GH vs SHC vs YDES Stock Comparison

Guardant Health, Sotera Health and YD Bio Prices as of Oct 27, 2026 Peers: Industry group
GH Guardant Health, Inc.
$178.06 +0.5% 1M +151.3% 1Y
Market cap
$23.79B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
4 wins
SHC Sotera Health Co
$18.49 +0.8% 1M +10.7% 1Y
Market cap
$5.28B
P/E
32.3x
Revenue (TTM)
$1.22B
Div. yield
–
Diagnostic Labs Healthcare
3 wins
YDES YD Bio Ltd
$6.04 +5.4% 1M -64.7% 1Y
Market cap
$427.57M
P/E
–
Revenue (TTM)
—
Div. yield
–
Biotechnology Healthcare

Head to Head

7 decided of 12

Guardant Health leads on 4 of the 12 questions below (Guardant Health 4, Sotera Health 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGHSHCYDESLeader
Larger companyMarket capitalisation $23.79B $5.28B $427.57M GH
Cheaper on earningsLower P/E, profitable companies only -52.2x 32.3x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 20.1x — –
Faster revenue growthRevenue growth, trailing twelve months +42.7% +8.1% — GH
More profitableNet margin, trailing twelve months -38.3% 13.4% — SHC
Better return on capitalReturn on invested capital — 9.1% — –
Less leveragedLower net debt / EBITDA — 3.3x — –
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +151.3% +10.7% -64.7% GH
Better 5-year returnAnnualised price return, 5 years +8.5%/yr -5.8%/yr -9.8%/yr GH
Less volatileAnnualised volatility, 1 year 57.4% 28.4% 134.9% SHC
Higher overall scoreMean of the five percentile scores vs peers 28/100 59/100 — SHC

Percentile Scorecard

GHSHCYDES

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGHSHCYDES
Valuation 18 #76 of 92 52 #45 of 92 –
Growth 49 #45 of 87 66 #30 of 87 –
Profitability 7 #80 of 86 82 #16 of 86 –
Financial Health 52 #47 of 97 37 #62 of 97 39 #403 of 656
Shareholder Returns 15 #48 of 56 – –
Overall 28 59 –
  • GH ranked among 102 companies in Healthcare Providers
  • SHC ranked among 102 companies in Healthcare Providers
  • YDES ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGHSHCYDESSPY
1 month +0.5%+0.8%+5.4% -0.2%
3 months +24.0%+4.1%+162.6% +3.9%
6 months +114.3%+19.0%+16.2% +8.2%
Year to date +74.3%+4.8%-50.5% +12.9%
1 year +151.3%+10.7%-64.7% +12.3%
3 years +613.4%+47.8%-45.1% +87.4%
3 years, per year +92.6%+13.9%-18.1% +23.3%
5 years +50.7%-25.6%-40.4% +67.9%
5 years, per year +8.5%-5.8%-9.8% +10.9%

Risk

MeasureGHSHCYDESSPY
Volatility, 1Y 57.4%28.4%134.9% 12.7%
Downside volatility, 1Y 48.7%27.0%132.8% 12.7%
Beta vs S&P 500, 1Y 1.031.010.35 1.00
Return / volatility, 1Y 2.640.38-0.48 0.97
Max drawdown, 5Y -86.7%-78.2%-91.8% -25.4%
From 52-week high -4.9%-5.5%-64.7% -1.2%
52-week high $187.22$19.57$17.11 $779.14
52-week low $69.58$13.13$1.90 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGHSHCYDES
P/E now vs peer median -52.2xmedian 24.6x 32.3xmedian 24.6x —median 17.2x
P/S now vs peer median 20.1xmedian 1.6x 4.3xmedian 1.6x —median 9.0x
EV/EBITDA now vs peer median -52.7xmedian 14.6x 13.0xmedian 14.6x —median 16.3x
P/FCF now vs peer median -98.8xmedian 21.6x 46.8xmedian 21.6x —median 18.7x
P/B now vs peer median -106.8xmedian 3.2x 7.9xmedian 3.2x 95.6xmedian 2.2x
PEG now vs peer median -5.25median 0.66 0.86median 0.66 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGHSHCYDES
Revenue $1.18B $1.22B –
Gross profit $769.16M $668.51M –
Operating income -$470.26M $411.34M –
Net income -$453.44M $163.48M –
Free cash flow -$240.72M $112.70M –
R&D $375.79M – –
EPS (diluted) $-3.41 $0.57 –
Cash & equivalents $1.05B $356.72M $2.66M
Total debt – $2.14B –
Shares (diluted) 132.87M 288.15M 66.72M
Enterprise value $19.85B $3.96B $415.30M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGHSHCYDES
P/E -52.2x 32.3x –
P/FCF -98.8x 46.8x –
P/Operating cash flow -128.5x 18.1x –
P/S 20.1x 4.3x –
P/B -106.8x 7.9x 95.6x
P/Tangible book -95.9x 13.3x 213.8x
EV/EBITDA -52.7x 13.0x –
EV/EBIT -48.4x 17.2x –
EV/Revenue 19.2x 5.8x –
EV/FCF -94.5x 62.6x –
EV/Operating cash flow -122.8x 24.2x –
PEG (3Y EPS CAGR) -5.25 0.86 –

Growth

14 metrics
MetricGHSHCYDES
Revenue growth (1Y) 42.7% 8.1% –
Revenue CAGR (3Y) 32.4% 7.6% –
Gross profit growth (1Y) 47.7% 7.1% –
Gross profit CAGR (3Y) – 8.1% –
Operating income growth (1Y) -2.1% 21.8% –
Operating income CAGR (3Y) 4.8% 23.2% –
Net income growth (1Y) -9.6% 580.5% –
Net income CAGR (3Y) 3.7% 37.7% –
EPS growth (1Y) -2.4% 574.9% –
EPS CAGR (3Y) 9.9% 37.5% –
Operating cash flow growth (1Y) 22.4% 9.8% –
Operating cash flow CAGR (3Y) 18.1% 61.3% –
Free cash flow growth (1Y) 11.4% 0.0% –
Free cash flow CAGR (3Y) 14.4% 32.6% –

Profitability

14 metrics
MetricGHSHCYDES
Gross margin 65.0% 55.0% –
EBITDA margin -36.5% 44.6% –
Operating margin -39.7% 33.8% –
Pretax margin -38.4% 21.7% –
Net margin -38.3% 13.4% –
FCF margin -20.3% 9.3% –
Operating cash flow margin -15.7% 24.0% –
Return on equity – 25.4% –
Return on assets -23.7% 5.0% –
Return on invested capital – 9.1% –
Return on capital employed -29.9% 13.5% –
Asset turnover 0.6x 0.4x –
Cash conversion (OCF / net income) 0.4x 1.8x –
Stock comp / revenue 16.2% 3.1% –

Financial Health

11 metrics
MetricGHSHCYDES
Debt / assets – 64.7% –
Debt / equity – 3.2x –
Net debt / EBITDA – 3.3x –
Debt / FCF – 19.0x –
Liabilities / assets 111.7% 79.9% 55.5%
Equity / assets -11.7% 20.1% 44.5%
Interest coverage -97.6x – –
Current ratio 4.0x 2.8x 5.2x
Quick ratio 3.5x 2.4x 2.7x
Cash ratio 3.1x 1.5x 2.5x
Altman Z-score 4.77 1.94 –

Shareholder Returns

7 metrics
MetricGHSHCYDES
Dividend yield – – –
Net buyback yield -1.7% – –
Shareholder yield -1.7% – –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGHSHCYDES
Forward P/E – 20.1xFY2026 –
EPS, next fiscal year $-3.33FY2026 $0.92FY2026 –
EPS growth, next FY – +7.0%FY2026 –
EPS growth, the year after – +21.7% –
Revenue, next fiscal year $1.42BFY2026 $1.33BFY2026 –
Revenue growth, next FY +44.5%FY2026 +14.8%FY2026 –
Revenue growth, the year after +27.0% -4.2% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGHSHCYDES
Held by institutions 100.0% 100.0% –
Institutions holding 594 316 –
Change in shares held, QoQ -2.6% +5.9% –
Institutions buying 353 220 –
Institutions selling 180 64 –
Buyers to sellers 1.96 3.44 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GHSHCYDES
GH 1.00 0.28 -0.09
SHC 0.28 1.00 -0.01
YDES -0.09 -0.01 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, GH, SHC and YDES?

Guardant Health (GH) is the largest by market capitalisation: Guardant Health (GH) $23.79B, Sotera Health (SHC) $5.28B, YD Bio (YDES) $427.57M.

Which company is growing faster?

Guardant Health (GH) grew revenue fastest over the trailing twelve months: Guardant Health (GH) +42.7%, Sotera Health (SHC) +8.1%.

Which company is more profitable?

Sotera Health (SHC) has the highest net margin (Guardant Health (GH) -38.3%, Sotera Health (SHC) 13.4%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Guardant Health (GH) +151.3%, Sotera Health (SHC) +10.7%, YD Bio (YDES) -64.7%. Over five years, Guardant Health (GH) compounded fastest (Guardant Health (GH) +8.5%/yr, Sotera Health (SHC) -5.8%/yr, YD Bio (YDES) -9.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Guardant Health (GH) 57.4%, Sotera Health (SHC) 28.4%, YD Bio (YDES) 134.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GH, SHC and YDES?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Guardant Health (GH) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.