ICLR vs NEO vs YDES Stock Comparison

Icon, Neogenomics and YD Bio Prices as of Oct 27, 2026 Peers: Industry group
ICLR Icon Plc
$182.98 +6.2% 1M +0.5% 1Y
Market cap
$16.37B
P/E
36.5x
Revenue (TTM)
$8.23B
Div. yield
–
Contract Research Healthcare
5 wins
NEO Neogenomics Inc
$17.27 -10.7% 1M +70.0% 1Y
Market cap
$2.31B
P/E
–
Revenue (TTM)
$766.30M
Div. yield
–
Diagnostic Labs Healthcare
3 wins
YDES YD Bio Ltd
$6.04 +5.4% 1M -64.7% 1Y
Market cap
$431.64M
P/E
–
Revenue (TTM)
—
Div. yield
–
Biotechnology Healthcare

Head to Head

8 decided of 12

Icon leads on 5 of the 12 questions below (Icon 5, Neogenomics 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionICLRNEOYDESLeader
Larger companyMarket capitalisation $16.37B $2.31B $431.64M ICLR
Cheaper on earningsLower P/E, profitable companies only 36.5x -44.6x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 17.9x 86.4x — ICLR
Faster revenue growthRevenue growth, trailing twelve months +1.8% +11.2% — NEO
More profitableNet margin, trailing twelve months 5.4% -6.8% — ICLR
Better return on capitalReturn on invested capital 4.7% — — –
Less leveragedLower net debt / EBITDA 2.3x — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +0.5% +70.0% -64.7% NEO
Better 5-year returnAnnualised price return, 5 years -8.6%/yr -17.8%/yr -9.8%/yr ICLR
Less volatileAnnualised volatility, 1 year 73.7% 53.8% 134.9% NEO
Higher overall scoreMean of the five percentile scores vs peers 81/100 50/100 — ICLR

Percentile Scorecard

ICLRNEOYDES

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisICLRNEOYDES
Valuation 100 #1 of 11 32 #63 of 92 –
Growth 70 #4 of 11 67 #29 of 87 –
Profitability 80 #3 of 11 32 #59 of 86 –
Financial Health 75 #4 of 13 71 #29 of 97 39 #403 of 656
Shareholder Returns – 49 #29 of 56 –
Overall 81 50 –
  • ICLR ranked among 13 companies in Pharma Services
  • NEO ranked among 102 companies in Healthcare Providers
  • YDES ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodICLRNEOYDESSPY
1 month +6.2%-10.7%+5.4% -0.2%
3 months +1.5%+28.9%+162.6% +3.9%
6 months +78.5%+91.5%+16.2% +8.2%
Year to date +0.4%+46.9%-50.5% +12.9%
1 year +0.5%+70.0%-64.7% +12.3%
3 years -22.2%+26.9%-45.1% +87.4%
3 years, per year -8.0%+8.3%-18.1% +23.3%
5 years -36.1%-62.5%-40.4% +67.9%
5 years, per year -8.6%-17.8%-9.8% +10.9%
10 years +127.4%+111.4%— +261.1%
10 years, per year +8.6%+7.8%— +13.7%

Risk

MeasureICLRNEOYDESSPY
Volatility, 1Y 73.7%53.8%134.9% 12.7%
Downside volatility, 1Y 87.6%53.3%132.8% 12.7%
Beta vs S&P 500, 1Y 1.441.060.35 1.00
Return / volatility, 1Y 0.011.30-0.48 0.97
Max drawdown, 5Y -76.9%-89.7%-91.8% -25.4%
From 52-week high -9.8%-13.3%-64.7% -1.2%
52-week high $202.92$19.91$17.11 $779.14
52-week low $80.08$7.19$1.90 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleICLRNEOYDES
P/E now vs peer median 32.0xmedian 32.1x -43.2xmedian 24.6x —median 17.2x
P/S now vs peer median 1.7xmedian 2.6x 2.9xmedian 1.6x —median 9.0x
EV/EBITDA now vs peer median 15.2xmedian 38.1x -921.7xmedian 14.6x —median 16.3x
P/FCF now vs peer median 16.3xmedian 21.5x -300.4xmedian 21.6x —median 18.7x
P/B now vs peer median 1.5xmedian 3.1x 2.8xmedian 3.2x 95.6xmedian 2.2x
PEG now vs peer median -13.47median 2.03 -1.77median 0.66 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsICLRNEOYDES
Revenue $8.23B $766.30M –
Gross profit $1.93B $336.53M –
Operating income $718.25M -$68.44M –
Net income $448.66M -$51.88M –
Free cash flow $857.06M -$7.36M –
R&D – $38.17M –
EPS (diluted) $5.68 $-0.40 –
Cash & equivalents $808.98M $145.54M $2.66M
Total debt $3.38B – –
Shares (diluted) 78.97M 130.83M 66.72M
Enterprise value $13.14B $1.70B $419.37M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricICLRNEOYDES
P/E 32.0x -43.2x –
P/FCF 16.3x -300.4x –
P/Operating cash flow 13.6x 100.2x –
P/S 1.7x 2.9x –
P/B 1.5x 2.8x 95.6x
P/Tangible book 2.3x 4.3x 213.8x
EV/EBITDA 15.2x -921.7x –
EV/EBIT 23.1x -30.2x –
EV/Revenue 2.0x 2.7x –
EV/FCF 19.3x -280.6x –
EV/Operating cash flow 16.1x 93.6x –
PEG (3Y EPS CAGR) -13.47 -1.77 –

Growth

14 metrics
MetricICLRNEOYDES
Revenue growth (1Y) 1.8% 11.2% –
Revenue CAGR (3Y) 0.9% 11.6% –
Gross profit growth (1Y) -13.4% 11.2% –
Gross profit CAGR (3Y) -6.5% 15.1% –
Operating income growth (1Y) 53.9% 40.5% –
Operating income CAGR (3Y) -7.0% 19.4% –
Net income growth (1Y) 55.9% 50.1% –
Net income CAGR (3Y) -4.4% 23.2% –
EPS growth (1Y) 30.1% 51.2% –
EPS CAGR (3Y) -2.4% 24.3% –
Operating cash flow growth (1Y) -9.9% 56.9% –
Operating cash flow CAGR (3Y) 15.8% 38.3% –
Free cash flow growth (1Y) -11.1% 61.6% –
Free cash flow CAGR (3Y) 18.4% 51.4% –

Profitability

14 metrics
MetricICLRNEOYDES
Gross margin 23.4% 43.9% –
EBITDA margin 13.3% -0.3% –
Operating margin 8.7% -8.9% –
Pretax margin 6.3% -7.1% –
Net margin 5.4% -6.8% –
FCF margin 10.4% -1.0% –
Operating cash flow margin 12.5% 2.9% –
Return on equity 7.6% -6.4% –
Return on assets 4.3% -3.8% –
Return on invested capital 4.7% – –
Return on capital employed 5.3% -5.5% –
Asset turnover 0.5x 0.6x –
Cash conversion (OCF / net income) 2.3x -0.4x –
Stock comp / revenue 1.1% 4.7% –

Financial Health

11 metrics
MetricICLRNEOYDES
Debt / assets 20.8% – –
Debt / equity 0.4x – –
Net debt / EBITDA 2.3x – –
Debt / FCF 3.9x – –
Liabilities / assets 43.8% 41.9% 55.5%
Equity / assets 56.2% 58.1% 44.5%
Interest coverage 3.4x -26.5x –
Current ratio 1.3x 3.6x 5.2x
Quick ratio 0.9x 3.0x 2.7x
Cash ratio 0.3x 1.4x 2.5x
Altman Z-score 2.07 2.52 –

Shareholder Returns

7 metrics
MetricICLRNEOYDES
Dividend yield – – –
Net buyback yield 2.7% -0.1% –
Shareholder yield 2.7% -0.1% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusICLRNEOYDES
Forward P/E 17.9xFY2026 86.4xFY2026 –
EPS, next fiscal year $10.25FY2026 $0.20FY2026 –
EPS growth, next FY -18.2%FY2026 +66.7%FY2026 –
EPS growth, the year after +22.2% +80.0% –
Revenue, next fiscal year $8.52BFY2026 $778.61MFY2026 –
Revenue growth, next FY +3.2%FY2026 +7.1%FY2026 –
Revenue growth, the year after -3.2% +6.5% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersICLRNEOYDES
Held by institutions 100.0% 100.0% –
Institutions holding 422 266 –
Change in shares held, QoQ +5.5% +8.1% –
Institutions buying 233 156 –
Institutions selling 138 62 –
Buyers to sellers 1.69 2.52 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ICLRNEOYDES
ICLR 1.00 0.26 0.09
NEO 0.26 1.00 0.03
YDES 0.09 0.03 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, ICLR, NEO and YDES?

Icon (ICLR) is the largest by market capitalisation: Icon (ICLR) $16.37B, Neogenomics (NEO) $2.31B, YD Bio (YDES) $431.64M.

Which company is growing faster?

Neogenomics (NEO) grew revenue fastest over the trailing twelve months: Icon (ICLR) +1.8%, Neogenomics (NEO) +11.2%.

Which company is more profitable?

Icon (ICLR) has the highest net margin (Icon (ICLR) 5.4%, Neogenomics (NEO) -6.8%).

Which stock has performed better?

Over the past year Neogenomics (NEO) returned the most: Icon (ICLR) +0.5%, Neogenomics (NEO) +70.0%, YD Bio (YDES) -64.7%. Over five years, Icon (ICLR) compounded fastest (Icon (ICLR) -8.6%/yr, Neogenomics (NEO) -17.8%/yr, YD Bio (YDES) -9.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Neogenomics (NEO) has been the steadiest (Icon (ICLR) 73.7%, Neogenomics (NEO) 53.8%, YD Bio (YDES) 134.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ICLR, NEO and YDES?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Icon (ICLR) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.