GRAL vs SHC vs GH Stock Comparison

Grail, Sotera Health and Guardant Health Prices as of Oct 27, 2026 Peers: Industry group
GRAL GRAIL, Inc.
$150.61 +18.7% 1M +77.2% 1Y
Market cap
$6.73B
P/E
–
Revenue (TTM)
$157.21M
Div. yield
–
Diagnostic Labs Healthcare
SHC Sotera Health Co
$18.49 +0.8% 1M +10.7% 1Y
Market cap
$5.28B
P/E
32.3x
Revenue (TTM)
$1.22B
Div. yield
–
Diagnostic Labs Healthcare
3 wins
GH Guardant Health, Inc.
$178.06 +0.5% 1M +151.3% 1Y
Market cap
$23.79B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
4 wins

Head to Head

7 decided of 12

Guardant Health leads on 4 of the 12 questions below (Guardant Health 4, Sotera Health 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGRALSHCGHLeader
Larger companyMarket capitalisation $6.73B $5.28B $23.79B GH
Cheaper on earningsLower P/E, profitable companies only -16.6x 32.3x -52.2x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 20.1x — –
Faster revenue growthRevenue growth, trailing twelve months +17.1% +8.1% +42.7% GH
More profitableNet margin, trailing twelve months -249.1% 13.4% -38.3% SHC
Better return on capitalReturn on invested capital — 9.1% — –
Less leveragedLower net debt / EBITDA — 3.3x — –
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +77.2% +10.7% +151.3% GH
Better 5-year returnAnnualised price return, 5 years — -5.8%/yr +8.5%/yr GH
Less volatileAnnualised volatility, 1 year 111.3% 28.4% 57.4% SHC
Higher overall scoreMean of the five percentile scores vs peers 43/100 59/100 28/100 SHC

Percentile Scorecard

GRALSHCGH

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGRALSHCGH
Valuation 8 #85 of 92 52 #45 of 92 18 #76 of 92
Growth 58 #37 of 87 66 #30 of 87 49 #45 of 87
Profitability 6 #81 of 86 82 #16 of 86 7 #80 of 86
Financial Health 99 #2 of 97 37 #62 of 97 52 #47 of 97
Shareholder Returns – – 15 #48 of 56
Overall 43 59 28
  • GRAL ranked among 102 companies in Healthcare Providers
  • SHC ranked among 102 companies in Healthcare Providers
  • GH ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGRALSHCGHSPY
1 month +18.7%+0.8%+0.5% -0.2%
3 months +133.8%+4.1%+24.0% +3.9%
6 months +188.5%+19.0%+114.3% +8.2%
Year to date +76.0%+4.8%+74.3% +12.9%
1 year +77.2%+10.7%+151.3% +12.3%
3 years —+47.8%+613.4% +87.4%
3 years, per year —+13.9%+92.6% +23.3%
5 years —-25.6%+50.7% +67.9%
5 years, per year —-5.8%+8.5% +10.9%

Risk

MeasureGRALSHCGHSPY
Volatility, 1Y 111.3%28.4%57.4% 12.7%
Downside volatility, 1Y 126.1%27.0%48.7% 12.7%
Beta vs S&P 500, 1Y 2.691.011.03 1.00
Return / volatility, 1Y 0.690.382.64 0.97
Max drawdown, 5Y -62.9%-78.2%-86.7% -25.4%
From 52-week high -2.3%-5.5%-4.9% -1.2%
52-week high $154.08$19.57$187.22 $779.14
52-week low $43.03$13.13$69.58 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGRALSHCGH
P/E now vs peer median -16.6xmedian 24.6x 32.3xmedian 24.6x -52.2xmedian 24.6x
P/S now vs peer median 42.8xmedian 1.6x 4.3xmedian 1.6x 20.1xmedian 1.6x
EV/EBITDA now vs peer median -14.5xmedian 14.6x 13.0xmedian 14.6x -52.7xmedian 14.6x
P/FCF now vs peer median -22.7xmedian 21.6x 46.8xmedian 21.6x -98.8xmedian 21.6x
P/B now vs peer median 2.6xmedian 3.2x 7.9xmedian 3.2x -106.8xmedian 3.2x
PEG now vs peer median —median 0.66 0.86median 0.66 -5.25median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGRALSHCGH
Revenue $157.21M $1.22B $1.18B
Gross profit $75.51M $668.51M $769.16M
Operating income -$559.25M $411.34M -$470.26M
Net income -$391.59M $163.48M -$453.44M
Free cash flow -$296.16M $112.70M -$240.72M
R&D $190.72M – $375.79M
EPS (diluted) $-9.08 $0.57 $-3.41
Cash & equivalents $55.65M $356.72M $1.05B
Total debt – $2.14B –
Shares (diluted) 43.11M 288.15M 132.87M
Enterprise value $3.60B $3.96B $19.85B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGRALSHCGH
P/E -16.6x 32.3x -52.2x
P/FCF -22.7x 46.8x -98.8x
P/Operating cash flow -22.8x 18.1x -128.5x
P/S 42.8x 4.3x 20.1x
P/B 2.6x 7.9x -106.8x
P/Tangible book 8.8x 13.3x -95.9x
EV/EBITDA -14.5x 13.0x -52.7x
EV/EBIT -10.5x 17.2x -48.4x
EV/Revenue 37.3x 5.8x 19.2x
EV/FCF -19.8x 62.6x -94.5x
EV/Operating cash flow -19.9x 24.2x -122.8x
PEG (3Y EPS CAGR) – 0.86 -5.25

Growth

14 metrics
MetricGRALSHCGH
Revenue growth (1Y) 17.1% 8.1% 42.7%
Revenue CAGR (3Y) – 7.6% 32.4%
Gross profit growth (1Y) 30.2% 7.1% 47.7%
Gross profit CAGR (3Y) – 8.1% –
Operating income growth (1Y) 11.6% 21.8% -2.1%
Operating income CAGR (3Y) – 23.2% 4.8%
Net income growth (1Y) 11.6% 580.5% -9.6%
Net income CAGR (3Y) – 37.7% 3.7%
EPS growth (1Y) 26.6% 574.9% -2.4%
EPS CAGR (3Y) – 37.5% 9.9%
Operating cash flow growth (1Y) 20.3% 9.8% 22.4%
Operating cash flow CAGR (3Y) – 61.3% 18.1%
Free cash flow growth (1Y) 20.3% 0.0% 11.4%
Free cash flow CAGR (3Y) – 32.6% 14.4%

Profitability

14 metrics
MetricGRALSHCGH
Gross margin 48.0% 55.0% 65.0%
EBITDA margin -257.6% 44.6% -36.5%
Operating margin -355.7% 33.8% -39.7%
Pretax margin -336.8% 21.7% -38.4%
Net margin -249.1% 13.4% -38.3%
FCF margin -188.4% 9.3% -20.3%
Operating cash flow margin -187.5% 24.0% -15.7%
Return on equity -15.5% 25.4% –
Return on assets -13.9% 5.0% -23.7%
Return on invested capital – 9.1% –
Return on capital employed -20.4% 13.5% -29.9%
Asset turnover 0.1x 0.4x 0.6x
Cash conversion (OCF / net income) 0.8x 1.8x 0.4x
Stock comp / revenue 40.9% 3.1% 16.2%

Financial Health

11 metrics
MetricGRALSHCGH
Debt / assets – 64.7% –
Debt / equity – 3.2x –
Net debt / EBITDA – 3.3x –
Debt / FCF – 19.0x –
Liabilities / assets 10.6% 79.9% 111.7%
Equity / assets 89.4% 20.1% -11.7%
Interest coverage – – -97.6x
Current ratio 10.9x 2.8x 4.0x
Quick ratio 10.6x 2.4x 3.5x
Cash ratio 10.3x 1.5x 3.1x
Altman Z-score 8.04 1.94 4.77

Shareholder Returns

7 metrics
MetricGRALSHCGH
Dividend yield – – –
Net buyback yield – – -1.7%
Shareholder yield – – -1.7%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGRALSHCGH
Forward P/E – 20.1xFY2026 –
EPS, next fiscal year $-9.05FY2026 $0.92FY2026 $-3.33FY2026
EPS growth, next FY – +7.0%FY2026 –
EPS growth, the year after – +21.7% –
Revenue, next fiscal year $169.78MFY2026 $1.33BFY2026 $1.42BFY2026
Revenue growth, next FY +15.4%FY2026 +14.8%FY2026 +44.5%FY2026
Revenue growth, the year after +38.2% -4.2% +27.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGRALSHCGH
Held by institutions 85.4% 100.0% 100.0%
Institutions holding 372 316 594
Change in shares held, QoQ +8.4% +5.9% -2.6%
Institutions buying 182 220 353
Institutions selling 100 64 180
Buyers to sellers 1.82 3.44 1.96

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GRALSHCGH
GRAL 1.00 0.22 0.41
SHC 0.22 1.00 0.28
GH 0.41 0.28 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, GRAL, SHC and GH?

Guardant Health (GH) is the largest by market capitalisation: Grail (GRAL) $6.73B, Sotera Health (SHC) $5.28B, Guardant Health (GH) $23.79B.

Which company is growing faster?

Guardant Health (GH) grew revenue fastest over the trailing twelve months: Grail (GRAL) +17.1%, Sotera Health (SHC) +8.1%, Guardant Health (GH) +42.7%.

Which company is more profitable?

Sotera Health (SHC) has the highest net margin (Grail (GRAL) -249.1%, Sotera Health (SHC) 13.4%, Guardant Health (GH) -38.3%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Grail (GRAL) +77.2%, Sotera Health (SHC) +10.7%, Guardant Health (GH) +151.3%. Over five years, Guardant Health (GH) compounded fastest (Sotera Health (SHC) -5.8%/yr, Guardant Health (GH) +8.5%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Grail (GRAL) 111.3%, Sotera Health (SHC) 28.4%, Guardant Health (GH) 57.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GRAL, SHC and GH?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Guardant Health (GH) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.