GILD vs MDGL vs AMGN Stock Comparison

Gilead Sciences, Madrigal Pharmaceuticals and Amgen Prices as of Oct 27, 2026 Peers: Industry group
GILD Gilead Sciences, Inc.
$159.08 +5.4% 1M +32.0% 1Y
Market cap
$197.18B
P/E
–
Revenue (TTM)
$30.46B
Div. yield
–
Biotechnology Healthcare
1 win
AMGN Amgen Inc
$447.95 +8.0% 1M +53.9% 1Y
Market cap
$242.16B
P/E
27.7x
Revenue (TTM)
$38.10B
Div. yield
2.22%
Biotechnology Healthcare
5 wins

Head to Head

9 decided of 12

Amgen leads on 5 of the 12 questions below (Amgen 5, Madrigal Pharmaceuticals 3, Gilead Sciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGILDMDGLAMGNLeader
Larger companyMarket capitalisation $197.18B $12.83B $242.16B AMGN
Cheaper on earningsLower P/E, profitable companies only -60.9x -39.5x 27.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 20.5x –
Faster revenue growthRevenue growth, trailing twelve months +5.5% +149.0% +9.1% MDGL
More profitableNet margin, trailing twelve months -10.6% -25.3% 23.0% AMGN
Better return on capitalReturn on invested capital -6.0% — 14.3% AMGN
Less leveragedLower net debt / EBITDA 87.7x 1.6x 2.7x MDGL
Higher dividend yieldTrailing dividend yield 0.00% — 2.22% –
Better 1-year returnPrice return, last 12 months +32.0% +1.0% +53.9% AMGN
Better 5-year returnAnnualised price return, 5 years +18.8%/yr +41.0%/yr +16.7%/yr MDGL
Less volatileAnnualised volatility, 1 year 26.9% 43.5% 29.6% GILD
Higher overall scoreMean of the five percentile scores vs peers 61/100 66/100 66/100 AMGN

Percentile Scorecard

GILDMDGLAMGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGILDMDGLAMGN
Valuation 90 #61 of 625 74 #163 of 625 86 #90 of 625
Growth 31 #416 of 602 68 #194 of 602 62 #231 of 602
Profitability 85 #83 of 551 74 #144 of 551 95 #31 of 551
Financial Health 21 #516 of 656 41 #389 of 656 22 #510 of 656
Shareholder Returns 77 #86 of 365 75 #91 of 365 68 #117 of 365
Overall 61 66 66
  • GILD ranked among 672 companies in Pharmaceuticals and Biotechnology
  • MDGL ranked among 672 companies in Pharmaceuticals and Biotechnology
  • AMGN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGILDMDGLAMGNSPY
1 month +5.4%-14.8%+8.0% -0.2%
3 months +18.4%-18.3%+14.0% +3.9%
6 months +23.1%-14.8%+31.9% +8.2%
Year to date +29.6%-24.4%+36.9% +12.9%
1 year +32.0%+1.0%+53.9% +12.3%
3 years +107.6%+265.7%+71.3% +87.4%
3 years, per year +27.6%+54.1%+19.7% +23.3%
5 years +136.2%+457.5%+116.2% +67.9%
5 years, per year +18.8%+41.0%+16.7% +10.9%
10 years +109.8%+2,491.7%+179.0% +261.1%
10 years, per year +7.7%+38.5%+10.8% +13.7%

Risk

MeasureGILDMDGLAMGNSPY
Volatility, 1Y 26.9%43.5%29.6% 12.7%
Downside volatility, 1Y 24.0%41.4%27.9% 12.7%
Beta vs S&P 500, 1Y 0.300.300.46 1.00
Return / volatility, 1Y 1.190.021.82 0.97
Max drawdown, 5Y -29.4%-61.4%-26.7% -25.4%
From 52-week high 0.0%-27.0%0.0% -1.2%
52-week high $159.08$602.83$447.95 $779.14
52-week low $117.88$412.35$291.16 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGILDMDGLAMGN
P/E now vs peer median -61.0xmedian 17.2x -39.5xmedian 17.2x 27.7xmedian 17.2x
P/S now vs peer median 6.5xmedian 9.0x 10.0xmedian 9.0x 6.4xmedian 9.0x
EV/EBITDA now vs peer median 838.3xmedian 16.3x -38.6xmedian 16.3x 17.7xmedian 16.3x
P/FCF now vs peer median 15.3xmedian 18.7x -62.2xmedian 18.7x 23.8xmedian 18.7x
P/B now vs peer median 16.7xmedian 2.2x 24.5xmedian 2.2x 20.7xmedian 2.2x
PEG now vs peer median 1.63median 0.33 -2.67median 0.33 10.44median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGILDMDGLAMGN
Revenue $30.46B $1.28B $38.10B
Gross profit $24.24B – $26.48B
Operating income -$2.50B -$322.62M $11.43B
Net income -$3.24B -$325.11M $8.74B
Free cash flow $12.94B -$206.29M $10.18B
R&D $6.07B $490.14M $7.63B
EPS (diluted) $-2.61 $-11.15 $16.07
Cash & equivalents $3.18B $292.73M $13.99B
Total debt $26.25B $340.79M $57.30B
Shares (diluted) 1.24B 29.15M 544.00M
Enterprise value $171.37B $9.09B $197.56B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGILDMDGLAMGN
P/E -61.0x -39.5x 27.7x
P/FCF 15.3x -62.2x 23.8x
P/Operating cash flow 14.6x -64.9x 19.4x
P/S 6.5x 10.0x 6.4x
P/B 16.7x 24.5x 20.7x
P/Tangible book -89.6x 24.8x -27.5x
EV/EBITDA 838.3x -38.6x 17.7x
EV/EBIT -88.3x -38.2x 25.0x
EV/Revenue 7.2x 9.6x 7.5x
EV/FCF 17.0x -59.8x 28.1x
EV/Operating cash flow 16.3x -62.4x 22.9x
PEG (3Y EPS CAGR) 1.63 -2.67 10.44

Growth

14 metrics
MetricGILDMDGLAMGN
Revenue growth (1Y) 5.5% 149.0% 9.1%
Revenue CAGR (3Y) 3.6% – 12.7%
Gross profit growth (1Y) 6.9% – 17.6%
Gross profit CAGR (3Y) 3.7% – 10.3%
Operating income growth (1Y) -131.0% -4.1% 39.5%
Operating income CAGR (3Y) -31.9% 0.8% 6.4%
Net income growth (1Y) -151.3% -15.3% 32.1%
Net income CAGR (3Y) -37.3% 0.5% 3.1%
EPS growth (1Y) -151.8% 12.1% 31.4%
EPS CAGR (3Y) -37.5% 14.8% 2.7%
Operating cash flow growth (1Y) 37.3% 35.7% 3.9%
Operating cash flow CAGR (3Y) 12.5% 10.6% 4.9%
Free cash flow growth (1Y) 38.1% 33.1% -4.1%
Free cash flow CAGR (3Y) 13.2% 9.4% 1.7%

Profitability

14 metrics
MetricGILDMDGLAMGN
Gross margin 79.6% – 69.5%
EBITDA margin 0.9% -24.9% 42.2%
Operating margin -8.2% -25.1% 30.0%
Pretax margin -6.4% -24.8% 27.0%
Net margin -10.6% -25.3% 23.0%
FCF margin 42.5% -16.1% 26.7%
Operating cash flow margin 44.5% -15.4% 32.8%
Return on equity -18.4% -59.8% 83.8%
Return on assets -6.1% -25.8% 9.3%
Return on invested capital -6.0% – 14.3%
Return on capital employed -6.0% -37.4% 16.7%
Asset turnover 0.6x 1.0x 0.4x
Cash conversion (OCF / net income) -4.2x 0.6x 1.4x
Stock comp / revenue 3.0% 9.5% 1.3%

Financial Health

11 metrics
MetricGILDMDGLAMGN
Debt / assets 53.2% 27.4% 59.9%
Debt / equity 2.2x 0.7x 4.9x
Net debt / EBITDA 87.7x 1.6x 2.7x
Debt / FCF 2.0x -1.7x 5.6x
Liabilities / assets 76.0% 57.9% 87.8%
Equity / assets 24.0% 42.1% 12.2%
Interest coverage -2.5x -10.2x 4.3x
Current ratio 1.3x 3.2x 1.4x
Quick ratio 0.7x 2.8x 0.9x
Cash ratio 0.3x 2.2x 0.5x
Altman Z-score 3.74 9.13 2.32

Shareholder Returns

7 metrics
MetricGILDMDGLAMGN
Dividend yield 2.0% – 2.2%
Net buyback yield 0.6% -0.3% –
Shareholder yield 2.6% -0.3% 2.2%
Payout ratio (earnings) – – 60.4%
Payout ratio (FCF) – – 51.9%
Dividend growth (1Y) – – 6.3%
Dividend CAGR (3Y) – – 6.7%

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGILDMDGLAMGN
Forward P/E – – 20.5xFY2026
EPS, next fiscal year $-0.39FY2026 $-6.25FY2026 $21.81FY2026
EPS growth, next FY -104.8%FY2026 – -0.1%FY2026
EPS growth, the year after – – +7.2%
Revenue, next fiscal year $28.65BFY2026 $1.46BFY2026 $41.51BFY2026
Revenue growth, next FY -2.7%FY2026 +52.7%FY2026 +12.9%FY2026
Revenue growth, the year after +18.1% +36.3% +2.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGILDMDGLAMGN
Held by institutions 89.6% 80.9% 82.7%
Institutions holding 2,290 412 3,159
Change in shares held, QoQ +5.1% -0.6% +4.5%
Institutions buying 1,113 225 1,451
Institutions selling 850 128 1,217
Buyers to sellers 1.31 1.76 1.19

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GILDMDGLAMGN
GILD 1.00 0.19 0.52
MDGL 0.19 1.00 0.24
AMGN 0.52 0.24 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, GILD, MDGL and AMGN?

Amgen (AMGN) is the largest by market capitalisation: Gilead Sciences (GILD) $197.18B, Madrigal Pharmaceuticals (MDGL) $12.83B, Amgen (AMGN) $242.16B.

Which company is growing faster?

Madrigal Pharmaceuticals (MDGL) grew revenue fastest over the trailing twelve months: Gilead Sciences (GILD) +5.5%, Madrigal Pharmaceuticals (MDGL) +149.0%, Amgen (AMGN) +9.1%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Gilead Sciences (GILD) -10.6%, Madrigal Pharmaceuticals (MDGL) -25.3%, Amgen (AMGN) 23.0%). On return on invested capital, Amgen (AMGN) leads (Gilead Sciences (GILD) -6.0%, Amgen (AMGN) 14.3%).

Which stock has performed better?

Over the past year Amgen (AMGN) returned the most: Gilead Sciences (GILD) +32.0%, Madrigal Pharmaceuticals (MDGL) +1.0%, Amgen (AMGN) +53.9%. Over five years, Madrigal Pharmaceuticals (MDGL) compounded fastest (Gilead Sciences (GILD) +18.8%/yr, Madrigal Pharmaceuticals (MDGL) +41.0%/yr, Amgen (AMGN) +16.7%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Gilead Sciences (GILD) 0.00%, Amgen (AMGN) 2.22%. Gilead Sciences (GILD) and Madrigal Pharmaceuticals (MDGL) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Gilead Sciences (GILD) has been the steadiest (Gilead Sciences (GILD) 26.9%, Madrigal Pharmaceuticals (MDGL) 43.5%, Amgen (AMGN) 29.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GILD, MDGL and AMGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.