DNA vs TMO vs ICLR Stock Comparison

Ginkgo Bioworks Holdings, Thermo Fisher Scientific and Icon Prices as of Oct 27, 2026 Peers: Industry group
ICLR Icon Plc
$182.98 +6.2% 1M +0.5% 1Y
Market cap
$14.01B
P/E
32.0x
Revenue (TTM)
$8.23B
Div. yield
–
Contract Research Healthcare
4 wins

Head to Head

9 decided of 12

Thermo Fisher Scientific leads on 5 of the 12 questions below (Thermo Fisher Scientific 5, Icon 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionDNATMOICLRLeader
Larger companyMarket capitalisation $718.02M $256.36B $14.01B TMO
Cheaper on earningsLower P/E, profitable companies only -2.4x 36.4x 32.0x ICLR
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 26.8x 17.9x ICLR
Faster revenue growthRevenue growth, trailing twelve months -46.8% +8.3% +1.8% TMO
More profitableNet margin, trailing twelve months -260.0% — 5.4% ICLR
Better return on capitalReturn on invested capital — — 4.7% –
Less leveragedLower net debt / EBITDA — — 2.3x –
Higher dividend yieldTrailing dividend yield — 0.27% — –
Better 1-year returnPrice return, last 12 months -15.8% +23.0% +0.5% TMO
Better 5-year returnAnnualised price return, 5 years -54.4%/yr +2.3%/yr -8.6%/yr TMO
Less volatileAnnualised volatility, 1 year 101.5% 29.8% 73.7% TMO
Higher overall scoreMean of the five percentile scores vs peers 43/100 51/100 81/100 ICLR

Percentile Scorecard

DNATMOICLR

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisDNATMOICLR
Valuation 10 #10 of 11 50 #113 of 227 100 #1 of 11
Growth 50 #6 of 11 41 #130 of 219 70 #4 of 11
Profitability 10 #10 of 11 70 #63 of 206 80 #3 of 11
Financial Health 100 #1 of 13 – 75 #4 of 13
Shareholder Returns – 44 #76 of 134 –
Overall 43 51 81
  • DNA ranked among 13 companies in Pharma Services
  • TMO ranked among 247 companies in Medical Devices and Diagnostics
  • ICLR ranked among 13 companies in Pharma Services

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodDNATMOICLRSPY
1 month +5.7%+2.9%+6.2% -0.2%
3 months +46.4%+20.3%+1.5% +3.9%
6 months +43.6%+47.4%+78.5% +8.2%
Year to date +35.6%+19.7%+0.4% +12.9%
1 year -15.8%+23.0%+0.5% +12.3%
3 years -79.1%+60.7%-22.2% +87.4%
3 years, per year -40.7%+17.1%-8.0% +23.3%
5 years -98.0%+11.8%-36.1% +67.9%
5 years, per year -54.4%+2.3%-8.6% +10.9%
10 years —+364.6%+127.4% +261.1%
10 years, per year —+16.6%+8.6% +13.7%

Risk

MeasureDNATMOICLRSPY
Volatility, 1Y 101.5%29.8%73.7% 12.7%
Downside volatility, 1Y 103.1%28.3%87.6% 12.7%
Beta vs S&P 500, 1Y 3.030.621.44 1.00
Return / volatility, 1Y -0.160.770.01 0.97
Max drawdown, 5Y -99.1%-41.5%-76.9% -25.4%
From 52-week high -24.8%-0.5%-9.8% -1.2%
52-week high $14.98$696.55$202.92 $779.14
52-week low $5.48$438.34$80.08 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleDNATMOICLR
P/E now vs peer median -2.4xmedian 32.1x 36.4xmedian 29.6x 32.0xmedian 32.1x
P/S now vs peer median 6.4xmedian 2.6x 5.4xmedian 2.9x 1.7xmedian 2.6x
EV/EBITDA now vs peer median -2.7xmedian 38.1x —median 17.4x 15.2xmedian 38.1x
P/FCF now vs peer median -4.1xmedian 21.5x 34.0xmedian 22.3x 16.3xmedian 21.5x
P/B now vs peer median 1.7xmedian 3.1x 4.7xmedian 2.3x 1.5xmedian 3.1x
PEG now vs peer median 0.02median 2.03 4.80median 1.04 -13.47median 2.03

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsDNATMOICLR
Revenue $111.86M $47.35B $8.23B
Gross profit $92.92M – $1.93B
Operating income -$290.69M $8.47B $718.25M
Net income -$290.80M $7.09B $448.66M
Free cash flow -$174.80M – $857.06M
R&D $215.61M $1.40B –
EPS (diluted) $-5.24 $19.06 $5.68
Cash & equivalents $84.54M $5.46B $808.98M
Total debt – – $3.38B
Shares (diluted) 55.46M 371.00M 78.97M
Enterprise value -$44.06M $256.48B $10.78B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricDNATMOICLR
P/E -2.4x 36.4x 32.0x
P/FCF -4.1x 34.0x 16.3x
P/Operating cash flow -4.2x 27.5x 13.6x
P/S 6.4x 5.4x 1.7x
P/B 1.7x 4.7x 1.5x
P/Tangible book 1.9x 7.0x 2.3x
EV/EBITDA -2.7x – 15.2x
EV/EBIT -2.2x – 23.1x
EV/Revenue 5.7x 5.4x 2.0x
EV/FCF -3.6x – 19.3x
EV/Operating cash flow -3.7x 27.5x 16.1x
PEG (3Y EPS CAGR) 0.02 4.80 -13.47

Growth

14 metrics
MetricDNATMOICLR
Revenue growth (1Y) -46.8% 8.3% 1.8%
Revenue CAGR (3Y) -30.0% 2.9% 0.9%
Gross profit growth (1Y) -49.3% – -13.4%
Gross profit CAGR (3Y) -28.2% – -6.5%
Operating income growth (1Y) 2.4% 12.8% 53.9%
Operating income CAGR (3Y) 39.1% 7.2% -7.0%
Net income growth (1Y) 7.7% 7.9% 55.9%
Net income CAGR (3Y) 38.0% 6.2% -4.4%
EPS growth (1Y) 8.7% 9.7% 30.1%
EPS CAGR (3Y) -102.3% 7.6% -2.4%
Operating cash flow growth (1Y) 28.4% 21.9% -9.9%
Operating cash flow CAGR (3Y) 16.9% 4.5% 15.8%
Free cash flow growth (1Y) 36.2% – -11.1%
Free cash flow CAGR (3Y) 22.1% – 18.4%

Profitability

14 metrics
MetricDNATMOICLR
Gross margin 83.1% – 23.4%
EBITDA margin -211.6% – 13.3%
Operating margin -259.9% – 8.7%
Pretax margin -264.1% – 6.3%
Net margin -260.0% – 5.4%
FCF margin -156.3% – 10.4%
Operating cash flow margin -152.2% 19.7% 12.5%
Return on equity -67.4% 13.2% 7.6%
Return on assets -28.7% 6.2% 4.3%
Return on invested capital – – 4.7%
Return on capital employed -31.0% – 5.3%
Asset turnover 0.1x 0.4x 0.5x
Cash conversion (OCF / net income) 0.6x 1.3x 2.3x
Stock comp / revenue 61.5% – 1.1%

Financial Health

11 metrics
MetricDNATMOICLR
Debt / assets – – 20.8%
Debt / equity – – 0.4x
Net debt / EBITDA – – 2.3x
Debt / FCF – – 3.9x
Liabilities / assets 57.5% – 43.8%
Equity / assets 42.5% 47.9% 56.2%
Interest coverage – – 3.4x
Current ratio 4.6x 1.8x 1.3x
Quick ratio 1.4x – 0.9x
Cash ratio 1.2x – 0.3x
Altman Z-score -8.66 – 2.07

Shareholder Returns

7 metrics
MetricDNATMOICLR
Dividend yield – 0.3% –
Net buyback yield – – 2.7%
Shareholder yield – 0.3% 2.7%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusDNATMOICLR
Forward P/E – 26.8xFY2026 17.9xFY2026
EPS, next fiscal year $-4.06FY2026 $25.91FY2026 $10.25FY2026
EPS growth, next FY – +13.3%FY2026 -18.2%FY2026
EPS growth, the year after – +2.0% +22.2%
Revenue, next fiscal year $88.21MFY2026 $50.12BFY2026 $8.52BFY2026
Revenue growth, next FY -48.2%FY2026 +12.5%FY2026 +3.2%FY2026
Revenue growth, the year after +5.8% -2.8% -3.2%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersDNATMOICLR
Held by institutions 55.2% 90.2% 100.0%
Institutions holding 182 2,622 422
Change in shares held, QoQ +12.3% +0.8% +5.5%
Institutions buying 100 1,142 233
Institutions selling 39 1,144 138
Buyers to sellers 2.56 1.00 1.69

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

DNATMOICLR
DNA 1.00 0.31 0.22
TMO 0.31 1.00 0.46
ICLR 0.22 0.46 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, DNA, TMO and ICLR?

Thermo Fisher Scientific (TMO) is the largest by market capitalisation: Ginkgo Bioworks Holdings (DNA) $718.02M, Thermo Fisher Scientific (TMO) $256.36B, Icon (ICLR) $14.01B.

Which stock is cheaper, DNA, TMO and ICLR?

Icon (ICLR) trades on the lowest price-to-earnings ratio (Ginkgo Bioworks Holdings (DNA) -2.4x, Thermo Fisher Scientific (TMO) 36.4x, Icon (ICLR) 32.0x). On next year's consensus earnings, Icon (ICLR) is cheapest (Thermo Fisher Scientific (TMO) 26.8x, Icon (ICLR) 17.9x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Thermo Fisher Scientific (TMO) grew revenue fastest over the trailing twelve months: Ginkgo Bioworks Holdings (DNA) -46.8%, Thermo Fisher Scientific (TMO) +8.3%, Icon (ICLR) +1.8%.

Which company is more profitable?

Icon (ICLR) has the highest net margin (Ginkgo Bioworks Holdings (DNA) -260.0%, Icon (ICLR) 5.4%).

Which stock has performed better?

Over the past year Thermo Fisher Scientific (TMO) returned the most: Ginkgo Bioworks Holdings (DNA) -15.8%, Thermo Fisher Scientific (TMO) +23.0%, Icon (ICLR) +0.5%. Over five years, Thermo Fisher Scientific (TMO) compounded fastest (Ginkgo Bioworks Holdings (DNA) -54.4%/yr, Thermo Fisher Scientific (TMO) +2.3%/yr, Icon (ICLR) -8.6%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Thermo Fisher Scientific (TMO) 0.27%. Ginkgo Bioworks Holdings (DNA) and Icon (ICLR) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Thermo Fisher Scientific (TMO) has been the steadiest (Ginkgo Bioworks Holdings (DNA) 101.5%, Thermo Fisher Scientific (TMO) 29.8%, Icon (ICLR) 73.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, DNA, TMO and ICLR?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Thermo Fisher Scientific (TMO) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.