GRFS vs AMGN vs REGN Stock Comparison

Grifols, Amgen and Regeneron Pharmaceuticals Prices as of Oct 26, 2026 Peers: Industry group
GRFS Grifols SA
$7.92 +7.8% 1M -16.3% 1Y
Market cap
$5.52B
P/E
11.9x
Revenue (TTM)
—
Div. yield
–
Biotechnology Healthcare
2 wins
AMGN Amgen Inc
$444.63 +7.2% 1M +52.4% 1Y
Market cap
$242.06B
P/E
27.7x
Revenue (TTM)
$38.10B
Div. yield
0.02%
Biotechnology Healthcare
5 wins

Head to Head

11 decided of 12

Amgen leads on 5 of the 12 questions below (Amgen 5, Regeneron Pharmaceuticals 4, Grifols 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGRFSAMGNREGNLeader
Larger companyMarket capitalisation $5.52B $242.06B $83.80B AMGN
Cheaper on earningsLower P/E, profitable companies only 11.9x 27.7x 19.4x GRFS
Cheaper on forward earningsLower price / next fiscal year consensus EPS 8.4x 20.4x 14.1x GRFS
Faster revenue growthRevenue growth, trailing twelve months — +9.1% +9.3% REGN
More profitableNet margin, trailing twelve months — 23.0% 27.9% REGN
Better return on capitalReturn on invested capital — 14.3% 9.6% AMGN
Less leveragedLower net debt / EBITDA — 2.7x -1.4x REGN
Higher dividend yieldTrailing dividend yield 0.00% 0.02% 0.00% –
Better 1-year returnPrice return, last 12 months -16.3% +52.4% +39.7% AMGN
Better 5-year returnAnnualised price return, 5 years -9.9%/yr +16.6%/yr +6.5%/yr AMGN
Less volatileAnnualised volatility, 1 year 32.4% 29.7% 32.9% AMGN
Higher overall scoreMean of the five percentile scores vs peers 57/100 66/100 72/100 REGN

Percentile Scorecard

GRFSAMGNREGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGRFSAMGNREGN
Valuation 99 #6 of 626 85 #94 of 626 89 #72 of 626
Growth – 61 #234 of 604 42 #353 of 604
Profitability – 94 #33 of 555 90 #55 of 555
Financial Health 14 #566 of 658 22 #512 of 658 74 #172 of 658
Shareholder Returns 56 #161 of 368 68 #117 of 368 65 #129 of 368
Overall 57 66 72
  • GRFS ranked among 673 companies in Pharmaceuticals and Biotechnology
  • AMGN ranked among 673 companies in Pharmaceuticals and Biotechnology
  • REGN ranked among 673 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGRFSAMGNREGNSPY
1 month +7.8%+7.2%+2.5% -0.8%
3 months +2.2%+18.2%+21.1% +3.5%
6 months -2.6%+30.7%+8.5% +7.0%
Year to date -15.3%+35.8%+4.6% +12.2%
1 year -16.3%+52.4%+39.7% +13.0%
3 years +1.0%+70.0%+4.2% +86.3%
3 years, per year +0.3%+19.4%+1.4% +23.1%
5 years -40.5%+115.2%+37.0% +68.6%
5 years, per year -9.9%+16.6%+6.5% +11.0%
10 years -46.6%+179.7%+122.4% +258.0%
10 years, per year -6.1%+10.8%+8.3% +13.6%

Risk

MeasureGRFSAMGNREGNSPY
Volatility, 1Y 32.4%29.7%32.9% 12.7%
Downside volatility, 1Y 34.1%27.9%30.0% 12.7%
Beta vs S&P 500, 1Y 0.950.450.46 1.00
Return / volatility, 1Y -0.501.761.21 1.02
Max drawdown, 5Y -58.9%-26.7%-59.8% -25.4%
From 52-week high -18.5%-0.6%-5.2% -1.8%
52-week high $9.72$447.28$852.03 $779.14
52-week low $7.02$291.16$585.31 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGRFSAMGNREGN
P/E now vs peer median 11.9xmedian 17.1x 27.5xmedian 17.1x 19.2xmedian 17.1x
P/S now vs peer median 0.6xmedian 8.8x 6.3xmedian 8.8x 5.3xmedian 8.8x
EV/EBITDA now vs peer median —median 17.1x 17.6xmedian 17.1x 17.6xmedian 17.1x
P/FCF now vs peer median 7.6xmedian 18.0x 23.6xmedian 18.0x 22.1xmedian 18.0x
P/B now vs peer median 0.6xmedian 2.1x 20.6xmedian 2.1x 2.6xmedian 2.1x
PEG now vs peer median —median 0.31 10.36median 0.31 7.21median 0.31

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGRFSAMGNREGN
Revenue – $38.10B $15.53B
Gross profit – $26.48B $13.18B
Operating income – $11.43B $3.84B
Net income – $8.74B $4.33B
Free cash flow – $10.18B $3.76B
R&D – $7.63B $6.28B
EPS (diluted) – $16.07 $40.84
Cash & equivalents $969.15M $13.99B $2.46B
Total debt $44.00B $57.30B $1.99B
Shares (diluted) 681.57M 544.00M 106.00M
Enterprise value $1.86B $197.46B $50.01B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGRFSAMGNREGN
P/E 11.9x 27.5x 19.2x
P/FCF 7.6x 23.6x 22.1x
P/Operating cash flow – 19.3x 17.7x
P/S 0.6x 6.3x 5.3x
P/B 0.6x 20.6x 2.6x
P/Tangible book 0.9x -27.3x 2.7x
EV/EBITDA – 17.6x 17.6x
EV/EBIT – 24.8x 20.0x
EV/Revenue – 7.4x 5.0x
EV/FCF – 27.9x 20.5x
EV/Operating cash flow – 22.7x 16.5x
PEG (3Y EPS CAGR) – 10.36 7.21

Growth

14 metrics
MetricGRFSAMGNREGN
Revenue growth (1Y) – 9.1% 9.3%
Revenue CAGR (3Y) – 12.7% 7.0%
Gross profit growth (1Y) – 17.6% 8.4%
Gross profit CAGR (3Y) – 10.3% 6.4%
Operating income growth (1Y) – 39.5% 0.1%
Operating income CAGR (3Y) – 6.4% -3.9%
Net income growth (1Y) – 32.1% -2.9%
Net income CAGR (3Y) – 3.1% 0.2%
EPS growth (1Y) – 31.4% -0.5%
EPS CAGR (3Y) – 2.7% 2.7%
Operating cash flow growth (1Y) – 3.9% -1.3%
Operating cash flow CAGR (3Y) – 4.9% -0.4%
Free cash flow growth (1Y) – -4.1% -2.4%
Free cash flow CAGR (3Y) – 1.7% -3.3%

Profitability

14 metrics
MetricGRFSAMGNREGN
Gross margin – 69.5% 84.9%
EBITDA margin – 42.2% 28.1%
Operating margin – 30.0% 24.7%
Pretax margin – 27.0% 33.3%
Net margin – 23.0% 27.9%
FCF margin – 26.7% 24.2%
Operating cash flow margin – 32.8% 30.1%
Return on equity – 83.8% 13.7%
Return on assets – 9.3% 10.5%
Return on invested capital – 14.3% 9.6%
Return on capital employed – 16.7% 10.7%
Asset turnover – 0.4x 0.4x
Cash conversion (OCF / net income) – 1.4x 1.1x
Stock comp / revenue – 1.3% 6.4%

Financial Health

11 metrics
MetricGRFSAMGNREGN
Debt / assets 48.9% 59.9% 4.8%
Debt / equity 1.3x 4.9x 0.1x
Net debt / EBITDA – 2.7x -1.4x
Debt / FCF – 5.6x 0.5x
Liabilities / assets 61.4% 87.8% 24.0%
Equity / assets 38.6% 12.2% 76.0%
Interest coverage – 4.3x 69.4x
Current ratio 2.5x 1.4x 3.3x
Quick ratio 0.8x 0.9x 2.6x
Cash ratio 0.4x 0.5x 1.4x
Altman Z-score – 2.30 7.28

Shareholder Returns

7 metrics
MetricGRFSAMGNREGN
Dividend yield 1.4% 2.2% 0.5%
Net buyback yield – – 3.1%
Shareholder yield 1.4% 2.2% 3.5%
Payout ratio (earnings) – 60.4% –
Payout ratio (FCF) – 51.9% –
Dividend growth (1Y) – 6.3% –
Dividend CAGR (3Y) – 6.7% –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGRFSAMGNREGN
Forward P/E 8.4xFY2026 20.4xFY2026 14.1xFY2026
EPS, next fiscal year $0.94FY2026 $21.81FY2026 $57.08FY2026
EPS growth, next FY +10.6%FY2026 -0.1%FY2026 +28.8%FY2026
EPS growth, the year after +26.6% +7.2% +15.5%
Revenue, next fiscal year $8.88BFY2026 $41.51BFY2026 $17.05BFY2026
Revenue growth, next FY +0.0%FY2026 +12.9%FY2026 +18.9%FY2026
Revenue growth, the year after +10.3% +2.3% +13.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGRFSAMGNREGN
Held by institutions 21.0% 82.7% 66.2%
Institutions holding 166 3,159 1,325
Change in shares held, QoQ -0.5% +4.5% +3.8%
Institutions buying 73 1,451 604
Institutions selling 65 1,217 534
Buyers to sellers 1.12 1.19 1.13

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GRFSAMGNREGN
GRFS 1.00 0.24 0.28
AMGN 0.24 1.00 0.51
REGN 0.28 0.51 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, GRFS, AMGN and REGN?

Amgen (AMGN) is the largest by market capitalisation: Grifols (GRFS) $5.52B, Amgen (AMGN) $242.06B, Regeneron Pharmaceuticals (REGN) $83.80B.

Which stock is cheaper, GRFS, AMGN and REGN?

Grifols (GRFS) trades on the lowest price-to-earnings ratio (Grifols (GRFS) 11.9x, Amgen (AMGN) 27.7x, Regeneron Pharmaceuticals (REGN) 19.4x). On next year's consensus earnings, Grifols (GRFS) is cheapest (Grifols (GRFS) 8.4x, Amgen (AMGN) 20.4x, Regeneron Pharmaceuticals (REGN) 14.1x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Regeneron Pharmaceuticals (REGN) grew revenue fastest over the trailing twelve months: Amgen (AMGN) +9.1%, Regeneron Pharmaceuticals (REGN) +9.3%.

Which company is more profitable?

Regeneron Pharmaceuticals (REGN) has the highest net margin (Amgen (AMGN) 23.0%, Regeneron Pharmaceuticals (REGN) 27.9%). On return on invested capital, Amgen (AMGN) leads (Amgen (AMGN) 14.3%, Regeneron Pharmaceuticals (REGN) 9.6%).

Which stock has performed better?

Over the past year Amgen (AMGN) returned the most: Grifols (GRFS) -16.3%, Amgen (AMGN) +52.4%, Regeneron Pharmaceuticals (REGN) +39.7%. Over five years, Amgen (AMGN) compounded fastest (Grifols (GRFS) -9.9%/yr, Amgen (AMGN) +16.6%/yr, Regeneron Pharmaceuticals (REGN) +6.5%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Grifols (GRFS) 0.00%, Amgen (AMGN) 0.02%, Regeneron Pharmaceuticals (REGN) 0.00%. Grifols (GRFS) and Regeneron Pharmaceuticals (REGN) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (Grifols (GRFS) 32.4%, Amgen (AMGN) 29.7%, Regeneron Pharmaceuticals (REGN) 32.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GRFS, AMGN and REGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.