GH vs CSTL vs SHC Stock Comparison

Guardant Health, Castle Biosciences and Sotera Health Prices as of Oct 27, 2026 Peers: Industry group
GH Guardant Health, Inc.
$178.06 +0.5% 1M +151.3% 1Y
Market cap
$23.79B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
4 wins
SHC Sotera Health Co
$18.49 +0.8% 1M +10.7% 1Y
Market cap
$5.28B
P/E
32.3x
Revenue (TTM)
$1.22B
Div. yield
–
Diagnostic Labs Healthcare
5 wins

Head to Head

9 decided of 12

Sotera Health leads on 5 of the 12 questions below (Sotera Health 5, Guardant Health 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGHCSTLSHCLeader
Larger companyMarket capitalisation $23.79B $1.05B $5.28B GH
Cheaper on earningsLower P/E, profitable companies only -52.2x -54.0x 32.3x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 20.1x –
Faster revenue growthRevenue growth, trailing twelve months +42.7% +3.2% +8.1% GH
More profitableNet margin, trailing twelve months -38.3% -5.4% 13.4% SHC
Better return on capitalReturn on invested capital — -6.7% 9.1% SHC
Less leveragedLower net debt / EBITDA — 15.5x 3.3x SHC
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +151.3% +44.0% +10.7% GH
Better 5-year returnAnnualised price return, 5 years +8.5%/yr -11.6%/yr -5.8%/yr GH
Less volatileAnnualised volatility, 1 year 57.4% 58.3% 28.4% SHC
Higher overall scoreMean of the five percentile scores vs peers 28/100 50/100 59/100 SHC

Percentile Scorecard

GHCSTLSHC

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGHCSTLSHC
Valuation 18 #76 of 92 47 #49 of 92 52 #45 of 92
Growth 49 #45 of 87 52 #42 of 87 66 #30 of 87
Profitability 7 #80 of 86 39 #53 of 86 82 #16 of 86
Financial Health 52 #47 of 97 92 #9 of 97 37 #62 of 97
Shareholder Returns 15 #48 of 56 20 #45 of 56 –
Overall 28 50 59
  • GH ranked among 102 companies in Healthcare Providers
  • CSTL ranked among 102 companies in Healthcare Providers
  • SHC ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGHCSTLSHCSPY
1 month +0.5%-3.6%+0.8% -0.2%
3 months +24.0%+44.5%+4.1% +3.9%
6 months +114.3%+39.8%+19.0% +8.2%
Year to date +74.3%-11.3%+4.8% +12.9%
1 year +151.3%+44.0%+10.7% +12.3%
3 years +613.4%+164.2%+47.8% +87.4%
3 years, per year +92.6%+38.3%+13.9% +23.3%
5 years +50.7%-46.0%-25.6% +67.9%
5 years, per year +8.5%-11.6%-5.8% +10.9%

Risk

MeasureGHCSTLSHCSPY
Volatility, 1Y 57.4%58.3%28.4% 12.7%
Downside volatility, 1Y 48.7%61.4%27.0% 12.7%
Beta vs S&P 500, 1Y 1.030.961.01 1.00
Return / volatility, 1Y 2.640.760.38 0.97
Max drawdown, 5Y -86.7%-82.1%-78.2% -25.4%
From 52-week high -4.9%-19.8%-5.5% -1.2%
52-week high $187.22$43.04$19.57 $779.14
52-week low $69.58$18.15$13.13 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGHCSTLSHC
P/E now vs peer median -52.2xmedian 24.6x -54.0xmedian 24.6x 32.3xmedian 24.6x
P/S now vs peer median 20.1xmedian 1.6x 2.9xmedian 1.6x 4.3xmedian 1.6x
EV/EBITDA now vs peer median -52.7xmedian 14.6x -48.2xmedian 14.6x 13.0xmedian 14.6x
P/FCF now vs peer median -98.8xmedian 21.6x -2,153xmedian 21.6x 46.8xmedian 21.6x
P/B now vs peer median -106.8xmedian 3.2x 2.2xmedian 3.2x 7.9xmedian 3.2x
PEG now vs peer median -5.25median 0.66 -1.28median 0.66 0.86median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGHCSTLSHC
Revenue $1.18B $357.28M $1.22B
Gross profit $769.16M $276.03M $668.51M
Operating income -$470.26M -$32.11M $411.34M
Net income -$453.44M -$19.42M $163.48M
Free cash flow -$240.72M -$489.00K $112.70M
R&D $375.79M $55.45M –
EPS (diluted) $-3.41 $-0.64 $0.57
Cash & equivalents $1.05B $62.12M $356.72M
Total debt – $10.08M $2.14B
Shares (diluted) 132.87M 30.40M 288.15M
Enterprise value $19.85B -$62.79M $3.96B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGHCSTLSHC
P/E -52.2x -54.0x 32.3x
P/FCF -98.8x -2,153x 46.8x
P/Operating cash flow -128.5x 24.7x 18.1x
P/S 20.1x 2.9x 4.3x
P/B -106.8x 2.2x 7.9x
P/Tangible book -95.9x 2.2x 13.3x
EV/EBITDA -52.7x -48.2x 13.0x
EV/EBIT -48.4x -24.8x 17.2x
EV/Revenue 19.2x 2.2x 5.8x
EV/FCF -94.5x -1,628x 62.6x
EV/Operating cash flow -122.8x 18.7x 24.2x
PEG (3Y EPS CAGR) -5.25 -1.28 0.86

Growth

14 metrics
MetricGHCSTLSHC
Revenue growth (1Y) 42.7% 3.2% 8.1%
Revenue CAGR (3Y) 32.4% 28.7% 7.6%
Gross profit growth (1Y) 47.7% -1.6% 7.1%
Gross profit CAGR (3Y) – 29.2% 8.1%
Operating income growth (1Y) -2.1% -39.3% 21.8%
Operating income CAGR (3Y) 4.8% 30.8% 23.2%
Net income growth (1Y) -9.6% -105.1% 580.5%
Net income CAGR (3Y) 3.7% 39.8% 37.7%
EPS growth (1Y) -2.4% -99.3% 574.9%
EPS CAGR (3Y) 9.9% 42.3% 37.5%
Operating cash flow growth (1Y) 22.4% -31.8% 9.8%
Operating cash flow CAGR (3Y) 18.1% 45.1% 61.3%
Free cash flow growth (1Y) 11.4% -101.4% 0.0%
Free cash flow CAGR (3Y) 14.4% 78.8% 32.6%

Profitability

14 metrics
MetricGHCSTLSHC
Gross margin 65.0% 77.3% 55.0%
EBITDA margin -36.5% -4.6% 44.6%
Operating margin -39.7% -9.0% 33.8%
Pretax margin -38.4% -5.4% 21.7%
Net margin -38.3% -5.4% 13.4%
FCF margin -20.3% -0.1% 9.3%
Operating cash flow margin -15.7% 11.9% 24.0%
Return on equity – -4.2% 25.4%
Return on assets -23.7% -3.5% 5.0%
Return on invested capital – -6.7% 9.1%
Return on capital employed -29.9% -6.4% 13.5%
Asset turnover 0.6x 0.6x 0.4x
Cash conversion (OCF / net income) 0.4x -2.2x 1.8x
Stock comp / revenue 16.2% 12.6% 3.1%

Financial Health

11 metrics
MetricGHCSTLSHC
Debt / assets – 1.8% 64.7%
Debt / equity – 0.0x 3.2x
Net debt / EBITDA – 15.5x 3.3x
Debt / FCF – -20.6x 19.0x
Liabilities / assets 111.7% 16.2% 79.9%
Equity / assets -11.7% 83.8% 20.1%
Interest coverage -97.6x -85.6x –
Current ratio 4.0x 6.0x 2.8x
Quick ratio 3.5x 5.6x 2.4x
Cash ratio 3.1x 4.7x 1.5x
Altman Z-score 4.77 7.39 1.94

Shareholder Returns

7 metrics
MetricGHCSTLSHC
Dividend yield – – –
Net buyback yield -1.7% -0.5% –
Shareholder yield -1.7% -0.5% –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGHCSTLSHC
Forward P/E – – 20.1xFY2026
EPS, next fiscal year $-3.33FY2026 $-1.31FY2026 $0.92FY2026
EPS growth, next FY – – +7.0%FY2026
EPS growth, the year after – – +21.7%
Revenue, next fiscal year $1.42BFY2026 $385.85MFY2026 $1.33BFY2026
Revenue growth, next FY +44.5%FY2026 +12.1%FY2026 +14.8%FY2026
Revenue growth, the year after +27.0% +2.3% -4.2%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGHCSTLSHC
Held by institutions 100.0% 89.6% 100.0%
Institutions holding 594 177 316
Change in shares held, QoQ -2.6% -1.0% +5.9%
Institutions buying 353 104 220
Institutions selling 180 55 64
Buyers to sellers 1.96 1.89 3.44

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GHCSTLSHC
GH 1.00 0.45 0.28
CSTL 0.45 1.00 0.33
SHC 0.28 0.33 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, GH, CSTL and SHC?

Guardant Health (GH) is the largest by market capitalisation: Guardant Health (GH) $23.79B, Castle Biosciences (CSTL) $1.05B, Sotera Health (SHC) $5.28B.

Which company is growing faster?

Guardant Health (GH) grew revenue fastest over the trailing twelve months: Guardant Health (GH) +42.7%, Castle Biosciences (CSTL) +3.2%, Sotera Health (SHC) +8.1%.

Which company is more profitable?

Sotera Health (SHC) has the highest net margin (Guardant Health (GH) -38.3%, Castle Biosciences (CSTL) -5.4%, Sotera Health (SHC) 13.4%). On return on invested capital, Sotera Health (SHC) leads (Castle Biosciences (CSTL) -6.7%, Sotera Health (SHC) 9.1%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Guardant Health (GH) +151.3%, Castle Biosciences (CSTL) +44.0%, Sotera Health (SHC) +10.7%. Over five years, Guardant Health (GH) compounded fastest (Guardant Health (GH) +8.5%/yr, Castle Biosciences (CSTL) -11.6%/yr, Sotera Health (SHC) -5.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Guardant Health (GH) 57.4%, Castle Biosciences (CSTL) 58.3%, Sotera Health (SHC) 28.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GH, CSTL and SHC?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sotera Health (SHC) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.