GRFS vs AMGN vs ALNY Stock Comparison

Grifols, Amgen and Alnylam Pharmaceuticals Prices as of Oct 28, 2026 Peers: Industry group
GRFS Grifols SA
$8.12 +9.6% 1M -13.2% 1Y
Market cap
$5.53B
P/E
12.2x
Revenue (TTM)
—
Div. yield
1.35%
Biotechnology Healthcare
2 wins
AMGN Amgen Inc
$451.83 +8.1% 1M +54.7% 1Y
Market cap
$244.26B
P/E
27.9x
Revenue (TTM)
$38.10B
Div. yield
2.20%
Biotechnology Healthcare
6 wins

Head to Head

10 decided of 12

Amgen leads on 6 of the 12 questions below (Amgen 6, Grifols 2, Alnylam Pharmaceuticals 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGRFSAMGNALNYLeader
Larger companyMarket capitalisation $5.53B $244.26B $31.08B AMGN
Cheaper on earningsLower P/E, profitable companies only 12.2x 27.9x 42.4x GRFS
Cheaper on forward earningsLower price / next fiscal year consensus EPS 8.6x 20.7x 34.4x GRFS
Faster revenue growthRevenue growth, trailing twelve months — +9.1% +90.1% ALNY
More profitableNet margin, trailing twelve months — 23.0% 15.3% AMGN
Better return on capitalReturn on invested capital — 14.3% — –
Less leveragedLower net debt / EBITDA — 2.7x — –
Higher dividend yieldTrailing dividend yield 1.35% 2.20% — AMGN
Better 1-year returnPrice return, last 12 months -13.2% +54.7% -51.2% AMGN
Better 5-year returnAnnualised price return, 5 years -9.1%/yr +16.9%/yr +7.8%/yr AMGN
Less volatileAnnualised volatility, 1 year 32.4% 29.7% 51.3% AMGN
Higher overall scoreMean of the five percentile scores vs peers 56/100 66/100 77/100 ALNY

Percentile Scorecard

GRFSAMGNALNY

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGRFSAMGNALNY
Valuation 99 #6 of 625 86 #91 of 625 81 #119 of 625
Growth – 62 #231 of 602 98 #13 of 602
Profitability – 95 #31 of 549 93 #41 of 549
Financial Health 14 #564 of 654 22 #510 of 654 46 #357 of 654
Shareholder Returns 56 #162 of 367 68 #118 of 367 68 #120 of 367
Overall 56 66 77
  • GRFS ranked among 672 companies in Pharmaceuticals and Biotechnology
  • AMGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • ALNY ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGRFSAMGNALNYSPY
1 month +9.6%+8.1%-9.0% +0.9%
3 months -0.4%+16.6%-18.9% +5.9%
6 months +2.7%+33.7%-22.8% +8.5%
Year to date -13.2%+38.0%-41.6% +13.3%
1 year -13.2%+54.7%-51.2% +12.4%
3 years +3.6%+72.7%+53.1% +88.1%
3 years, per year +1.2%+20.0%+15.3% +23.5%
5 years -38.1%+118.3%+45.7% +68.2%
5 years, per year -9.1%+16.9%+7.8% +11.0%
10 years -44.0%+211.2%+539.5% +263.4%
10 years, per year -5.6%+12.0%+20.4% +13.8%

Risk

MeasureGRFSAMGNALNYSPY
Volatility, 1Y 32.4%29.7%51.3% 12.7%
Downside volatility, 1Y 34.2%27.9%62.9% 12.7%
Beta vs S&P 500, 1Y 0.950.460.35 1.00
Return / volatility, 1Y -0.411.84-1.00 0.98
Max drawdown, 5Y -58.8%-26.7%-58.2% -25.4%
From 52-week high -16.5%0.0%-51.7% -0.9%
52-week high $9.72$451.83$481.59 $779.14
52-week low $7.02$291.77$205.48 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGRFSAMGNALNY
P/E now vs peer median 12.2xmedian 17.4x 27.9xmedian 17.4x 42.4xmedian 17.4x
P/S now vs peer median 0.7xmedian 9.1x 6.4xmedian 9.1x 6.5xmedian 9.1x
EV/EBITDA now vs peer median —median 17.1x 17.9xmedian 17.1x 26.3xmedian 17.1x
P/FCF now vs peer median 7.8xmedian 19.0x 24.0xmedian 19.0x 37.9xmedian 19.0x
P/B now vs peer median 0.6xmedian 2.2x 20.9xmedian 2.2x 23.0xmedian 2.2x
PEG now vs peer median —median 0.34 10.53median 0.34 1.12median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGRFSAMGNALNY
Revenue – $38.10B $4.80B
Gross profit – $26.48B $3.83B
Operating income – $11.43B $999.78M
Net income – $8.74B $733.11M
Free cash flow – $10.18B $819.87M
R&D – $7.63B $1.51B
EPS (diluted) – $16.07 $5.30
Cash & equivalents $969.15M $13.99B $1.71B
Total debt $44.00B $57.30B –
Shares (diluted) 681.57M 544.00M 138.28M
Enterprise value $4.61B $199.66B $19.13B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGRFSAMGNALNY
P/E 12.2x 27.9x 42.4x
P/FCF 7.8x 24.0x 37.9x
P/Operating cash flow – 19.6x 34.1x
P/S 0.7x 6.4x 6.5x
P/B 0.6x 20.9x 23.0x
P/Tangible book 1.0x -27.8x 23.0x
EV/EBITDA – 17.9x 26.3x
EV/EBIT – 25.2x 27.8x
EV/Revenue – 7.5x 5.8x
EV/FCF – 28.3x 33.9x
EV/Operating cash flow – 23.0x 30.5x
PEG (3Y EPS CAGR) – 10.53 1.12

Growth

14 metrics
MetricGRFSAMGNALNY
Revenue growth (1Y) – 9.1% 90.1%
Revenue CAGR (3Y) – 12.7% 57.2%
Gross profit growth (1Y) – 17.6% 79.7%
Gross profit CAGR (3Y) – 10.3% 54.6%
Operating income growth (1Y) – 39.5% 654.9%
Operating income CAGR (3Y) – 6.4% 47.5%
Net income growth (1Y) – 32.1% 356.5%
Net income CAGR (3Y) – 3.1% 39.1%
EPS growth (1Y) – 31.4% 342.3%
EPS CAGR (3Y) – 2.7% 37.9%
Operating cash flow growth (1Y) – 3.9% 2,299%
Operating cash flow CAGR (3Y) – 4.9% 57.8%
Free cash flow growth (1Y) – -4.1% 1,151%
Free cash flow CAGR (3Y) – 1.7% 52.1%

Profitability

14 metrics
MetricGRFSAMGNALNY
Gross margin – 69.5% 79.8%
EBITDA margin – 42.2% 22.0%
Operating margin – 30.0% 20.8%
Pretax margin – 27.0% 16.0%
Net margin – 23.0% 15.3%
FCF margin – 26.7% 17.1%
Operating cash flow margin – 32.8% 19.0%
Return on equity – 83.8% 63.8%
Return on assets – 9.3% 14.5%
Return on invested capital – 14.3% –
Return on capital employed – 16.7% 26.1%
Asset turnover – 0.4x 0.9x
Cash conversion (OCF / net income) – 1.4x 1.2x
Stock comp / revenue – 1.3% 7.0%

Financial Health

11 metrics
MetricGRFSAMGNALNY
Debt / assets 48.9% 59.9% –
Debt / equity 1.3x 4.9x –
Net debt / EBITDA – 2.7x –
Debt / FCF – 5.6x –
Liabilities / assets 61.4% 87.8% 75.6%
Equity / assets 38.6% 12.2% 24.4%
Interest coverage – 4.3x 3.8x
Current ratio 2.5x 1.4x 3.1x
Quick ratio 0.8x 0.9x 2.8x
Cash ratio 0.4x 0.5x 2.2x
Altman Z-score – 2.33 4.97

Shareholder Returns

7 metrics
MetricGRFSAMGNALNY
Dividend yield 1.4% 2.2% –
Net buyback yield – – -0.5%
Shareholder yield 1.4% 2.2% -0.5%
Payout ratio (earnings) – 60.4% –
Payout ratio (FCF) – 51.9% –
Dividend growth (1Y) – 6.3% –
Dividend CAGR (3Y) – 6.7% –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGRFSAMGNALNY
Forward P/E 8.6xFY2026 20.7xFY2026 34.4xFY2026
EPS, next fiscal year $0.94FY2026 $21.81FY2026 $6.76FY2026
EPS growth, next FY +10.6%FY2026 -0.1%FY2026 +190.1%FY2026
EPS growth, the year after +26.6% +7.2% +34.3%
Revenue, next fiscal year $8.88BFY2026 $41.51BFY2026 $5.68BFY2026
Revenue growth, next FY +0.0%FY2026 +12.9%FY2026 +53.1%FY2026
Revenue growth, the year after +10.3% +2.3% +27.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGRFSAMGNALNY
Held by institutions 21.0% 82.7% 99.7%
Institutions holding 166 3,160 786
Change in shares held, QoQ -0.5% +4.5% +3.8%
Institutions buying 73 1,452 412
Institutions selling 65 1,217 277
Buyers to sellers 1.12 1.19 1.49

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GRFSAMGNALNY
GRFS 1.00 0.24 0.21
AMGN 0.24 1.00 0.33
ALNY 0.21 0.33 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, GRFS, AMGN and ALNY?

Amgen (AMGN) is the largest by market capitalisation: Grifols (GRFS) $5.53B, Amgen (AMGN) $244.26B, Alnylam Pharmaceuticals (ALNY) $31.08B.

Which stock is cheaper, GRFS, AMGN and ALNY?

Grifols (GRFS) trades on the lowest price-to-earnings ratio (Grifols (GRFS) 12.2x, Amgen (AMGN) 27.9x, Alnylam Pharmaceuticals (ALNY) 42.4x). On next year's consensus earnings, Grifols (GRFS) is cheapest (Grifols (GRFS) 8.6x, Amgen (AMGN) 20.7x, Alnylam Pharmaceuticals (ALNY) 34.4x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Alnylam Pharmaceuticals (ALNY) grew revenue fastest over the trailing twelve months: Amgen (AMGN) +9.1%, Alnylam Pharmaceuticals (ALNY) +90.1%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Amgen (AMGN) 23.0%, Alnylam Pharmaceuticals (ALNY) 15.3%).

Which stock has performed better?

Over the past year Amgen (AMGN) returned the most: Grifols (GRFS) -13.2%, Amgen (AMGN) +54.7%, Alnylam Pharmaceuticals (ALNY) -51.2%. Over five years, Amgen (AMGN) compounded fastest (Grifols (GRFS) -9.1%/yr, Amgen (AMGN) +16.9%/yr, Alnylam Pharmaceuticals (ALNY) +7.8%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Amgen (AMGN) has the highest dividend yield: Grifols (GRFS) 1.35%, Amgen (AMGN) 2.20%. Alnylam Pharmaceuticals (ALNY) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (Grifols (GRFS) 32.4%, Amgen (AMGN) 29.7%, Alnylam Pharmaceuticals (ALNY) 51.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GRFS, AMGN and ALNY?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.