.35B $406.99M $257.69B TMO
Cheaper on earningsLower P/E, profitable companies only 43.6x — 36.4x TMO
Cheaper on forward earningsLower price / next fiscal year consensus EPS 17.9x — 26.4x ICLR
Faster revenue growthRevenue growth, trailing twelve months +3.7% — +8.3% TMO
More profitableNet margin, trailing twelve months 3.9% — — –
Better return on capitalReturn on invested capital 1.3% — — –
Less leveragedLower net debt / EBITDA 3.5x — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +3.2% -69.2% +19.6% TMO
Better 5-year returnAnnualised price return, 5 years -8.2%/yr -12.2%/yr +2.3%/yr TMO
Less volatileAnnualised volatility, 1 year 73.8% 134.5% 29.9% TMO
Higher overall scoreMean of the five percentile scores vs peers 69/100 — 51/100 ICLR

Percentile Scorecard

ICLRYDESTMO

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisICLRYDESTMO
Valuation 90 #2 of 11 – 49 #116 of 228
Growth 30 #8 of 11 – 40 #133 of 221
Profitability 80 #3 of 11 – 70 #63 of 208
Financial Health 75 #4 of 13 39 #405 of 658 –
Shareholder Returns – – 44 #77 of 137
Overall 69 – 51
  • ICLR ranked among 13 companies in Pharma Services
  • YDES ranked among 673 companies in Pharmaceuticals and Biotechnology
  • TMO ranked among 248 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodICLRYDESTMOSPY
1 month +6.6%-7.7%+1.7% -0.8%
3 months +8.9%+131.0%+22.4% +3.5%
6 months +78.1%-3.1%+46.3% +7.0%
Year to date +0.9%-56.6%+18.2% +12.2%
1 year +3.2%-69.2%+19.6% +13.0%
3 years -21.9%-51.9%+58.7% +86.3%
3 years, per year -7.9%-21.7%+16.7% +23.1%
5 years -34.8%-47.8%+11.8% +68.6%
5 years, per year -8.2%-12.2%+2.3% +11.0%
10 years +125.7%—+362.6% +258.0%
10 years, per year +8.5%—+16.6% +13.6%

Risk

MeasureICLRYDESTMOSPY
Volatility, 1Y 73.8%134.5%29.9% 12.7%
Downside volatility, 1Y 87.9%132.8%28.3% 12.7%
Beta vs S&P 500, 1Y 1.450.300.62 1.00
Return / volatility, 1Y 0.04-0.510.66 1.02
Max drawdown, 5Y -76.9%-91.8%-41.5% -25.4%
From 52-week high -9.4%-69.1%-1.7% -1.8%
52-week high $202.92$17.11$696.55 $779.14
52-week low $80.08$1.90$438.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleICLRYDESTMO
P/E now vs peer median 43.8xmedian 36.5x —median 17.1x 35.9xmedian 30.6x
P/S now vs peer median 1.7xmedian 2.7x —median 8.8x 5.3xmedian 3.0x
EV/EBITDA now vs peer median 23.5xmedian 37.7x —median 17.1x —median 17.5x
P/FCF now vs peer median 15.9xmedian 20.7x —median 18.0x 34.0xmedian 23.3x
P/B now vs peer median 1.5xmedian 2.9x 83.7xmedian 2.1x 4.6xmedian 2.4x
PEG now vs peer median -3.55median 2.04 —median 0.31 4.74median 0.87

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsICLRYDESTMO
Revenue $8.33B – $47.35B
Gross profit $2.01B – –
Operating income $325.64M – $8.47B
Net income $69.55M – $7.09B
Free cash flow $883.82M – –
R&D – – $1.40B
EPS (diluted) $4.16 – $19.06
Cash & equivalents $928.39M $2.66M $5.46B
Total debt $13.60B – –
Shares (diluted) 78.97M 66.72M 371.00M
Enterprise value $11.46B $394.72M $257.69B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricICLRYDESTMO
P/E 43.8x – 35.9x
P/FCF 15.9x – 34.0x
P/Operating cash flow 13.2x – 27.2x
P/S 1.7x – 5.3x
P/B 1.5x 83.7x 4.6x
P/Tangible book 2.3x 187.2x 6.9x
EV/EBITDA 23.5x – –
EV/EBIT 50.8x – –
EV/Revenue 2.0x – 5.3x
EV/FCF 18.7x – –
EV/Operating cash flow 15.5x – 27.2x
PEG (3Y EPS CAGR) -3.55 – 4.74

Growth

14 metrics
MetricICLRYDESTMO
Revenue growth (1Y) 3.7% – 8.3%
Revenue CAGR (3Y) 1.8% – 2.9%
Gross profit growth (1Y) -11.5% – –
Gross profit CAGR (3Y) -4.7% – –
Operating income growth (1Y) -66.6% – 12.8%
Operating income CAGR (3Y) -28.0% – 7.2%
Net income growth (1Y) -91.0% – 7.9%
Net income CAGR (3Y) -48.5% – 6.2%
EPS growth (1Y) -59.0% – 9.7%
EPS CAGR (3Y) -12.3% – 7.6%
Operating cash flow growth (1Y) -7.4% – 21.9%
Operating cash flow CAGR (3Y) 26.1% – 4.5%
Free cash flow growth (1Y) -10.7% – –
Free cash flow CAGR (3Y) 32.4% – –

Profitability

14 metrics
MetricICLRYDESTMO
Gross margin 24.2% – –
EBITDA margin 8.4% – –
Operating margin 3.9% – –
Pretax margin 1.6% – –
Net margin 3.9% – –
FCF margin 10.6% – –
Operating cash flow margin 12.8% – 19.7%
Return on equity 6.4% – 13.2%
Return on assets 3.7% – 6.2%
Return on invested capital 1.3% – –
Return on capital employed 2.6% – –
Asset turnover 0.5x – 0.4x
Cash conversion (OCF / net income) 15.4x – 1.3x
Stock comp / revenue 1.4% – –

Financial Health

11 metrics
MetricICLRYDESTMO
Debt / assets 20.7% – –
Debt / equity 0.4x – –
Net debt / EBITDA 3.5x – –
Debt / FCF 3.8x – –
Liabilities / assets 42.8% 55.5% –
Equity / assets 57.2% 44.5% 47.9%
Interest coverage 1.7x – –
Current ratio 1.0x 5.2x 1.8x
Quick ratio 0.6x 2.7x –
Cash ratio 0.2x 2.5x –
Altman Z-score 1.96 – –

Shareholder Returns

7 metrics
MetricICLRYDESTMO
Dividend yield – – 0.3%
Net buyback yield 1.7% – –
Shareholder yield 1.7% – 0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusICLRYDESTMO
Forward P/E 17.9xFY2026 – 26.4xFY2026
EPS, next fiscal year $10.25FY2026 – $25.91FY2026
EPS growth, next FY -18.2%FY2026 – +13.3%FY2026
EPS growth, the year after +22.2% – +2.0%
Revenue, next fiscal year $8.52BFY2026 – $50.12BFY2026
Revenue growth, next FY +3.2%FY2026 – +12.5%FY2026
Revenue growth, the year after -3.2% – -2.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersICLRYDESTMO
Held by institutions 100.0% – 90.2%
Institutions holding 422 – 2,621
Change in shares held, QoQ +5.5% – +0.8%
Institutions buying 233 – 1,141
Institutions selling 138 – 1,144
Buyers to sellers 1.69 – 1.00

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ICLRYDESTMO
ICLR 1.00 0.10 0.46
YDES 0.10 1.00 -0.03
TMO 0.46 -0.03 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, ICLR, YDES and TMO?

Thermo Fisher Scientific (TMO) is the largest by market capitalisation: Icon (ICLR) $14.35B, YD Bio (YDES) $406.99M, Thermo Fisher Scientific (TMO) $257.69B.

Which stock is cheaper, ICLR, YDES and TMO?

Thermo Fisher Scientific (TMO) trades on the lowest price-to-earnings ratio (Icon (ICLR) 43.6x, Thermo Fisher Scientific (TMO) 36.4x). On next year's consensus earnings, Icon (ICLR) is cheapest (Icon (ICLR) 17.9x, Thermo Fisher Scientific (TMO) 26.4x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Thermo Fisher Scientific (TMO) grew revenue fastest over the trailing twelve months: Icon (ICLR) +3.7%, Thermo Fisher Scientific (TMO) +8.3%.

Which stock has performed better?

Over the past year Thermo Fisher Scientific (TMO) returned the most: Icon (ICLR) +3.2%, YD Bio (YDES) -69.2%, Thermo Fisher Scientific (TMO) +19.6%. Over five years, Thermo Fisher Scientific (TMO) compounded fastest (Icon (ICLR) -8.2%/yr, YD Bio (YDES) -12.2%/yr, Thermo Fisher Scientific (TMO) +2.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Thermo Fisher Scientific (TMO) has been the steadiest (Icon (ICLR) 73.8%, YD Bio (YDES) 134.5%, Thermo Fisher Scientific (TMO) 29.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ICLR, YDES and TMO?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Thermo Fisher Scientific (TMO) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.