GRAL vs TEM vs CAI Stock Comparison

Grail, Tempus AI and Caris Life Sciences Prices as of Oct 26, 2026 Peers: Industry group
GRAL GRAIL, Inc.
$139.91 +10.3% 1M +56.5% 1Y
Market cap
$6.16B
P/E
–
Revenue (TTM)
$157.21M
Div. yield
–
Diagnostic Labs Healthcare
1 win
TEM Tempus AI, Inc.
$67.16 -21.0% 1M -24.7% 1Y
Market cap
$12.15B
P/E
–
Revenue (TTM)
$1.43B
Div. yield
–
Diagnostic Labs Healthcare
1 win

Head to Head

7 decided of 12

Caris Life Sciences leads on 5 of the 12 questions below (Caris Life Sciences 5, Tempus AI 1, Grail 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGRALTEMCAILeader
Larger companyMarket capitalisation $6.16B $12.15B $9.16B TEM
Cheaper on earningsLower P/E, profitable companies only -15.7x -47.8x 87.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 295.1x –
Faster revenue growthRevenue growth, trailing twelve months +17.1% +50.4% +85.4% CAI
More profitableNet margin, trailing twelve months -249.1% -17.8% 10.6% CAI
Better return on capitalReturn on invested capital — -52.0% 15.6% CAI
Less leveragedLower net debt / EBITDA — — -2.2x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +56.5% -24.7% +4.5% GRAL
Better 5-year returnAnnualised price return, 5 years — — — –
Less volatileAnnualised volatility, 1 year 111.3% 76.6% 69.6% CAI
Higher overall scoreMean of the five percentile scores vs peers 42/100 26/100 69/100 CAI

Percentile Scorecard

GRALTEMCAI

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGRALTEMCAI
Valuation 8 #86 of 93 9 #85 of 93 23 #72 of 93
Growth 58 #38 of 88 26 #65 of 88 99 #2 of 88
Profitability 6 #82 of 87 11 #78 of 87 87 #12 of 87
Financial Health 99 #2 of 100 57 #44 of 100 82 #19 of 100
Shareholder Returns – – 53 #27 of 56
Overall 42 26 69
  • GRAL ranked among 103 companies in Healthcare Providers
  • TEM ranked among 103 companies in Healthcare Providers
  • CAI ranked among 103 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGRALTEMCAISPY
1 month +10.3%-21.0%+1.5% -0.8%
3 months +109.5%+56.5%+107.7% +3.5%
6 months +154.3%+27.5%+62.9% +7.0%
Year to date +63.5%+13.7%+20.3% +12.2%
1 year +56.5%-24.7%+4.5% +13.0%

Risk

MeasureGRALTEMCAISPY
Volatility, 1Y 111.3%76.6%69.6% 12.7%
Downside volatility, 1Y 126.1%66.8%69.3% 12.7%
Beta vs S&P 500, 1Y 2.672.541.38 1.00
Return / volatility, 1Y 0.51-0.320.06 1.02
Max drawdown, 5Y -62.9%-59.8%-63.0% -25.4%
From 52-week high -9.2%-26.7%0.0% -1.8%
52-week high $154.08$91.58$32.46 $779.14
52-week low $43.03$41.55$14.55 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGRALTEMCAI
P/E now vs peer median -15.4xmedian 25.1x -47.5xmedian 25.1x 87.3xmedian 25.1x
P/S now vs peer median 39.8xmedian 1.6x 8.2xmedian 1.6x 9.3xmedian 1.6x
EV/EBITDA now vs peer median -13.3xmedian 14.5x —median 14.5x 48.7xmedian 14.5x
P/FCF now vs peer median -21.1xmedian 22.4x -44.7xmedian 22.4x 74.0xmedian 22.4x
P/B now vs peer median 2.5xmedian 3.1x 26.4xmedian 3.1x 15.5xmedian 3.1x
PEG now vs peer median —median 0.66 —median 0.66 —median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGRALTEMCAI
Revenue $157.21M $1.43B $989.61M
Gross profit $75.51M $916.19M $689.36M
Operating income -$559.25M -$283.03M $153.26M
Net income -$391.59M -$254.43M $105.14M
Free cash flow -$296.16M -$263.22M $123.96M
R&D $190.72M $196.31M $117.14M
EPS (diluted) $-9.08 $-1.39 $0.37
Cash & equivalents $55.65M $599.61M $690.92M
Total debt – – $393.15M
Shares (diluted) 43.11M 182.40M 282.89M
Enterprise value $3.03B $9.18B $5.99B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGRALTEMCAI
P/E -15.4x -47.5x 87.3x
P/FCF -21.1x -44.7x 74.0x
P/Operating cash flow -21.2x -49.6x 54.4x
P/S 39.8x 8.2x 9.3x
P/B 2.5x 26.4x 15.5x
P/Tangible book 8.2x 88.8x 15.5x
EV/EBITDA -13.3x – 48.7x
EV/EBIT -9.6x -38.7x 57.2x
EV/Revenue 34.3x 7.6x 8.9x
EV/FCF -18.2x -41.6x 70.8x
EV/Operating cash flow -18.3x -46.1x 52.0x
PEG (3Y EPS CAGR) – – –

Growth

14 metrics
MetricGRALTEMCAI
Revenue growth (1Y) 17.1% 50.4% 85.4%
Revenue CAGR (3Y) – – –
Gross profit growth (1Y) 30.2% 58.5% 141.2%
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) 11.6% -20.6% 188.2%
Operating income CAGR (3Y) – – –
Net income growth (1Y) 11.6% -27.4% 137.7%
Net income CAGR (3Y) – – –
EPS growth (1Y) 26.6% -21.1% 103.0%
EPS CAGR (3Y) – – –
Operating cash flow growth (1Y) 20.3% -356.2% 227.3%
Operating cash flow CAGR (3Y) – – –
Free cash flow growth (1Y) 20.3% -278.0% 188.2%
Free cash flow CAGR (3Y) – – –

Profitability

14 metrics
MetricGRALTEMCAI
Gross margin 48.0% 64.0% 69.7%
EBITDA margin -257.6% – 18.2%
Operating margin -355.7% -19.8% 15.5%
Pretax margin -336.8% -17.6% 10.6%
Net margin -249.1% -17.8% 10.6%
FCF margin -188.4% -18.4% 12.5%
Operating cash flow margin -187.5% -16.6% 17.0%
Return on equity -15.5% -57.3% 17.7%
Return on assets -13.9% -11.0% 8.8%
Return on invested capital – -52.0% 15.6%
Return on capital employed -20.4% -15.2% 15.3%
Asset turnover 0.1x 0.6x 0.8x
Cash conversion (OCF / net income) 0.8x 0.9x 1.6x
Stock comp / revenue 40.9% 13.0% 6.6%

Financial Health

11 metrics
MetricGRALTEMCAI
Debt / assets – – 32.0%
Debt / equity – – 0.7x
Net debt / EBITDA – – -2.2x
Debt / FCF – – 3.2x
Liabilities / assets 10.6% 81.2% 51.9%
Equity / assets 89.4% 18.8% 48.1%
Interest coverage – -5.1x 3.3x
Current ratio 10.9x 3.3x 5.5x
Quick ratio 10.6x 3.1x 4.8x
Cash ratio 10.3x 2.1x 4.1x
Altman Z-score 7.09 2.85 7.79

Shareholder Returns

7 metrics
MetricGRALTEMCAI
Dividend yield – – –
Net buyback yield – – 0.1%
Shareholder yield – 0.0% 0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGRALTEMCAI
Forward P/E – – 295.1xFY2026
EPS, next fiscal year $-9.20FY2026 $-0.20FY2026 $0.11FY2026
EPS growth, the year after – – +236.4%
Revenue, next fiscal year $169.83MFY2026 $1.64BFY2026 $1.06BFY2026
Revenue growth, next FY +15.4%FY2026 +29.0%FY2026 +30.1%FY2026
Revenue growth, the year after +38.0% +24.1% +21.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGRALTEMCAI
Held by institutions 85.4% 61.3% 52.0%
Institutions holding 372 483 245
Change in shares held, QoQ +8.4% +5.0% -6.3%
Institutions buying 182 284 175
Institutions selling 100 118 47
Buyers to sellers 1.82 2.41 3.72

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GRALTEMCAI
GRAL 1.00 0.41 0.33
TEM 0.41 1.00 0.57
CAI 0.33 0.57 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, GRAL, TEM and CAI?

Tempus AI (TEM) is the largest by market capitalisation: Grail (GRAL) $6.16B, Tempus AI (TEM) $12.15B, Caris Life Sciences (CAI) $9.16B.

Which company is growing faster?

Caris Life Sciences (CAI) grew revenue fastest over the trailing twelve months: Grail (GRAL) +17.1%, Tempus AI (TEM) +50.4%, Caris Life Sciences (CAI) +85.4%.

Which company is more profitable?

Caris Life Sciences (CAI) has the highest net margin (Grail (GRAL) -249.1%, Tempus AI (TEM) -17.8%, Caris Life Sciences (CAI) 10.6%). On return on invested capital, Caris Life Sciences (CAI) leads (Tempus AI (TEM) -52.0%, Caris Life Sciences (CAI) 15.6%).

Which stock has performed better?

Over the past year Grail (GRAL) returned the most: Grail (GRAL) +56.5%, Tempus AI (TEM) -24.7%, Caris Life Sciences (CAI) +4.5%. Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Caris Life Sciences (CAI) has been the steadiest (Grail (GRAL) 111.3%, Tempus AI (TEM) 76.6%, Caris Life Sciences (CAI) 69.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GRAL, TEM and CAI?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Caris Life Sciences (CAI) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.