GRAL vs NTRA vs GH Stock Comparison

Grail, Natera and Guardant Health Prices as of Oct 23, 2026 Peers: Industry group
GRAL GRAIL, Inc.
$132.55 +22.1% 1M +60.4% 1Y
Market cap
$6.04B
P/E
–
Revenue (TTM)
$157.21M
Div. yield
–
Diagnostic Labs Healthcare
NTRA Natera, Inc.
$403.95 +3.4% 1M +107.2% 1Y
Market cap
$58.02B
P/E
–
Revenue (TTM)
$2.71B
Div. yield
–
Diagnostic Labs Healthcare
5 wins
GH Guardant Health, Inc.
$169.08 -4.1% 1M +143.8% 1Y
Market cap
$23.05B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
2 wins

Head to Head

7 decided of 12

Natera leads on 5 of the 12 questions below (Natera 5, Guardant Health 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGRALNTRAGHLeader
Larger companyMarket capitalisation $6.04B $58.02B $23.05B NTRA
Cheaper on earningsLower P/E, profitable companies only -15.4x -301.5x -50.8x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months +17.1% +37.8% +42.7% GH
More profitableNet margin, trailing twelve months -249.1% -7.1% -38.3% NTRA
Better return on capitalReturn on invested capital — -11.7% — –
Less leveragedLower net debt / EBITDA — 4.5x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +60.4% +107.2% +143.8% GH
Better 5-year returnAnnualised price return, 5 years — +28.6%/yr +9.1%/yr NTRA
Less volatileAnnualised volatility, 1 year 111.3% 47.9% 57.4% NTRA
Higher overall scoreMean of the five percentile scores vs peers 42/100 50/100 27/100 NTRA

Percentile Scorecard

GRALNTRAGH

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGRALNTRAGH
Valuation 8 #86 of 93 16 #78 of 93 17 #77 of 93
Growth 58 #38 of 88 71 #26 of 88 48 #46 of 88
Profitability 6 #82 of 87 33 #59 of 87 7 #81 of 87
Financial Health 99 #2 of 100 86 #15 of 100 50 #51 of 100
Shareholder Returns – 44 #32 of 56 15 #48 of 56
Overall 42 50 27
  • GRAL ranked among 103 companies in Healthcare Providers
  • NTRA ranked among 103 companies in Healthcare Providers
  • GH ranked among 103 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGRALNTRAGHSPY
1 month +22.1%+3.4%-4.1% -1.0%
3 months +95.4%+54.2%+14.8% +2.9%
6 months +143.6%+98.3%+90.2% +6.4%
Year to date +54.9%+76.3%+65.5% +11.4%
1 year +60.4%+107.2%+143.8% +13.1%
3 years —+890.3%+541.9% +79.4%
3 years, per year —+114.9%+85.9% +21.5%
5 years —+251.5%+54.6% +67.7%
5 years, per year —+28.6%+9.1% +10.9%
10 years —+3,943.5%— +255.2%
10 years, per year —+44.8%— +13.5%

Risk

MeasureGRALNTRAGHSPY
Volatility, 1Y 111.3%47.9%57.4% 12.7%
Downside volatility, 1Y 125.8%44.1%48.6% 12.7%
Beta vs S&P 500, 1Y 2.621.211.01 1.00
Return / volatility, 1Y 0.542.242.50 1.03
Max drawdown, 5Y -62.9%-76.4%-86.7% -25.4%
From 52-week high -14.0%-5.1%-9.7% -2.5%
52-week high $154.08$425.64$187.22 $779.14
52-week low $43.03$182.65$69.35 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGRALNTRAGH
P/E now vs peer median -14.6xmedian 25.3x -300.8xmedian 25.3x -49.5xmedian 25.3x
P/S now vs peer median 37.7xmedian 1.6x 21.4xmedian 1.6x 19.1xmedian 1.6x
EV/EBITDA now vs peer median -12.5xmedian 14.6x -254.2xmedian 14.6x -49.9xmedian 14.6x
P/FCF now vs peer median -20.0xmedian 22.7x 689.0xmedian 22.7x -93.8xmedian 22.7x
P/B now vs peer median 2.3xmedian 3.3x 31.8xmedian 3.3x -101.4xmedian 3.3x
PEG now vs peer median —median 0.66 -9.07median 0.66 -4.99median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGRALNTRAGH
Revenue $157.21M $2.71B $1.18B
Gross profit $75.51M $1.71B $769.16M
Operating income -$559.25M -$289.67M -$470.26M
Net income -$391.59M -$192.36M -$453.44M
Free cash flow -$296.16M $84.20M -$240.72M
R&D $190.72M $787.38M $375.79M
EPS (diluted) $-9.08 $-1.34 $-3.41
Cash & equivalents $55.65M $1.10B $1.05B
Total debt – $321.26M –
Shares (diluted) 43.11M 143.28M 132.87M
Enterprise value $2.91B $53.70B $19.11B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGRALNTRAGH
P/E -14.6x -300.8x -49.5x
P/FCF -20.0x 689.0x -93.8x
P/Operating cash flow -20.1x 254.2x -122.0x
P/S 37.7x 21.4x 19.1x
P/B 2.3x 31.8x -101.4x
P/Tangible book 7.8x 39.7x -91.0x
EV/EBITDA -12.5x -254.2x -49.9x
EV/EBIT -9.0x -196.7x -45.8x
EV/Revenue 32.2x 21.1x 18.2x
EV/FCF -17.1x 676.9x -89.5x
EV/Operating cash flow -17.2x 249.7x -116.3x
PEG (3Y EPS CAGR) – -9.07 -4.99

Growth

14 metrics
MetricGRALNTRAGH
Revenue growth (1Y) 17.1% 37.8% 42.7%
Revenue CAGR (3Y) – 42.7% 32.4%
Gross profit growth (1Y) 30.2% 43.6% 47.7%
Gross profit CAGR (3Y) – 68.1% –
Operating income growth (1Y) 11.6% 1.3% -2.1%
Operating income CAGR (3Y) – 17.3% 4.8%
Net income growth (1Y) 11.6% 24.0% -9.6%
Net income CAGR (3Y) – 27.8% 3.7%
EPS growth (1Y) 26.6% 27.7% -2.4%
EPS CAGR (3Y) – 33.2% 9.9%
Operating cash flow growth (1Y) 20.3% 22.2% 22.4%
Operating cash flow CAGR (3Y) – 38.6% 18.1%
Free cash flow growth (1Y) 20.3% -26.8% 11.4%
Free cash flow CAGR (3Y) – 30.4% 14.4%

Profitability

14 metrics
MetricGRALNTRAGH
Gross margin 48.0% 63.2% 65.0%
EBITDA margin -257.6% -8.3% -36.5%
Operating margin -355.7% -10.7% -39.7%
Pretax margin -336.8% -9.3% -38.4%
Net margin -249.1% -7.1% -38.3%
FCF margin -188.4% 3.1% -20.3%
Operating cash flow margin -187.5% 8.4% -15.7%
Return on equity -15.5% -10.7% –
Return on assets -13.9% -7.3% -23.7%
Return on invested capital – -11.7% –
Return on capital employed -20.4% -13.9% -29.9%
Asset turnover 0.1x 1.0x 0.6x
Cash conversion (OCF / net income) 0.8x -1.2x 0.4x
Stock comp / revenue 40.9% 14.1% 16.2%

Financial Health

11 metrics
MetricGRALNTRAGH
Debt / assets – 3.0% –
Debt / equity – 0.0x –
Net debt / EBITDA – 4.5x –
Debt / FCF – 1.0x –
Liabilities / assets 10.6% 31.5% 111.7%
Equity / assets 89.4% 68.5% -11.7%
Interest coverage – -75.9x -97.6x
Current ratio 10.9x 3.0x 4.0x
Quick ratio 10.6x 2.8x 3.5x
Cash ratio 10.3x 2.0x 3.1x
Altman Z-score 6.43 41.25 4.44

Shareholder Returns

7 metrics
MetricGRALNTRAGH
Dividend yield – – –
Net buyback yield – -0.1% -1.8%
Shareholder yield – -0.1% -1.8%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGRALNTRAGH
EPS, next fiscal year $-9.20FY2026 $-1.47FY2026 $-3.34FY2026
Revenue, next fiscal year $169.83MFY2026 $3.07BFY2026 $1.42BFY2026
Revenue growth, next FY +15.4%FY2026 +32.8%FY2026 +44.5%FY2026
Revenue growth, the year after +38.0% +6.9% +27.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGRALNTRAGH
Held by institutions 85.4% 95.5% 100.0%
Institutions holding 372 847 594
Change in shares held, QoQ +8.4% +2.7% -2.6%
Institutions buying 182 513 353
Institutions selling 100 240 180
Buyers to sellers 1.82 2.14 1.96

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GRALNTRAGH
GRAL 1.00 0.43 0.41
NTRA 0.43 1.00 0.54
GH 0.41 0.54 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, GRAL, NTRA and GH?

Natera (NTRA) is the largest by market capitalisation: Grail (GRAL) $6.04B, Natera (NTRA) $58.02B, Guardant Health (GH) $23.05B.

Which company is growing faster?

Guardant Health (GH) grew revenue fastest over the trailing twelve months: Grail (GRAL) +17.1%, Natera (NTRA) +37.8%, Guardant Health (GH) +42.7%.

Which company is more profitable?

Natera (NTRA) has the highest net margin (Grail (GRAL) -249.1%, Natera (NTRA) -7.1%, Guardant Health (GH) -38.3%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Grail (GRAL) +60.4%, Natera (NTRA) +107.2%, Guardant Health (GH) +143.8%. Over five years, Natera (NTRA) compounded fastest (Natera (NTRA) +28.6%/yr, Guardant Health (GH) +9.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Natera (NTRA) has been the steadiest (Grail (GRAL) 111.3%, Natera (NTRA) 47.9%, Guardant Health (GH) 57.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GRAL, NTRA and GH?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Natera (NTRA) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.