GH vs BNR vs CSTL Stock Comparison

Guardant Health, Burning Rock Biotech and Castle Biosciences Prices as of Oct 26, 2026 Peers: Industry group
GH Guardant Health, Inc.
$173.25 -2.3% 1M +140.1% 1Y
Market cap
$23.15B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
5 wins
BNR Burning Rock Biotech Ltd
$11.15 -40.1% 1M -14.6% 1Y
Market cap
$117.28M
P/E
–
Revenue (TTM)
$72.00M
Div. yield
–
Diagnostic Labs Healthcare
1 win
CSTL Castle Biosciences Inc
$33.30 -7.0% 1M +35.9% 1Y
Market cap
$1.02B
P/E
–
Revenue (TTM)
$357.28M
Div. yield
–
Diagnostic Labs Healthcare
2 wins

Head to Head

8 decided of 12

Guardant Health leads on 5 of the 12 questions below (Guardant Health 5, Castle Biosciences 2, Burning Rock Biotech 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionGHBNRCSTLLeader
Larger companyMarket capitalisation $23.15B $117.28M $1.02B GH
Cheaper on earningsLower P/E, profitable companies only -50.8x -10.1x -52.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 3.3x — –
Faster revenue growthRevenue growth, trailing twelve months +42.7% -3.9% +3.2% GH
More profitableNet margin, trailing twelve months -38.3% -13.6% -5.4% CSTL
Better return on capitalReturn on invested capital — -12.3% -6.7% CSTL
Less leveragedLower net debt / EBITDA — — 15.5x –
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +140.1% -14.6% +35.9% GH
Better 5-year returnAnnualised price return, 5 years +9.1%/yr -40.0%/yr -11.3%/yr GH
Less volatileAnnualised volatility, 1 year 57.4% 127.9% 58.3% GH
Higher overall scoreMean of the five percentile scores vs peers 26/100 62/100 49/100 BNR

Percentile Scorecard

GHBNRCSTL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisGHBNRCSTL
Valuation 30 #20 of 28 37 #18 of 28 56 #13 of 28
Growth 35 #16 of 24 87 #4 of 24 39 #15 of 24
Profitability 5 #21 of 22 33 #15 of 22 48 #12 of 22
Financial Health 59 #15 of 35 91 #4 of 35 94 #3 of 35
Shareholder Returns 0 #11 of 11 – 10 #10 of 11
Overall 26 62 49
  • GH ranked among 36 companies in Healthcare Providers
  • BNR ranked among 36 companies in Healthcare Providers
  • CSTL ranked among 36 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodGHBNRCSTLSPY
1 month -2.3%-40.1%-7.0% -0.8%
3 months +19.1%+18.6%+36.3% +3.5%
6 months +95.8%-41.5%+33.3% +7.0%
Year to date +69.6%-44.7%-14.4% +12.2%
1 year +140.1%-14.6%+35.9% +13.0%
3 years +594.1%+5.7%+155.0% +86.3%
3 years, per year +90.8%+1.9%+36.6% +23.1%
5 years +54.3%-92.2%-45.2% +68.6%
5 years, per year +9.1%-40.0%-11.3% +11.0%

Risk

MeasureGHBNRCSTLSPY
Volatility, 1Y 57.4%127.9%58.3% 12.7%
Downside volatility, 1Y 48.7%125.5%61.4% 12.7%
Beta vs S&P 500, 1Y 1.021.980.95 1.00
Return / volatility, 1Y 2.44-0.110.61 1.02
Max drawdown, 5Y -86.7%-98.6%-82.1% -25.4%
From 52-week high -7.5%-72.8%-22.6% -1.8%
52-week high $187.22$41.06$43.04 $779.14
52-week low $69.58$7.04$18.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleGHBNRCSTL
P/E now vs peer median -50.8xmedian 17.7x -10.1xmedian 17.7x -52.1xmedian 17.7x
P/S now vs peer median 19.6xmedian 1.3x 1.6xmedian 1.3x 2.8xmedian 1.3x
EV/EBITDA now vs peer median -51.2xmedian 17.4x —median 17.4x -46.0xmedian 17.4x
P/FCF now vs peer median -96.2xmedian 24.8x -60.6xmedian 24.8x -2,078xmedian 24.8x
P/B now vs peer median -103.9xmedian 2.7x 1.6xmedian 2.7x 2.2xmedian 2.7x
PEG now vs peer median -5.11median 0.58 -0.18median 0.58 -1.23median 0.58

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsGHBNRCSTL
Revenue $1.18B $72.00M $357.28M
Gross profit $769.16M $53.66M $276.03M
Operating income -$470.26M -$9.36M -$32.11M
Net income -$453.44M -$11.22M -$19.42M
Free cash flow -$240.72M -$1.93M -$489.00K
R&D $375.79M $19.39M $55.45M
EPS (diluted) $-3.41 $-0.92 $-0.64
Cash & equivalents $1.05B $61.43M $62.12M
Total debt – $1.09M $10.08M
Shares (diluted) 132.87M 10.63M 30.40M
Enterprise value $19.21B -$142.37M -$99.71M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricGHBNRCSTL
P/E -50.8x -10.1x -52.1x
P/FCF -96.2x -60.6x -2,078x
P/Operating cash flow -125.0x -60.6x 23.8x
P/S 19.6x 1.6x 2.8x
P/B -103.9x 1.6x 2.2x
P/Tangible book -93.3x 1.6x 2.2x
EV/EBITDA -51.2x – -46.0x
EV/EBIT -47.0x -6.0x -23.6x
EV/Revenue 18.7x 0.8x 2.1x
EV/FCF -91.8x -29.0x -1,553x
EV/Operating cash flow -119.3x -29.0x 17.8x
PEG (3Y EPS CAGR) -5.11 -0.18 -1.23

Growth

14 metrics
MetricGHBNRCSTL
Revenue growth (1Y) 42.7% -3.9% 3.2%
Revenue CAGR (3Y) 32.4% -4.7% 28.7%
Gross profit growth (1Y) 47.7% -0.7% -1.6%
Gross profit CAGR (3Y) – -2.7% 29.2%
Operating income growth (1Y) -2.1% 54.6% -39.3%
Operating income CAGR (3Y) 4.8% 56.1% 30.8%
Net income growth (1Y) -9.6% 43.6% -105.1%
Net income CAGR (3Y) 3.7% 52.7% 39.8%
EPS growth (1Y) -2.4% 51.7% -99.3%
EPS CAGR (3Y) 9.9% 55.6% 42.3%
Operating cash flow growth (1Y) 22.4% 92.5% -31.8%
Operating cash flow CAGR (3Y) 18.1% 67.4% 45.1%
Free cash flow growth (1Y) 11.4% 86.5% -101.4%
Free cash flow CAGR (3Y) 14.4% 67.4% 78.8%

Profitability

14 metrics
MetricGHBNRCSTL
Gross margin 65.0% 74.5% 77.3%
EBITDA margin -36.5% – -4.6%
Operating margin -39.7% -13.0% -9.0%
Pretax margin -38.4% -13.3% -5.4%
Net margin -38.3% -13.6% -5.4%
FCF margin -20.3% -2.7% -0.1%
Operating cash flow margin -15.7% -2.7% 11.9%
Return on equity – -15.1% -4.2%
Return on assets -23.7% -10.0% -3.5%
Return on invested capital – -12.3% -6.7%
Return on capital employed -29.9% -11.7% -6.4%
Asset turnover 0.6x 0.6x 0.6x
Cash conversion (OCF / net income) 0.4x 0.2x -2.2x
Stock comp / revenue 16.2% – 12.6%

Financial Health

11 metrics
MetricGHBNRCSTL
Debt / assets – 0.2% 1.8%
Debt / equity – 0.0x 0.0x
Net debt / EBITDA – – 15.5x
Debt / FCF – -0.1x -20.6x
Liabilities / assets 111.7% 33.8% 16.2%
Equity / assets -11.7% 66.2% 83.8%
Interest coverage -97.6x – -85.6x
Current ratio 4.0x 3.1x 6.0x
Quick ratio 3.5x 2.8x 5.6x
Cash ratio 3.1x 1.9x 4.7x
Altman Z-score 4.59 -5.04 7.14

Shareholder Returns

7 metrics
MetricGHBNRCSTL
Dividend yield – – –
Net buyback yield -1.7% – -0.6%
Shareholder yield -1.7% – -0.6%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusGHBNRCSTL
Forward P/E – 3.3xFY2026 –
EPS, next fiscal year $-3.34FY2026 $3.38FY2026 $-1.31FY2026
Revenue, next fiscal year $1.42BFY2026 $171.24MFY2026 $385.85MFY2026
Revenue growth, next FY +44.5%FY2026 +121.9%FY2026 +12.1%FY2026
Revenue growth, the year after +27.0% – +2.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersGHBNRCSTL
Held by institutions 100.0% 16.5% 89.6%
Institutions holding 594 17 177
Change in shares held, QoQ -2.6% +1.5% -1.0%
Institutions buying 353 9 104
Institutions selling 180 4 55
Buyers to sellers 1.96 2.25 1.89

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

GHBNRCSTL
GH 1.00 0.02 0.44
BNR 0.02 1.00 0.06
CSTL 0.44 0.06 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, GH, BNR and CSTL?

Guardant Health (GH) is the largest by market capitalisation: Guardant Health (GH) $23.15B, Burning Rock Biotech (BNR) $117.28M, Castle Biosciences (CSTL) $1.02B.

Which company is growing faster?

Guardant Health (GH) grew revenue fastest over the trailing twelve months: Guardant Health (GH) +42.7%, Burning Rock Biotech (BNR) -3.9%, Castle Biosciences (CSTL) +3.2%.

Which company is more profitable?

Castle Biosciences (CSTL) has the highest net margin (Guardant Health (GH) -38.3%, Burning Rock Biotech (BNR) -13.6%, Castle Biosciences (CSTL) -5.4%). On return on invested capital, Castle Biosciences (CSTL) leads (Burning Rock Biotech (BNR) -12.3%, Castle Biosciences (CSTL) -6.7%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Guardant Health (GH) +140.1%, Burning Rock Biotech (BNR) -14.6%, Castle Biosciences (CSTL) +35.9%. Over five years, Guardant Health (GH) compounded fastest (Guardant Health (GH) +9.1%/yr, Burning Rock Biotech (BNR) -40.0%/yr, Castle Biosciences (CSTL) -11.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Guardant Health (GH) has been the steadiest (Guardant Health (GH) 57.4%, Burning Rock Biotech (BNR) 127.9%, Castle Biosciences (CSTL) 58.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, GH, BNR and CSTL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Guardant Health (GH) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.